GREMLIN Database
Q9HQ85 - Uncharacterized protein
UniProt: Q9HQ85 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 200 (173)
Sequences: 28393 (21496)
Seq/√Len: 1634.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_C69_G3.0061.00
45_T66_R2.9511.00
74_D96_T2.8951.00
133_A180_Y2.7501.00
50_G116_A2.5631.00
80_A94_F2.4711.00
68_V108_A2.3981.00
70_R97_G2.3321.00
68_V95_D2.2321.00
77_L94_F2.2201.00
47_L108_A2.2101.00
57_A67_V2.1291.00
131_T134_G2.0941.00
132_I140_I2.0781.00
77_L96_T2.0421.00
66_R93_A1.9891.00
111_V132_I1.9821.00
103_N108_A1.9431.00
74_D78_T1.9261.00
122_D125_K1.9111.00
49_L99_F1.8941.00
41_G44_D1.8871.00
49_L132_I1.7931.00
58_L84_A1.7831.00
62_A87_R1.7581.00
84_A94_F1.7351.00
79_Q82_E1.7231.00
72_I98_R1.7061.00
13_D73_S1.6781.00
45_T68_V1.6731.00
44_D110_V1.6581.00
116_A120_L1.6101.00
13_D75_G1.5961.00
51_C57_A1.5911.00
123_A174_A1.5691.00
71_D77_L1.5631.00
58_L83_K1.5571.00
172_A176_T1.5431.00
131_T135_L1.5431.00
46_V110_V1.5171.00
68_V93_A1.4981.00
113_S116_A1.4931.00
57_A69_G1.4901.00
97_G102_P1.4701.00
124_E177_D1.4471.00
167_T170_V1.4411.00
40_V44_D1.4381.00
75_G78_T1.4281.00
46_V60_L1.4221.00
173_D177_D1.4041.00
45_T109_D1.3841.00
77_L81_R1.3611.00
118_H144_D1.3211.00
120_L128_A1.3201.00
99_F120_L1.3201.00
95_D103_N1.3181.00
99_F116_A1.3161.00
104_Y107_D1.3121.00
129_I175_F1.2901.00
33_L36_E1.2871.00
45_T108_A1.2821.00
45_T107_D1.2401.00
84_A92_V1.2211.00
130_D178_A1.2211.00
115_F118_H1.2161.00
59_G62_A1.1921.00
124_E130_D1.1831.00
44_D65_G1.1721.00
98_R101_E1.1671.00
115_F119_H1.1641.00
69_G94_F1.1631.00
133_A178_A1.1551.00
27_Y31_V1.1461.00
20_D83_K1.1461.00
27_Y30_C1.1371.00
105_D134_G1.1251.00
20_D53_T1.1191.00
78_T81_R1.1181.00
124_E174_A1.1161.00
61_A91_N1.1161.00
111_V135_L1.1011.00
43_A65_G1.0981.00
48_D51_C1.0851.00
60_L112_V1.0641.00
59_G63_D1.0531.00
71_D76_M1.0471.00
58_L62_A1.0471.00
68_V103_N1.0441.00
51_C80_A1.0211.00
57_A94_F1.0191.00
73_S76_M1.0181.00
172_A185_V1.0141.00
173_D176_T1.0121.00
32_A36_E1.0011.00
47_L111_V0.9881.00
50_G113_S0.9851.00
56_I114_N0.9781.00
56_I112_V0.9721.00
128_A132_I0.9651.00
119_H144_D0.9611.00
35_L63_D0.9591.00
58_L87_R0.9381.00
69_G80_A0.9311.00
18_A21_D0.9131.00
28_N32_A0.9091.00
82_E86_T0.9071.00
170_V173_D0.9001.00
12_F119_H0.9001.00
117_M120_L0.9001.00
33_L37_H0.8971.00
37_H186_E0.8941.00
159_S162_V0.8871.00
82_E85_T0.8801.00
81_R85_T0.8711.00
79_Q83_K0.8711.00
29_E32_A0.8611.00
78_T82_E0.8571.00
54_G80_A0.8571.00
12_F118_H0.8481.00
125_K130_D0.8471.00
23_Q26_E0.8451.00
114_N143_G0.8441.00
57_A92_V0.8431.00
70_R95_D0.8421.00
55_A83_K0.8311.00
103_N135_L0.8311.00
62_A89_V0.8301.00
113_S132_I0.8291.00
32_A59_G0.8231.00
17_A79_Q0.8191.00
110_V139_R0.8171.00
117_M129_I0.8121.00
33_L186_E0.8111.00
44_D109_D0.7961.00
83_K86_T0.7951.00
129_I178_A0.7931.00
51_C77_L0.7891.00
61_A89_V0.7861.00
40_V43_A0.7861.00
47_L135_L0.7851.00
46_V112_V0.7831.00
102_P131_T0.7791.00
55_A59_G0.7771.00
153_P157_F0.7761.00
31_V35_L0.7741.00
168_V172_A0.7731.00
84_A90_D0.7701.00
34_V141_V0.7671.00
100_R125_K0.7651.00
58_L61_A0.7631.00
158_Y161_A0.7601.00
53_T76_M0.7511.00
46_V67_V0.7331.00
100_R128_A0.7321.00
105_D131_T0.7301.00
30_C33_L0.7281.00
108_A135_L0.7281.00
117_M128_A0.7261.00
117_M142_L0.7241.00
103_N107_D0.7161.00
101_E125_K0.7111.00
115_F145_V0.7111.00
83_K87_R0.7081.00
46_V65_G0.7001.00
129_I174_A0.6991.00
47_L70_R0.6991.00
154_D157_F0.6921.00
81_R94_F0.6921.00
124_E178_A0.6911.00
45_T65_G0.6901.00
115_F143_G0.6851.00
64_A67_V0.6851.00
28_N31_V0.6811.00
113_S142_L0.6811.00
49_L111_V0.6801.00
81_R93_A0.6771.00
51_C71_D0.6731.00
32_A63_D0.6721.00
37_H184_A0.6721.00
182_V185_V0.6701.00
48_D112_V0.6651.00
129_I171_L0.6621.00
140_I180_Y0.6621.00
81_R84_A0.6611.00
174_A178_A0.6601.00
105_D135_L0.6591.00
113_S120_L0.6561.00
84_A89_V0.6481.00
72_I96_T0.6481.00
75_G79_Q0.6451.00
31_V34_V0.6421.00
56_I59_G0.6401.00
74_D81_R0.6391.00
100_R122_D0.6311.00
174_A177_D0.6311.00
163_D166_A0.6301.00
130_D134_G0.6291.00
54_G94_F0.6291.00
20_D79_Q0.6281.00
150_G153_P0.6261.00
101_E131_T0.6261.00
30_C34_V0.6221.00
58_L89_V0.6111.00
22_D26_E0.6081.00
85_T90_D0.6071.00
51_C94_F0.6061.00
15_V18_A0.6001.00
16_A20_D0.5951.00
140_I175_F0.5941.00
50_G72_I0.5931.00
53_T83_K0.5891.00
89_V92_V0.5891.00
61_A92_V0.5821.00
118_H145_V0.5821.00
45_T106_G0.5791.00
72_I99_F0.5721.00
139_R142_L0.5691.00
49_L70_R0.5641.00
31_V56_I0.5611.00
48_D70_R0.5581.00
107_D135_L0.5571.00
39_D139_R0.5561.00
114_N118_H0.5551.00
106_G136_N0.5531.00
57_A61_A0.5531.00
175_F178_A0.5531.00
100_R120_L0.5501.00
13_D74_D0.5491.00
12_F15_V0.5481.00
142_L175_F0.5461.00
58_L94_F0.5461.00
40_V65_G0.5451.00
35_L38_A0.5451.00
147_L167_T0.5441.00
27_Y34_V0.5431.00
110_V141_V0.5401.00
36_E63_D0.5391.00
44_D139_R0.5371.00
102_P135_L0.5351.00
113_S140_I0.5321.00
169_G172_A0.5281.00
22_D25_P0.5281.00
153_P156_P0.5271.00
146_M150_G0.5271.00
130_D133_A0.5261.00
158_Y162_V0.5231.00
53_T79_Q0.5191.00
24_T27_Y0.5191.00
85_T88_G0.5141.00
56_I60_L0.5141.00
169_G173_D0.5121.00
176_T182_V0.5101.00
176_T183_T0.5091.00
84_A88_G0.5091.00
151_P155_A0.5091.00
41_G65_G0.5071.00
146_M149_G0.5051.00
56_I118_H0.5041.00
132_I135_L0.5001.00
34_V38_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4obxA 2 0.925 100 0.341 Contact Map
4pneA 2 0.98 100 0.362 Contact Map
2o57A 2 0.985 100 0.367 Contact Map
3busA 1 0.885 100 0.392 Contact Map
3ou2A 1 0.93 100 0.396 Contact Map
2fk8A 1 0.955 100 0.398 Contact Map
2p7iA 6 0.86 100 0.399 Contact Map
4kdcA 1 0.915 99.9 0.401 Contact Map
3bkxA 2 0.955 99.9 0.402 Contact Map
3hemA 2 0.965 99.9 0.408 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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