Q9HQ85 - HALSA - GREMLIN Contacts

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Q9HQ85 - Uncharacterized protein

UniProt:	Q9HQ85	Sequences: MKKTLEEHAARFDDVAAAYDDDQTPEYNECVALVLEHADVGGADTVLDLGCGTGAIALGLAADAGRVVGRDISDGMLTQAREKATTRGVDNVAFDTGRFREPNYDGDADVVVSNFAMHHLSDAEKRSAIDTIAGLNPHRIVLGDVMLFGGPNPDAPFYSPAVDDPATVGVLADAFTDAGYAVTAVEMVHEQVGVLVAETR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	200 (173)
Sequences:	28393 (21496)
Seq/√Len:	1634.3

ECOLI - UBIE UBIG CMOA SMTA YJHP BIOC TEHB TAM YAFE CMOB RLMA CFA
BACSU - MENG YCGJ YRRT YXBB YBAJ YRHH YODH YDAC YQEM YXJB
HALSA - Q9HQ85 Q9HR81 Q9HND6 Q9HMT2 ARSM Q9HR63 Q9HRX3 Q9HSK6
SULSO - Q7LXN7 Q97X57 Q97WT7 Q97WN4 Q97YX4 Q97XD7 Q97ZU8 Q97WH3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
51_C	69_G	3.006	1.00
45_T	66_R	2.951	1.00
74_D	96_T	2.895	1.00
133_A	180_Y	2.750	1.00
50_G	116_A	2.563	1.00
80_A	94_F	2.471	1.00
68_V	108_A	2.398	1.00
70_R	97_G	2.332	1.00
68_V	95_D	2.232	1.00
77_L	94_F	2.220	1.00
47_L	108_A	2.210	1.00
57_A	67_V	2.129	1.00
131_T	134_G	2.094	1.00
132_I	140_I	2.078	1.00
77_L	96_T	2.042	1.00
66_R	93_A	1.989	1.00
111_V	132_I	1.982	1.00
103_N	108_A	1.943	1.00
74_D	78_T	1.926	1.00
122_D	125_K	1.911	1.00
49_L	99_F	1.894	1.00
41_G	44_D	1.887	1.00
49_L	132_I	1.793	1.00
58_L	84_A	1.783	1.00
62_A	87_R	1.758	1.00
84_A	94_F	1.735	1.00
79_Q	82_E	1.723	1.00
72_I	98_R	1.706	1.00
13_D	73_S	1.678	1.00
45_T	68_V	1.673	1.00
44_D	110_V	1.658	1.00
116_A	120_L	1.610	1.00
13_D	75_G	1.596	1.00
51_C	57_A	1.591	1.00
123_A	174_A	1.569	1.00
71_D	77_L	1.563	1.00
58_L	83_K	1.557	1.00
172_A	176_T	1.543	1.00
131_T	135_L	1.543	1.00
46_V	110_V	1.517	1.00
68_V	93_A	1.498	1.00
113_S	116_A	1.493	1.00
57_A	69_G	1.490	1.00
97_G	102_P	1.470	1.00
124_E	177_D	1.447	1.00
167_T	170_V	1.441	1.00
40_V	44_D	1.438	1.00
75_G	78_T	1.428	1.00
46_V	60_L	1.422	1.00
173_D	177_D	1.404	1.00
45_T	109_D	1.384	1.00
77_L	81_R	1.361	1.00
118_H	144_D	1.321	1.00
120_L	128_A	1.320	1.00
99_F	120_L	1.320	1.00
95_D	103_N	1.318	1.00
99_F	116_A	1.316	1.00
104_Y	107_D	1.312	1.00
129_I	175_F	1.290	1.00
33_L	36_E	1.287	1.00
45_T	108_A	1.282	1.00
45_T	107_D	1.240	1.00
84_A	92_V	1.221	1.00
130_D	178_A	1.221	1.00
115_F	118_H	1.216	1.00
59_G	62_A	1.192	1.00
124_E	130_D	1.183	1.00
44_D	65_G	1.172	1.00
98_R	101_E	1.167	1.00
115_F	119_H	1.164	1.00
69_G	94_F	1.163	1.00
133_A	178_A	1.155	1.00
27_Y	31_V	1.146	1.00
20_D	83_K	1.146	1.00
27_Y	30_C	1.137	1.00
105_D	134_G	1.125	1.00
20_D	53_T	1.119	1.00
78_T	81_R	1.118	1.00
124_E	174_A	1.116	1.00
61_A	91_N	1.116	1.00
111_V	135_L	1.101	1.00
43_A	65_G	1.098	1.00
48_D	51_C	1.085	1.00
60_L	112_V	1.064	1.00
59_G	63_D	1.053	1.00
71_D	76_M	1.047	1.00
58_L	62_A	1.047	1.00
68_V	103_N	1.044	1.00
51_C	80_A	1.021	1.00
57_A	94_F	1.019	1.00
73_S	76_M	1.018	1.00
172_A	185_V	1.014	1.00
173_D	176_T	1.012	1.00
32_A	36_E	1.001	1.00
47_L	111_V	0.988	1.00
50_G	113_S	0.985	1.00
56_I	114_N	0.978	1.00
56_I	112_V	0.972	1.00
128_A	132_I	0.965	1.00
119_H	144_D	0.961	1.00
35_L	63_D	0.959	1.00
58_L	87_R	0.938	1.00
69_G	80_A	0.931	1.00
18_A	21_D	0.913	1.00
28_N	32_A	0.909	1.00
82_E	86_T	0.907	1.00
170_V	173_D	0.900	1.00
12_F	119_H	0.900	1.00
117_M	120_L	0.900	1.00
33_L	37_H	0.897	1.00
37_H	186_E	0.894	1.00
159_S	162_V	0.887	1.00
82_E	85_T	0.880	1.00
81_R	85_T	0.871	1.00
79_Q	83_K	0.871	1.00
29_E	32_A	0.861	1.00
78_T	82_E	0.857	1.00
54_G	80_A	0.857	1.00
12_F	118_H	0.848	1.00
125_K	130_D	0.847	1.00
23_Q	26_E	0.845	1.00
114_N	143_G	0.844	1.00
57_A	92_V	0.843	1.00
70_R	95_D	0.842	1.00
55_A	83_K	0.831	1.00
103_N	135_L	0.831	1.00
62_A	89_V	0.830	1.00
113_S	132_I	0.829	1.00
32_A	59_G	0.823	1.00
17_A	79_Q	0.819	1.00
110_V	139_R	0.817	1.00
117_M	129_I	0.812	1.00
33_L	186_E	0.811	1.00
44_D	109_D	0.796	1.00
83_K	86_T	0.795	1.00
129_I	178_A	0.793	1.00
51_C	77_L	0.789	1.00
61_A	89_V	0.786	1.00
40_V	43_A	0.786	1.00
47_L	135_L	0.785	1.00
46_V	112_V	0.783	1.00
102_P	131_T	0.779	1.00
55_A	59_G	0.777	1.00
153_P	157_F	0.776	1.00
31_V	35_L	0.774	1.00
168_V	172_A	0.773	1.00
84_A	90_D	0.770	1.00
34_V	141_V	0.767	1.00
100_R	125_K	0.765	1.00
58_L	61_A	0.763	1.00
158_Y	161_A	0.760	1.00
53_T	76_M	0.751	1.00
46_V	67_V	0.733	1.00
100_R	128_A	0.732	1.00
105_D	131_T	0.730	1.00
30_C	33_L	0.728	1.00
108_A	135_L	0.728	1.00
117_M	128_A	0.726	1.00
117_M	142_L	0.724	1.00
103_N	107_D	0.716	1.00
101_E	125_K	0.711	1.00
115_F	145_V	0.711	1.00
83_K	87_R	0.708	1.00
46_V	65_G	0.700	1.00
129_I	174_A	0.699	1.00
47_L	70_R	0.699	1.00
154_D	157_F	0.692	1.00
81_R	94_F	0.692	1.00
124_E	178_A	0.691	1.00
45_T	65_G	0.690	1.00
115_F	143_G	0.685	1.00
64_A	67_V	0.685	1.00
28_N	31_V	0.681	1.00
113_S	142_L	0.681	1.00
49_L	111_V	0.680	1.00
81_R	93_A	0.677	1.00
51_C	71_D	0.673	1.00
32_A	63_D	0.672	1.00
37_H	184_A	0.672	1.00
182_V	185_V	0.670	1.00
48_D	112_V	0.665	1.00
129_I	171_L	0.662	1.00
140_I	180_Y	0.662	1.00
81_R	84_A	0.661	1.00
174_A	178_A	0.660	1.00
105_D	135_L	0.659	1.00
113_S	120_L	0.656	1.00
84_A	89_V	0.648	1.00
72_I	96_T	0.648	1.00
75_G	79_Q	0.645	1.00
31_V	34_V	0.642	1.00
56_I	59_G	0.640	1.00
74_D	81_R	0.639	1.00
100_R	122_D	0.631	1.00
174_A	177_D	0.631	1.00
163_D	166_A	0.630	1.00
130_D	134_G	0.629	1.00
54_G	94_F	0.629	1.00
20_D	79_Q	0.628	1.00
150_G	153_P	0.626	1.00
101_E	131_T	0.626	1.00
30_C	34_V	0.622	1.00
58_L	89_V	0.611	1.00
22_D	26_E	0.608	1.00
85_T	90_D	0.607	1.00
51_C	94_F	0.606	1.00
15_V	18_A	0.600	1.00
16_A	20_D	0.595	1.00
140_I	175_F	0.594	1.00
50_G	72_I	0.593	1.00
53_T	83_K	0.589	1.00
89_V	92_V	0.589	1.00
61_A	92_V	0.582	1.00
118_H	145_V	0.582	1.00
45_T	106_G	0.579	1.00
72_I	99_F	0.572	1.00
139_R	142_L	0.569	1.00
49_L	70_R	0.564	1.00
31_V	56_I	0.561	1.00
48_D	70_R	0.558	1.00
107_D	135_L	0.557	1.00
39_D	139_R	0.556	1.00
114_N	118_H	0.555	1.00
106_G	136_N	0.553	1.00
57_A	61_A	0.553	1.00
175_F	178_A	0.553	1.00
100_R	120_L	0.550	1.00
13_D	74_D	0.549	1.00
12_F	15_V	0.548	1.00
142_L	175_F	0.546	1.00
58_L	94_F	0.546	1.00
40_V	65_G	0.545	1.00
35_L	38_A	0.545	1.00
147_L	167_T	0.544	1.00
27_Y	34_V	0.543	1.00
110_V	141_V	0.540	1.00
36_E	63_D	0.539	1.00
44_D	139_R	0.537	1.00
102_P	135_L	0.535	1.00
113_S	140_I	0.532	1.00
169_G	172_A	0.528	1.00
22_D	25_P	0.528	1.00
153_P	156_P	0.527	1.00
146_M	150_G	0.527	1.00
130_D	133_A	0.526	1.00
158_Y	162_V	0.523	1.00
53_T	79_Q	0.519	1.00
24_T	27_Y	0.519	1.00
85_T	88_G	0.514	1.00
56_I	60_L	0.514	1.00
169_G	173_D	0.512	1.00
176_T	182_V	0.510	1.00
176_T	183_T	0.509	1.00
84_A	88_G	0.509	1.00
151_P	155_A	0.509	1.00
41_G	65_G	0.507	1.00
146_M	149_G	0.505	1.00
56_I	118_H	0.504	1.00
132_I	135_L	0.500	1.00
34_V	38_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4obxA	2	0.925	100	0.341	Contact Map
4pneA	2	0.98	100	0.362	Contact Map
2o57A	2	0.985	100	0.367	Contact Map
3busA	1	0.885	100	0.392	Contact Map
3ou2A	1	0.93	100	0.396	Contact Map
2fk8A	1	0.955	100	0.398	Contact Map
2p7iA	6	0.86	100	0.399	Contact Map
4kdcA	1	0.915	99.9	0.401	Contact Map
3bkxA	2	0.955	99.9	0.402	Contact Map
3hemA	2	0.965	99.9	0.408	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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