GREMLIN Database
Q9HQ84 - Uncharacterized protein
UniProt: Q9HQ84 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 126 (116)
Sequences: 130 (89)
Seq/√Len: 8.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_V22_L5.8321.00
52_E89_Q4.1400.98
21_R96_E3.2970.93
21_R100_L2.8370.85
19_G100_L2.5780.79
107_R118_K2.2480.69
48_R85_F2.1740.66
22_L83_I2.1280.64
79_V91_R1.9830.58
4_G75_E1.9670.58
15_A66_S1.9410.57
17_T63_R1.8880.55
86_T100_L1.8840.54
86_T89_Q1.8790.54
24_F51_V1.8270.52
79_V85_F1.7880.50
96_E100_L1.7460.49
35_G38_V1.6830.46
18_H72_S1.6610.45
73_P80_G1.6530.45
61_S73_P1.6100.43
39_Q92_A1.6000.43
50_L119_R1.5810.42
69_H77_V1.4780.38
17_T86_T1.4200.35
110_A113_I1.4190.35
79_V95_R1.4030.35
47_L51_V1.3800.34
18_H26_F1.3720.34
57_P94_L1.3220.32
24_F94_L1.3100.31
41_L49_E1.3090.31
25_D50_L1.2570.29
86_T90_V1.2480.29
23_E61_S1.2300.29
39_Q89_Q1.1970.27
16_R42_R1.1880.27
96_E99_H1.1590.26
17_T65_A1.1330.25
6_D53_H1.1020.24
20_V94_L1.0850.24
53_H90_V1.0840.24
24_F38_V1.0830.24
58_F93_G1.0640.23
30_L83_I1.0550.23
30_L82_E1.0480.23
19_G45_R1.0370.22
53_H100_L1.0330.22
9_H23_E1.0270.22
23_E112_F1.0250.22
56_A79_V1.0230.22
60_V93_G1.0200.22
8_N45_R1.0000.21
54_Y58_F0.9900.21
42_R54_Y0.9800.21
25_D63_R0.9720.21
21_R64_P0.9590.20
22_L47_L0.9460.20
99_H118_K0.9440.20
13_K54_Y0.9400.20
61_S90_V0.9390.20
63_R110_A0.9380.20
31_R45_R0.9260.19
16_R41_L0.9240.19
111_E114_A0.9230.19
14_A104_N0.9210.19
16_R50_L0.9180.19
41_L94_L0.9160.19
77_V85_F0.9030.19
71_R79_V0.8940.19
52_E95_R0.8840.18
66_S86_T0.8830.18
85_F95_R0.8800.18
36_D86_T0.8780.18
75_E82_E0.8730.18
42_R91_R0.8710.18
83_I89_Q0.8630.18
56_A94_L0.8620.18
34_G59_V0.8550.18
15_A37_R0.8430.17
32_A65_A0.8240.17
40_A94_L0.8220.17
46_K56_A0.8200.17
24_F35_G0.8190.17
8_N54_Y0.8190.17
61_S103_R0.8000.16
7_V16_R0.7960.16
39_Q90_V0.7960.16
28_G86_T0.7940.16
30_L76_L0.7880.16
19_G61_S0.7870.16
11_I42_R0.7850.16
29_V55_D0.7820.16
25_D58_F0.7790.16
48_R51_V0.7730.16
34_G78_A0.7720.16
50_L63_R0.7580.15
29_V117_V0.7510.15
75_E119_R0.7500.15
69_H89_Q0.7480.15
12_V69_H0.7390.15
16_R19_G0.7370.15
36_D69_H0.7370.15
26_F94_L0.7350.15
8_N113_I0.7340.15
67_H104_N0.7280.15
41_L82_E0.7260.15
25_D113_I0.7230.15
75_E112_F0.7190.15
52_E83_I0.7150.14
7_V43_G0.7070.14
33_S41_L0.7060.14
13_K19_G0.7040.14
29_V56_A0.7030.14
17_T34_G0.7010.14
106_R118_K0.6990.14
11_I118_K0.6950.14
5_G49_E0.6950.14
64_P96_E0.6850.14
112_F120_G0.6850.14
26_F30_L0.6840.14
26_F107_R0.6830.14
110_A119_R0.6820.14
54_Y69_H0.6700.14
9_H68_L0.6670.14
13_K69_H0.6630.13
100_L107_R0.6620.13
8_N64_P0.6550.13
16_R118_K0.6540.13
44_L81_A0.6500.13
15_A47_L0.6500.13
59_V76_L0.6450.13
47_L59_V0.6430.13
57_P72_S0.6410.13
29_V53_H0.6360.13
55_D100_L0.6340.13
41_L73_P0.6340.13
59_V93_G0.6300.13
8_N18_H0.6260.13
65_A87_D0.6250.13
35_G58_F0.6250.13
22_L118_K0.6230.13
10_V94_L0.6120.12
15_A22_L0.6080.12
58_F111_E0.6050.12
24_F73_P0.6000.12
28_G111_E0.5970.12
33_S63_R0.5950.12
10_V40_A0.5910.12
13_K36_D0.5690.12
31_R62_G0.5670.12
53_H83_I0.5660.12
4_G73_P0.5650.12
21_R99_H0.5630.12
4_G119_R0.5590.12
76_L80_G0.5550.11
45_R57_P0.5530.11
15_A78_A0.5470.11
33_S82_E0.5450.11
22_L53_H0.5440.11
22_L94_L0.5420.11
55_D102_A0.5420.11
4_G53_H0.5350.11
24_F58_F0.5290.11
92_A113_I0.5290.11
56_A67_H0.5280.11
3_D90_V0.5210.11
92_A118_K0.5180.11
12_V70_V0.5140.11
3_D22_L0.5110.11
21_R53_H0.5080.11
8_N29_V0.5080.11
32_A79_V0.5070.11
94_L115_P0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v77A 1 0.8095 99.4 0.715 Contact Map
1m65A 3 0.7778 97.3 0.845 Contact Map
3b0xA 1 0.7778 97 0.853 Contact Map
2w9mA 1 0.7778 96.3 0.865 Contact Map
2wjeA 1 0.8016 87.6 0.9 Contact Map
2yxoA 3 0.7778 82.9 0.907 Contact Map
4gc3A 1 0.7302 81.8 0.908 Contact Map
2anuA 5 0.6429 79 0.91 Contact Map
3qy7A 1 0.8254 78.6 0.91 Contact Map
3dcpA 1 0.619 74.5 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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