GREMLIN Database
Q9HQ83 - TRK potassium uptake system protein
UniProt: Q9HQ83 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 222 (207)
Sequences: 8785 (6232)
Seq/√Len: 433.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_A57_T3.7001.00
152_V196_I3.6941.00
183_R200_D3.4791.00
6_V52_A3.2701.00
69_I86_A3.2571.00
4_I66_A3.0761.00
181_I194_T2.7551.00
52_A82_V2.6721.00
33_P49_N2.6521.00
183_R197_H2.6381.00
164_Q193_E2.5481.00
5_V16_I2.4201.00
83_M112_V2.4091.00
162_T165_D2.3251.00
154_E198_A2.2281.00
207_K210_V2.2261.00
59_V64_E2.1881.00
36_A47_V2.0821.00
167_D172_L2.0551.00
161_Q165_D1.9871.00
183_R194_T1.9431.00
62_G65_K1.9161.00
30_E36_A1.9111.00
104_M117_N1.9101.00
163_L178_V1.8761.00
6_V69_I1.8641.00
162_T195_T1.8501.00
83_M96_S1.8391.00
87_D94_K1.8281.00
69_I82_V1.8281.00
33_P37_D1.8081.00
87_D113_N1.7771.00
175_D210_V1.7711.00
9_G12_G1.7631.00
160_E197_H1.7471.00
4_I69_I1.7471.00
20_T45_C1.7211.00
159_A198_A1.6681.00
71_T86_A1.6401.00
4_I63_S1.6391.00
8_A28_V1.6191.00
35_V38_Q1.5991.00
15_V70_I1.5631.00
61_A66_A1.5571.00
160_E198_A1.5311.00
164_Q192_G1.5261.00
71_T79_N1.4881.00
8_A39_V1.4831.00
30_E47_V1.4611.00
93_S113_N1.4541.00
158_L166_A1.4281.00
55_K59_V1.4261.00
59_V89_L1.4261.00
83_M94_K1.4211.00
149_E201_L1.4111.00
88_E109_R1.4061.00
6_V82_V1.3591.00
149_E203_T1.3541.00
50_A61_A1.3491.00
178_V204_A1.3471.00
48_L61_A1.3271.00
191_R194_T1.3221.00
28_V44_D1.3111.00
13_S39_V1.2741.00
9_G97_V1.2731.00
56_D59_V1.2701.00
71_T83_M1.2651.00
12_G72_T1.2411.00
196_I202_I1.2211.00
27_V66_A1.2161.00
32_D35_V1.2131.00
3_I68_A1.1971.00
197_H200_D1.1711.00
181_I200_D1.1661.00
104_M108_R1.1501.00
73_T82_V1.1451.00
96_S112_V1.1291.00
206_S211_T1.1291.00
123_G127_V1.1081.00
176_V206_S1.1071.00
151_T199_G1.1061.00
151_T201_L1.1041.00
39_V47_V1.1031.00
210_V213_S1.0991.00
48_L57_T1.0861.00
16_I28_V1.0851.00
78_T82_V1.0841.00
15_V123_G1.0791.00
6_V29_I1.0781.00
15_V72_T1.0671.00
8_A36_A1.0641.00
159_A197_H1.0571.00
56_D60_D1.0561.00
57_T61_A1.0461.00
55_K85_L1.0411.00
93_S114_V1.0381.00
73_T78_T1.0211.00
12_G30_E1.0081.00
146_E208_H1.0081.00
17_Q43_Y1.0051.00
29_I50_A1.0051.00
145_A205_F0.9971.00
152_V159_A0.9951.00
29_I61_A0.9891.00
180_A187_V0.9831.00
174_D210_V0.9801.00
94_K113_N0.9681.00
63_S90_D0.9671.00
8_A30_E0.9541.00
101_P120_R0.9541.00
206_S210_V0.9501.00
29_I57_T0.9331.00
44_D47_V0.9311.00
16_I43_Y0.9291.00
150_I204_A0.9291.00
11_I97_V0.9131.00
190_P194_T0.8981.00
3_I24_N0.8961.00
166_A196_I0.8951.00
69_I91_I0.8821.00
68_A95_V0.8751.00
24_N67_D0.8721.00
9_G30_E0.8611.00
37_D41_R0.8601.00
4_I61_A0.8601.00
73_T79_N0.8591.00
75_R78_T0.8581.00
14_Q17_Q0.8581.00
20_T26_I0.8571.00
30_E49_N0.8561.00
121_L125_Y0.8511.00
204_A214_V0.8471.00
87_D111_G0.8431.00
164_Q191_R0.8411.00
98_V107_F0.8411.00
5_V12_G0.8371.00
8_A13_S0.8371.00
160_E195_T0.8361.00
20_T43_Y0.8331.00
34_D38_Q0.8321.00
182_E201_L0.8311.00
13_S17_Q0.8301.00
162_T193_E0.8231.00
34_D37_D0.8231.00
211_T215_M0.8181.00
180_A203_T0.8181.00
27_V61_A0.8121.00
163_L190_P0.8111.00
161_Q166_A0.8091.00
24_N131_Q0.8071.00
63_S89_L0.8031.00
13_S43_Y0.8011.00
58_L63_S0.7971.00
26_I45_C0.7961.00
12_G16_I0.7931.00
5_V28_V0.7891.00
104_M120_R0.7861.00
158_L214_V0.7851.00
162_T166_A0.7851.00
94_K112_V0.7841.00
77_P81_M0.7831.00
58_L89_L0.7801.00
63_S66_A0.7771.00
72_T97_V0.7761.00
5_V26_I0.7751.00
30_E35_V0.7731.00
132_R135_I0.7731.00
177_L192_G0.7671.00
12_G97_V0.7651.00
189_T192_G0.7551.00
20_T44_D0.7521.00
184_G197_H0.7491.00
179_V205_F0.7481.00
28_V39_V0.7481.00
55_K89_L0.7471.00
188_I194_T0.7461.00
68_A93_S0.7441.00
183_R186_D0.7421.00
28_V45_C0.7401.00
14_Q18_L0.7381.00
40_S47_V0.7381.00
167_D173_G0.7371.00
176_V214_V0.7351.00
4_I27_V0.7331.00
86_A90_D0.7301.00
183_R188_I0.7261.00
9_G52_A0.7241.00
27_V48_L0.7141.00
125_Y129_A0.7141.00
5_V15_V0.7121.00
84_L88_E0.7111.00
84_L121_L0.7101.00
165_D195_T0.6981.00
3_I19_L0.6941.00
175_D207_K0.6901.00
58_L61_A0.6901.00
153_T198_A0.6881.00
213_S216_Q0.6841.00
144_E207_K0.6791.00
120_R124_E0.6781.00
29_I48_L0.6781.00
66_A69_I0.6771.00
54_A57_T0.6771.00
39_V44_D0.6751.00
163_L192_G0.6751.00
19_L26_I0.6701.00
27_V46_L0.6671.00
84_L110_I0.6661.00
187_V194_T0.6641.00
79_N103_N0.6641.00
212_S215_M0.6631.00
194_T197_H0.6581.00
101_P104_M0.6570.99
31_T51_D0.6570.99
59_V63_S0.6570.99
112_V115_L0.6560.99
14_Q123_G0.6530.99
106_L109_R0.6530.99
18_L21_K0.6500.99
12_G52_A0.6480.99
79_N96_S0.6450.99
108_R114_V0.6450.99
39_V43_Y0.6430.99
85_L89_L0.6420.99
76_D79_N0.6390.99
53_T78_T0.6350.99
173_G176_V0.6350.99
17_Q21_K0.6340.99
147_V179_V0.6300.99
18_L123_G0.6220.99
114_V129_A0.6210.99
121_L124_E0.6180.99
77_P100_D0.6170.99
11_I103_N0.6160.99
36_A40_S0.6100.99
8_A12_G0.6090.99
80_I107_F0.6090.99
36_A49_N0.6050.99
82_V86_A0.6010.99
9_G73_T0.6010.99
37_D40_S0.6000.99
182_E203_T0.6000.99
13_S35_V0.5990.99
11_I72_T0.5950.99
18_L22_S0.5940.99
142_G145_A0.5940.99
182_E187_V0.5940.99
127_V130_V0.5910.99
55_K88_E0.5910.99
16_I26_I0.5900.99
39_V45_C0.5900.99
69_I94_K0.5880.99
135_I141_L0.5860.99
181_I188_I0.5840.99
3_I70_I0.5840.99
63_S69_I0.5800.99
4_I50_A0.5770.99
54_A102_D0.5760.99
88_E105_E0.5760.99
71_T94_K0.5730.99
100_D103_N0.5700.99
51_D54_A0.5680.99
99_Q119_Q0.5670.99
98_V117_N0.5660.99
17_Q20_T0.5660.99
146_E204_A0.5660.99
59_V62_G0.5590.98
28_V36_A0.5590.98
13_S38_Q0.5580.98
11_I119_Q0.5540.98
58_L86_A0.5540.98
132_R137_D0.5540.98
77_P103_N0.5510.98
140_T146_E0.5490.98
125_Y128_R0.5490.98
102_D105_E0.5490.98
46_L49_N0.5470.98
87_D91_I0.5440.98
204_A211_T0.5430.98
16_I45_C0.5410.98
63_S86_A0.5410.98
185_D201_L0.5410.98
77_P80_I0.5400.98
6_V71_T0.5360.98
76_D122_I0.5350.98
183_R199_G0.5350.98
163_L196_I0.5340.98
124_E127_V0.5270.98
149_E182_E0.5260.98
15_V81_M0.5250.98
75_R99_Q0.5240.98
6_V86_A0.5240.98
30_E52_A0.5230.98
71_T82_V0.5210.97
30_E118_P0.5180.97
40_S48_L0.5180.97
117_N120_R0.5120.97
158_L196_I0.5120.97
31_T34_D0.5120.97
52_A58_L0.5120.97
161_Q167_D0.5110.97
7_G12_G0.5110.97
76_D99_Q0.5100.97
8_A16_I0.5080.97
148_F206_S0.5070.97
166_A173_G0.5060.97
105_E109_R0.5050.97
165_D193_E0.5000.97
154_E159_A0.5000.97
3_I67_D0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g65A 2 0.9775 100 0.214 Contact Map
4gx0A 3 0.9414 100 0.233 Contact Map
2aefA 2 0.973 100 0.246 Contact Map
1lnqA 6 0.964 100 0.254 Contact Map
3l4bC 2 0.9685 100 0.282 Contact Map
3mt5A 5 0.9595 100 0.299 Contact Map
3nafA 3 0.9775 100 0.317 Contact Map
4hpfA 3 0.9279 100 0.341 Contact Map
4j91A 3 0.9595 100 0.358 Contact Map
3l9wA 2 0.7883 99.9 0.529 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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