GREMLIN Database
Q9HQ81 - TRK potassium uptake system protein
UniProt: Q9HQ81 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 537 (381)
Sequences: 5053 (3728)
Seq/√Len: 191.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
387_A393_V4.1741.00
458_A511_N4.0901.00
129_N505_K3.6071.00
268_I349_L3.4141.00
128_L506_A3.3301.00
222_I236_I3.3261.00
225_L267_L3.2991.00
221_S270_V3.0601.00
165_W218_T2.9571.00
461_V507_M2.8841.00
228_A260_S2.6931.00
253_N257_T2.6041.00
251_T257_T2.5801.00
365_G370_G2.5671.00
228_A262_A2.5291.00
164_E241_T2.4851.00
161_S237_N2.4571.00
474_T477_N2.4451.00
131_F509_L2.3951.00
224_L266_A2.3721.00
340_T343_Q2.3581.00
388_A398_L2.2981.00
462_F504_T2.2311.00
226_W232_M2.2171.00
157_Q233_W2.1891.00
135_M509_L2.1671.00
228_A266_A2.1571.00
241_T361_F2.1221.00
154_H158_W2.1001.00
355_A379_V2.0981.00
459_A479_L2.0851.00
228_A263_I2.0751.00
128_L509_L2.0711.00
238_H249_S2.0541.00
264_D346_R2.0441.00
222_I232_M2.0441.00
264_D347_Y2.0241.00
125_Q151_A1.9861.00
275_S357_S1.9841.00
147_D150_A1.9711.00
268_I353_V1.9091.00
155_T159_W1.9071.00
404_L448_T1.8591.00
126_N129_N1.8501.00
243_L274_G1.8471.00
255_I267_L1.8381.00
275_S301_V1.8351.00
128_L502_T1.8051.00
342_F346_R1.8031.00
226_W235_A1.7611.00
261_A346_R1.7611.00
455_L483_A1.7471.00
365_G369_S1.7361.00
272_V353_V1.7281.00
265_F269_P1.7251.00
144_T148_N1.7241.00
481_E496_T1.7131.00
224_L262_A1.7011.00
380_A483_A1.6971.00
262_A266_A1.6971.00
403_T432_L1.6871.00
458_A507_M1.6511.00
264_D363_T1.6511.00
484_S489_V1.6451.00
265_F346_R1.6421.00
461_V503_V1.6201.00
148_N151_A1.6191.00
125_Q152_L1.6051.00
409_L413_R1.5761.00
358_C489_V1.5721.00
135_M513_W1.5611.00
455_L486_Q1.5441.00
222_I239_A1.5401.00
385_V398_L1.5331.00
396_I401_L1.5291.00
265_F342_F1.5281.00
136_S248_F1.5251.00
242_G267_L1.5071.00
237_N250_I1.4961.00
208_R212_W1.4941.00
271_M354_S1.4791.00
471_D501_P1.4781.00
230_M263_I1.4671.00
224_L228_A1.4631.00
234_D251_T1.4601.00
271_M359_T1.4441.00
164_E246_G1.4441.00
313_T317_L1.4411.00
477_N493_S1.4401.00
251_T258_Y1.4391.00
157_Q161_S1.4371.00
133_E145_M1.4371.00
127_P131_F1.4341.00
259_G347_Y1.4241.00
506_A510_F1.4221.00
265_F349_L1.4201.00
149_E252_D1.4081.00
310_A314_A1.3991.00
352_F355_A1.3991.00
473_Y495_I1.3961.00
131_F506_A1.3921.00
492_S496_T1.3921.00
309_T313_T1.3881.00
459_A482_V1.3871.00
458_A482_V1.3831.00
269_P273_L1.3791.00
366_A379_V1.3731.00
128_L505_K1.3671.00
403_T437_A1.3621.00
314_A317_L1.3521.00
451_W486_Q1.3421.00
230_M234_D1.3421.00
380_A479_L1.3391.00
424_T431_A1.3251.00
90_F163_I1.3161.00
238_H250_I1.3031.00
232_M236_I1.3021.00
148_N252_D1.2931.00
204_V208_R1.2921.00
311_L315_V1.2921.00
506_A509_L1.2861.00
137_G248_F1.2811.00
265_F345_V1.2801.00
225_L263_I1.2781.00
134_S163_I1.2771.00
381_F385_V1.2771.00
376_Q493_S1.2721.00
253_N256_A1.2671.00
473_Y478_V1.2631.00
351_Q363_T1.2611.00
154_H233_W1.2541.00
272_V302_F1.2501.00
495_I499_G1.2481.00
300_W402_L1.2331.00
147_D252_D1.2291.00
221_S239_A1.2261.00
131_F135_M1.2221.00
312_L402_L1.2221.00
226_W231_P1.2191.00
343_Q347_Y1.2151.00
317_L353_V1.2151.00
366_A371_W1.2141.00
242_G361_F1.2111.00
261_A264_D1.2021.00
500_M508_F1.1951.00
283_L303_G1.1911.00
510_F514_I1.1891.00
242_G270_V1.1771.00
384_V455_L1.1681.00
347_Y351_Q1.1661.00
256_A362_Q1.1631.00
385_V401_L1.1581.00
347_Y364_A1.1551.00
152_L160_R1.1531.00
482_V511_N1.1531.00
129_N145_M1.1491.00
341_L345_V1.1451.00
455_L459_A1.1431.00
264_D268_I1.1431.00
380_A480_F1.1311.00
161_S236_I1.1311.00
272_V305_F1.1281.00
158_W162_F1.1161.00
217_F281_H1.1091.00
161_S233_W1.1081.00
471_D504_T1.1021.00
126_N502_T1.0941.00
221_S267_L1.0941.00
259_G264_D1.0921.00
218_T239_A1.0921.00
249_S254_S1.0901.00
256_A365_G1.0871.00
372_T375_A1.0851.00
434_D438_A1.0801.00
310_A313_T1.0731.00
91_L127_P1.0721.00
347_Y363_T1.0711.00
265_F268_I1.0641.00
309_T349_L1.0601.00
217_F273_L1.0581.00
407_G445_A1.0501.00
261_A265_F1.0501.00
161_S240_M1.0501.00
231_P235_A1.0461.00
223_L227_I1.0461.00
462_F508_F1.0461.00
271_M353_V1.0451.00
366_A493_S1.0421.00
389_A399_I1.0401.00
463_M478_V1.0361.00
471_D503_V1.0341.00
221_S225_L1.0341.00
154_H157_Q1.0331.00
302_F306_A1.0311.00
290_R294_T1.0291.00
125_Q146_A1.0201.00
261_A342_F1.0181.00
500_M504_T1.0141.00
135_M522_V1.0131.00
225_L242_G0.9991.00
169_V211_W0.9910.99
146_A152_L0.9910.99
315_V319_Q0.9890.99
133_E148_N0.9880.99
221_S242_G0.9860.99
485_A508_F0.9850.99
296_L428_D0.9830.99
221_S266_A0.9780.99
403_T444_A0.9760.99
383_M489_V0.9710.99
501_P504_T0.9710.99
295_D428_D0.9660.99
411_R438_A0.9650.99
376_Q477_N0.9640.99
462_F482_V0.9640.99
133_E160_R0.9620.99
158_W233_W0.9620.99
145_M148_N0.9560.99
260_S263_I0.9550.99
339_A347_Y0.9550.99
448_T452_L0.9540.99
374_P460_F0.9520.99
276_I298_T0.9520.99
255_I263_I0.9470.99
308_G312_L0.9450.99
137_G160_R0.9450.99
249_S252_D0.9440.99
273_L281_H0.9410.99
225_L266_A0.9390.99
312_L315_V0.9380.99
212_W216_L0.9370.99
300_W398_L0.9350.99
459_A478_V0.9340.99
308_G382_G0.9340.99
369_S376_Q0.9290.99
259_G339_A0.9280.99
405_V409_L0.9260.99
289_L293_Y0.9240.99
454_F514_I0.9190.99
314_A318_Q0.9180.99
355_A491_L0.9170.99
504_T508_F0.9160.99
352_F382_G0.9150.99
225_L255_I0.9150.99
227_I262_A0.9150.99
331_G337_S0.9130.99
238_H251_T0.9130.99
406_K425_F0.9120.99
389_A398_L0.9070.99
503_V507_M0.9040.99
315_V375_A0.8990.99
481_E492_S0.8980.99
148_N152_L0.8980.99
231_P234_D0.8950.99
482_V508_F0.8950.99
250_I258_Y0.8940.99
315_V318_Q0.8920.99
378_T460_F0.8920.99
484_S492_S0.8910.99
150_A252_D0.8870.99
217_F243_L0.8850.99
313_T348_A0.8820.99
339_A344_T0.8790.99
161_S164_E0.8740.99
366_A369_S0.8740.99
95_W153_P0.8740.99
164_E244_A0.8690.99
280_I298_T0.8570.98
289_L292_L0.8540.98
127_P506_A0.8490.98
143_L484_S0.8490.98
454_F511_N0.8490.98
288_D291_N0.8420.98
304_F308_G0.8420.98
138_F163_I0.8420.98
311_L428_D0.8400.98
202_S205_S0.8390.98
351_Q379_V0.8350.98
486_Q511_N0.8330.98
373_A476_E0.8290.98
223_L226_W0.8280.98
148_N160_R0.8240.98
161_S241_T0.8240.98
96_T125_Q0.8120.98
222_I226_W0.8110.98
187_L191_E0.8090.98
369_S493_S0.8090.98
246_G358_C0.8090.98
406_K427_L0.8030.98
308_G315_V0.8020.98
231_P258_Y0.8020.98
383_M484_S0.8020.98
483_A487_G0.8020.98
219_F223_L0.8000.98
451_W487_G0.8000.98
408_I446_I0.7970.98
174_L211_W0.7940.97
384_V451_W0.7920.97
93_A156_L0.7860.97
281_H292_L0.7860.97
306_A310_A0.7860.97
153_P156_L0.7850.97
450_L520_I0.7730.97
205_S208_R0.7700.97
332_V337_S0.7680.97
209_T282_Y0.7660.97
245_T357_S0.7650.97
308_G406_K0.7580.97
188_T191_E0.7580.97
304_F398_L0.7560.97
453_V457_V0.7560.97
338_A344_T0.7550.97
313_T316_L0.7550.97
476_E493_S0.7530.97
283_L306_A0.7510.96
305_F309_T0.7500.96
133_E144_T0.7500.96
304_F385_V0.7500.96
362_Q491_L0.7490.96
459_A475_V0.7480.96
380_A476_E0.7460.96
499_G502_T0.7430.96
292_L298_T0.7410.96
307_L311_L0.7390.96
245_T392_T0.7390.96
237_N241_T0.7380.96
496_T500_M0.7370.96
404_L449_F0.7350.96
306_A309_T0.7330.96
410_F434_D0.7330.96
341_L344_T0.7320.96
298_T302_F0.7300.96
309_T312_L0.7300.96
408_I450_L0.7280.96
213_I217_F0.7270.96
91_L94_A0.7260.96
268_I272_V0.7250.96
480_F491_L0.7230.96
214_F244_A0.7210.96
290_R293_Y0.7190.96
410_F425_F0.7160.95
216_L220_F0.7160.95
262_A265_F0.7160.95
462_F478_V0.7140.95
221_S224_L0.7130.95
463_M475_V0.7110.95
218_T222_I0.7100.95
144_T160_R0.7080.95
238_H267_L0.7080.95
339_A343_Q0.7060.95
234_D238_H0.7030.95
351_Q354_S0.7030.95
404_L408_I0.7020.95
128_L508_F0.7000.95
351_Q366_A0.6990.95
255_I258_Y0.6960.95
407_G437_A0.6950.95
362_Q365_G0.6940.95
164_E240_M0.6940.95
275_S387_A0.6940.95
404_L445_A0.6920.94
245_T274_G0.6910.94
150_A251_T0.6880.94
238_H361_F0.6870.94
396_I448_T0.6800.94
229_G233_W0.6790.94
192_S195_R0.6790.94
90_F156_L0.6740.94
307_L428_D0.6740.94
143_L485_A0.6710.94
281_H285_L0.6690.93
233_W237_N0.6680.93
377_L475_V0.6660.93
272_V313_T0.6660.93
245_T359_T0.6660.93
317_L349_L0.6640.93
284_V292_L0.6630.93
342_F345_V0.6630.93
276_I281_H0.6620.93
264_D351_Q0.6610.93
480_F492_S0.6600.93
380_A384_V0.6570.93
280_I295_D0.6550.93
232_M235_A0.6540.93
374_P464_L0.6540.93
371_W375_A0.6540.93
447_I451_W0.6530.93
255_I264_D0.6510.93
366_A498_P0.6490.92
519_I523_L0.6480.92
406_K409_L0.6480.92
514_I522_V0.6480.92
188_T202_S0.6480.92
126_N130_G0.6470.92
216_L219_F0.6470.92
355_A382_G0.6460.92
345_V349_L0.6460.92
218_T240_M0.6430.92
140_G358_C0.6420.92
144_T241_T0.6420.92
454_F486_Q0.6410.92
218_T243_L0.6400.92
364_A371_W0.6400.92
206_T391_S0.6390.92
143_L491_L0.6380.92
146_A151_A0.6370.92
478_V495_I0.6360.92
473_Y500_M0.6350.92
239_A270_V0.6340.92
349_L353_V0.6340.92
169_V210_I0.6330.91
352_F379_V0.6330.91
502_T505_K0.6320.91
505_K509_L0.6310.91
387_A398_L0.6300.91
217_F274_G0.6270.91
380_A493_S0.6270.91
255_I350_F0.6260.91
414_G438_A0.6250.91
502_T506_A0.6230.91
155_T158_W0.6230.91
125_Q153_P0.6220.91
355_A366_A0.6220.91
459_A483_A0.6210.91
462_F473_Y0.6200.91
358_C394_G0.6180.90
256_A363_T0.6180.90
306_A313_T0.6180.90
480_F484_S0.6160.90
477_N495_I0.6160.90
475_V478_V0.6150.90
213_I281_H0.6150.90
146_A149_E0.6140.90
477_N500_M0.6140.90
149_E157_Q0.6140.90
143_L492_S0.6130.90
234_D250_I0.6110.90
381_F456_G0.6100.90
412_I527_R0.6080.90
350_F361_F0.6080.90
240_M244_A0.6070.90
308_G402_L0.6050.90
486_Q519_I0.6030.89
254_S489_V0.6000.89
433_S436_E0.5970.89
127_P134_S0.5970.89
272_V317_L0.5930.89
309_T315_V0.5900.88
370_G373_A0.5860.88
219_F222_I0.5860.88
228_A258_Y0.5860.88
354_S359_T0.5850.88
91_L130_G0.5840.88
312_L398_L0.5830.88
225_L361_F0.5830.88
460_F464_L0.5810.88
300_W303_G0.5810.88
211_W215_L0.5800.87
189_L193_E0.5800.87
227_I235_A0.5790.87
528_G532_T0.5790.87
454_F458_A0.5790.87
143_L481_E0.5790.87
164_E361_F0.5790.87
132_F145_M0.5780.87
295_D298_T0.5770.87
309_T388_A0.5770.87
171_V207_V0.5770.87
279_P390_G0.5720.87
459_A463_M0.5710.87
296_L300_W0.5700.87
383_M487_G0.5700.87
445_A449_F0.5690.86
140_G245_T0.5680.86
317_L352_F0.5670.86
139_T244_A0.5630.86
455_L482_V0.5630.86
377_L381_F0.5630.86
95_W156_L0.5620.86
172_I500_M0.5620.86
479_L483_A0.5610.86
296_L402_L0.5600.86
151_A154_H0.5580.85
136_S141_T0.5580.85
481_E491_L0.5560.85
165_W240_M0.5550.85
362_Q498_P0.5550.85
473_Y477_N0.5550.85
279_P283_L0.5540.85
158_W237_N0.5540.85
445_A450_L0.5520.85
481_E508_F0.5520.85
499_G503_V0.5520.85
455_L479_L0.5520.85
144_T149_E0.5510.85
373_A376_Q0.5490.84
355_A487_G0.5480.84
151_A252_D0.5470.84
254_S363_T0.5460.84
403_T407_G0.5450.84
267_L361_F0.5450.84
481_E484_S0.5440.84
358_C488_N0.5430.84
416_F524_V0.5420.84
143_L496_T0.5420.84
145_M149_E0.5410.84
130_G152_L0.5390.83
351_Q371_W0.5380.83
139_T214_F0.5370.83
272_V349_L0.5370.83
354_S491_L0.5360.83
158_W161_S0.5350.83
264_D350_F0.5340.83
139_T390_G0.5340.83
255_I363_T0.5340.83
254_S258_Y0.5340.83
242_G274_G0.5330.83
484_S496_T0.5330.83
358_C486_Q0.5330.83
308_G311_L0.5330.83
392_T397_K0.5330.83
179_L525_L0.5320.83
353_V484_S0.5320.83
301_V305_F0.5320.83
256_A259_G0.5310.83
408_I449_F0.5290.82
91_L125_Q0.5290.82
377_L459_A0.5280.82
241_T489_V0.5280.82
210_I282_Y0.5270.82
226_W266_A0.5270.82
141_T488_N0.5270.82
138_F516_R0.5260.82
144_T362_Q0.5250.82
171_V175_T0.5230.82
478_V482_V0.5220.81
451_W455_L0.5220.81
187_L190_Y0.5210.81
268_I352_F0.5190.81
374_P463_M0.5190.81
124_F153_P0.5180.81
362_Q366_A0.5180.81
199_I206_T0.5160.81
495_I498_P0.5160.81
351_Q355_A0.5150.81
146_A160_R0.5150.81
528_G531_S0.5130.80
523_L527_R0.5130.80
236_I239_A0.5130.80
366_A370_G0.5130.80
395_G401_L0.5130.80
252_D257_T0.5130.80
227_I231_P0.5120.80
485_A511_N0.5120.80
450_L454_F0.5110.80
192_S411_R0.5110.80
296_L299_R0.5100.80
302_F305_F0.5080.80
143_L480_F0.5080.80
228_A232_M0.5070.80
227_I232_M0.5070.80
318_Q341_L0.5060.79
239_A243_L0.5060.79
249_S253_N0.5060.79
294_T298_T0.5050.79
351_Q364_A0.5050.79
137_G163_I0.5040.79
481_E500_M0.5020.79
147_D151_A0.5020.79
139_T516_R0.5010.79
148_N153_P0.5010.79
206_T211_W0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pjzA 2 0.8585 100 0.184 Contact Map
4j7cI 2 0.7654 100 0.337 Contact Map
3ukmA 2 0.3706 96.8 0.944 Contact Map
4twkA 2 0.4004 96.8 0.944 Contact Map
4wfeA 2 0.3855 96 0.948 Contact Map
4bw5A 2 0.3873 96 0.948 Contact Map
2a9hA 4 0.1806 84.5 0.963 Contact Map
2k1eA 3 0.1769 81.3 0.964 Contact Map
3pjsK 4 0.2402 80.8 0.964 Contact Map
3vouA 4 0.2495 79.7 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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