GREMLIN Database
Q9HQ79 - Uncharacterized protein
UniProt: Q9HQ79 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 140 (131)
Sequences: 163 (130)
Seq/√Len: 11.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_Y49_D3.9520.99
89_D93_S3.5620.98
71_L98_L3.2610.97
24_V103_A3.0180.95
99_D102_A2.3700.84
32_L96_V2.2690.82
18_T101_Q2.2400.81
9_I33_P2.2380.81
39_E44_E2.2260.80
6_F118_A2.2050.80
77_I92_C2.1010.76
103_A124_P2.0410.74
16_Y125_A1.9620.71
13_V126_K1.8050.64
80_I94_L1.7780.63
83_Q87_R1.7560.62
22_S80_I1.6840.59
89_D92_C1.6810.58
6_F137_A1.6500.57
94_L110_L1.5590.52
28_L32_L1.5550.52
12_R130_A1.5450.52
30_H114_I1.5260.51
105_L112_D1.5130.50
103_A130_A1.4720.48
57_R98_L1.4700.48
12_R121_E1.4680.48
80_I96_V1.4460.47
93_S117_R1.4250.46
27_A104_Y1.4230.46
8_Y11_L1.3930.44
37_E107_D1.3890.44
33_P103_A1.3780.44
67_V71_L1.3760.44
12_R103_A1.3650.43
42_D127_K1.3610.43
102_A107_D1.3540.43
115_S136_D1.3260.41
63_D89_D1.3250.41
7_H122_A1.3240.41
6_F120_V1.3170.41
47_L112_D1.2940.40
26_D69_D1.2870.39
11_L38_I1.2470.38
127_K135_R1.2430.37
51_I76_D1.2260.37
88_V95_F1.2190.36
23_R92_C1.2140.36
8_Y57_R1.2060.36
22_S69_D1.1780.34
119_K130_A1.1670.34
32_L55_S1.1650.34
114_I123_Y1.1610.34
89_D94_L1.1300.32
85_D107_D1.1260.32
76_D82_D1.1220.32
75_A97_H1.1100.31
28_L38_I1.0940.31
97_H110_L1.0920.31
32_L62_D1.0750.30
21_D47_L1.0730.30
81_R114_I1.0660.30
127_K131_V1.0650.30
41_T56_T1.0630.30
97_H131_V1.0610.29
14_F52_G1.0590.29
90_D119_K1.0540.29
79_Q83_Q1.0500.29
23_R50_R1.0490.29
38_I86_E1.0330.28
14_F49_D1.0310.28
44_E89_D0.9990.27
92_C125_A0.9940.27
20_A90_D0.9910.27
24_V104_Y0.9880.27
47_L86_E0.9730.26
12_R28_L0.9710.26
6_F38_I0.9690.26
49_D137_A0.9680.26
13_V33_P0.9510.25
17_D80_I0.9420.25
75_A95_F0.9420.25
113_G123_Y0.9390.25
110_L132_E0.9350.25
27_A33_P0.9310.24
21_D95_F0.9200.24
79_Q110_L0.9190.24
23_R62_D0.9130.24
51_I107_D0.9120.24
39_E112_D0.9100.24
12_R55_S0.9090.24
132_E136_D0.9070.24
56_T120_V0.9040.24
11_L116_L0.9040.24
59_E67_V0.8750.23
33_P109_Q0.8700.22
38_I56_T0.8700.22
21_D40_R0.8690.22
77_I93_S0.8600.22
46_H101_Q0.8510.22
75_A81_R0.8490.22
30_H103_A0.8240.21
14_F53_V0.8140.21
39_E83_Q0.8090.20
18_T49_D0.8050.20
103_A114_I0.8030.20
47_L97_H0.8030.20
49_D101_Q0.7980.20
24_V27_A0.7790.19
13_V40_R0.7780.19
81_R107_D0.7740.19
43_S64_M0.7720.19
111_G117_R0.7600.19
99_D134_A0.7570.19
9_I82_D0.7520.19
73_D116_L0.7410.18
110_L136_D0.7400.18
119_K124_P0.7330.18
114_I125_A0.7330.18
21_D99_D0.7270.18
38_I87_R0.7250.18
14_F122_A0.7230.18
129_A132_E0.7130.17
90_D94_L0.7130.17
10_D57_R0.6890.17
54_L73_D0.6880.17
28_L48_G0.6850.17
53_V77_I0.6850.17
27_A95_F0.6840.17
103_A128_D0.6840.17
86_E120_V0.6790.17
55_S121_E0.6790.17
123_Y130_A0.6560.16
46_H134_A0.6540.16
84_L88_V0.6500.16
23_R104_Y0.6460.16
57_R130_A0.6430.16
78_E119_K0.6420.16
72_R98_L0.6410.16
82_D99_D0.6340.15
9_I104_Y0.6260.15
11_L88_V0.6220.15
14_F68_L0.6210.15
17_D97_H0.6200.15
89_D112_D0.6160.15
31_F129_A0.6120.15
22_S29_G0.6090.15
19_E100_K0.6040.15
23_R85_D0.6040.15
75_A110_L0.6030.15
34_E59_E0.5970.14
47_L137_A0.5840.14
26_D129_A0.5830.14
29_G33_P0.5830.14
18_T46_H0.5820.14
15_C132_E0.5790.14
7_H119_K0.5770.14
99_D109_Q0.5760.14
10_D117_R0.5730.14
16_Y111_G0.5680.14
23_R102_A0.5620.14
32_L49_D0.5610.14
111_G120_V0.5560.13
97_H112_D0.5520.13
37_E69_D0.5490.13
88_V92_C0.5480.13
26_D35_D0.5460.13
42_D81_R0.5440.13
7_H94_L0.5420.13
25_A118_A0.5410.13
108_A114_I0.5400.13
77_I89_D0.5390.13
84_L106_G0.5390.13
122_A125_A0.5380.13
12_R33_P0.5350.13
73_D110_L0.5350.13
53_V57_R0.5340.13
50_R104_Y0.5320.13
17_D82_D0.5300.13
111_G126_K0.5270.13
38_I76_D0.5250.13
55_S78_E0.5220.13
80_I97_H0.5200.13
99_D110_L0.5200.13
71_L92_C0.5190.13
60_R63_D0.5160.13
43_S53_V0.5160.13
43_S46_H0.5150.13
16_Y79_Q0.5100.12
76_D79_Q0.5100.12
7_H12_R0.5100.12
111_G119_K0.5030.12
76_D129_A0.5010.12
27_A124_P0.5010.12
88_V111_G0.5010.12
82_D94_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wnyA 1 0.9643 100 0.248 Contact Map
2ogkA 4 0.9714 100 0.275 Contact Map
2nrqA 1 0.9 100 0.285 Contact Map
3d7aA 2 0.8786 99.9 0.466 Contact Map
2pzzA 2 0.8571 99.9 0.502 Contact Map
2nwuA 2 0.8429 99.9 0.504 Contact Map
3c9gA 2 0.8357 99.9 0.534 Contact Map
4jbuA 1 0.9214 23.2 0.937 Contact Map
3f4mA 1 0.5786 17.2 0.941 Contact Map
1mw7A 1 0.5571 13.8 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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