Q9HQ74 - HALSA - GREMLIN Contacts

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Q9HQ74 - Uncharacterized protein

UniProt:	Q9HQ74	Sequences: MYEVEVKVPGEYETVRAALADVDAAEHTTVAQADTYYDAPHRAFEQTDEAFRLRRVATAARGFERGDDLTADIDAVLSGPARADGESRVTYKGPLVEAESKTREEFETAVGDDAQMAAIIEQLGFESAAVVRKLRTKHHFEGFTVLLDAVEDVGEYVEIETTVEAEHAVSGAREDAYAVLRRLGLDPTDQIRTSYLGLRTSNA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	203 (172)
Sequences:	517 (417)
Seq/√Len:	31.8

HALSA - Q9HQ74
SULSO - Q980N7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
16_R	136_T	5.349	1.00
11_E	14_T	3.723	1.00
8_V	180_L	3.579	1.00
132_R	151_E	3.326	1.00
37_Y	117_A	3.294	1.00
135_R	148_D	3.080	1.00
159_I	176_A	2.574	1.00
24_A	140_F	2.547	1.00
19_L	145_V	2.510	1.00
93_G	103_R	2.491	0.99
103_R	194_S	2.310	0.99
149_A	155_E	2.156	0.99
153_V	199_R	2.071	0.98
50_A	196_L	2.059	0.98
39_A	125_F	1.974	0.97
32_Q	135_R	1.893	0.97
106_F	115_Q	1.868	0.96
145_V	157_V	1.836	0.96
38_D	43_A	1.825	0.96
145_V	159_I	1.816	0.96
51_F	123_L	1.814	0.96
32_Q	56_V	1.797	0.95
89_V	120_I	1.797	0.95
50_A	93_G	1.787	0.95
50_A	103_R	1.749	0.95
8_V	185_L	1.688	0.93
180_L	185_L	1.656	0.93
108_T	119_I	1.599	0.91
33_A	132_R	1.574	0.91
44_F	47_T	1.541	0.90
101_K	148_D	1.538	0.90
31_A	132_R	1.536	0.90
159_I	180_L	1.515	0.89
38_D	44_F	1.511	0.89
29_T	136_T	1.481	0.88
148_D	194_S	1.472	0.88
36_Y	153_V	1.462	0.87
150_V	153_V	1.430	0.86
48_D	95_L	1.424	0.86
36_Y	196_L	1.421	0.86
49_E	91_Y	1.415	0.85
52_R	160_E	1.414	0.85
23_D	140_F	1.413	0.85
32_Q	148_D	1.408	0.85
12_Y	147_L	1.407	0.85
90_T	124_G	1.386	0.84
2_Y	180_L	1.379	0.84
16_R	20_A	1.378	0.84
112_D	115_Q	1.300	0.80
90_T	107_E	1.288	0.80
143_F	179_V	1.284	0.79
143_F	175_D	1.276	0.79
95_L	194_S	1.270	0.79
46_Q	126_E	1.268	0.78
119_I	143_F	1.267	0.78
34_D	131_V	1.246	0.77
93_G	196_L	1.229	0.76
48_D	103_R	1.228	0.76
22_V	183_L	1.225	0.76
103_R	135_R	1.225	0.76
13_E	178_A	1.224	0.76
53_L	110_V	1.221	0.76
42_R	128_A	1.213	0.75
15_V	157_V	1.207	0.75
22_V	182_R	1.200	0.74
52_R	90_T	1.174	0.73
9_P	156_Y	1.173	0.73
103_R	196_L	1.167	0.72
131_V	135_R	1.158	0.72
103_R	148_D	1.153	0.71
10_G	189_D	1.149	0.71
55_R	113_D	1.143	0.71
147_L	155_E	1.125	0.70
193_T	201_S	1.109	0.68
50_A	95_L	1.101	0.68
36_Y	150_V	1.083	0.67
52_R	105_E	1.080	0.66
131_V	199_R	1.078	0.66
161_T	172_A	1.065	0.65
53_L	116_M	1.062	0.65
42_R	49_E	1.047	0.64
8_V	190_Q	1.025	0.62
34_D	150_V	1.019	0.62
23_D	132_R	1.016	0.61
6_V	99_E	1.010	0.61
163_V	172_A	1.008	0.61
3_E	92_K	1.008	0.61
50_A	101_K	1.002	0.60
191_I	198_L	0.997	0.60
48_D	93_G	0.985	0.59
50_A	194_S	0.967	0.58
101_K	135_R	0.967	0.58
100_S	173_R	0.954	0.57
117_A	121_E	0.949	0.56
45_E	200_T	0.946	0.56
15_V	147_L	0.943	0.56
92_K	105_E	0.939	0.55
13_E	181_R	0.929	0.55
97_E	100_S	0.928	0.54
19_L	24_A	0.927	0.54
52_R	92_K	0.924	0.54
6_V	145_V	0.917	0.54
11_E	188_T	0.916	0.54
51_F	120_I	0.906	0.53
51_F	119_I	0.894	0.52
108_T	111_G	0.892	0.52
44_F	49_E	0.889	0.51
15_V	19_L	0.885	0.51
98_A	111_G	0.882	0.51
46_Q	114_A	0.863	0.49
43_A	49_E	0.857	0.49
17_A	21_D	0.851	0.48
89_V	116_M	0.849	0.48
53_L	120_I	0.839	0.47
28_T	89_V	0.836	0.47
36_Y	91_Y	0.834	0.47
89_V	115_Q	0.833	0.47
139_H	144_T	0.825	0.46
90_T	160_E	0.824	0.46
22_V	145_V	0.823	0.46
168_A	178_A	0.819	0.46
172_A	183_L	0.817	0.45
101_K	194_S	0.816	0.45
135_R	194_S	0.815	0.45
146_L	191_I	0.815	0.45
38_D	185_L	0.811	0.45
145_V	164_E	0.809	0.45
88_R	107_E	0.803	0.44
33_A	130_V	0.801	0.44
3_E	105_E	0.800	0.44
52_R	107_E	0.796	0.44
143_F	176_A	0.792	0.43
8_V	32_Q	0.785	0.43
114_A	141_E	0.784	0.43
167_H	171_G	0.782	0.43
44_F	91_Y	0.778	0.42
139_H	174_E	0.777	0.42
36_Y	50_A	0.771	0.42
93_G	148_D	0.770	0.42
116_M	119_I	0.768	0.41
32_Q	131_V	0.768	0.41
50_A	135_R	0.766	0.41
92_K	176_A	0.764	0.41
118_A	122_Q	0.757	0.41
127_S	130_V	0.750	0.40
91_Y	150_V	0.747	0.40
32_Q	137_K	0.745	0.40
105_E	160_E	0.744	0.40
17_A	25_A	0.743	0.40
34_D	153_V	0.736	0.39
93_G	194_S	0.726	0.38
12_Y	198_L	0.725	0.38
139_H	142_G	0.725	0.38
100_S	194_S	0.717	0.38
134_L	152_D	0.714	0.37
29_T	134_L	0.711	0.37
18_A	170_S	0.705	0.37
29_T	167_H	0.696	0.36
176_A	180_L	0.693	0.36
55_R	106_F	0.692	0.36
35_T	127_S	0.688	0.35
117_A	127_S	0.687	0.35
101_K	196_L	0.675	0.34
131_V	198_L	0.675	0.34
107_E	160_E	0.674	0.34
178_A	182_R	0.673	0.34
148_D	196_L	0.673	0.34
38_D	108_T	0.673	0.34
97_E	173_R	0.672	0.34
5_E	158_E	0.671	0.34
32_Q	180_L	0.671	0.34
35_T	113_D	0.671	0.34
95_L	103_R	0.668	0.34
41_H	125_F	0.665	0.34
47_T	91_Y	0.664	0.34
108_T	115_Q	0.659	0.33
89_V	156_Y	0.654	0.33
25_A	178_A	0.652	0.33
133_K	195_Y	0.651	0.33
151_E	201_S	0.651	0.33
40_P	126_E	0.647	0.32
39_A	44_F	0.647	0.32
26_E	153_V	0.647	0.32
3_E	52_R	0.644	0.32
34_D	161_T	0.637	0.32
113_D	116_M	0.637	0.32
39_A	200_T	0.633	0.31
36_Y	199_R	0.627	0.31
29_T	182_R	0.623	0.31
18_A	22_V	0.623	0.31
32_Q	103_R	0.621	0.30
13_E	17_A	0.620	0.30
36_Y	131_V	0.618	0.30
174_E	186_D	0.616	0.30
3_E	7_K	0.614	0.30
49_E	150_V	0.613	0.30
112_D	197_G	0.612	0.30
35_T	117_A	0.610	0.30
10_G	155_E	0.606	0.29
10_G	147_L	0.604	0.29
187_P	190_Q	0.603	0.29
89_V	136_T	0.602	0.29
7_K	154_G	0.602	0.29
111_G	201_S	0.601	0.29
148_D	158_E	0.596	0.29
109_A	149_A	0.595	0.29
156_Y	191_I	0.593	0.29
112_D	116_M	0.591	0.28
34_D	156_Y	0.583	0.28
27_H	111_G	0.583	0.28
50_A	148_D	0.578	0.28
2_Y	30_V	0.570	0.27
169_V	172_A	0.570	0.27
46_Q	178_A	0.563	0.27
30_V	159_I	0.555	0.26
36_Y	48_D	0.554	0.26
8_V	135_R	0.552	0.26
56_V	191_I	0.551	0.26
140_F	201_S	0.550	0.26
24_A	176_A	0.548	0.26
7_K	101_K	0.547	0.26
55_R	107_E	0.547	0.26
44_F	131_V	0.547	0.26
5_E	107_E	0.546	0.26
49_E	93_G	0.545	0.25
25_A	139_H	0.545	0.25
101_K	191_I	0.543	0.25
94_P	109_A	0.536	0.25
33_A	55_R	0.536	0.25
162_T	180_L	0.536	0.25
59_A	164_E	0.535	0.25
143_F	172_A	0.533	0.25
17_A	138_H	0.533	0.25
53_L	172_A	0.532	0.25
18_A	55_R	0.532	0.25
11_E	141_E	0.528	0.24
5_E	54_R	0.527	0.24
42_R	50_A	0.523	0.24
100_S	163_V	0.523	0.24
6_V	59_A	0.523	0.24
181_R	185_L	0.522	0.24
158_E	195_Y	0.521	0.24
93_G	101_K	0.521	0.24
152_D	175_D	0.521	0.24
17_A	46_Q	0.515	0.24
101_K	146_L	0.511	0.23
91_Y	119_I	0.509	0.23
112_D	155_E	0.509	0.23
14_T	18_A	0.507	0.23
154_G	157_V	0.507	0.23
43_A	200_T	0.506	0.23
21_D	60_A	0.505	0.23
142_G	145_V	0.505	0.23
153_V	198_L	0.505	0.23
131_V	148_D	0.504	0.23
107_E	157_V	0.503	0.23
2_Y	147_L	0.502	0.23
145_V	152_D	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2eenA	2	0.8621	100	0.422	Contact Map
2acaA	2	0.8374	100	0.427	Contact Map
3n10A	2	0.8374	100	0.429	Contact Map
1yemA	2	0.8079	100	0.45	Contact Map
2dc4A	2	0.803	100	0.463	Contact Map
3bhdA	1	0.8424	100	0.507	Contact Map
5a67A	1	0.8719	99.9	0.581	Contact Map
5a61A	1	0.8571	99.9	0.62	Contact Map
3tj7A	2	0.7586	99.8	0.638	Contact Map
2gfgA	2	0.803	99.8	0.646	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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