GREMLIN Database
Q9HQ74 - Uncharacterized protein
UniProt: Q9HQ74 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 203 (172)
Sequences: 517 (417)
Seq/√Len: 31.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_R136_T5.3491.00
11_E14_T3.7231.00
8_V180_L3.5791.00
132_R151_E3.3261.00
37_Y117_A3.2941.00
135_R148_D3.0801.00
159_I176_A2.5741.00
24_A140_F2.5471.00
19_L145_V2.5101.00
93_G103_R2.4910.99
103_R194_S2.3100.99
149_A155_E2.1560.99
153_V199_R2.0710.98
50_A196_L2.0590.98
39_A125_F1.9740.97
32_Q135_R1.8930.97
106_F115_Q1.8680.96
145_V157_V1.8360.96
38_D43_A1.8250.96
145_V159_I1.8160.96
51_F123_L1.8140.96
32_Q56_V1.7970.95
89_V120_I1.7970.95
50_A93_G1.7870.95
50_A103_R1.7490.95
8_V185_L1.6880.93
180_L185_L1.6560.93
108_T119_I1.5990.91
33_A132_R1.5740.91
44_F47_T1.5410.90
101_K148_D1.5380.90
31_A132_R1.5360.90
159_I180_L1.5150.89
38_D44_F1.5110.89
29_T136_T1.4810.88
148_D194_S1.4720.88
36_Y153_V1.4620.87
150_V153_V1.4300.86
48_D95_L1.4240.86
36_Y196_L1.4210.86
49_E91_Y1.4150.85
52_R160_E1.4140.85
23_D140_F1.4130.85
32_Q148_D1.4080.85
12_Y147_L1.4070.85
90_T124_G1.3860.84
2_Y180_L1.3790.84
16_R20_A1.3780.84
112_D115_Q1.3000.80
90_T107_E1.2880.80
143_F179_V1.2840.79
143_F175_D1.2760.79
95_L194_S1.2700.79
46_Q126_E1.2680.78
119_I143_F1.2670.78
34_D131_V1.2460.77
93_G196_L1.2290.76
48_D103_R1.2280.76
22_V183_L1.2250.76
103_R135_R1.2250.76
13_E178_A1.2240.76
53_L110_V1.2210.76
42_R128_A1.2130.75
15_V157_V1.2070.75
22_V182_R1.2000.74
52_R90_T1.1740.73
9_P156_Y1.1730.73
103_R196_L1.1670.72
131_V135_R1.1580.72
103_R148_D1.1530.71
10_G189_D1.1490.71
55_R113_D1.1430.71
147_L155_E1.1250.70
193_T201_S1.1090.68
50_A95_L1.1010.68
36_Y150_V1.0830.67
52_R105_E1.0800.66
131_V199_R1.0780.66
161_T172_A1.0650.65
53_L116_M1.0620.65
42_R49_E1.0470.64
8_V190_Q1.0250.62
34_D150_V1.0190.62
23_D132_R1.0160.61
6_V99_E1.0100.61
163_V172_A1.0080.61
3_E92_K1.0080.61
50_A101_K1.0020.60
191_I198_L0.9970.60
48_D93_G0.9850.59
50_A194_S0.9670.58
101_K135_R0.9670.58
100_S173_R0.9540.57
117_A121_E0.9490.56
45_E200_T0.9460.56
15_V147_L0.9430.56
92_K105_E0.9390.55
13_E181_R0.9290.55
97_E100_S0.9280.54
19_L24_A0.9270.54
52_R92_K0.9240.54
6_V145_V0.9170.54
11_E188_T0.9160.54
51_F120_I0.9060.53
51_F119_I0.8940.52
108_T111_G0.8920.52
44_F49_E0.8890.51
15_V19_L0.8850.51
98_A111_G0.8820.51
46_Q114_A0.8630.49
43_A49_E0.8570.49
17_A21_D0.8510.48
89_V116_M0.8490.48
53_L120_I0.8390.47
28_T89_V0.8360.47
36_Y91_Y0.8340.47
89_V115_Q0.8330.47
139_H144_T0.8250.46
90_T160_E0.8240.46
22_V145_V0.8230.46
168_A178_A0.8190.46
172_A183_L0.8170.45
101_K194_S0.8160.45
135_R194_S0.8150.45
146_L191_I0.8150.45
38_D185_L0.8110.45
145_V164_E0.8090.45
88_R107_E0.8030.44
33_A130_V0.8010.44
3_E105_E0.8000.44
52_R107_E0.7960.44
143_F176_A0.7920.43
8_V32_Q0.7850.43
114_A141_E0.7840.43
167_H171_G0.7820.43
44_F91_Y0.7780.42
139_H174_E0.7770.42
36_Y50_A0.7710.42
93_G148_D0.7700.42
116_M119_I0.7680.41
32_Q131_V0.7680.41
50_A135_R0.7660.41
92_K176_A0.7640.41
118_A122_Q0.7570.41
127_S130_V0.7500.40
91_Y150_V0.7470.40
32_Q137_K0.7450.40
105_E160_E0.7440.40
17_A25_A0.7430.40
34_D153_V0.7360.39
93_G194_S0.7260.38
12_Y198_L0.7250.38
139_H142_G0.7250.38
100_S194_S0.7170.38
134_L152_D0.7140.37
29_T134_L0.7110.37
18_A170_S0.7050.37
29_T167_H0.6960.36
176_A180_L0.6930.36
55_R106_F0.6920.36
35_T127_S0.6880.35
117_A127_S0.6870.35
101_K196_L0.6750.34
131_V198_L0.6750.34
107_E160_E0.6740.34
178_A182_R0.6730.34
148_D196_L0.6730.34
38_D108_T0.6730.34
97_E173_R0.6720.34
5_E158_E0.6710.34
32_Q180_L0.6710.34
35_T113_D0.6710.34
95_L103_R0.6680.34
41_H125_F0.6650.34
47_T91_Y0.6640.34
108_T115_Q0.6590.33
89_V156_Y0.6540.33
25_A178_A0.6520.33
133_K195_Y0.6510.33
151_E201_S0.6510.33
40_P126_E0.6470.32
39_A44_F0.6470.32
26_E153_V0.6470.32
3_E52_R0.6440.32
34_D161_T0.6370.32
113_D116_M0.6370.32
39_A200_T0.6330.31
36_Y199_R0.6270.31
29_T182_R0.6230.31
18_A22_V0.6230.31
32_Q103_R0.6210.30
13_E17_A0.6200.30
36_Y131_V0.6180.30
174_E186_D0.6160.30
3_E7_K0.6140.30
49_E150_V0.6130.30
112_D197_G0.6120.30
35_T117_A0.6100.30
10_G155_E0.6060.29
10_G147_L0.6040.29
187_P190_Q0.6030.29
89_V136_T0.6020.29
7_K154_G0.6020.29
111_G201_S0.6010.29
148_D158_E0.5960.29
109_A149_A0.5950.29
156_Y191_I0.5930.29
112_D116_M0.5910.28
34_D156_Y0.5830.28
27_H111_G0.5830.28
50_A148_D0.5780.28
2_Y30_V0.5700.27
169_V172_A0.5700.27
46_Q178_A0.5630.27
30_V159_I0.5550.26
36_Y48_D0.5540.26
8_V135_R0.5520.26
56_V191_I0.5510.26
140_F201_S0.5500.26
24_A176_A0.5480.26
7_K101_K0.5470.26
55_R107_E0.5470.26
44_F131_V0.5470.26
5_E107_E0.5460.26
49_E93_G0.5450.25
25_A139_H0.5450.25
101_K191_I0.5430.25
94_P109_A0.5360.25
33_A55_R0.5360.25
162_T180_L0.5360.25
59_A164_E0.5350.25
143_F172_A0.5330.25
17_A138_H0.5330.25
53_L172_A0.5320.25
18_A55_R0.5320.25
11_E141_E0.5280.24
5_E54_R0.5270.24
42_R50_A0.5230.24
100_S163_V0.5230.24
6_V59_A0.5230.24
181_R185_L0.5220.24
158_E195_Y0.5210.24
93_G101_K0.5210.24
152_D175_D0.5210.24
17_A46_Q0.5150.24
101_K146_L0.5110.23
91_Y119_I0.5090.23
112_D155_E0.5090.23
14_T18_A0.5070.23
154_G157_V0.5070.23
43_A200_T0.5060.23
21_D60_A0.5050.23
142_G145_V0.5050.23
153_V198_L0.5050.23
131_V148_D0.5040.23
107_E157_V0.5030.23
2_Y147_L0.5020.23
145_V152_D0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eenA 2 0.8621 100 0.422 Contact Map
2acaA 2 0.8374 100 0.427 Contact Map
3n10A 2 0.8374 100 0.429 Contact Map
1yemA 2 0.8079 100 0.45 Contact Map
2dc4A 2 0.803 100 0.463 Contact Map
3bhdA 1 0.8424 100 0.507 Contact Map
5a67A 1 0.8719 99.9 0.581 Contact Map
5a61A 1 0.8571 99.9 0.62 Contact Map
3tj7A 2 0.7586 99.8 0.638 Contact Map
2gfgA 2 0.803 99.8 0.646 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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