GREMLIN Database
METK - S-adenosylmethionine synthase
UniProt: Q9HQ73 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 408 (392)
Sequences: 265 (200)
Seq/√Len: 10.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_C68_L6.1971.00
296_A311_T5.7691.00
365_V386_V4.4240.99
108_I113_I4.3080.99
210_K350_L3.9940.99
301_T306_M3.9800.99
50_E108_I3.4830.97
43_V63_T3.4230.97
334_A389_Q3.2630.95
205_V347_V3.1460.94
399_R404_E3.0920.94
38_G121_Y2.9330.92
367_V382_I2.8920.91
331_I385_I2.8570.91
50_E54_R2.8230.90
215_H257_E2.7920.90
335_V345_L2.7300.89
65_E289_S2.6730.88
215_H259_T2.5390.85
152_F318_N2.4960.84
39_I118_A2.4710.83
128_H228_H2.4050.81
50_E113_I2.4050.81
323_I396_L2.3710.80
40_A290_V2.3080.79
6_I186_A2.2730.77
230_P234_A2.2390.76
200_A234_A2.2010.75
214_D256_R2.1890.75
302_P306_M2.1790.74
330_Q399_R2.1770.74
35_I126_L2.1700.74
92_G285_G2.1650.74
343_R370_E2.1640.74
87_Y138_D2.1470.73
181_R185_E2.0980.71
191_N195_A2.0850.71
237_A241_A2.0710.70
200_A229_V2.0640.70
349_L363_A2.0620.70
154_D203_E2.0470.69
28_G187_E2.0300.69
183_V209_G1.9700.66
151_V265_A1.9010.63
164_A351_S1.9010.63
363_A386_V1.8960.63
36_C289_S1.8810.62
372_G400_V1.8480.61
231_D384_R1.8460.61
63_T89_L1.8210.60
231_D234_A1.8210.60
151_V350_L1.8090.59
363_A387_D1.8070.59
86_I162_P1.7730.58
173_H329_T1.7460.56
76_A226_D1.7360.56
58_V317_V1.7170.55
47_L51_Y1.6990.54
396_L405_R1.6710.53
72_D84_D1.6590.53
95_T347_V1.6520.52
18_D343_R1.6470.52
200_A238_Q1.6460.52
28_G274_Y1.6210.51
234_A238_Q1.6180.51
140_K229_V1.5990.50
187_E191_N1.5800.49
92_G287_D1.5740.49
69_V87_Y1.5650.48
299_L306_M1.5590.48
303_N328_S1.5520.48
186_A249_L1.5270.46
8_V330_Q1.5160.46
90_V139_V1.5120.46
178_E254_T1.5090.46
57_H82_V1.5080.46
168_S283_E1.5070.46
127_P203_E1.4960.45
119_R382_I1.4960.45
15_A18_D1.4910.45
51_Y148_L1.4880.45
67_Q89_L1.4880.45
148_L353_I1.4800.44
128_H203_E1.4760.44
48_A222_A1.4730.44
150_D272_S1.4640.44
75_P277_T1.4580.43
34_S121_Y1.4510.43
355_R359_E1.4490.43
331_I335_V1.4470.43
352_Q355_R1.4450.43
299_L302_P1.4390.42
40_A92_G1.4360.42
232_M273_I1.4330.42
70_A323_I1.4320.42
47_L148_L1.4300.42
84_D391_A1.4210.42
34_S38_G1.4150.41
236_I239_V1.3890.40
264_T307_S1.3790.40
121_Y308_M1.3780.40
49_R247_F1.3680.39
75_P223_A1.3520.39
121_Y289_S1.3460.38
16_V177_T1.3440.38
170_G308_M1.3420.38
53_D371_D1.3410.38
208_M281_S1.3360.38
62_N93_R1.3260.37
382_I386_V1.3230.37
176_L317_V1.3170.37
15_A78_G1.3120.37
50_E70_A1.3060.37
173_H320_I1.2780.35
40_A89_L1.2720.35
39_I43_V1.2710.35
163_M386_V1.2680.35
164_A393_V1.2670.35
121_Y134_D1.2590.35
236_I268_Y1.2500.34
336_V345_L1.2340.34
44_C61_F1.2260.33
28_G207_V1.2180.33
174_A332_A1.2100.33
287_D301_T1.1970.32
14_S368_V1.1910.32
65_E312_S1.1670.31
278_T287_D1.1670.31
43_V114_A1.1630.31
178_E256_R1.1630.31
201_V222_A1.1630.31
243_R247_F1.1620.31
163_M328_S1.1600.31
63_T67_Q1.1570.30
171_V303_N1.1520.30
224_L238_Q1.1510.30
20_A213_D1.1470.30
380_A383_E1.1450.30
170_G283_E1.1440.30
289_S348_R1.1320.30
51_Y353_I1.1270.29
268_Y401_I1.1250.29
39_I90_V1.1240.29
63_T289_S1.1170.29
173_H176_L1.1040.28
327_L358_D1.1030.28
334_A388_A1.1020.28
47_L353_I1.0980.28
130_D248_D1.0900.28
170_G301_T1.0850.28
376_A404_E1.0850.28
191_N205_V1.0830.28
16_V19_D1.0810.28
242_I246_V1.0800.28
185_E253_H1.0800.28
138_D142_G1.0700.27
92_G301_T1.0650.27
287_D302_P1.0640.27
9_Q364_D1.0630.27
349_L370_E1.0560.27
320_I401_I1.0540.27
69_V352_Q1.0520.27
108_I365_V1.0510.27
35_I282_A1.0510.27
54_R108_I1.0460.26
60_H71_G1.0440.26
170_G302_P1.0430.26
36_C173_H1.0400.26
23_I212_E1.0360.26
261_H264_T1.0270.26
286_D324_Y1.0260.26
93_R145_S1.0260.26
330_Q333_E1.0250.26
23_I361_H1.0240.26
63_T350_L1.0190.25
68_L289_S1.0120.25
62_N353_I1.0100.25
51_Y281_S1.0080.25
186_A195_A1.0050.25
339_V367_V1.0030.25
334_A338_E0.9990.25
75_P320_I0.9990.25
35_I125_T0.9980.25
187_E195_A0.9930.24
65_E91_V0.9930.24
114_A290_V0.9890.24
70_A91_V0.9880.24
205_V274_Y0.9880.24
35_I396_L0.9820.24
119_R132_E0.9750.24
176_L406_T0.9730.24
170_G299_L0.9720.24
130_D367_V0.9700.24
43_V89_L0.9680.24
121_Y401_I0.9670.24
66_T289_S0.9670.24
90_V114_A0.9640.24
224_L229_V0.9620.23
63_T348_R0.9570.23
49_R251_T0.9550.23
51_Y283_E0.9530.23
192_G195_A0.9510.23
9_Q108_I0.9490.23
265_A287_D0.9480.23
98_Y146_G0.9470.23
265_A272_S0.9440.23
29_L391_A0.9430.23
343_R365_V0.9410.23
318_N323_I0.9390.23
194_Y201_V0.9370.23
295_R301_T0.9320.22
11_L366_E0.9310.22
65_E121_Y0.9310.22
134_D280_T0.9310.22
10_S132_E0.9270.22
68_L171_V0.9260.22
331_I386_V0.9210.22
63_T114_A0.9200.22
148_L221_A0.9200.22
169_F302_P0.9190.22
92_G169_F0.9180.22
275_L343_R0.9150.22
289_S318_N0.9120.22
342_I382_I0.9100.22
323_I405_R0.9100.22
207_V237_A0.9090.22
395_D398_R0.9080.22
92_G302_P0.9080.22
13_R176_L0.9060.22
58_V393_V0.9040.22
116_E133_T0.9010.21
152_F199_P0.8980.21
308_M394_T0.8940.21
221_A353_I0.8940.21
92_G278_T0.8870.21
70_A92_G0.8860.21
70_A284_Q0.8860.21
247_F251_T0.8850.21
98_Y191_N0.8850.21
326_L396_L0.8820.21
179_T221_A0.8810.21
352_Q357_I0.8800.21
79_G353_I0.8790.21
214_D254_T0.8780.21
256_R326_L0.8770.21
93_R168_S0.8770.21
170_G287_D0.8750.21
67_Q312_S0.8710.21
173_H301_T0.8690.21
203_E280_T0.8660.20
326_L405_R0.8650.20
65_E70_A0.8650.20
83_I388_A0.8650.20
305_A346_R0.8620.20
262_V296_A0.8600.20
76_A229_V0.8600.20
178_E216_I0.8490.20
222_A262_V0.8470.20
96_S111_E0.8450.20
169_F287_D0.8430.20
122_L131_L0.8410.20
50_E72_D0.8410.20
295_R306_M0.8380.20
69_V138_D0.8380.20
62_N320_I0.8370.20
38_G284_Q0.8370.20
43_V117_A0.8370.20
24_V187_E0.8350.20
296_A401_I0.8340.19
59_L93_R0.8310.19
124_E271_G0.8300.19
89_L312_S0.8280.19
205_V404_E0.8250.19
257_E333_E0.8180.19
66_T142_G0.8180.19
121_Y151_V0.8160.19
47_L281_S0.8120.19
333_E337_A0.8110.19
225_V370_E0.8110.19
246_V262_V0.8090.19
113_I274_Y0.8090.19
128_H154_D0.8090.19
35_I280_T0.8080.19
358_D387_D0.8070.19
327_L393_V0.8060.19
217_D361_H0.8050.19
173_H192_G0.8030.19
239_V268_Y0.8010.19
82_V135_V0.7960.18
94_A281_S0.7960.18
47_L223_A0.7950.18
73_A277_T0.7920.18
148_L168_S0.7920.18
283_E325_N0.7910.18
36_C143_E0.7860.18
295_R307_S0.7840.18
247_F367_V0.7830.18
295_R299_L0.7770.18
147_D265_A0.7750.18
240_E388_A0.7740.18
220_I392_S0.7730.18
67_Q289_S0.7710.18
242_I308_M0.7690.18
327_L332_A0.7680.18
148_L281_S0.7660.18
347_V365_V0.7640.18
70_A150_D0.7570.17
150_D265_A0.7570.17
244_E248_D0.7570.17
209_G302_P0.7560.17
47_L221_A0.7560.17
62_N168_S0.7550.17
65_E348_R0.7550.17
90_V349_L0.7540.17
58_V260_V0.7540.17
208_M353_I0.7440.17
95_T138_D0.7400.17
68_L406_T0.7380.17
231_D259_T0.7370.17
67_Q91_V0.7350.17
36_C66_T0.7340.17
281_S353_I0.7340.17
286_D295_R0.7340.17
70_A179_T0.7310.17
81_N115_L0.7270.17
220_I376_A0.7260.17
182_I303_N0.7250.17
195_A203_E0.7250.17
194_Y245_H0.7240.17
69_V147_D0.7240.17
152_F358_D0.7240.17
107_H230_P0.7230.16
290_V310_A0.7220.16
145_S187_E0.7210.16
332_A349_L0.7210.16
48_A209_G0.7200.16
38_G122_L0.7190.16
285_G301_T0.7140.16
120_E271_G0.7110.16
235_Y286_D0.7100.16
197_H260_V0.7100.16
339_V382_I0.7080.16
382_I397_T0.7070.16
40_A285_G0.7070.16
379_D383_E0.7050.16
6_I136_I0.7050.16
48_A347_V0.7040.16
151_V307_S0.7030.16
18_D344_D0.7020.16
185_E244_E0.7020.16
168_S353_I0.7010.16
375_V395_D0.7000.16
178_E214_D0.6990.16
14_S393_V0.6980.16
67_Q121_Y0.6970.16
92_G265_A0.6950.16
231_D250_A0.6920.16
287_D306_M0.6920.16
387_D391_A0.6920.16
142_G287_D0.6910.16
87_Y142_G0.6900.16
12_D242_I0.6900.16
92_G306_M0.6900.16
147_D273_I0.6880.16
355_R368_V0.6870.16
122_L391_A0.6870.16
336_V342_I0.6860.16
92_G396_L0.6850.16
86_I265_A0.6830.15
210_K218_L0.6820.15
43_V95_T0.6820.15
179_T344_D0.6800.15
168_S281_S0.6770.15
150_D154_D0.6760.15
170_G223_A0.6730.15
162_P357_I0.6730.15
217_D259_T0.6720.15
347_V397_T0.6720.15
72_D83_I0.6690.15
234_A399_R0.6690.15
63_T70_A0.6680.15
57_H220_I0.6680.15
62_N148_L0.6680.15
164_A171_V0.6680.15
41_E285_G0.6670.15
39_I231_D0.6670.15
276_T287_D0.6670.15
67_Q70_A0.6660.15
218_L234_A0.6660.15
90_V201_V0.6650.15
197_H213_D0.6650.15
13_R217_D0.6650.15
128_H227_A0.6650.15
63_T179_T0.6630.15
36_C197_H0.6630.15
214_D326_L0.6600.15
297_N351_S0.6600.15
267_D270_S0.6590.15
299_L356_P0.6590.15
266_D286_D0.6570.15
48_A401_I0.6550.15
237_A270_S0.6540.15
50_E109_P0.6480.15
39_I365_V0.6460.15
289_S312_S0.6460.15
14_S55_V0.6450.15
71_G276_T0.6440.15
237_A251_T0.6440.15
69_V135_V0.6440.15
168_S208_M0.6440.15
92_G138_D0.6430.15
225_V317_V0.6420.15
33_D37_D0.6410.15
25_E31_H0.6410.15
31_H37_D0.6410.15
32_P37_D0.6410.15
27_K37_D0.6410.15
27_K33_D0.6410.15
27_K32_P0.6410.15
27_K31_H0.6410.15
25_E37_D0.6410.15
25_E33_D0.6410.15
25_E32_P0.6410.15
142_G289_S0.6400.14
164_A176_L0.6390.14
94_A114_A0.6390.14
358_D363_A0.6390.14
169_F285_G0.6360.14
168_S325_N0.6350.14
226_D277_T0.6340.14
185_E188_R0.6320.14
223_A287_D0.6300.14
220_I246_V0.6300.14
150_D273_I0.6290.14
278_T301_T0.6280.14
376_A379_D0.6280.14
343_R377_D0.6280.14
48_A194_Y0.6280.14
285_G306_M0.6270.14
70_A365_V0.6270.14
47_L283_E0.6270.14
170_G295_R0.6260.14
168_S351_S0.6260.14
372_G403_G0.6240.14
164_A169_F0.6240.14
51_Y221_A0.6230.14
87_Y136_I0.6230.14
169_F301_T0.6200.14
384_R388_A0.6200.14
190_L205_V0.6180.14
162_P394_T0.6170.14
329_T349_L0.6170.14
359_E363_A0.6170.14
54_R176_L0.6160.14
235_Y324_Y0.6160.14
70_A303_N0.6160.14
75_P285_G0.6150.14
351_S354_G0.6140.14
75_P287_D0.6140.14
53_D66_T0.6130.14
15_A355_R0.6110.14
34_S289_S0.6100.14
12_D367_V0.6090.14
73_A393_V0.6080.14
75_P170_G0.6080.14
198_T241_A0.6050.14
164_A193_P0.6040.14
9_Q113_I0.6040.14
170_G281_S0.6020.14
93_R152_F0.6020.14
205_V240_E0.6010.14
47_L75_P0.6010.14
7_Q404_E0.6010.14
65_E68_L0.6000.14
270_S393_V0.6000.14
88_I135_V0.5970.14
128_H131_L0.5970.14
16_V84_D0.5960.14
362_V387_D0.5960.14
49_R188_R0.5950.13
127_P141_L0.5930.13
170_G325_N0.5930.13
107_H359_E0.5910.13
223_A276_T0.5900.13
8_V214_D0.5890.13
51_Y168_S0.5890.13
318_N344_D0.5880.13
265_A318_N0.5870.13
23_I191_N0.5870.13
66_T91_V0.5860.13
311_T317_V0.5830.13
75_P226_D0.5830.13
70_A285_G0.5800.13
107_H252_E0.5790.13
372_G377_D0.5780.13
47_L62_N0.5770.13
91_V147_D0.5770.13
229_V238_Q0.5770.13
194_Y198_T0.5770.13
40_A66_T0.5750.13
154_D272_S0.5740.13
19_D323_I0.5740.13
97_H230_P0.5730.13
109_P114_A0.5700.13
137_V152_F0.5690.13
176_L181_R0.5690.13
147_D287_D0.5680.13
148_L283_E0.5680.13
208_M304_R0.5680.13
235_Y266_D0.5660.13
59_L283_E0.5650.13
217_D225_V0.5650.13
339_V394_T0.5610.13
160_A196_E0.5610.13
227_A268_Y0.5600.13
257_E349_L0.5600.13
61_F195_A0.5600.13
39_I345_L0.5550.13
189_S245_H0.5550.13
10_S371_D0.5550.13
93_R318_N0.5540.13
28_G183_V0.5530.13
148_L287_D0.5520.13
104_T240_E0.5520.13
305_A366_E0.5500.13
59_L168_S0.5500.13
43_V224_L0.5480.13
7_Q193_P0.5480.13
225_V278_T0.5470.12
264_T351_S0.5470.12
207_V365_V0.5460.12
307_S348_R0.5460.12
48_A312_S0.5460.12
137_V387_D0.5440.12
47_L168_S0.5420.12
17_E371_D0.5400.12
36_C233_D0.5390.12
207_V241_A0.5380.12
135_V331_I0.5380.12
163_M192_G0.5370.12
307_S357_I0.5370.12
111_E245_H0.5360.12
370_E391_A0.5350.12
55_V108_I0.5340.12
129_L287_D0.5340.12
331_I391_A0.5330.12
94_A144_G0.5330.12
98_Y253_H0.5330.12
128_H342_I0.5310.12
18_D73_A0.5290.12
104_T371_D0.5290.12
104_T260_V0.5270.12
217_D343_R0.5270.12
113_I137_V0.5240.12
8_V331_I0.5220.12
65_E134_D0.5220.12
193_P220_I0.5210.12
241_A244_E0.5210.12
58_V133_T0.5210.12
177_T184_L0.5190.12
380_A398_R0.5180.12
29_L252_E0.5160.12
55_V70_A0.5150.12
90_V336_V0.5150.12
181_R259_T0.5140.12
38_G134_D0.5140.12
307_S325_N0.5140.12
8_V188_R0.5140.12
287_D299_L0.5130.12
92_G129_L0.5120.12
140_K301_T0.5120.12
65_E190_L0.5110.12
343_R346_R0.5110.12
311_T350_L0.5100.12
70_A339_V0.5090.12
93_R121_Y0.5080.12
232_M269_E0.5080.12
182_I254_T0.5070.12
229_V236_I0.5050.12
86_I400_V0.5040.12
200_A265_A0.5040.12
193_P252_E0.5030.12
34_S65_E0.5030.12
16_V123_R0.5030.12
51_Y62_N0.5010.12
343_R375_V0.5010.12
153_T338_E0.5010.12
346_R366_E0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l4qA 3 0.9804 100 0.016 Contact Map
4l7iA 3 0.9828 100 0.311 Contact Map
4le5A 2 0.8162 100 0.666 Contact Map
4odjA 2 0.8064 100 0.668 Contact Map
1p7lA 4 0.8162 100 0.677 Contact Map
2p02A 2 0.8211 100 0.678 Contact Map
3imlA 2 0.7721 100 0.68 Contact Map
3s82A 4 0.7892 100 0.688 Contact Map
3so4A 4 0.7966 100 0.69 Contact Map
2kddA 2 0.1103 33.8 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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