GREMLIN Database
THII - Probable tRNA sulfurtransferase
UniProt: Q9HQ72 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 392 (373)
Sequences: 1462 (995)
Seq/√Len: 51.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_A198_A5.7261.00
311_R366_R5.1871.00
379_A383_D4.5081.00
252_D380_V3.9451.00
233_T337_D3.6261.00
86_P116_G3.3641.00
228_E245_L3.1171.00
86_P163_A3.0991.00
129_G156_V2.9201.00
112_A126_N2.8631.00
109_A147_L2.7731.00
184_L290_V2.6781.00
125_V158_V2.6591.00
85_A90_A2.6391.00
71_D236_D2.6371.00
373_L376_W2.6181.00
279_H379_A2.5921.00
110_V133_V2.5321.00
112_A125_V2.4761.00
333_A338_T2.4391.00
233_T341_D2.4081.00
92_S132_A2.3661.00
306_L322_L2.3241.00
380_V384_T2.2581.00
12_R79_S2.2191.00
187_L289_I2.2061.00
200_E332_A2.2031.00
185_V286_A2.1961.00
90_A93_D2.1801.00
225_A229_A2.1711.00
91_I163_A2.1641.00
48_V57_V2.1631.00
99_A154_F2.1411.00
341_D344_L2.1281.00
305_N360_A2.1261.00
12_R77_S2.1151.00
278_E313_T2.0741.00
107_A144_V2.0501.00
95_L129_G2.0331.00
184_L288_G2.0251.00
279_H282_E2.0241.00
111_D153_T2.0141.00
184_L206_A1.9881.00
331_A335_S1.9731.00
224_R228_E1.9591.00
304_A359_A1.9420.99
261_T268_S1.9410.99
87_D90_A1.9030.99
332_A335_S1.8950.99
288_G318_H1.8880.99
367_A370_P1.8720.99
331_A334_R1.8630.99
256_R260_A1.8510.99
199_W237_Y1.8500.99
275_R369_E1.8260.99
41_D68_A1.8230.99
120_F128_V1.8190.99
132_A136_A1.8000.99
287_A304_A1.7970.99
229_A344_L1.7880.99
382_A385_G1.7810.99
323_T328_R1.7650.99
271_R369_E1.7640.99
278_E314_T1.7550.99
368_D371_D1.7540.99
96_A136_A1.7490.99
185_V211_L1.7310.99
96_A132_A1.7300.99
88_L125_V1.7170.99
112_A158_V1.7100.99
264_T368_D1.6830.99
91_I129_G1.6830.99
70_A78_A1.6710.98
90_A94_A1.6640.98
54_R157_E1.6640.98
83_S162_E1.6570.98
42_R68_A1.6480.98
248_A385_G1.6330.98
30_T180_T1.6100.98
125_V129_G1.6070.98
183_P209_I1.5780.98
84_V94_A1.5760.98
283_H383_D1.5650.98
154_F165_V1.5420.97
272_F374_F1.5140.97
211_L280_V1.5080.97
46_G57_V1.4790.97
327_Q331_A1.4660.96
11_V75_V1.4640.96
376_W380_V1.4560.96
278_E315_L1.4540.96
188_V231_V1.4370.96
69_A75_V1.4260.96
311_R362_I1.4150.96
128_V131_D1.4130.96
192_I339_F1.3960.95
185_V280_V1.3920.95
31_L34_N1.3910.95
308_V362_I1.3900.95
211_L277_A1.3800.95
272_F372_A1.3770.95
362_I365_V1.3760.95
111_D126_N1.3720.95
146_D149_D1.3680.95
256_R259_A1.3650.95
308_V365_V1.3620.95
281_A315_L1.3580.94
14_G76_V1.3560.94
209_I246_R1.3540.94
339_F343_S1.3470.94
28_E53_G1.3420.94
158_V163_A1.3400.94
264_T365_V1.3330.94
218_Y255_D1.3280.94
224_R386_P1.3250.94
201_S290_V1.3160.93
210_P243_L1.3150.93
267_L305_N1.3120.93
257_L268_S1.3090.93
295_V322_L1.3050.93
47_D58_R1.3040.93
229_A232_R1.3010.93
378_R382_A1.2720.92
374_F378_R1.2690.92
233_T236_D1.2670.92
11_V57_V1.2660.92
272_F275_R1.2460.91
176_M181_Q1.2450.91
80_P168_T1.2370.91
94_A97_A1.2360.91
113_R157_E1.2230.91
92_S128_V1.2190.91
262_G368_D1.2030.90
93_D97_A1.1920.90
99_A133_V1.1810.89
35_V72_T1.1800.89
102_H168_T1.1790.89
110_V154_F1.1760.89
266_M269_F1.1750.89
70_A170_R1.1730.89
9_V78_A1.1640.88
282_E315_L1.1580.88
288_G303_T1.1560.88
198_A208_V1.1540.88
324_W332_A1.1530.88
276_V378_R1.1510.88
35_V48_V1.1490.88
249_P384_T1.1470.88
187_L291_T1.1410.87
29_R33_D1.1400.87
198_A210_P1.1360.87
10_V81_A1.1310.87
30_T33_D1.1310.87
362_I366_R1.1140.86
228_E247_V1.1100.86
275_R378_R1.1080.86
176_M204_R1.1080.86
110_V129_G1.1000.85
45_P62_P1.0970.85
127_R131_D1.0960.85
32_R50_R1.0940.85
318_H322_L1.0930.85
249_P252_D1.0900.85
121_D124_D1.0720.84
185_V209_I1.0710.84
77_S169_H1.0700.84
252_D255_D1.0680.84
95_L133_V1.0590.83
89_D93_D1.0490.83
277_A289_I1.0480.82
224_R247_V1.0470.82
231_V243_L1.0440.82
275_R312_A1.0350.82
209_I244_S1.0320.82
279_H378_R1.0320.82
91_I158_V1.0310.81
327_Q334_R1.0250.81
274_Y313_T1.0240.81
29_R50_R1.0140.80
66_A78_A1.0110.80
171_D331_A1.0080.80
272_F378_R1.0000.79
283_H385_G0.9990.79
106_G152_I0.9950.79
7_D59_S0.9940.79
332_A337_D0.9930.79
187_L277_A0.9930.79
89_D92_S0.9900.79
98_A165_V0.9830.78
363_E366_R0.9830.78
133_V154_F0.9810.78
28_E50_R0.9790.78
96_A137_V0.9700.77
212_Y347_G0.9640.77
87_D92_S0.9610.77
8_S81_A0.9590.76
308_V360_A0.9560.76
264_T357_L0.9560.76
357_L360_A0.9530.76
278_E281_A0.9520.76
250_A269_F0.9520.76
12_R54_R0.9520.76
99_A152_I0.9500.76
309_V318_H0.9480.76
79_S166_F0.9480.76
209_I286_A0.9390.75
274_Y293_E0.9360.75
69_A78_A0.9310.74
88_L120_F0.9310.74
269_F276_V0.9270.74
208_V243_L0.9230.74
280_V284_A0.9170.73
345_D349_N0.9150.73
173_P199_W0.9120.73
265_R350_R0.9110.73
248_A381_A0.9090.73
366_R370_P0.9090.73
80_P170_R0.9070.72
95_L110_V0.9040.72
109_A148_D0.9030.72
310_D317_V0.9000.72
49_E58_R0.8990.72
105_G152_I0.8990.72
68_A72_T0.8810.70
254_I345_D0.8790.70
92_S96_A0.8780.70
203_R328_R0.8750.70
109_A150_P0.8730.69
280_V385_G0.8720.69
291_T321_L0.8720.69
106_G151_D0.8680.69
201_S323_T0.8670.69
244_S284_A0.8660.69
186_A210_P0.8640.69
206_A303_T0.8620.68
295_V318_H0.8620.68
229_A341_D0.8550.68
67_D70_A0.8530.68
199_W332_A0.8490.67
267_L309_V0.8470.67
361_P364_S0.8460.67
73_F173_P0.8450.67
35_V55_V0.8390.66
279_H283_H0.8380.66
88_L128_V0.8350.66
42_R113_R0.8330.66
130_G151_D0.8300.66
39_L57_V0.8300.66
303_T318_H0.8230.65
307_G311_R0.8230.65
219_G223_H0.8220.65
254_I346_V0.8200.65
263_R354_R0.8200.65
159_R293_E0.8200.65
66_A170_R0.8180.64
20_S181_Q0.8080.63
12_R166_F0.8040.63
30_T358_T0.8030.63
200_E323_T0.8030.63
100_R137_V0.7990.63
83_S164_F0.7980.62
67_D236_D0.7980.62
17_G53_G0.7980.62
96_A100_R0.7950.62
11_V55_V0.7940.62
226_R230_A0.7920.62
225_A228_E0.7920.62
192_I343_S0.7900.62
279_H375_E0.7890.62
13_H17_G0.7860.61
95_L165_V0.7840.61
92_S136_A0.7810.61
185_V277_A0.7790.61
281_A286_A0.7770.60
184_L303_T0.7760.60
228_E232_R0.7760.60
282_E314_T0.7750.60
254_I349_N0.7680.59
100_R136_A0.7680.59
34_N178_L0.7630.59
206_A295_V0.7590.59
89_D132_A0.7570.58
39_L65_A0.7560.58
35_V69_A0.7560.58
15_D24_Q0.7530.58
269_F349_N0.7520.58
265_R269_F0.7520.58
227_A352_A0.7520.58
50_R53_G0.7510.58
291_T322_L0.7490.58
268_S275_R0.7480.57
209_I284_A0.7470.57
212_Y223_H0.7470.57
234_L238_A0.7460.57
183_P207_P0.7460.57
133_V143_P0.7440.57
202_M238_A0.7440.57
276_V382_A0.7420.57
212_Y352_A0.7410.57
116_G160_D0.7370.56
10_V157_E0.7350.56
324_W328_R0.7350.56
22_H270_R0.7340.56
16_V55_V0.7280.55
46_G65_A0.7260.55
223_H347_G0.7250.55
91_I164_F0.7230.55
38_M239_P0.7200.55
96_A133_V0.7170.54
39_L43_G0.7160.54
17_G28_E0.7150.54
32_R36_A0.7140.54
22_H27_M0.7140.54
314_T317_V0.7090.53
269_F305_N0.7070.53
310_D319_R0.7020.53
270_R309_V0.7010.53
293_E319_R0.6950.52
230_A341_D0.6950.52
15_D31_L0.6930.52
308_V311_R0.6850.51
269_F352_A0.6830.51
367_A371_D0.6810.51
73_F336_I0.6800.50
179_G204_R0.6790.50
250_A268_S0.6790.50
270_R348_C0.6790.50
220_G223_H0.6760.50
9_V69_A0.6750.50
220_G299_S0.6750.50
306_L313_T0.6740.50
166_F169_H0.6710.50
48_V55_V0.6710.50
220_G356_P0.6710.50
116_G120_F0.6680.49
253_A381_A0.6680.49
201_S206_A0.6680.49
59_S65_A0.6670.49
73_F237_Y0.6660.49
108_F145_V0.6660.49
290_V303_T0.6650.49
56_L164_F0.6640.49
99_A129_G0.6640.49
15_D19_K0.6620.49
130_G145_V0.6620.49
291_T306_L0.6610.48
87_D168_T0.6600.48
135_A330_T0.6600.48
13_H54_R0.6580.48
27_M226_R0.6540.48
279_H382_A0.6540.48
85_A118_H0.6530.48
274_Y317_V0.6520.48
107_A134_W0.6520.48
211_L248_A0.6490.47
98_A102_H0.6480.47
218_Y258_A0.6460.47
129_G132_A0.6460.47
128_V132_A0.6440.47
306_L318_H0.6440.47
183_P284_A0.6430.47
254_I347_G0.6410.46
64_R67_D0.6380.46
212_Y288_G0.6370.46
55_V202_M0.6360.46
16_V291_T0.6340.46
346_V349_N0.6340.46
131_D135_A0.6330.46
125_V295_V0.6300.45
306_L316_P0.6280.45
271_R275_R0.6280.45
7_D82_V0.6270.45
226_R346_V0.6260.45
184_L201_S0.6250.45
214_A224_R0.6250.45
246_R280_V0.6240.45
115_A159_R0.6240.45
123_H126_N0.6230.45
123_H127_R0.6220.44
211_L289_I0.6220.44
246_R284_A0.6220.44
185_V198_A0.6190.44
85_A242_D0.6190.44
318_H321_L0.6190.44
178_L181_Q0.6180.44
278_E289_I0.6180.44
312_A369_E0.6160.44
293_E312_A0.6130.44
198_A234_L0.6120.43
115_A157_E0.6120.43
48_V157_E0.6100.43
47_D154_F0.6090.43
269_F348_C0.6090.43
95_L164_F0.6080.43
305_N357_L0.6080.43
226_R343_S0.6070.43
223_H227_A0.6060.43
266_M270_R0.6050.43
271_R312_A0.6040.43
111_D147_L0.6040.43
124_D127_R0.6030.42
375_E379_A0.6020.42
267_L365_V0.6020.42
220_G345_D0.6000.42
72_T337_D0.5990.42
155_F169_H0.5980.42
124_D233_T0.5980.42
217_D223_H0.5980.42
42_R60_P0.5970.42
13_H48_V0.5970.42
274_Y291_T0.5970.42
192_I196_V0.5960.42
9_V66_A0.5960.42
18_V286_A0.5940.42
222_D280_V0.5930.41
258_A265_R0.5930.41
22_H226_R0.5930.41
293_E309_V0.5920.41
289_I315_L0.5910.41
190_G348_C0.5900.41
293_E310_D0.5900.41
195_P342_S0.5880.41
293_E350_R0.5880.41
181_Q296_G0.5870.41
32_R53_G0.5870.41
43_G324_W0.5860.41
105_G143_P0.5850.41
260_A277_A0.5840.41
379_A382_A0.5840.41
92_S129_G0.5830.40
364_S368_D0.5820.40
266_M348_C0.5820.40
220_G231_V0.5810.40
27_M117_T0.5790.40
199_W336_I0.5780.40
266_M309_V0.5780.40
254_I351_L0.5780.40
202_M309_V0.5770.40
270_R353_P0.5770.40
202_M272_F0.5760.40
137_V144_V0.5760.40
349_N352_A0.5760.40
109_A351_L0.5750.40
248_A280_V0.5730.39
31_L204_R0.5710.39
293_E351_L0.5700.39
85_A317_V0.5700.39
84_V165_V0.5700.39
328_R331_A0.5670.39
32_R55_V0.5670.39
257_L261_T0.5670.39
95_L154_F0.5670.39
64_R68_A0.5660.39
221_P224_R0.5640.39
290_V323_T0.5640.39
155_F166_F0.5640.39
103_Y151_D0.5630.38
161_A164_F0.5620.38
273_M349_N0.5620.38
153_T203_R0.5600.38
166_F352_A0.5590.38
122_S126_N0.5590.38
230_A342_S0.5580.38
107_A150_P0.5580.38
237_Y336_I0.5580.38
53_G166_F0.5570.38
220_G329_I0.5560.38
265_R352_A0.5540.38
195_P338_T0.5530.37
246_R385_G0.5530.37
181_Q306_L0.5520.37
75_V173_P0.5510.37
22_H254_I0.5500.37
17_G24_Q0.5490.37
207_P244_S0.5460.37
98_A137_V0.5450.37
29_R36_A0.5450.37
266_M349_N0.5440.37
88_L91_I0.5440.37
263_R352_A0.5430.37
114_R122_S0.5420.36
17_G50_R0.5420.36
35_V327_Q0.5420.36
282_E311_R0.5410.36
266_M274_Y0.5400.36
86_P118_H0.5390.36
22_H118_H0.5390.36
28_E323_T0.5390.36
104_D133_V0.5390.36
214_A218_Y0.5380.36
81_A328_R0.5370.36
89_D289_I0.5370.36
219_G230_A0.5360.36
278_E282_E0.5350.36
86_P90_A0.5340.36
76_V327_Q0.5340.36
36_A201_S0.5330.36
284_A385_G0.5320.35
258_A352_A0.5310.35
219_G346_V0.5310.35
199_W264_T0.5300.35
12_R159_R0.5290.35
13_H16_V0.5290.35
103_Y139_D0.5290.35
51_E164_F0.5280.35
197_A201_S0.5280.35
87_D91_I0.5280.35
128_V156_V0.5280.35
329_I356_P0.5270.35
20_S358_T0.5260.35
146_D150_P0.5260.35
131_D134_W0.5260.35
117_T226_R0.5250.35
375_E378_R0.5240.35
206_A290_V0.5240.35
183_P244_S0.5230.35
22_H351_L0.5230.35
113_R126_N0.5230.35
112_A129_G0.5220.35
290_V337_D0.5220.35
27_M219_G0.5210.34
279_H335_S0.5210.34
213_L217_D0.5190.34
84_V163_A0.5190.34
230_A346_V0.5180.34
25_S29_R0.5180.34
125_V330_T0.5180.34
84_V156_V0.5170.34
218_Y223_H0.5160.34
110_V199_W0.5160.34
224_R245_L0.5150.34
184_L208_V0.5150.34
287_A303_T0.5140.34
28_E32_R0.5130.34
200_E324_W0.5130.34
21_S24_Q0.5130.34
97_A383_D0.5120.34
274_Y309_V0.5110.33
251_G269_F0.5110.33
373_L377_A0.5080.33
91_I95_L0.5070.33
219_G226_R0.5070.33
66_A70_A0.5070.33
190_G226_R0.5060.33
261_T266_M0.5060.33
51_E56_L0.5060.33
93_D379_A0.5050.33
376_W383_D0.5050.33
13_H216_G0.5040.33
307_G366_R0.5030.33
15_D204_R0.5020.33
73_F159_R0.5020.33
55_V309_V0.5020.33
226_R344_L0.5020.33
111_D123_H0.5020.33
71_D237_Y0.5020.33
68_A285_G0.5010.33
13_H176_M0.5010.33
185_V284_A0.5010.33
216_G351_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c5sA 2 0.926 100 0.391 Contact Map
4kr6A 2 0.9668 100 0.391 Contact Map
1vbkA 2 0.7628 100 0.487 Contact Map
3uowA 2 0.8495 99.9 0.838 Contact Map
2dplA 2 0.5153 99.9 0.852 Contact Map
1gpmA 3 0.8673 99.9 0.854 Contact Map
3tqiA 3 0.8342 99.9 0.858 Contact Map
2ywbA 4 0.8724 99.8 0.861 Contact Map
2derA 1 0.4974 99.8 0.867 Contact Map
2hmaA 2 0.5179 99.8 0.871 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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