GREMLIN Database
Q9HQ70 - Cysteine synthase
UniProt: Q9HQ70 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (281)
Sequences: 21153 (10911)
Seq/√Len: 650.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_A84_L4.0881.00
23_T278_L3.3921.00
120_V123_R3.3911.00
15_R23_T3.0881.00
239_A268_R2.7261.00
246_R250_E2.6301.00
94_T98_Q2.5961.00
153_I280_C2.5741.00
164_A192_V2.5501.00
48_A52_A2.5001.00
83_D106_D2.4541.00
60_Q85_T2.4471.00
123_R127_D2.4071.00
90_A111_D2.3621.00
197_E236_A2.3571.00
48_A140_A2.3341.00
50_E82_Y2.3311.00
190_S231_T2.3251.00
85_T106_D2.2931.00
87_V124_V2.2611.00
221_S224_L2.1211.00
179_A228_L2.0721.00
47_L80_R2.0501.00
262_A281_P2.0191.00
186_H189_M2.0091.00
236_A239_A2.0071.00
85_T108_E2.0061.00
151_E181_R1.9811.00
198_A237_V1.9791.00
25_A278_L1.9701.00
137_E222_D1.9541.00
203_S207_S1.9301.00
146_Y184_E1.9271.00
179_A191_V1.8851.00
165_L182_L1.8781.00
50_E53_G1.8211.00
169_V193_A1.8121.00
221_S225_D1.7941.00
194_V265_A1.7901.00
192_V231_T1.7871.00
200_A204_T1.7841.00
247_L255_V1.7621.00
13_L280_C1.7611.00
34_A75_L1.7391.00
134_G137_E1.7311.00
122_D126_A1.7171.00
146_Y180_T1.6951.00
25_A157_V1.6781.00
183_R230_D1.6491.00
231_T272_R1.6451.00
243_E264_L1.6241.00
274_A277_S1.6131.00
165_L178_T1.6081.00
247_L263_A1.6021.00
246_R267_T1.6011.00
15_R25_A1.5871.00
175_I229_I1.5831.00
97_K109_L1.5781.00
65_T70_G1.5631.00
215_M261_A1.5371.00
50_E80_R1.5271.00
163_D277_S1.5111.00
163_D278_L1.5091.00
43_R47_L1.5031.00
26_A283_V1.5011.00
222_D225_D1.4951.00
162_I280_C1.4941.00
150_A178_T1.4891.00
98_Q101_R1.4811.00
150_A182_L1.4141.00
45_M138_N1.4121.00
164_A277_S1.4031.00
97_K101_R1.4031.00
108_E120_V1.3861.00
166_V269_T1.3541.00
243_E267_T1.3291.00
125_A132_R1.3291.00
164_A190_S1.3091.00
204_T207_S1.2941.00
60_Q83_D1.2931.00
113_G116_T1.2861.00
88_M100_L1.2781.00
97_K107_L1.2761.00
150_A181_R1.2731.00
166_V194_V1.2721.00
47_L51_R1.2631.00
94_T97_K1.2561.00
100_L105_A1.2531.00
157_V162_I1.2521.00
239_A264_L1.2401.00
48_A51_R1.2261.00
264_L268_R1.2241.00
182_L189_M1.2231.00
70_G100_L1.2081.00
197_E234_T1.2031.00
203_S234_T1.1971.00
46_V61_L1.1891.00
91_S112_A1.1861.00
180_T225_D1.1761.00
44_E147_R1.1721.00
243_E263_A1.1701.00
269_T272_R1.1691.00
154_L185_A1.1691.00
115_E119_Q1.1661.00
200_A205_G1.1641.00
268_R271_E1.1621.00
154_L181_R1.1581.00
204_T208_G1.1571.00
181_R185_A1.1501.00
14_V28_L1.1501.00
118_N122_D1.1471.00
175_I191_V1.1451.00
151_E155_D1.1391.00
259_S283_V1.1351.00
242_A246_R1.1291.00
119_Q122_D1.1281.00
122_D125_A1.1281.00
87_V120_V1.1271.00
13_L153_I1.1261.00
200_A234_T1.1201.00
88_M109_L1.1181.00
239_A242_A1.1121.00
248_A254_L1.1061.00
90_A112_A1.1061.00
212_F240_A1.1021.00
13_L157_V1.1021.00
154_L186_H1.0941.00
44_E144_A1.0921.00
193_A232_V1.0881.00
255_V283_V1.0871.00
120_V124_V1.0661.00
235_V264_L1.0651.00
233_E265_A1.0631.00
12_P31_F1.0581.00
175_I193_A1.0541.00
238_D242_A1.0531.00
42_A72_G1.0481.00
114_M117_A1.0431.00
52_A140_A1.0401.00
273_I277_S1.0381.00
164_A273_I1.0381.00
19_P246_R1.0341.00
192_V233_E1.0281.00
44_E48_A1.0281.00
46_V80_R1.0271.00
153_I162_I1.0201.00
145_H149_T1.0201.00
206_E232_V1.0131.00
61_L77_A1.0121.00
101_R106_D1.0071.00
157_V280_C1.0071.00
44_E47_L1.0051.00
245_R249_R1.0031.00
78_A84_L1.0011.00
116_T119_Q0.9971.00
45_M133_V0.9951.00
46_V76_T0.9951.00
211_D241_E0.9931.00
160_R278_L0.9921.00
119_Q123_R0.9911.00
19_P250_E0.9871.00
62_V130_A0.9861.00
75_L103_Y0.9801.00
22_A276_P0.9741.00
72_G76_T0.9711.00
18_A251_E0.9671.00
62_V124_V0.9661.00
73_L84_L0.9641.00
200_A203_S0.9611.00
24_I266_A0.9601.00
22_A277_S0.9601.00
178_T282_D0.9511.00
16_L263_A0.9431.00
244_T260_G0.9391.00
74_A105_A0.9341.00
63_E86_I0.9291.00
121_A125_A0.9271.00
284_S287_A0.9251.00
210_D216_G0.9241.00
123_R126_A0.9231.00
169_V175_I0.9191.00
176_T223_N0.9131.00
233_E268_R0.9121.00
49_A53_G0.9061.00
255_V259_S0.9031.00
166_V266_A0.8881.00
21_G275_D0.8861.00
49_A131_F0.8851.00
146_Y181_R0.8821.00
60_Q130_A0.8801.00
142_P223_N0.8801.00
215_M258_S0.8771.00
263_A283_V0.8771.00
266_A281_P0.8741.00
125_A130_A0.8721.00
190_S230_D0.8711.00
124_V128_T0.8611.00
147_R151_E0.8571.00
167_A178_T0.8541.00
259_S284_S0.8441.00
164_A274_A0.8341.00
254_L287_A0.8311.00
59_D129_G0.8301.00
151_E185_A0.8301.00
283_V286_D0.8261.00
62_V121_A0.8231.00
181_R184_E0.8181.00
164_A279_D0.8151.00
243_E246_R0.8111.00
162_I189_M0.8101.00
98_Q102_A0.8091.00
166_V265_A0.8091.00
166_V192_V0.8061.00
85_T124_V0.8041.00
16_L26_A0.8041.00
101_R109_L0.8031.00
11_T32_N0.7941.00
71_I100_L0.7921.00
262_A284_S0.7891.00
85_T130_A0.7891.00
190_S277_S0.7831.00
211_D237_V0.7821.00
144_A147_R0.7781.00
20_E267_T0.7761.00
28_L283_V0.7751.00
263_A281_P0.7741.00
164_A269_T0.7711.00
180_T184_E0.7701.00
149_T174_T0.7701.00
202_L232_V0.7681.00
28_L31_F0.7671.00
75_L79_A0.7641.00
202_L220_V0.7601.00
78_A103_Y0.7601.00
149_T178_T0.7581.00
154_L182_L0.7551.00
199_N205_G0.7491.00
64_A114_M0.7481.00
267_T271_E0.7461.00
8_A43_R0.7451.00
62_V125_A0.7451.00
95_E292_D0.7431.00
203_S232_V0.7421.00
23_T276_P0.7391.00
59_D83_D0.7381.00
50_E54_E0.7351.00
87_V108_E0.7351.00
154_L158_E0.7341.00
142_P180_T0.7341.00
121_A132_R0.7311.00
157_V278_L0.7281.00
169_V232_V0.7281.00
226_R229_I0.7281.00
201_V218_G0.7261.00
149_T153_I0.7231.00
96_R213_Q0.7231.00
84_L105_A0.7221.00
178_T182_L0.7211.00
112_A116_T0.7191.00
44_E140_A0.7161.00
71_I99_L0.7161.00
86_I100_L0.7141.00
255_V260_G0.7131.00
241_E257_Q0.7111.00
54_E82_Y0.7091.00
149_T282_D0.7071.00
110_V120_V0.7061.00
201_V204_T0.7051.00
37_A174_T0.7001.00
196_P215_M0.6971.00
233_E272_R0.6931.00
61_L82_Y0.6921.00
269_T273_I0.6911.00
64_A132_R0.6901.00
90_A109_L0.6861.00
134_G138_N0.6861.00
83_D130_A0.6841.00
268_R272_R0.6831.00
22_A279_D0.6821.00
26_A281_P0.6771.00
26_A263_A0.6761.00
168_G284_S0.6741.00
114_M118_N0.6691.00
205_G208_G0.6671.00
217_P220_V0.6671.00
155_D185_A0.6671.00
162_I278_L0.6661.00
165_L282_D0.6631.00
131_F138_N0.6621.00
240_A261_A0.6601.00
192_V269_T0.6571.00
139_P142_P0.6531.00
85_T128_T0.6521.00
231_T269_T0.6521.00
87_V110_V0.6501.00
154_L157_V0.6491.00
124_V127_D0.6491.00
247_L251_E0.6481.00
67_G70_G0.6461.00
201_V205_G0.6451.00
61_L84_L0.6441.00
42_A76_T0.6381.00
41_P45_M0.6371.00
270_A273_I0.6371.00
168_G262_A0.6361.00
94_T101_R0.6361.00
165_L189_M0.6321.00
92_M97_K0.6321.00
35_G286_D0.6311.00
45_M141_N0.6291.00
74_A100_L0.6291.00
22_A270_A0.6291.00
58_G83_D0.6291.00
61_L133_V0.6271.00
153_I178_T0.6231.00
212_F215_M0.6211.00
13_L25_A0.6171.00
88_M97_K0.6151.00
214_G258_S0.6141.00
22_A274_A0.6141.00
58_G129_G0.6131.00
63_E73_L0.6131.00
48_A54_E0.6111.00
247_L253_V0.6091.00
116_T120_V0.6071.00
106_D128_T0.6061.00
92_M213_Q0.6061.00
39_D75_L0.6021.00
113_G117_A0.6011.00
62_V87_V0.6001.00
45_M140_A0.5981.00
281_P284_S0.5981.00
114_M135_Q0.5971.00
283_V287_A0.5961.00
34_A103_Y0.5951.00
27_K152_E0.5951.00
237_V241_E0.5941.00
18_A250_E0.5921.00
8_A31_F0.5911.00
244_T257_Q0.5891.00
54_E131_F0.5891.00
194_V261_A0.5871.00
165_L191_V0.5861.00
194_V233_E0.5861.00
166_V279_D0.5851.00
207_S231_T0.5841.00
263_A267_T0.5831.00
265_A269_T0.5821.00
51_R58_G0.5811.00
10_G33_P0.5801.00
88_M92_M0.5791.00
183_R228_L0.5791.00
183_R227_E0.5761.00
176_T180_T0.5761.00
169_V202_L0.5761.00
28_L253_V0.5751.00
118_N121_A0.5751.00
167_A175_I0.5741.00
9_I43_R0.5741.00
144_A180_T0.5721.00
259_S262_A0.5721.00
19_P267_T0.5721.00
193_A229_I0.5711.00
69_T133_V0.5701.00
70_G86_I0.5701.00
9_I39_D0.5671.00
99_L102_A0.5661.00
120_V127_D0.5661.00
154_L159_G0.5651.00
74_A84_L0.5651.00
26_A247_L0.5601.00
73_L133_V0.5571.00
41_P69_T0.5571.00
33_P39_D0.5551.00
30_G286_D0.5541.00
65_T86_I0.5521.00
10_G32_N0.5511.00
13_L156_Q0.5471.00
144_A148_T0.5441.00
33_P75_L0.5411.00
69_T146_Y0.5411.00
124_V130_A0.5411.00
140_A144_A0.5401.00
273_I279_D0.5401.00
73_L86_I0.5381.00
247_L283_V0.5371.00
178_T181_R0.5371.00
235_V261_A0.5361.00
195_E201_V0.5351.00
7_D10_G0.5341.00
197_E200_A0.5341.00
45_M131_F0.5320.99
62_V132_R0.5320.99
266_A270_A0.5300.99
198_A209_D0.5280.99
63_E69_T0.5280.99
9_I32_N0.5270.99
30_G253_V0.5260.99
87_V123_R0.5250.99
108_E124_V0.5240.99
242_A249_R0.5240.99
64_A133_V0.5210.99
122_D132_R0.5200.99
14_V253_V0.5180.99
41_P142_P0.5170.99
178_T191_V0.5160.99
20_E246_R0.5150.99
53_G131_F0.5140.99
236_A268_R0.5140.99
183_R187_P0.5140.99
237_V240_A0.5140.99
59_D130_A0.5130.99
242_A245_R0.5130.99
99_L254_L0.5120.99
111_D116_T0.5100.99
106_D109_L0.5090.99
211_D214_G0.5050.99
213_Q216_G0.5040.99
153_I165_L0.5040.99
45_M48_A0.5030.99
26_A30_G0.5010.99
285_F288_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y7lA 2 0.9021 100 0.214 Contact Map
4r2vA 2 0.9021 100 0.215 Contact Map
2pqmA 2 0.9572 100 0.216 Contact Map
4ofxA 2 0.8563 100 0.216 Contact Map
4ql4A 2 0.8073 100 0.216 Contact Map
2eguA 2 0.8012 100 0.217 Contact Map
4lmbA 2 0.9052 100 0.221 Contact Map
2q3bA 2 0.8869 100 0.221 Contact Map
3x44A 3 0.9358 100 0.221 Contact Map
3tbhA 2 0.9205 100 0.222 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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