Q9HQ70 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HQ70 - Cysteine synthase

UniProt:	Q9HQ70	Sequences: MKDSILDAIGTPLVRLTAPEGATIAAKLEGFNPAGSAKDRPAREMVLAAERAGEIQPGDQLVEATSGNTGIGLALTAAARGYDLTIVMPASMSTERKQLLRAYGADLELVDAGMETANQVADRVAADTGAFRVGQFENPANPRAHYRTTAEEILDQVEGREIDALVAGVGTGGTITGTATRLREAHPEMSVVAVEPEANAVLSTGESGDDDFQGMGPGFVSDNLDRELIDTVETVAVDAAEAETRRLAREEGVLVGQSSGAAALAATRTAERIADPSLDCPDVSFDADAVGDPDAIADGGDGPDDCPLVVTILPDTGERYLSAGVFD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	327 (281)
Sequences:	21153 (10911)
Seq/√Len:	650.9

ECOLI - CYSK CYSM ILVA DPAL TRPB TDCB SDHD DCYD THRC
BACSU - MCCA CYSK CYSM ILVA THRC TRPB SDHD
HALSA - Q9HQ70 Q9HNH6 Q9HRU4 Q9HMQ7 TRPB Q9HNH0 Q9HRP3
SULSO - Q980P1 Q97ZL6 TRPB1 Q980F2 TRPB2 Q97ZT5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
77_A	84_L	4.088	1.00
23_T	278_L	3.392	1.00
120_V	123_R	3.391	1.00
15_R	23_T	3.088	1.00
239_A	268_R	2.726	1.00
246_R	250_E	2.630	1.00
94_T	98_Q	2.596	1.00
153_I	280_C	2.574	1.00
164_A	192_V	2.550	1.00
48_A	52_A	2.500	1.00
83_D	106_D	2.454	1.00
60_Q	85_T	2.447	1.00
123_R	127_D	2.407	1.00
90_A	111_D	2.362	1.00
197_E	236_A	2.357	1.00
48_A	140_A	2.334	1.00
50_E	82_Y	2.331	1.00
190_S	231_T	2.325	1.00
85_T	106_D	2.293	1.00
87_V	124_V	2.261	1.00
221_S	224_L	2.121	1.00
179_A	228_L	2.072	1.00
47_L	80_R	2.050	1.00
262_A	281_P	2.019	1.00
186_H	189_M	2.009	1.00
236_A	239_A	2.007	1.00
85_T	108_E	2.006	1.00
151_E	181_R	1.981	1.00
198_A	237_V	1.979	1.00
25_A	278_L	1.970	1.00
137_E	222_D	1.954	1.00
203_S	207_S	1.930	1.00
146_Y	184_E	1.927	1.00
179_A	191_V	1.885	1.00
165_L	182_L	1.878	1.00
50_E	53_G	1.821	1.00
169_V	193_A	1.812	1.00
221_S	225_D	1.794	1.00
194_V	265_A	1.790	1.00
192_V	231_T	1.787	1.00
200_A	204_T	1.784	1.00
247_L	255_V	1.762	1.00
13_L	280_C	1.761	1.00
34_A	75_L	1.739	1.00
134_G	137_E	1.731	1.00
122_D	126_A	1.717	1.00
146_Y	180_T	1.695	1.00
25_A	157_V	1.678	1.00
183_R	230_D	1.649	1.00
231_T	272_R	1.645	1.00
243_E	264_L	1.624	1.00
274_A	277_S	1.613	1.00
165_L	178_T	1.608	1.00
247_L	263_A	1.602	1.00
246_R	267_T	1.601	1.00
15_R	25_A	1.587	1.00
175_I	229_I	1.583	1.00
97_K	109_L	1.578	1.00
65_T	70_G	1.563	1.00
215_M	261_A	1.537	1.00
50_E	80_R	1.527	1.00
163_D	277_S	1.511	1.00
163_D	278_L	1.509	1.00
43_R	47_L	1.503	1.00
26_A	283_V	1.501	1.00
222_D	225_D	1.495	1.00
162_I	280_C	1.494	1.00
150_A	178_T	1.489	1.00
98_Q	101_R	1.481	1.00
150_A	182_L	1.414	1.00
45_M	138_N	1.412	1.00
164_A	277_S	1.403	1.00
97_K	101_R	1.403	1.00
108_E	120_V	1.386	1.00
166_V	269_T	1.354	1.00
243_E	267_T	1.329	1.00
125_A	132_R	1.329	1.00
164_A	190_S	1.309	1.00
204_T	207_S	1.294	1.00
60_Q	83_D	1.293	1.00
113_G	116_T	1.286	1.00
88_M	100_L	1.278	1.00
97_K	107_L	1.276	1.00
150_A	181_R	1.273	1.00
166_V	194_V	1.272	1.00
47_L	51_R	1.263	1.00
94_T	97_K	1.256	1.00
100_L	105_A	1.253	1.00
157_V	162_I	1.252	1.00
239_A	264_L	1.240	1.00
48_A	51_R	1.226	1.00
264_L	268_R	1.224	1.00
182_L	189_M	1.223	1.00
70_G	100_L	1.208	1.00
197_E	234_T	1.203	1.00
203_S	234_T	1.197	1.00
46_V	61_L	1.189	1.00
91_S	112_A	1.186	1.00
180_T	225_D	1.176	1.00
44_E	147_R	1.172	1.00
243_E	263_A	1.170	1.00
269_T	272_R	1.169	1.00
154_L	185_A	1.169	1.00
115_E	119_Q	1.166	1.00
200_A	205_G	1.164	1.00
268_R	271_E	1.162	1.00
154_L	181_R	1.158	1.00
204_T	208_G	1.157	1.00
181_R	185_A	1.150	1.00
14_V	28_L	1.150	1.00
118_N	122_D	1.147	1.00
175_I	191_V	1.145	1.00
151_E	155_D	1.139	1.00
259_S	283_V	1.135	1.00
242_A	246_R	1.129	1.00
119_Q	122_D	1.128	1.00
122_D	125_A	1.128	1.00
87_V	120_V	1.127	1.00
13_L	153_I	1.126	1.00
200_A	234_T	1.120	1.00
88_M	109_L	1.118	1.00
239_A	242_A	1.112	1.00
248_A	254_L	1.106	1.00
90_A	112_A	1.106	1.00
212_F	240_A	1.102	1.00
13_L	157_V	1.102	1.00
154_L	186_H	1.094	1.00
44_E	144_A	1.092	1.00
193_A	232_V	1.088	1.00
255_V	283_V	1.087	1.00
120_V	124_V	1.066	1.00
235_V	264_L	1.065	1.00
233_E	265_A	1.063	1.00
12_P	31_F	1.058	1.00
175_I	193_A	1.054	1.00
238_D	242_A	1.053	1.00
42_A	72_G	1.048	1.00
114_M	117_A	1.043	1.00
52_A	140_A	1.040	1.00
273_I	277_S	1.038	1.00
164_A	273_I	1.038	1.00
19_P	246_R	1.034	1.00
192_V	233_E	1.028	1.00
44_E	48_A	1.028	1.00
46_V	80_R	1.027	1.00
153_I	162_I	1.020	1.00
145_H	149_T	1.020	1.00
206_E	232_V	1.013	1.00
61_L	77_A	1.012	1.00
101_R	106_D	1.007	1.00
157_V	280_C	1.007	1.00
44_E	47_L	1.005	1.00
245_R	249_R	1.003	1.00
78_A	84_L	1.001	1.00
116_T	119_Q	0.997	1.00
45_M	133_V	0.995	1.00
46_V	76_T	0.995	1.00
211_D	241_E	0.993	1.00
160_R	278_L	0.992	1.00
119_Q	123_R	0.991	1.00
19_P	250_E	0.987	1.00
62_V	130_A	0.986	1.00
75_L	103_Y	0.980	1.00
22_A	276_P	0.974	1.00
72_G	76_T	0.971	1.00
18_A	251_E	0.967	1.00
62_V	124_V	0.966	1.00
73_L	84_L	0.964	1.00
200_A	203_S	0.961	1.00
24_I	266_A	0.960	1.00
22_A	277_S	0.960	1.00
178_T	282_D	0.951	1.00
16_L	263_A	0.943	1.00
244_T	260_G	0.939	1.00
74_A	105_A	0.934	1.00
63_E	86_I	0.929	1.00
121_A	125_A	0.927	1.00
284_S	287_A	0.925	1.00
210_D	216_G	0.924	1.00
123_R	126_A	0.923	1.00
169_V	175_I	0.919	1.00
176_T	223_N	0.913	1.00
233_E	268_R	0.912	1.00
49_A	53_G	0.906	1.00
255_V	259_S	0.903	1.00
166_V	266_A	0.888	1.00
21_G	275_D	0.886	1.00
49_A	131_F	0.885	1.00
146_Y	181_R	0.882	1.00
60_Q	130_A	0.880	1.00
142_P	223_N	0.880	1.00
215_M	258_S	0.877	1.00
263_A	283_V	0.877	1.00
266_A	281_P	0.874	1.00
125_A	130_A	0.872	1.00
190_S	230_D	0.871	1.00
124_V	128_T	0.861	1.00
147_R	151_E	0.857	1.00
167_A	178_T	0.854	1.00
259_S	284_S	0.844	1.00
164_A	274_A	0.834	1.00
254_L	287_A	0.831	1.00
59_D	129_G	0.830	1.00
151_E	185_A	0.830	1.00
283_V	286_D	0.826	1.00
62_V	121_A	0.823	1.00
181_R	184_E	0.818	1.00
164_A	279_D	0.815	1.00
243_E	246_R	0.811	1.00
162_I	189_M	0.810	1.00
98_Q	102_A	0.809	1.00
166_V	265_A	0.809	1.00
166_V	192_V	0.806	1.00
85_T	124_V	0.804	1.00
16_L	26_A	0.804	1.00
101_R	109_L	0.803	1.00
11_T	32_N	0.794	1.00
71_I	100_L	0.792	1.00
262_A	284_S	0.789	1.00
85_T	130_A	0.789	1.00
190_S	277_S	0.783	1.00
211_D	237_V	0.782	1.00
144_A	147_R	0.778	1.00
20_E	267_T	0.776	1.00
28_L	283_V	0.775	1.00
263_A	281_P	0.774	1.00
164_A	269_T	0.771	1.00
180_T	184_E	0.770	1.00
149_T	174_T	0.770	1.00
202_L	232_V	0.768	1.00
28_L	31_F	0.767	1.00
75_L	79_A	0.764	1.00
202_L	220_V	0.760	1.00
78_A	103_Y	0.760	1.00
149_T	178_T	0.758	1.00
154_L	182_L	0.755	1.00
199_N	205_G	0.749	1.00
64_A	114_M	0.748	1.00
267_T	271_E	0.746	1.00
8_A	43_R	0.745	1.00
62_V	125_A	0.745	1.00
95_E	292_D	0.743	1.00
203_S	232_V	0.742	1.00
23_T	276_P	0.739	1.00
59_D	83_D	0.738	1.00
50_E	54_E	0.735	1.00
87_V	108_E	0.735	1.00
154_L	158_E	0.734	1.00
142_P	180_T	0.734	1.00
121_A	132_R	0.731	1.00
157_V	278_L	0.728	1.00
169_V	232_V	0.728	1.00
226_R	229_I	0.728	1.00
201_V	218_G	0.726	1.00
149_T	153_I	0.723	1.00
96_R	213_Q	0.723	1.00
84_L	105_A	0.722	1.00
178_T	182_L	0.721	1.00
112_A	116_T	0.719	1.00
44_E	140_A	0.716	1.00
71_I	99_L	0.716	1.00
86_I	100_L	0.714	1.00
255_V	260_G	0.713	1.00
241_E	257_Q	0.711	1.00
54_E	82_Y	0.709	1.00
149_T	282_D	0.707	1.00
110_V	120_V	0.706	1.00
201_V	204_T	0.705	1.00
37_A	174_T	0.700	1.00
196_P	215_M	0.697	1.00
233_E	272_R	0.693	1.00
61_L	82_Y	0.692	1.00
269_T	273_I	0.691	1.00
64_A	132_R	0.690	1.00
90_A	109_L	0.686	1.00
134_G	138_N	0.686	1.00
83_D	130_A	0.684	1.00
268_R	272_R	0.683	1.00
22_A	279_D	0.682	1.00
26_A	281_P	0.677	1.00
26_A	263_A	0.676	1.00
168_G	284_S	0.674	1.00
114_M	118_N	0.669	1.00
205_G	208_G	0.667	1.00
217_P	220_V	0.667	1.00
155_D	185_A	0.667	1.00
162_I	278_L	0.666	1.00
165_L	282_D	0.663	1.00
131_F	138_N	0.662	1.00
240_A	261_A	0.660	1.00
192_V	269_T	0.657	1.00
139_P	142_P	0.653	1.00
85_T	128_T	0.652	1.00
231_T	269_T	0.652	1.00
87_V	110_V	0.650	1.00
154_L	157_V	0.649	1.00
124_V	127_D	0.649	1.00
247_L	251_E	0.648	1.00
67_G	70_G	0.646	1.00
201_V	205_G	0.645	1.00
61_L	84_L	0.644	1.00
42_A	76_T	0.638	1.00
41_P	45_M	0.637	1.00
270_A	273_I	0.637	1.00
168_G	262_A	0.636	1.00
94_T	101_R	0.636	1.00
165_L	189_M	0.632	1.00
92_M	97_K	0.632	1.00
35_G	286_D	0.631	1.00
45_M	141_N	0.629	1.00
74_A	100_L	0.629	1.00
22_A	270_A	0.629	1.00
58_G	83_D	0.629	1.00
61_L	133_V	0.627	1.00
153_I	178_T	0.623	1.00
212_F	215_M	0.621	1.00
13_L	25_A	0.617	1.00
88_M	97_K	0.615	1.00
214_G	258_S	0.614	1.00
22_A	274_A	0.614	1.00
58_G	129_G	0.613	1.00
63_E	73_L	0.613	1.00
48_A	54_E	0.611	1.00
247_L	253_V	0.609	1.00
116_T	120_V	0.607	1.00
106_D	128_T	0.606	1.00
92_M	213_Q	0.606	1.00
39_D	75_L	0.602	1.00
113_G	117_A	0.601	1.00
62_V	87_V	0.600	1.00
45_M	140_A	0.598	1.00
281_P	284_S	0.598	1.00
114_M	135_Q	0.597	1.00
283_V	287_A	0.596	1.00
34_A	103_Y	0.595	1.00
27_K	152_E	0.595	1.00
237_V	241_E	0.594	1.00
18_A	250_E	0.592	1.00
8_A	31_F	0.591	1.00
244_T	257_Q	0.589	1.00
54_E	131_F	0.589	1.00
194_V	261_A	0.587	1.00
165_L	191_V	0.586	1.00
194_V	233_E	0.586	1.00
166_V	279_D	0.585	1.00
207_S	231_T	0.584	1.00
263_A	267_T	0.583	1.00
265_A	269_T	0.582	1.00
51_R	58_G	0.581	1.00
10_G	33_P	0.580	1.00
88_M	92_M	0.579	1.00
183_R	228_L	0.579	1.00
183_R	227_E	0.576	1.00
176_T	180_T	0.576	1.00
169_V	202_L	0.576	1.00
28_L	253_V	0.575	1.00
118_N	121_A	0.575	1.00
167_A	175_I	0.574	1.00
9_I	43_R	0.574	1.00
144_A	180_T	0.572	1.00
259_S	262_A	0.572	1.00
19_P	267_T	0.572	1.00
193_A	229_I	0.571	1.00
69_T	133_V	0.570	1.00
70_G	86_I	0.570	1.00
9_I	39_D	0.567	1.00
99_L	102_A	0.566	1.00
120_V	127_D	0.566	1.00
154_L	159_G	0.565	1.00
74_A	84_L	0.565	1.00
26_A	247_L	0.560	1.00
73_L	133_V	0.557	1.00
41_P	69_T	0.557	1.00
33_P	39_D	0.555	1.00
30_G	286_D	0.554	1.00
65_T	86_I	0.552	1.00
10_G	32_N	0.551	1.00
13_L	156_Q	0.547	1.00
144_A	148_T	0.544	1.00
33_P	75_L	0.541	1.00
69_T	146_Y	0.541	1.00
124_V	130_A	0.541	1.00
140_A	144_A	0.540	1.00
273_I	279_D	0.540	1.00
73_L	86_I	0.538	1.00
247_L	283_V	0.537	1.00
178_T	181_R	0.537	1.00
235_V	261_A	0.536	1.00
195_E	201_V	0.535	1.00
7_D	10_G	0.534	1.00
197_E	200_A	0.534	1.00
45_M	131_F	0.532	0.99
62_V	132_R	0.532	0.99
266_A	270_A	0.530	0.99
198_A	209_D	0.528	0.99
63_E	69_T	0.528	0.99
9_I	32_N	0.527	0.99
30_G	253_V	0.526	0.99
87_V	123_R	0.525	0.99
108_E	124_V	0.524	0.99
242_A	249_R	0.524	0.99
64_A	133_V	0.521	0.99
122_D	132_R	0.520	0.99
14_V	253_V	0.518	0.99
41_P	142_P	0.517	0.99
178_T	191_V	0.516	0.99
20_E	246_R	0.515	0.99
53_G	131_F	0.514	0.99
236_A	268_R	0.514	0.99
183_R	187_P	0.514	0.99
237_V	240_A	0.514	0.99
59_D	130_A	0.513	0.99
242_A	245_R	0.513	0.99
99_L	254_L	0.512	0.99
111_D	116_T	0.510	0.99
106_D	109_L	0.509	0.99
211_D	214_G	0.505	0.99
213_Q	216_G	0.504	0.99
153_I	165_L	0.504	0.99
45_M	48_A	0.503	0.99
26_A	30_G	0.501	0.99
285_F	288_D	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1y7lA	2	0.9021	100	0.214	Contact Map
4r2vA	2	0.9021	100	0.215	Contact Map
2pqmA	2	0.9572	100	0.216	Contact Map
4ofxA	2	0.8563	100	0.216	Contact Map
4ql4A	2	0.8073	100	0.216	Contact Map
2eguA	2	0.8012	100	0.217	Contact Map
4lmbA	2	0.9052	100	0.221	Contact Map
2q3bA	2	0.8869	100	0.221	Contact Map
3x44A	3	0.9358	100	0.221	Contact Map
3tbhA	2	0.9205	100	0.222	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0098 seconds.