GREMLIN Database
Q9HQ69 - Uncharacterized protein
UniProt: Q9HQ69 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 116 (100)
Sequences: 10823 (7243)
Seq/√Len: 724.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_D74_V3.2231.00
17_E76_E2.4901.00
11_S63_S2.3871.00
86_V97_R2.3801.00
13_P72_P2.2701.00
13_P73_R2.0161.00
52_A107_E1.9191.00
36_C39_C1.8971.00
27_T61_P1.8921.00
77_Y88_E1.8911.00
66_D69_K1.8821.00
67_D82_I1.8431.00
30_V64_R1.8361.00
94_E97_R1.7741.00
25_D61_P1.7651.00
53_S107_E1.7571.00
107_E111_A1.7271.00
46_F62_V1.6791.00
45_D48_A1.6751.00
86_V94_E1.6751.00
13_P70_T1.6561.00
105_P108_R1.6521.00
26_A87_V1.6291.00
15_V19_F1.5531.00
98_F102_D1.5371.00
28_V46_F1.5051.00
34_D66_D1.4961.00
49_A62_V1.4881.00
53_S111_A1.4691.00
19_F61_P1.4371.00
49_A107_E1.4171.00
28_V85_V1.4091.00
101_R105_P1.3931.00
27_T63_S1.3851.00
11_S19_F1.3591.00
9_A19_F1.3581.00
12_Y15_V1.3421.00
42_Q85_V1.3371.00
12_Y70_T1.2871.00
96_A109_Y1.2621.00
42_Q45_D1.2581.00
65_G73_R1.2481.00
98_F109_Y1.2411.00
17_E21_S1.2041.00
87_V109_Y1.1971.00
30_V43_L1.1571.00
9_A61_P1.1421.00
55_V59_V1.0911.00
29_H88_E1.0771.00
47_A64_R1.0731.00
102_D105_P1.0691.00
19_F27_T1.0551.00
43_L47_A1.0451.00
71_G75_D1.0101.00
10_E64_R1.0091.00
43_L64_R1.0021.00
31_W77_Y0.9351.00
49_A53_S0.9271.00
32_G64_R0.9131.00
32_G66_D0.8871.00
42_Q106_P0.8821.00
45_D103_S0.8721.00
87_V110_L0.8721.00
85_V106_P0.8711.00
41_S101_R0.8521.00
72_P76_E0.8511.00
46_F85_V0.8481.00
90_A95_H0.8351.00
10_E69_K0.8281.00
45_D49_A0.8221.00
59_V111_A0.8201.00
65_G74_V0.8141.00
50_L62_V0.8101.00
15_V63_S0.8071.00
32_G82_I0.7971.00
20_E27_T0.7951.00
49_A106_P0.7871.00
108_R111_A0.7851.00
53_S60_H0.7801.00
104_L108_R0.7771.00
28_V62_V0.7741.00
37_G40_R0.7511.00
34_D68_G0.7481.00
51_A54_G0.7391.00
60_H110_L0.7341.00
16_I31_W0.7331.00
30_V38_D0.7301.00
42_Q102_D0.7261.00
16_I20_E0.7261.00
31_W79_I0.7201.00
31_W86_V0.7171.00
30_V42_Q0.6951.00
25_D91_D0.6911.00
8_D50_L0.6891.00
70_T73_R0.6841.00
38_D81_R0.6821.00
48_A51_A0.6811.00
31_W67_D0.6761.00
72_P75_D0.6731.00
29_H63_S0.6651.00
26_A90_A0.6621.00
53_S59_V0.6621.00
45_D101_R0.6551.00
24_A27_T0.6491.00
28_V87_V0.6451.00
46_F110_L0.6371.00
11_S15_V0.6351.00
16_I73_R0.6331.00
16_I77_Y0.6291.00
42_Q46_F0.6281.00
80_D97_R0.6271.00
102_D109_Y0.6221.00
73_R76_E0.6181.00
42_Q101_R0.6141.00
38_D41_S0.6131.00
79_I84_T0.6081.00
16_I29_H0.5921.00
28_V106_P0.5921.00
33_G68_G0.5871.00
28_V110_L0.5871.00
13_P76_E0.5841.00
85_V98_F0.5821.00
37_G41_S0.5721.00
18_A23_P0.5691.00
19_F63_S0.5691.00
34_D69_K0.5641.00
54_G59_V0.5621.00
31_W65_G0.5601.00
10_E63_S0.5561.00
109_Y112_D0.5561.00
24_A91_D0.5551.00
11_S29_H0.5541.00
25_D59_V0.5501.00
15_V18_A0.5481.00
33_G36_C0.5461.00
71_G74_V0.5451.00
10_E32_G0.5431.00
65_G70_T0.5421.00
34_D40_R0.5361.00
67_D79_I0.5361.00
81_R99_E0.5331.00
35_W40_R0.5311.00
92_G95_H0.5241.00
39_C44_P0.5211.00
46_F106_P0.5181.00
8_D46_F0.5141.00
35_W68_G0.5061.00
88_E94_E0.5020.99
9_A27_T0.5010.99
9_A63_S0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r2jA 2 0.9138 99.8 0.204 Contact Map
3f8uA 2 0.9138 99.8 0.204 Contact Map
2b5eA 1 0.9655 99.8 0.21 Contact Map
3apoA 1 0.8879 99.8 0.213 Contact Map
4ekzA 1 0.9828 99.8 0.231 Contact Map
3ed3A 1 0.9655 99.8 0.25 Contact Map
1sjiA 2 0.9569 99.8 0.262 Contact Map
3us3A 2 0.9569 99.8 0.265 Contact Map
3t58A 1 1 99.7 0.286 Contact Map
3uemA 1 0.9741 99.7 0.287 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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