GREMLIN Database
Q9HQ67 - Phosphoribosylamine--glycine ligase
UniProt: Q9HQ67 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 430 (383)
Sequences: 20539 (11292)
Seq/√Len: 577.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_T162_Q4.0591.00
4_R28_Y3.4631.00
133_A166_P3.4121.00
161_D164_S3.3201.00
58_D62_A3.3031.00
128_D131_A3.2541.00
122_D184_E2.9461.00
52_D55_A2.9211.00
245_Q249_D2.8921.00
141_G162_Q2.7891.00
82_D100_R2.7611.00
385_S388_A2.6581.00
82_D86_D2.6531.00
307_A312_E2.6231.00
248_V252_R2.6221.00
383_G388_A2.5201.00
114_A253_A2.4341.00
160_G164_S2.3511.00
241_D245_Q2.3331.00
237_P241_D2.3051.00
61_T87_A2.3031.00
272_T275_G2.2841.00
124_E138_G2.2511.00
112_M250_T2.2391.00
77_A103_T2.2281.00
83_A87_A2.1241.00
236_V239_A2.1111.00
199_N262_R2.1061.00
135_Y138_G2.0371.00
230_A296_T2.0231.00
298_E320_S1.9871.00
303_D307_A1.9811.00
110_E114_A1.9791.00
162_Q166_P1.9701.00
7_L18_A1.9691.00
160_G187_D1.9691.00
107_F110_E1.9581.00
298_E318_A1.9301.00
158_V185_R1.9171.00
187_D273_A1.9151.00
246_A276_P1.9001.00
343_T368_S1.8821.00
53_P83_A1.8591.00
129_S166_P1.8551.00
57_V87_A1.8491.00
242_A245_Q1.8471.00
384_D388_A1.8381.00
5_V92_F1.8241.00
21_L29_A1.8141.00
135_Y139_V1.8051.00
133_A162_Q1.7881.00
166_P170_D1.7861.00
129_S170_D1.7581.00
129_S133_A1.7571.00
24_D303_D1.7511.00
111_F253_A1.7471.00
110_E113_A1.7371.00
100_R107_F1.7241.00
115_N253_A1.7041.00
57_V61_T1.6951.00
326_C393_V1.6931.00
362_D365_D1.6921.00
239_A242_A1.6831.00
196_L304_V1.6581.00
55_A58_D1.6511.00
134_D138_G1.6421.00
241_D244_Y1.6411.00
358_Y361_V1.6321.00
68_V89_I1.6061.00
6_L32_S1.6031.00
20_A23_D1.5991.00
339_T342_T1.5961.00
101_I111_F1.5871.00
127_D131_A1.5861.00
239_A271_L1.5761.00
173_R178_D1.5661.00
95_T98_D1.5591.00
59_H63_I1.5491.00
167_A171_Y1.5421.00
83_A86_D1.5261.00
85_S96_Q1.5231.00
106_Q110_E1.5151.00
196_L264_V1.5081.00
54_A83_A1.5071.00
5_V27_L1.5051.00
20_A303_D1.5041.00
143_V182_I1.5021.00
58_D61_T1.4981.00
249_D252_R1.4961.00
15_H45_L1.4721.00
106_Q125_T1.4681.00
148_A179_D1.4591.00
111_F114_A1.4561.00
295_T380_V1.4561.00
133_A137_T1.4531.00
196_L308_A1.4491.00
101_I107_F1.4471.00
84_L89_I1.4411.00
53_P57_V1.4391.00
134_D137_T1.4291.00
244_Y248_V1.4261.00
5_V21_L1.4211.00
85_S95_T1.4051.00
31_A42_A1.3951.00
136_V141_G1.3941.00
242_A246_A1.3791.00
111_F115_N1.3791.00
109_R183_E1.3601.00
295_T382_T1.3591.00
90_Y310_D1.3581.00
131_A134_D1.3531.00
129_S169_A1.3451.00
184_E277_K1.3441.00
97_A101_I1.3241.00
186_L279_V1.3181.00
136_V143_V1.3181.00
197_V251_I1.3081.00
141_G161_D1.3051.00
130_D134_D1.3021.00
126_F135_Y1.3021.00
395_A399_D1.3021.00
113_A122_D1.2931.00
4_R30_A1.2931.00
38_I44_D1.2821.00
195_A251_I1.2701.00
193_V243_D1.2671.00
327_T330_V1.2661.00
326_C378_A1.2601.00
108_Q112_M1.2591.00
130_D133_A1.2571.00
387_P391_T1.2571.00
48_L52_D1.2561.00
95_T262_R1.2531.00
124_E135_Y1.2531.00
102_E281_F1.2501.00
394_D398_A1.2481.00
343_T367_G1.2451.00
195_A247_A1.2451.00
388_A392_S1.2331.00
125_T179_D1.2321.00
104_D148_A1.2281.00
191_I271_L1.2261.00
60_A89_I1.2221.00
197_V203_R1.2211.00
27_L310_D1.2191.00
329_A374_S1.1931.00
383_G392_S1.1911.00
285_F301_L1.1801.00
84_L91_A1.1751.00
170_D174_T1.1741.00
238_F242_A1.1731.00
237_P240_T1.1731.00
82_D97_A1.1681.00
112_M278_V1.1671.00
127_D179_D1.1661.00
25_C307_A1.1651.00
113_A119_G1.1531.00
109_R119_G1.1521.00
325_V330_V1.1421.00
381_G393_V1.1401.00
60_A68_V1.1361.00
195_A267_G1.1271.00
122_D139_V1.1221.00
235_L239_A1.1201.00
362_D366_D1.1161.00
167_A170_D1.1131.00
390_A394_D1.1121.00
85_S262_R1.1071.00
144_A158_V1.0991.00
118_P246_A1.0931.00
240_T244_Y1.0911.00
200_G313_A1.0861.00
26_T303_D1.0811.00
110_E123_F1.0741.00
157_R172_I1.0681.00
33_T38_I1.0681.00
346_I349_A1.0671.00
188_G273_A1.0661.00
299_T304_V1.0621.00
383_G389_A1.0621.00
320_S382_T1.0601.00
392_S395_A1.0581.00
106_Q148_A1.0521.00
328_Y331_P1.0501.00
322_P384_D1.0481.00
44_D362_D1.0471.00
144_A185_R1.0461.00
314_L317_L1.0431.00
113_A124_E1.0411.00
395_A398_A1.0411.00
379_V400_L1.0401.00
6_L60_A1.0381.00
5_V306_A1.0371.00
68_V84_L1.0361.00
137_T166_P1.0351.00
304_V307_A1.0331.00
74_A77_A1.0241.00
18_A29_A1.0241.00
139_V143_V1.0111.00
129_S173_R1.0071.00
157_R168_A1.0031.00
19_D357_F1.0021.00
169_A173_R1.0001.00
26_T306_A0.9991.00
391_T395_A0.9981.00
32_S56_V0.9951.00
365_D368_S0.9931.00
132_A169_A0.9931.00
80_V84_L0.9921.00
95_T260_D0.9901.00
294_L380_V0.9891.00
164_S167_A0.9881.00
379_V396_A0.9871.00
271_L276_P0.9851.00
187_D272_T0.9811.00
197_V202_I0.9741.00
163_L167_A0.9741.00
97_A100_R0.9731.00
157_R171_Y0.9711.00
17_L69_V0.9711.00
349_A400_L0.9691.00
74_A78_A0.9591.00
200_G311_G0.9591.00
54_A58_D0.9551.00
25_C303_D0.9511.00
306_A310_D0.9481.00
335_P338_P0.9471.00
250_T281_F0.9451.00
4_R66_T0.9431.00
57_V83_A0.9421.00
243_D246_A0.9411.00
132_A165_K0.9401.00
145_V180_W0.9381.00
329_A397_L0.9381.00
325_V328_Y0.9371.00
381_G396_A0.9361.00
193_V244_Y0.9361.00
242_A275_G0.9341.00
344_I361_V0.9251.00
59_H65_A0.9221.00
141_G165_K0.9191.00
56_V84_L0.9171.00
247_A267_G0.9141.00
169_A180_W0.9081.00
149_G177_H0.9051.00
69_V305_L0.9051.00
124_E127_D0.9011.00
23_D47_I0.8991.00
330_V333_G0.8971.00
82_D85_S0.8951.00
90_Y199_N0.8931.00
113_A123_F0.8921.00
247_A269_F0.8921.00
82_D96_Q0.8901.00
106_Q179_D0.8871.00
267_G281_F0.8861.00
193_V247_A0.8801.00
131_A135_Y0.8801.00
21_L306_A0.8771.00
189_V271_L0.8761.00
7_L21_L0.8751.00
30_A63_I0.8731.00
117_V278_V0.8711.00
18_A45_L0.8671.00
238_F241_D0.8661.00
122_D138_G0.8661.00
81_V91_A0.8631.00
343_T346_I0.8621.00
202_I252_R0.8591.00
354_A357_F0.8581.00
35_N38_I0.8561.00
197_V252_R0.8491.00
24_D300_P0.8471.00
143_V159_T0.8461.00
205_T244_Y0.8451.00
195_A265_L0.8441.00
234_R271_L0.8441.00
21_L69_V0.8441.00
207_V210_D0.8361.00
203_R248_V0.8321.00
163_L166_P0.8311.00
242_A276_P0.8311.00
159_T168_A0.8281.00
350_S353_D0.8261.00
326_C330_V0.8241.00
396_A399_D0.8241.00
198_A202_I0.8211.00
92_F306_A0.8191.00
229_I386_I0.8151.00
251_I265_L0.8121.00
73_E76_L0.8081.00
245_Q248_V0.8061.00
186_L277_K0.8041.00
20_A24_D0.8031.00
249_D253_A0.8011.00
8_L80_V0.7971.00
353_D392_S0.7951.00
353_D357_F0.7921.00
201_D252_R0.7901.00
30_A65_A0.7891.00
129_S165_K0.7871.00
104_D179_D0.7791.00
324_T389_A0.7781.00
79_G83_A0.7751.00
98_D260_D0.7731.00
357_F361_V0.7721.00
202_I251_I0.7701.00
144_A156_V0.7671.00
145_V168_A0.7661.00
29_A32_S0.7661.00
230_A292_N0.7651.00
136_V165_K0.7651.00
208_V232_P0.7641.00
71_G75_P0.7641.00
322_P382_T0.7601.00
299_T315_P0.7591.00
206_P230_A0.7581.00
49_N52_D0.7581.00
271_L275_G0.7571.00
102_E254_V0.7551.00
208_V240_T0.7521.00
44_D47_I0.7521.00
60_A84_L0.7501.00
332_D335_P0.7481.00
327_T331_P0.7471.00
206_P297_M0.7371.00
85_S97_A0.7331.00
262_R308_A0.7311.00
347_D400_L0.7301.00
85_S91_A0.7291.00
326_C331_P0.7291.00
228_S292_N0.7291.00
381_G389_A0.7281.00
4_R64_D0.7281.00
98_D262_R0.7261.00
110_E125_T0.7261.00
250_T253_A0.7241.00
171_Y174_T0.7211.00
197_V262_R0.7211.00
326_C329_A0.7191.00
84_L87_A0.7181.00
354_A358_Y0.7161.00
4_R63_I0.7151.00
388_A391_T0.7151.00
25_C306_A0.7141.00
19_D23_D0.7131.00
48_L55_A0.7111.00
126_F132_A0.7091.00
345_T401_P0.7081.00
81_V85_S0.7061.00
351_T355_E0.7051.00
133_A170_D0.7051.00
53_P80_V0.7051.00
270_M279_V0.7041.00
175_S178_D0.7041.00
136_V140_D0.7041.00
205_T210_D0.7031.00
79_G100_R0.7031.00
145_V159_T0.7021.00
31_A46_T0.7001.00
116_D249_D0.6991.00
196_L205_T0.6981.00
305_L309_R0.6971.00
145_V169_A0.6961.00
246_A269_F0.6941.00
220_G225_G0.6931.00
139_V184_E0.6901.00
355_E381_G0.6841.00
342_T346_I0.6821.00
280_E284_R0.6811.00
186_L272_T0.6811.00
30_A59_H0.6811.00
351_T354_A0.6801.00
57_V86_D0.6791.00
339_T346_I0.6791.00
254_V260_D0.6781.00
106_Q181_V0.6781.00
104_D149_G0.6771.00
135_Y182_I0.6771.00
189_V234_R0.6761.00
15_H42_A0.6761.00
6_L65_A0.6741.00
339_T343_T0.6731.00
126_F131_A0.6721.00
243_D276_P0.6721.00
247_A251_I0.6721.00
23_D29_A0.6681.00
90_Y262_R0.6651.00
18_A31_A0.6621.00
361_V366_D0.6601.00
191_I232_P0.6601.00
136_V169_A0.6601.00
354_A396_A0.6581.00
352_G355_E0.6581.00
205_T248_V0.6551.00
124_E131_A0.6521.00
324_T390_A0.6521.00
207_V296_T0.6521.00
353_D356_L0.6511.00
343_T347_D0.6491.00
194_Q264_V0.6471.00
235_L240_T0.6441.00
336_T339_T0.6441.00
205_T314_L0.6401.00
377_F400_L0.6391.00
350_S354_A0.6381.00
19_D24_D0.6381.00
57_V89_I0.6351.00
31_A38_I0.6331.00
7_L31_A0.6301.00
366_D369_L0.6291.00
172_I180_W0.6271.00
272_T277_K0.6261.00
346_I401_P0.6241.00
210_D232_P0.6241.00
387_P390_A0.6231.00
271_L274_D0.6231.00
242_A249_D0.6231.00
304_V317_L0.6221.00
96_Q100_R0.6221.00
168_A172_I0.6221.00
246_A249_D0.6211.00
359_A362_D0.6211.00
15_H41_L0.6181.00
132_A182_I0.6171.00
362_D370_T0.6171.00
225_G228_S0.6171.00
173_R180_W0.6171.00
159_T165_K0.6161.00
331_P342_T0.6131.00
296_T323_A0.6121.00
53_P78_A0.6121.00
357_F377_F0.6121.00
129_S132_A0.6111.00
209_H229_I0.6071.00
123_F181_V0.6061.00
332_D339_T0.6061.00
291_M294_L0.6051.00
20_A25_C0.6051.00
206_P210_D0.6051.00
136_V139_V0.6051.00
107_F111_F0.6041.00
349_A399_D0.6031.00
360_S363_A0.6001.00
67_L309_R0.5991.00
207_V317_L0.5991.00
206_P296_T0.5981.00
160_G185_R0.5961.00
148_A181_V0.5951.00
43_D46_T0.5931.00
198_A311_G0.5931.00
393_V397_L0.5931.00
307_A315_P0.5921.00
101_I114_A0.5891.00
8_L56_V0.5881.00
261_Y265_L0.5881.00
21_L27_L0.5821.00
104_D107_F0.5811.00
344_I349_A0.5811.00
79_G82_D0.5791.00
140_D162_Q0.5791.00
336_T343_T0.5791.00
338_P343_T0.5781.00
193_V208_V0.5771.00
199_N311_G0.5751.00
338_P341_G0.5751.00
36_P369_L0.5741.00
337_D340_G0.5731.00
42_A45_L0.5711.00
348_D363_A0.5711.00
105_K146_K0.5711.00
60_A65_A0.5701.00
41_L44_D0.5681.00
341_G345_T0.5670.99
55_A59_H0.5660.99
239_A276_P0.5660.99
137_T141_G0.5660.99
191_I269_F0.5650.99
342_T345_T0.5640.99
354_A392_S0.5640.99
344_I347_D0.5630.99
191_I243_D0.5620.99
267_G278_V0.5610.99
360_S366_D0.5590.99
207_V319_F0.5560.99
358_Y363_A0.5560.99
18_A46_T0.5550.99
71_G76_L0.5540.99
5_V29_A0.5540.99
200_G252_R0.5530.99
358_Y362_D0.5530.99
346_I389_A0.5510.99
21_L302_L0.5510.99
59_H62_A0.5500.99
325_V390_A0.5500.99
34_R48_L0.5500.99
194_Q208_V0.5500.99
315_P318_A0.5490.99
61_T86_D0.5490.99
194_Q266_Y0.5490.99
347_D369_L0.5490.99
398_A401_P0.5490.99
365_D370_T0.5480.99
33_T43_D0.5480.99
359_A363_A0.5480.99
292_N295_T0.5460.99
227_G326_C0.5460.99
168_A171_Y0.5450.99
92_F309_R0.5440.99
38_I41_L0.5430.99
306_A309_R0.5420.99
357_F400_L0.5410.99
297_M319_F0.5400.99
352_G357_F0.5390.99
191_I235_L0.5360.99
348_D401_P0.5350.99
323_A327_T0.5340.99
304_V308_A0.5340.99
143_V184_E0.5330.99
389_A393_V0.5310.99
23_D45_L0.5310.99
291_M325_V0.5300.99
121_A277_K0.5300.99
346_I363_A0.5300.99
136_V182_I0.5290.99
99_A283_A0.5290.99
128_D169_A0.5280.99
296_T319_F0.5270.99
164_S168_A0.5270.99
236_V271_L0.5270.99
145_V165_K0.5250.99
327_T333_G0.5250.99
39_D43_D0.5240.99
274_D277_K0.5230.99
355_E396_A0.5230.99
72_P76_L0.5230.99
221_P226_M0.5230.99
53_P79_G0.5220.99
336_T341_G0.5210.99
54_A57_V0.5210.99
159_T164_S0.5210.99
41_L45_L0.5190.99
81_V84_L0.5180.99
39_D44_D0.5180.99
295_T355_E0.5180.99
145_V182_I0.5160.99
97_A107_F0.5160.99
156_V223_T0.5160.99
236_V275_G0.5150.99
206_P209_H0.5150.99
345_T349_A0.5150.99
301_L305_L0.5130.99
56_V68_V0.5130.99
292_N324_T0.5120.99
339_T344_I0.5110.99
109_R123_F0.5090.99
5_V302_L0.5090.99
220_G224_G0.5090.99
341_G349_A0.5080.99
261_Y283_A0.5080.99
357_F360_S0.5070.99
48_L59_H0.5070.99
314_L318_A0.5070.99
158_V223_T0.5070.99
90_Y306_A0.5050.99
342_T349_A0.5040.99
130_D166_P0.5040.99
363_A367_G0.5030.99
109_R113_A0.5020.99
337_D342_T0.5020.99
222_N225_G0.5020.99
117_V249_D0.5020.99
165_K169_A0.5010.99
118_P277_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qk4A 1 0.9628 100 0.343 Contact Map
3lp8A 1 0.9488 100 0.345 Contact Map
2yrxA 1 0.9465 100 0.349 Contact Map
2yw2A 2 0.9628 100 0.352 Contact Map
4rcnA 6 0.893 100 0.356 Contact Map
3n6rA 1 0.8163 100 0.359 Contact Map
3u9tA 3 0.9442 100 0.362 Contact Map
3mjfA 1 0.9581 100 0.362 Contact Map
4qshA 4 0.8372 100 0.363 Contact Map
3va7A 1 0.8093 100 0.367 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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