GREMLIN Database
Q9HQ65 - Succinate dehydrogenase subunit B
UniProt: Q9HQ65 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 292 (230)
Sequences: 2528 (967)
Seq/√Len: 63.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_E77_T4.3601.00
92_F96_S4.2161.00
57_K139_R3.7061.00
167_D171_D3.5841.00
102_T153_V3.5751.00
56_L89_A3.4351.00
57_K75_T3.2421.00
57_K137_P3.1601.00
91_I103_F3.1521.00
224_I280_L3.1271.00
56_L93_A2.8991.00
117_F126_G2.7991.00
89_A131_I2.7441.00
62_D65_I2.7421.00
74_D98_D2.5471.00
172_P237_G2.5391.00
231_Y280_L2.4241.00
196_S276_H2.3911.00
159_F203_G2.3671.00
78_V93_A2.2211.00
210_N260_Q2.1641.00
53_T79_P2.1181.00
55_E137_P2.0861.00
220_G276_H2.0851.00
86_V119_V2.0421.00
53_T77_T2.0401.00
123_Q208_S2.0341.00
167_D243_E1.9991.00
187_R191_E1.9891.00
124_R129_T1.9791.00
174_D237_G1.8961.00
261_F273_L1.8141.00
279_E282_R1.7931.00
79_P92_F1.7701.00
92_F97_Y1.7571.00
56_L138_V1.7541.00
171_D240_K1.6940.99
225_N271_I1.6830.99
116_A204_A1.6510.99
248_I252_H1.6400.99
57_K73_F1.6290.99
119_V124_R1.6100.99
122_S266_V1.5680.99
228_Y283_E1.5650.99
118_F207_S1.5600.99
84_M92_F1.5600.99
173_D237_G1.5590.99
55_E75_T1.5490.99
185_Q234_D1.4930.98
231_Y283_E1.4780.98
264_T274_T1.4750.98
59_F73_F1.4740.98
248_I251_E1.4680.98
73_F139_R1.4520.98
189_N234_D1.4510.98
162_Q252_H1.4450.98
197_T203_G1.4410.98
190_R194_K1.4390.98
264_T272_P1.3950.98
58_V101_L1.3810.97
161_D164_E1.3670.97
240_K243_E1.3520.97
78_V92_F1.3490.97
210_N220_G1.3480.97
69_E72_R1.3430.97
116_A143_L1.3290.97
189_N192_N1.3120.96
228_Y232_M1.2760.96
172_P183_Q1.2690.96
81_E92_F1.2280.95
225_N276_H1.2220.95
86_V131_I1.2200.95
104_R114_S1.2180.95
79_P96_S1.2090.94
59_F71_P1.2010.94
246_E287_E1.2000.94
59_F141_E1.2000.94
122_S265_D1.1720.93
242_Q246_E1.1630.93
146_S207_S1.1580.93
224_I248_I1.1530.93
93_A101_L1.1470.93
76_F102_T1.1420.92
208_S266_V1.1410.92
186_S189_N1.1230.92
228_Y279_E1.1110.91
218_Y232_M1.1110.91
219_L223_A1.1100.91
177_D183_Q1.1010.91
62_D72_R1.0970.91
225_N279_E1.0910.91
108_R111_V1.0880.90
179_E182_E1.0800.90
73_F141_E1.0620.89
58_V140_V1.0590.89
192_N275_E1.0550.89
87_L108_R1.0530.89
117_F138_V1.0480.89
78_V89_A1.0420.88
242_Q287_E1.0340.88
117_F140_V1.0300.88
156_M159_F1.0280.88
147_D158_H1.0260.88
54_V136_W1.0230.87
63_P69_E1.0140.87
162_Q248_I1.0040.86
171_D243_E1.0010.86
195_L198_R0.9860.85
74_D97_Y0.9850.85
78_V96_S0.9760.85
190_R198_R0.9730.85
156_M203_G0.9680.84
167_D247_I0.9670.84
143_L220_G0.9660.84
78_V101_L0.9590.84
91_I95_D0.9570.84
159_F197_T0.9450.83
156_M160_Y0.9440.83
114_S236_E0.9420.83
134_L137_P0.9360.82
176_P183_Q0.9320.82
73_F148_V0.9250.82
101_L152_L0.9170.81
108_R115_D0.9090.80
90_L103_F0.9030.80
54_V89_A0.9000.80
173_D240_K0.9000.80
75_T137_P0.8970.80
118_F123_Q0.8960.79
70_E74_D0.8920.79
198_R271_I0.8920.79
56_L86_V0.8890.79
229_R279_E0.8890.79
262_S266_V0.8840.79
119_V138_V0.8820.78
105_H204_A0.8790.78
216_N280_L0.8790.78
118_F260_Q0.8780.78
114_S125_L0.8730.78
86_V89_A0.8700.77
118_F144_P0.8610.77
81_E84_M0.8550.76
94_R227_A0.8540.76
182_E229_R0.8530.76
170_F230_F0.8520.76
159_F206_M0.8450.75
283_E286_K0.8430.75
264_T273_L0.8410.75
240_K244_R0.8410.75
146_S156_M0.8400.75
85_T109_Q0.8360.75
261_F265_D0.8350.74
261_F264_T0.8290.74
216_N224_I0.8280.74
76_F98_D0.8280.74
115_D145_H0.8240.74
149_V153_V0.8200.73
237_G240_K0.8200.73
174_D177_D0.8190.73
80_F84_M0.8170.73
210_N262_S0.8160.73
195_L276_H0.8070.72
166_V223_A0.8030.72
110_A128_Q0.7940.71
116_A235_R0.7900.70
114_S117_F0.7880.70
98_D235_R0.7870.70
162_Q212_A0.7800.69
158_H212_A0.7770.69
70_E147_D0.7750.69
211_I260_Q0.7730.69
54_V138_V0.7680.68
123_Q262_S0.7610.67
54_V80_F0.7570.67
126_G166_V0.7470.66
195_L273_L0.7450.66
194_K198_R0.7430.66
103_F108_R0.7420.66
111_V128_Q0.7410.65
170_F235_R0.7370.65
131_I218_Y0.7330.65
138_V242_Q0.7320.64
204_A266_V0.7310.64
57_K138_V0.7220.63
92_F95_D0.7190.63
65_I246_E0.7190.63
98_D229_R0.7150.63
158_H162_Q0.7140.63
232_M283_E0.7130.62
85_T108_R0.7110.62
94_R102_T0.7040.61
249_E253_G0.7030.61
241_R283_E0.7010.61
58_V93_A0.6980.61
231_Y245_L0.6920.60
175_L178_G0.6890.60
259_T278_Q0.6890.60
123_Q204_A0.6880.60
123_Q213_A0.6880.60
116_A165_S0.6850.59
241_R246_E0.6810.59
93_A96_S0.6780.59
187_R218_Y0.6780.59
57_K150_K0.6770.58
94_R105_H0.6750.58
173_D176_P0.6730.58
111_V115_D0.6730.58
185_Q189_N0.6710.58
122_S129_T0.6710.58
159_F223_A0.6700.58
195_L272_P0.6680.57
93_A278_Q0.6670.57
120_N138_V0.6660.57
277_I280_L0.6650.57
54_V286_K0.6640.57
65_I70_E0.6640.57
135_E191_E0.6630.57
210_N276_H0.6620.57
104_R273_L0.6610.57
54_V131_I0.6600.56
186_S234_D0.6590.56
229_R235_R0.6570.56
144_P207_S0.6560.56
246_E249_E0.6550.56
61_Y65_I0.6550.56
62_D135_E0.6510.55
96_S184_R0.6500.55
124_R134_L0.6470.55
118_F210_N0.6430.55
73_F218_Y0.6420.54
60_R90_L0.6380.54
159_F222_A0.6380.54
128_Q196_S0.6370.54
122_S165_S0.6330.53
111_V165_S0.6330.53
245_L284_A0.6320.53
272_P275_E0.6300.53
173_D183_Q0.6300.53
240_K246_E0.6290.53
242_Q245_L0.6290.53
165_S252_H0.6280.53
199_C209_C0.6270.53
217_K252_H0.6240.52
236_E244_R0.6240.52
59_F148_V0.6240.52
114_S244_R0.6220.52
55_E254_V0.6220.52
168_P185_Q0.6220.52
199_C205_C0.6150.51
216_N250_Q0.6130.51
196_S232_M0.6120.51
188_Q191_E0.6120.51
104_R125_L0.6090.51
258_Q271_I0.6080.51
190_R193_I0.6020.50
258_Q281_K0.6020.50
86_V129_T0.6020.50
78_V139_R0.6000.50
75_T133_D0.6000.50
110_A200_I0.6000.50
102_T150_K0.5970.49
153_V221_P0.5960.49
168_P227_A0.5950.49
144_P269_K0.5950.49
85_T130_Q0.5910.49
235_R244_R0.5910.49
55_E136_W0.5900.48
115_D274_T0.5880.48
52_E80_F0.5880.48
115_D230_F0.5870.48
88_D103_F0.5850.48
88_D104_R0.5830.48
77_T188_Q0.5820.48
90_L117_F0.5760.47
248_I280_L0.5750.47
170_F272_P0.5740.47
109_Q226_K0.5740.47
226_K260_Q0.5730.46
145_H195_L0.5730.46
271_I274_T0.5720.46
210_N226_K0.5720.46
275_E278_Q0.5700.46
178_G191_E0.5670.46
177_D226_K0.5660.46
165_S219_L0.5650.46
188_Q240_K0.5650.46
123_Q260_Q0.5640.45
103_F111_V0.5630.45
109_Q201_W0.5620.45
62_D75_T0.5610.45
204_A271_I0.5570.45
176_P179_E0.5570.45
124_R160_Y0.5540.44
110_A213_A0.5520.44
272_P276_H0.5520.44
70_E136_W0.5520.44
250_Q256_R0.5510.44
221_P280_L0.5510.44
181_E184_R0.5510.44
86_V140_V0.5490.44
80_F89_A0.5490.44
175_L254_V0.5480.44
53_T93_A0.5470.43
110_A271_I0.5460.43
83_G132_E0.5460.43
120_N134_L0.5440.43
178_G181_E0.5440.43
129_T134_L0.5390.43
188_Q286_K0.5370.42
54_V145_H0.5360.42
133_D138_V0.5360.42
115_D258_Q0.5350.42
69_E133_D0.5350.42
120_N130_Q0.5330.42
178_G265_D0.5320.42
74_D120_N0.5320.42
259_T274_T0.5310.42
58_V78_V0.5300.42
167_D175_L0.5290.41
69_E77_T0.5290.41
117_F124_R0.5290.41
195_L271_I0.5270.41
119_V160_Y0.5260.41
65_I149_V0.5250.41
240_K247_I0.5240.41
198_R273_L0.5230.41
76_F100_S0.5210.41
133_D237_G0.5180.40
218_Y223_A0.5170.40
146_S218_Y0.5160.40
148_V189_N0.5160.40
72_R75_T0.5150.40
265_D274_T0.5140.40
77_T136_W0.5130.40
146_S203_G0.5130.40
164_E191_E0.5110.39
104_R244_R0.5100.39
88_D281_K0.5090.39
81_E143_L0.5080.39
246_E251_E0.5070.39
162_Q237_G0.5030.39
119_V126_G0.5010.38
210_N266_V0.5010.38
77_T135_E0.5000.38
134_L138_V0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.6952 100 0.439 Contact Map
4ysxB 1 0.8253 100 0.495 Contact Map
2h88B 1 0.8082 100 0.503 Contact Map
1kf6B 1 0.8185 100 0.509 Contact Map
2wdqB 1 0.7945 100 0.521 Contact Map
2bs2B 1 0.8048 100 0.533 Contact Map
3c8yA 1 0.7055 99.9 0.786 Contact Map
3i9v3 1 0.6575 99.9 0.795 Contact Map
1ffvA 1 0.524 99.8 0.802 Contact Map
1rm6C 1 0.5308 99.8 0.811 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0086 seconds.