GREMLIN Database
Q9HQ62 - 3-methyladenine DNA glycosylase
UniProt: Q9HQ62 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 191 (181)
Sequences: 3977 (2780)
Seq/√Len: 206.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_R130_S3.1291.00
72_D75_V3.0051.00
52_T56_R2.8801.00
37_V89_V2.8571.00
110_S113_A2.7211.00
172_D175_R2.5181.00
111_D139_R2.5141.00
64_T67_G2.3161.00
94_A98_E2.2931.00
163_T166_E2.2551.00
84_Q87_D2.2251.00
148_L152_T2.2191.00
117_E120_A2.1421.00
91_N95_A2.1031.00
40_I92_V2.0811.00
49_A52_T2.0531.00
87_D122_T1.9311.00
73_P90_T1.9261.00
141_D178_R1.8961.00
134_L179_S1.8531.00
33_F65_P1.8361.00
119_T129_A1.8331.00
95_A100_D1.8141.00
91_N121_I1.7681.00
154_M167_M1.7581.00
36_L92_V1.7451.00
126_D130_S1.7311.00
90_T94_A1.6931.00
57_V68_I1.6891.00
119_T126_D1.6721.00
115_R119_T1.6661.00
96_F103_R1.6641.00
46_S49_A1.6611.00
55_E59_D1.6231.00
41_I54_R1.6101.00
114_V133_L1.6021.00
87_D91_N1.5961.00
61_V71_A1.5591.00
152_T155_Q1.5551.00
36_L132_F1.5461.00
102_T105_R1.5291.00
174_W181_A1.5261.00
32_L132_F1.4751.00
11_D158_Y1.4601.00
33_F93_A1.4481.00
143_F171_A1.4431.00
105_R117_E1.4431.00
16_P20_A1.4291.00
95_A121_I1.4231.00
133_L139_R1.4031.00
142_V179_S1.3571.00
73_P86_T1.3341.00
41_I81_L1.3231.00
115_R133_L1.3111.00
66_A97_R1.3101.00
46_S148_L1.3091.00
91_N94_A1.2951.00
60_A75_V1.2861.00
149_G153_G1.2561.00
48_D51_A1.2481.00
11_D174_W1.2361.00
112_A116_E1.2311.00
171_A174_W1.2071.00
40_I88_Y1.2071.00
153_G185_V1.2051.00
141_D175_R1.1911.00
56_R80_G1.1901.00
39_A128_T1.1811.00
113_A116_E1.1771.00
150_I182_S1.1571.00
75_V78_D1.1551.00
84_Q88_Y1.1541.00
92_V121_I1.1541.00
42_R47_T1.1531.00
13_T158_Y1.1491.00
177_Y180_Y1.1441.00
91_N122_T1.1361.00
45_L49_A1.1361.00
41_I53_I1.1361.00
72_D90_T1.1071.00
39_A131_M1.1071.00
60_A79_A1.0991.00
115_R129_A1.0861.00
69_A93_A1.0831.00
33_F37_V1.0751.00
118_L124_V1.0751.00
164_R168_R1.0681.00
65_P93_A1.0601.00
86_T90_T1.0511.00
73_P87_D1.0481.00
109_L117_E1.0401.00
53_I56_R1.0281.00
38_V54_R1.0251.00
144_P182_S1.0251.00
57_V79_A1.0211.00
109_L113_A1.0191.00
114_V137_L1.0171.00
82_S85_K1.0111.00
65_P96_F1.0101.00
124_V128_T0.9901.00
113_A117_E0.9891.00
139_R142_V0.9851.00
170_I173_S0.9821.00
111_D141_D0.9771.00
57_V61_V0.9741.00
15_A19_D0.9711.00
56_R59_D0.9621.00
111_D133_L0.9611.00
53_I81_L0.9520.99
74_A78_D0.9480.99
151_R155_Q0.9470.99
145_V168_R0.9450.99
143_F174_W0.9320.99
71_A75_V0.9200.99
69_A97_R0.9140.99
183_L187_R0.9140.99
49_A53_I0.9070.99
157_L185_V0.9070.99
33_F96_F0.9030.99
77_R83_R0.9020.99
29_H35_R0.8930.99
88_Y91_N0.8890.99
81_L89_V0.8880.99
169_E172_D0.8870.99
105_R109_L0.8850.99
101_Y121_I0.8820.99
166_E169_E0.8730.99
131_M135_F0.8680.99
175_R178_R0.8660.99
61_V68_I0.8650.99
28_P138_G0.8610.99
74_A83_R0.8560.99
114_V139_R0.8460.99
179_S182_S0.8440.99
159_G162_T0.8380.99
167_M171_A0.8320.99
58_F63_V0.8280.99
8_L19_D0.8200.98
16_P19_D0.8200.98
115_R126_D0.8090.98
43_Q127_W0.8070.98
130_S144_P0.8050.98
58_F62_D0.8020.98
47_T131_M0.7950.98
45_L53_I0.7930.98
100_D120_A0.7920.98
69_A94_A0.7910.98
21_H187_R0.7820.98
24_L183_L0.7700.98
106_F114_V0.7640.98
57_V63_V0.7580.97
35_R136_A0.7570.97
49_A80_G0.7560.97
150_I185_V0.7550.97
47_T148_L0.7540.97
116_E120_A0.7530.97
109_L114_V0.7530.97
14_L17_L0.7510.97
38_V42_R0.7470.97
143_F182_S0.7430.97
76_L89_V0.7390.97
8_L18_L0.7370.97
66_A70_A0.7370.97
44_Q49_A0.7310.97
88_Y122_T0.7300.97
51_A55_E0.7300.97
168_R171_A0.7290.97
23_E27_T0.7250.97
111_D115_R0.7230.97
35_R38_V0.7190.96
134_L144_P0.7140.96
180_Y183_L0.7120.96
53_I80_G0.7120.96
69_A90_T0.7080.96
131_M134_L0.7040.96
165_A169_E0.7020.96
124_V132_F0.6990.96
150_I154_M0.6940.96
83_R87_D0.6860.95
18_L184_Y0.6860.95
45_L85_K0.6840.95
154_M171_A0.6830.95
11_D14_L0.6810.95
67_G70_A0.6810.95
65_P97_R0.6800.95
111_D142_V0.6790.95
126_D146_G0.6750.95
140_A180_Y0.6650.95
168_R175_R0.6640.94
150_I153_G0.6610.94
73_P77_R0.6570.94
83_R86_T0.6570.94
39_A42_R0.6560.94
24_L184_Y0.6560.94
168_R172_D0.6550.94
145_V164_R0.6530.94
36_L124_V0.6520.94
92_V95_A0.6490.94
133_L137_L0.6420.93
61_V75_V0.6420.93
68_I93_A0.6390.93
45_L127_W0.6380.93
52_T82_S0.6320.93
25_A63_V0.6300.93
26_V183_L0.6290.93
42_R45_L0.6260.93
149_G152_T0.6260.93
160_A166_E0.6250.92
133_L136_A0.6190.92
44_Q82_S0.6140.92
42_R50_A0.6130.92
32_L103_R0.6130.92
146_G164_R0.6120.92
181_A185_V0.6110.92
7_A10_T0.6070.91
120_A129_A0.6040.91
171_A178_R0.6010.91
19_D22_G0.6000.91
131_M144_P0.5960.91
158_Y170_I0.5960.91
54_R58_F0.5930.90
60_A78_D0.5920.90
136_A183_L0.5890.90
42_R131_M0.5870.90
44_Q149_G0.5820.90
95_A98_E0.5820.90
29_H135_F0.5780.89
77_R82_S0.5750.89
141_D176_P0.5700.89
111_D130_S0.5700.89
14_L181_A0.5640.88
53_I86_T0.5610.88
61_V67_G0.5610.88
50_A127_W0.5560.87
112_A115_R0.5560.87
112_A126_D0.5530.87
133_L142_V0.5510.87
95_A101_Y0.5510.87
39_A50_A0.5510.87
32_L136_A0.5440.86
42_R186_W0.5440.86
136_A143_F0.5440.86
94_A100_D0.5430.86
71_A78_D0.5430.86
53_I79_A0.5430.86
63_V67_G0.5430.86
111_D114_V0.5420.86
34_E58_F0.5400.86
129_A132_F0.5380.86
92_V132_F0.5340.85
34_E54_R0.5310.85
105_R108_E0.5310.85
151_R167_M0.5290.85
29_H138_G0.5280.85
85_K125_G0.5210.84
35_R135_F0.5200.84
17_L184_Y0.5200.84
167_M170_I0.5190.84
182_S186_W0.5190.84
45_L52_T0.5190.84
44_Q148_L0.5180.83
114_V129_A0.5170.83
95_A120_A0.5170.83
46_S80_G0.5120.83
14_L158_Y0.5110.83
144_P150_I0.5080.82
70_A75_V0.5070.82
23_E26_V0.5070.82
151_R161_D0.5030.82
164_R167_M0.5020.82
44_Q53_I0.5010.81
70_A97_R0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yg9A 1 0.9738 100 0.225 Contact Map
4b21A 2 1 100 0.241 Contact Map
2h56A 1 1 100 0.242 Contact Map
3i0wA 1 0.9843 100 0.265 Contact Map
4ejyA 1 0.9843 100 0.271 Contact Map
2jhnA 1 0.9686 100 0.277 Contact Map
3s6iA 1 0.9948 100 0.283 Contact Map
2xhiA 1 0.9843 100 0.302 Contact Map
1mpgA 1 0.9634 100 0.304 Contact Map
3fhfA 1 0.9215 100 0.449 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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