Q9HQ61 - HALSA - GREMLIN Contacts

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Q9HQ61 - 3-hydroxyacyl-CoA dehydrogenase

UniProt:	Q9HQ61	Sequences: MDVDDIHSIAVLGAGNMGHGIAEVAAMAGYTVRLRDISAELVQDGYDQIEWSLGKLAESDQLTEAAADAALDRISTHVEVSDAVDDVDVVIEAVPEKMEIKTDVYTEVEAHAPADAVFATNTSSLSITDLSEVTERPARFCGMHFFNPPVRMELVEVISGAHTDDAVLECIESLAADFGKTPVRVRKDSPGFVVNRILVPLLNEAAWLVHDDEATIAEVDSTTKYDMGLPMGAFELADQVGIDVSHDVLDYMQDVLGTAYEPCPVLVDHVEAGDLGRKSGAGFYDYGDDAAGADVPTDAIRADIADRLTAVMANEVAKLVGGGVADPAEIDEAVMLGAGYPEGPAKMADAAGITYLHETLVAAHEATGQARYEPADTLAEMAAAGESFHGRGDEDADGRREFDAVSVSVDGNVGHIELDRPHRMNTISGELLADLSDAIDVLGDDDDVRAVLLTGAGEKAFSAGADVTSMAGNADPVEAVELSRMGQQTFGKLEAADEPVVAAIDGYCLGGGMELATCADMRLASERSELGQPEHDLGLLPGWGGTQRLKHIVGEGRAKEIIFTADRFAPETLADYGFINEVVTTEAFEERAWELARDLAAGPPIAMKYTKRAMRAGRDDTDAGLEIEAQSFGQLMNTQDLMEGVSAFSADREPEFNGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	659 (640)
Sequences:	898 (617)
Seq/√Len:	24.4

BACSU - FADN
HALSA - Q9HQ61
SULSO - Q97VU5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
604_P	607_M	3.788	1.00
71_L	74_I	3.650	1.00
502_A	519_A	3.617	1.00
137_P	162_H	3.533	1.00
604_P	609_Y	3.312	1.00
463_A	507_Y	3.173	1.00
608_K	611_K	3.138	1.00
607_M	611_K	3.115	1.00
558_A	564_T	3.098	1.00
622_D	626_E	3.058	1.00
558_A	565_A	3.022	1.00
558_A	562_I	2.995	1.00
416_I	435_L	2.981	1.00
606_A	609_Y	2.970	1.00
138_A	164_D	2.963	1.00
606_A	611_K	2.922	1.00
593_W	597_R	2.903	1.00
94_V	100_I	2.867	1.00
604_P	608_K	2.845	0.99
484_R	488_Q	2.830	0.99
58_E	61_Q	2.803	0.99
603_P	611_K	2.773	0.99
275_L	279_S	2.757	0.99
605_I	611_K	2.749	0.99
559_K	562_I	2.741	0.99
604_P	611_K	2.727	0.99
599_L	604_P	2.720	0.99
440_D	492_K	2.716	0.99
79_E	82_D	2.709	0.99
90_V	112_A	2.694	0.99
603_P	607_M	2.663	0.99
559_K	565_A	2.648	0.99
603_P	606_A	2.632	0.99
558_A	566_D	2.632	0.99
405_V	419_D	2.610	0.99
604_P	610_T	2.538	0.99
450_A	596_A	2.525	0.99
599_L	607_M	2.509	0.99
599_L	606_A	2.504	0.99
603_P	609_Y	2.493	0.99
605_I	608_K	2.490	0.99
560_E	564_T	2.448	0.98
68_D	74_I	2.443	0.98
12_L	108_V	2.441	0.98
523_L	582_V	2.432	0.98
562_I	565_A	2.428	0.98
562_I	566_D	2.413	0.98
582_V	591_R	2.400	0.98
561_I	564_T	2.388	0.98
142_G	158_I	2.353	0.98
560_E	565_A	2.342	0.98
599_L	602_G	2.331	0.98
559_K	563_F	2.315	0.98
326_D	329_E	2.289	0.98
70_A	74_I	2.284	0.98
559_K	564_T	2.268	0.97
558_A	561_I	2.249	0.97
589_E	593_W	2.248	0.97
601_A	604_P	2.241	0.97
607_M	610_T	2.229	0.97
413_V	596_A	2.216	0.97
599_L	603_P	2.176	0.97
12_L	76_T	2.172	0.97
306_D	359_T	2.172	0.97
559_K	566_D	2.145	0.96
68_D	71_L	2.145	0.96
288_D	292_G	2.144	0.96
647_A	651_D	2.121	0.96
606_A	610_T	2.106	0.96
599_L	609_Y	2.072	0.96
268_D	272_A	2.072	0.96
603_P	610_T	2.033	0.95
378_L	384_A	2.019	0.95
232_G	236_L	2.011	0.95
112_A	139_R	1.987	0.94
605_I	609_Y	1.984	0.94
414_G	448_V	1.973	0.94
470_M	636_M	1.968	0.94
502_A	516_A	1.962	0.94
379_A	384_A	1.937	0.94
588_F	593_W	1.934	0.93
441_V	447_D	1.910	0.93
561_I	565_A	1.908	0.93
563_F	566_D	1.901	0.93
521_M	595_L	1.899	0.93
608_K	612_R	1.895	0.93
89_V	119_A	1.895	0.93
9_I	25_A	1.890	0.93
291_A	294_D	1.879	0.92
561_I	566_D	1.868	0.92
558_A	563_F	1.858	0.92
605_I	610_T	1.854	0.92
28_A	583_V	1.849	0.92
601_A	611_K	1.848	0.92
602_G	606_A	1.821	0.91
560_E	566_D	1.816	0.91
94_V	104_V	1.809	0.91
291_A	295_V	1.782	0.90
401_E	408_S	1.782	0.90
374_P	378_L	1.753	0.90
601_A	606_A	1.751	0.89
250_D	254_D	1.719	0.89
603_P	608_K	1.704	0.88
173_S	177_D	1.696	0.88
115_D	139_R	1.693	0.88
443_G	497_D	1.675	0.87
599_L	608_K	1.656	0.87
606_A	612_R	1.641	0.86
589_E	595_L	1.632	0.86
401_E	406_S	1.631	0.86
80_V	107_E	1.627	0.86
335_M	346_K	1.627	0.86
588_F	591_R	1.627	0.86
401_E	409_V	1.623	0.85
589_E	592_A	1.621	0.85
523_L	591_R	1.610	0.85
70_A	73_R	1.609	0.85
398_G	408_S	1.609	0.85
233_A	236_L	1.593	0.84
557_R	565_A	1.592	0.84
208_L	211_D	1.588	0.84
82_D	86_D	1.578	0.84
374_P	379_A	1.571	0.84
560_E	563_F	1.570	0.83
281_A	285_D	1.562	0.83
10_A	87_V	1.559	0.83
486_G	543_W	1.556	0.83
46_Y	49_I	1.551	0.83
588_F	597_R	1.547	0.83
181_T	336_L	1.546	0.83
129_D	132_E	1.540	0.82
557_R	564_T	1.538	0.82
426_T	463_A	1.532	0.82
550_K	554_G	1.530	0.82
113_P	116_A	1.530	0.82
600_A	604_P	1.529	0.82
46_Y	50_E	1.528	0.82
44_D	47_D	1.528	0.82
43_Q	50_E	1.527	0.82
634_Q	637_N	1.509	0.81
52_S	56_L	1.503	0.81
589_E	597_R	1.501	0.81
442_L	498_E	1.499	0.80
109_E	135_E	1.499	0.80
525_S	585_T	1.499	0.80
68_D	73_R	1.496	0.80
634_Q	638_T	1.493	0.80
494_E	548_R	1.490	0.80
105_Y	130_L	1.487	0.80
52_S	59_S	1.486	0.80
599_L	611_K	1.486	0.80
289_D	292_G	1.482	0.80
104_V	107_E	1.481	0.80
601_A	607_M	1.479	0.80
406_S	409_V	1.475	0.79
288_D	295_V	1.472	0.79
587_A	593_W	1.465	0.79
439_I	453_L	1.459	0.79
399_R	437_D	1.458	0.79
292_G	295_V	1.456	0.78
237_A	245_S	1.453	0.78
358_E	362_A	1.452	0.78
46_Y	58_E	1.439	0.78
551_H	554_G	1.433	0.77
56_L	59_S	1.427	0.77
354_T	358_E	1.421	0.77
368_G	372_Y	1.420	0.77
46_Y	61_Q	1.418	0.77
103_D	106_T	1.411	0.76
367_T	378_L	1.410	0.76
398_G	401_E	1.409	0.76
152_M	339_G	1.408	0.76
398_G	406_S	1.407	0.76
588_F	595_L	1.404	0.76
550_K	553_V	1.391	0.75
51_W	55_K	1.389	0.75
103_D	107_E	1.389	0.75
557_R	561_I	1.388	0.75
306_D	363_A	1.386	0.75
222_T	304_I	1.386	0.75
214_A	304_I	1.375	0.74
321_G	330_I	1.371	0.74
119_A	141_C	1.365	0.74
601_A	608_K	1.359	0.73
288_D	291_A	1.355	0.73
557_R	560_E	1.354	0.73
378_L	386_E	1.349	0.73
601_A	609_Y	1.348	0.73
306_D	310_A	1.334	0.72
599_L	610_T	1.333	0.72
398_G	409_V	1.333	0.72
310_A	365_E	1.331	0.72
552_I	556_G	1.329	0.72
373_E	378_L	1.324	0.71
106_T	134_T	1.319	0.71
52_S	58_E	1.318	0.71
109_E	134_T	1.309	0.71
267_V	271_E	1.309	0.71
453_L	493_L	1.308	0.70
128_T	161_A	1.306	0.70
44_D	50_E	1.301	0.70
273_G	279_S	1.297	0.70
112_A	116_A	1.296	0.70
460_A	463_A	1.288	0.69
493_L	520_D	1.282	0.69
630_Q	634_Q	1.279	0.69
601_A	610_T	1.277	0.69
53_L	58_E	1.273	0.68
588_F	592_A	1.267	0.68
571_E	574_A	1.263	0.68
14_A	93_A	1.260	0.68
609_Y	612_R	1.259	0.67
351_A	356_L	1.255	0.67
612_R	615_R	1.246	0.67
71_L	75_S	1.245	0.67
379_A	386_E	1.242	0.66
31_T	70_A	1.231	0.66
274_D	281_A	1.229	0.66
390_G	393_D	1.227	0.65
399_R	408_S	1.217	0.65
118_F	134_T	1.216	0.65
239_Q	339_G	1.214	0.65
480_V	484_R	1.213	0.65
297_T	302_A	1.213	0.65
76_T	80_V	1.211	0.64
211_D	307_R	1.209	0.64
372_Y	378_L	1.209	0.64
490_F	515_L	1.209	0.64
600_A	610_T	1.203	0.64
557_R	562_I	1.199	0.64
389_H	393_D	1.197	0.63
516_A	519_A	1.196	0.63
218_E	300_I	1.193	0.63
382_A	386_E	1.192	0.63
422_H	463_A	1.185	0.63
50_E	58_E	1.179	0.62
80_V	104_V	1.179	0.62
600_A	609_Y	1.176	0.62
388_F	392_G	1.168	0.62
8_S	86_D	1.163	0.61
433_A	485_M	1.163	0.61
10_A	84_V	1.162	0.61
246_H	270_V	1.158	0.61
367_T	372_Y	1.157	0.61
378_L	382_A	1.157	0.61
42_V	46_Y	1.155	0.61
379_A	389_H	1.155	0.61
214_A	300_I	1.154	0.61
155_V	175_A	1.152	0.60
51_W	58_E	1.148	0.60
48_Q	52_S	1.143	0.60
52_S	61_Q	1.135	0.59
587_A	591_R	1.135	0.59
398_G	414_G	1.133	0.59
374_P	384_A	1.131	0.59
72_D	82_D	1.128	0.59
604_P	612_R	1.127	0.59
16_N	244_V	1.126	0.59
128_T	160_G	1.126	0.59
605_I	612_R	1.122	0.58
560_E	576_Y	1.121	0.58
378_L	388_F	1.121	0.58
403_D	430_E	1.120	0.58
50_E	55_K	1.120	0.58
390_G	394_E	1.120	0.58
404_A	408_S	1.117	0.58
378_L	385_G	1.115	0.58
120_T	127_I	1.114	0.58
46_Y	52_S	1.112	0.58
70_A	75_S	1.103	0.57
200_P	311_V	1.101	0.57
607_M	612_R	1.100	0.57
401_E	404_A	1.099	0.57
60_D	63_T	1.099	0.57
586_E	589_E	1.096	0.57
524_A	570_P	1.095	0.56
49_I	61_Q	1.090	0.56
367_T	379_A	1.087	0.56
39_A	42_V	1.087	0.56
239_Q	277_R	1.084	0.56
470_M	542_G	1.081	0.55
289_D	293_A	1.081	0.55
119_A	143_M	1.078	0.55
209_V	234_F	1.073	0.55
108_V	111_H	1.072	0.55
439_I	489_T	1.070	0.55
399_R	409_V	1.068	0.55
600_A	611_K	1.067	0.54
46_Y	51_W	1.067	0.54
61_Q	65_A	1.066	0.54
50_E	54_G	1.065	0.54
56_L	61_Q	1.056	0.54
59_S	62_L	1.053	0.53
425_N	455_G	1.051	0.53
386_E	392_G	1.050	0.53
41_L	47_D	1.049	0.53
601_A	605_I	1.048	0.53
567_R	573_L	1.043	0.53
397_D	400_R	1.043	0.53
411_G	593_W	1.040	0.53
24_V	27_M	1.039	0.52
379_A	385_G	1.038	0.52
600_A	603_P	1.038	0.52
602_G	607_M	1.037	0.52
414_G	442_L	1.036	0.52
385_G	393_D	1.033	0.52
524_A	579_I	1.032	0.52
81_S	85_D	1.031	0.52
552_I	555_E	1.028	0.52
102_T	133_V	1.028	0.52
378_L	389_H	1.025	0.51
374_P	377_T	1.024	0.51
384_A	389_H	1.024	0.51
384_A	388_F	1.016	0.51
81_S	111_H	1.009	0.50
494_E	547_Q	1.005	0.50
58_E	63_T	1.002	0.50
287_G	290_A	1.002	0.50
368_G	378_L	1.001	0.50
386_E	389_H	0.998	0.50
639_Q	643_E	0.997	0.49
367_T	374_P	0.997	0.49
90_V	139_R	0.997	0.49
310_A	359_T	0.991	0.49
227_M	305_A	0.990	0.49
418_L	455_G	0.986	0.49
599_L	605_I	0.985	0.49
222_T	305_A	0.982	0.48
176_A	587_A	0.982	0.48
269_H	274_D	0.979	0.48
258_T	261_E	0.979	0.48
43_Q	46_Y	0.978	0.48
288_D	294_D	0.977	0.48
516_A	522_R	0.974	0.48
540_L	631_S	0.974	0.48
289_D	295_V	0.971	0.48
141_C	171_I	0.970	0.48
55_K	58_E	0.968	0.47
592_A	597_R	0.967	0.47
90_V	108_V	0.965	0.47
194_V	324_V	0.963	0.47
89_V	143_M	0.962	0.47
602_G	609_Y	0.959	0.47
388_F	394_E	0.959	0.47
76_T	108_V	0.956	0.47
422_H	431_L	0.956	0.47
109_E	112_A	0.949	0.46
404_A	409_V	0.948	0.46
58_E	66_A	0.947	0.46
49_I	58_E	0.947	0.46
46_Y	59_S	0.943	0.46
373_E	379_A	0.940	0.45
58_E	65_A	0.940	0.45
504_I	528_S	0.939	0.45
53_L	73_R	0.938	0.45
48_Q	51_W	0.936	0.45
379_A	382_A	0.935	0.45
287_G	294_D	0.935	0.45
45_G	48_Q	0.934	0.45
373_E	384_A	0.934	0.45
388_F	391_R	0.926	0.44
488_Q	622_D	0.925	0.44
402_F	408_S	0.923	0.44
587_A	597_R	0.923	0.44
378_L	381_M	0.921	0.44
50_E	61_Q	0.921	0.44
483_S	633_G	0.920	0.44
246_H	262_P	0.919	0.44
174_L	524_A	0.919	0.44
398_G	404_A	0.919	0.44
413_V	450_A	0.918	0.44
50_E	53_L	0.918	0.44
49_I	53_L	0.915	0.44
50_E	59_S	0.915	0.44
12_L	111_H	0.909	0.43
359_T	363_A	0.908	0.43
64_E	575_D	0.908	0.43
332_E	335_M	0.906	0.43
432_L	489_T	0.906	0.43
388_F	393_D	0.906	0.43
518_C	547_Q	0.901	0.43
491_G	547_Q	0.900	0.43
600_A	607_M	0.897	0.42
470_M	539_L	0.895	0.42
57_A	61_Q	0.893	0.42
645_V	649_S	0.891	0.42
517_T	567_R	0.891	0.42
223_T	233_A	0.890	0.42
52_S	55_K	0.890	0.42
42_V	61_Q	0.890	0.42
504_I	516_A	0.889	0.42
505_D	588_F	0.886	0.42
153_E	181_T	0.884	0.41
265_V	269_H	0.883	0.41
401_E	407_V	0.882	0.41
45_G	49_I	0.882	0.41
168_L	184_R	0.882	0.41
378_L	383_A	0.881	0.41
591_R	595_L	0.879	0.41
9_I	30_Y	0.878	0.41
172_E	184_R	0.878	0.41
310_A	363_A	0.876	0.41
197_I	316_V	0.875	0.41
372_Y	377_T	0.872	0.41
90_V	111_H	0.871	0.41
600_A	606_A	0.871	0.41
590_E	594_E	0.870	0.40
243_D	278_K	0.869	0.40
342_E	350_A	0.868	0.40
591_R	597_R	0.865	0.40
310_A	356_L	0.864	0.40
418_L	425_N	0.864	0.40
368_G	388_F	0.862	0.40
42_V	45_G	0.856	0.40
586_E	593_W	0.854	0.39
462_S	513_M	0.852	0.39
201_L	236_L	0.851	0.39
127_I	131_S	0.850	0.39
236_L	245_S	0.849	0.39
378_L	387_S	0.848	0.39
187_K	231_M	0.845	0.39
410_D	593_W	0.841	0.39
633_G	637_N	0.841	0.39
191_G	251_Y	0.840	0.38
58_E	62_L	0.839	0.38
116_A	139_R	0.838	0.38
49_I	59_S	0.838	0.38
560_E	578_F	0.837	0.38
8_S	33_R	0.836	0.38
77_H	107_E	0.834	0.38
380_E	387_S	0.833	0.38
43_Q	49_I	0.833	0.38
416_I	451_V	0.831	0.38
542_G	546_T	0.830	0.38
391_R	394_E	0.827	0.38
530_L	579_I	0.826	0.37
82_D	113_P	0.826	0.37
262_P	266_L	0.825	0.37
61_Q	66_A	0.824	0.37
573_L	579_I	0.824	0.37
401_E	405_V	0.822	0.37
516_A	530_L	0.822	0.37
385_G	389_H	0.822	0.37
49_I	52_S	0.822	0.37
288_D	293_A	0.819	0.37
476_P	637_N	0.818	0.37
208_L	311_V	0.817	0.37
601_A	612_R	0.817	0.37
602_G	605_I	0.816	0.37
112_A	115_D	0.816	0.37
226_D	305_A	0.815	0.37
298_D	303_D	0.812	0.37
436_S	492_K	0.812	0.37
193_V	426_T	0.809	0.36
591_R	594_E	0.808	0.36
518_C	548_R	0.804	0.36
382_A	385_G	0.804	0.36
62_L	71_L	0.804	0.36
130_L	244_V	0.804	0.36
475_D	478_E	0.804	0.36
55_K	59_S	0.803	0.36
68_D	75_S	0.799	0.36
400_R	408_S	0.798	0.36
466_D	469_S	0.798	0.36
414_G	441_V	0.797	0.36
189_S	323_G	0.796	0.35
58_E	67_A	0.794	0.35
270_V	280_G	0.793	0.35
98_M	129_D	0.793	0.35
194_V	312_M	0.793	0.35
268_D	271_E	0.792	0.35
357_H	360_L	0.792	0.35
289_D	294_D	0.791	0.35
371_R	379_A	0.789	0.35
384_A	387_S	0.788	0.35
152_M	239_Q	0.787	0.35
557_R	566_D	0.783	0.35
376_D	379_A	0.782	0.35
640_D	643_E	0.782	0.35
368_G	373_E	0.779	0.34
229_L	236_L	0.778	0.34
398_G	448_V	0.778	0.34
33_R	82_D	0.776	0.34
56_L	60_D	0.775	0.34
51_W	57_A	0.773	0.34
500_V	520_D	0.772	0.34
409_V	415_H	0.770	0.34
206_A	237_A	0.770	0.34
30_Y	70_A	0.769	0.34
42_V	52_S	0.768	0.34
439_I	493_L	0.767	0.34
491_G	548_R	0.766	0.34
384_A	393_D	0.763	0.33
42_V	50_E	0.763	0.33
53_L	57_A	0.763	0.33
593_W	596_A	0.762	0.33
355_Y	359_T	0.760	0.33
428_S	466_D	0.756	0.33
183_V	193_V	0.755	0.33
16_N	24_V	0.754	0.33
20_G	93_A	0.753	0.33
73_R	76_T	0.753	0.33
11_V	15_G	0.752	0.33
51_W	61_Q	0.752	0.33
51_W	59_S	0.748	0.32
61_Q	67_A	0.747	0.32
35_R	74_I	0.745	0.32
368_G	374_P	0.744	0.32
379_A	387_S	0.743	0.32
202_L	237_A	0.742	0.32
42_V	47_D	0.742	0.32
436_S	489_T	0.740	0.32
42_V	48_Q	0.739	0.32
425_N	457_G	0.738	0.32
381_M	384_A	0.738	0.32
626_E	637_N	0.738	0.32
81_S	110_A	0.736	0.32
250_D	267_V	0.735	0.32
109_E	118_F	0.734	0.32
42_V	105_Y	0.734	0.32
166_A	170_C	0.732	0.31
42_V	51_W	0.732	0.31
47_D	51_W	0.732	0.31
46_Y	53_L	0.731	0.31
374_P	382_A	0.731	0.31
643_E	647_A	0.729	0.31
378_L	393_D	0.725	0.31
49_I	56_L	0.724	0.31
529_E	536_D	0.724	0.31
367_T	371_R	0.724	0.31
374_P	385_G	0.722	0.31
201_L	229_L	0.722	0.31
95_P	100_I	0.721	0.31
386_E	391_R	0.721	0.31
108_V	118_F	0.721	0.31
225_Y	244_V	0.720	0.31
119_A	171_I	0.719	0.31
38_S	42_V	0.719	0.31
43_Q	51_W	0.719	0.31
486_G	490_F	0.718	0.31
379_A	383_A	0.717	0.31
375_A	378_L	0.717	0.31
9_I	32_V	0.717	0.31
26_A	540_L	0.716	0.30
426_T	431_L	0.716	0.30
454_T	505_D	0.714	0.30
374_P	386_E	0.714	0.30
130_L	140_F	0.714	0.30
181_T	197_I	0.711	0.30
120_T	130_L	0.709	0.30
157_V	172_E	0.709	0.30
265_V	283_F	0.709	0.30
212_D	307_R	0.709	0.30
81_S	114_A	0.708	0.30
7_H	118_F	0.708	0.30
215_T	299_A	0.708	0.30
377_T	381_M	0.708	0.30
600_A	608_K	0.707	0.30
8_S	31_T	0.707	0.30
68_D	72_D	0.705	0.30
355_Y	358_E	0.705	0.30
405_V	408_S	0.704	0.30
397_D	409_V	0.703	0.30
463_A	473_N	0.702	0.30
194_V	517_T	0.702	0.30
392_G	395_D	0.701	0.30
428_S	486_G	0.700	0.29
396_A	406_S	0.700	0.29
524_A	573_L	0.699	0.29
427_I	431_L	0.698	0.29
396_A	408_S	0.698	0.29
386_E	390_G	0.698	0.29
387_S	392_G	0.697	0.29
84_V	108_V	0.696	0.29
402_F	409_V	0.695	0.29
358_E	361_V	0.694	0.29
383_A	388_F	0.693	0.29
299_A	302_A	0.692	0.29
59_S	63_T	0.691	0.29
329_E	523_L	0.690	0.29
245_S	338_A	0.686	0.29
108_V	112_A	0.685	0.29
112_A	118_F	0.683	0.28
103_D	161_A	0.683	0.28
586_E	597_R	0.682	0.28
398_G	405_V	0.680	0.28
212_D	304_I	0.679	0.28
39_A	43_Q	0.679	0.28
106_T	110_A	0.679	0.28
55_K	61_Q	0.678	0.28
46_Y	56_L	0.678	0.28
388_F	395_D	0.676	0.28
45_G	61_Q	0.674	0.28
382_A	393_D	0.674	0.28
164_D	218_E	0.672	0.28
626_E	630_Q	0.672	0.28
191_G	336_L	0.672	0.28
56_L	79_E	0.669	0.28
6_I	9_I	0.668	0.28
38_S	59_S	0.668	0.28
48_Q	61_Q	0.665	0.27
12_L	24_V	0.665	0.27
592_A	596_A	0.663	0.27
90_V	116_A	0.663	0.27
386_E	393_D	0.663	0.27
379_A	388_F	0.663	0.27
319_L	322_G	0.663	0.27
402_F	406_S	0.663	0.27
587_A	590_E	0.661	0.27
456_A	585_T	0.660	0.27
236_L	260_Y	0.660	0.27
339_G	476_P	0.660	0.27
368_G	393_D	0.659	0.27
413_V	417_E	0.658	0.27
56_L	62_L	0.658	0.27
202_L	205_A	0.656	0.27
495_A	621_T	0.655	0.27
430_E	433_A	0.655	0.27
427_I	516_A	0.654	0.27
183_V	333_A	0.654	0.27
491_G	494_E	0.653	0.27
271_E	519_A	0.653	0.27
209_V	236_L	0.652	0.27
376_D	381_M	0.652	0.27
523_L	595_L	0.651	0.27
397_D	403_D	0.651	0.27
45_G	58_E	0.651	0.27
574_A	579_I	0.651	0.27
238_D	276_G	0.650	0.27
142_G	223_T	0.649	0.27
304_I	311_V	0.648	0.26
107_E	137_P	0.648	0.26
504_I	508_C	0.647	0.26
269_H	273_G	0.646	0.26
602_G	608_K	0.646	0.26
429_G	542_G	0.645	0.26
125_L	552_I	0.644	0.26
389_H	394_E	0.644	0.26
438_A	451_V	0.643	0.26
14_A	34_L	0.643	0.26
54_G	59_S	0.643	0.26
602_G	610_T	0.642	0.26
314_N	365_E	0.642	0.26
376_D	385_G	0.641	0.26
399_R	406_S	0.638	0.26
44_D	48_Q	0.637	0.26
87_V	116_A	0.637	0.26
377_T	380_E	0.636	0.26
513_M	530_L	0.634	0.26
582_V	585_T	0.634	0.26
158_I	223_T	0.634	0.26
225_Y	280_G	0.633	0.26
215_T	218_E	0.633	0.26
38_S	77_H	0.633	0.26
595_L	598_D	0.632	0.26
46_Y	54_G	0.632	0.26
397_D	408_S	0.632	0.26
368_G	389_H	0.632	0.26
454_T	589_E	0.632	0.26
379_A	393_D	0.630	0.25
546_T	624_G	0.630	0.25
235_E	277_R	0.629	0.25
378_L	392_G	0.629	0.25
313_A	351_A	0.629	0.25
43_Q	52_S	0.628	0.25
42_V	59_S	0.628	0.25
340_Y	486_G	0.628	0.25
107_E	267_V	0.628	0.25
357_H	361_V	0.627	0.25
402_F	405_V	0.626	0.25
586_E	592_A	0.625	0.25
616_A	619_D	0.625	0.25
602_G	611_K	0.625	0.25
380_E	383_A	0.625	0.25
49_I	55_K	0.625	0.25
50_E	56_L	0.623	0.25
45_G	55_K	0.623	0.25
435_L	440_D	0.622	0.25
368_G	380_E	0.622	0.25
110_A	116_A	0.621	0.25
110_A	114_A	0.621	0.25
106_T	133_V	0.620	0.25
431_L	494_E	0.620	0.25
379_A	391_R	0.620	0.25
460_A	507_Y	0.618	0.25
42_V	58_E	0.618	0.25
399_R	402_F	0.617	0.25
373_E	386_E	0.617	0.25
219_V	427_I	0.617	0.25
565_A	572_T	0.617	0.25
643_E	646_S	0.616	0.25
49_I	57_A	0.616	0.25
384_A	391_R	0.616	0.25
97_K	250_D	0.616	0.25
80_V	103_D	0.615	0.25
381_M	387_S	0.615	0.25
373_E	377_T	0.614	0.25
142_G	159_S	0.614	0.25
127_I	142_G	0.614	0.25
626_E	634_Q	0.613	0.25
400_R	419_D	0.612	0.25
389_H	395_D	0.611	0.24
600_A	614_M	0.611	0.24
60_D	66_A	0.610	0.24
385_G	388_F	0.609	0.24
208_L	308_L	0.608	0.24
520_D	559_K	0.608	0.24
217_A	284_Y	0.607	0.24
456_A	505_D	0.605	0.24
7_H	362_A	0.604	0.24
396_A	409_V	0.604	0.24
371_R	377_T	0.603	0.24
399_R	404_A	0.603	0.24
42_V	49_I	0.603	0.24
376_D	388_F	0.602	0.24
175_A	182_P	0.602	0.24
125_L	302_A	0.602	0.24
6_I	530_L	0.602	0.24
577_G	616_A	0.600	0.24
126_S	617_G	0.600	0.24
418_L	431_L	0.600	0.24
435_L	439_I	0.600	0.24
498_E	520_D	0.600	0.24
46_Y	55_K	0.599	0.24
405_V	409_V	0.598	0.24
194_V	522_R	0.597	0.24
375_A	379_A	0.597	0.24
382_A	387_S	0.596	0.24
626_E	629_A	0.595	0.24
367_T	388_F	0.595	0.24
398_G	407_V	0.595	0.24
466_D	472_G	0.594	0.24
102_T	106_T	0.594	0.24
212_D	300_I	0.593	0.24
367_T	373_E	0.592	0.23
102_T	134_T	0.591	0.23
109_E	133_V	0.591	0.23
485_M	489_T	0.590	0.23
400_R	409_V	0.590	0.23
450_A	453_L	0.589	0.23
90_V	118_F	0.588	0.23
202_L	206_A	0.587	0.23
130_L	498_E	0.587	0.23
410_D	597_R	0.586	0.23
114_A	118_F	0.585	0.23
41_L	61_Q	0.585	0.23
312_M	479_A	0.585	0.23
202_L	457_G	0.585	0.23
620_D	636_M	0.584	0.23
390_G	395_D	0.584	0.23
600_A	605_I	0.584	0.23
204_E	311_V	0.583	0.23
98_M	125_L	0.583	0.23
232_G	235_E	0.582	0.23
310_A	314_N	0.582	0.23
206_A	249_L	0.581	0.23
235_E	280_G	0.580	0.23
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592_A	595_L	0.578	0.23
48_Q	58_E	0.577	0.23
429_G	433_A	0.577	0.23
256_L	498_E	0.576	0.23
252_M	256_L	0.576	0.23
250_D	253_Q	0.575	0.23
383_A	393_D	0.574	0.23
124_S	251_Y	0.574	0.23
219_V	233_A	0.573	0.23
212_D	303_D	0.573	0.23
368_G	379_A	0.572	0.22
54_G	58_E	0.571	0.22
455_G	505_D	0.571	0.22
467_V	649_S	0.571	0.22
124_S	191_G	0.571	0.22
195_N	337_G	0.571	0.22
17_M	21_I	0.570	0.22
25_A	197_I	0.570	0.22
119_A	155_V	0.569	0.22
118_F	133_V	0.569	0.22
255_V	576_Y	0.569	0.22
373_E	376_D	0.568	0.22
197_I	334_V	0.568	0.22
162_H	519_A	0.568	0.22
372_Y	384_A	0.567	0.22
620_D	623_A	0.567	0.22
377_T	384_A	0.567	0.22
426_T	521_M	0.567	0.22
236_L	263_C	0.567	0.22
94_V	265_V	0.567	0.22
414_G	438_A	0.566	0.22
373_E	381_M	0.565	0.22
90_V	135_E	0.565	0.22
120_T	125_L	0.565	0.22
437_D	441_V	0.564	0.22
589_E	596_A	0.564	0.22
76_T	94_V	0.564	0.22
361_V	554_G	0.564	0.22
605_I	614_M	0.564	0.22
215_T	517_T	0.563	0.22
204_E	208_L	0.562	0.22
444_D	447_D	0.562	0.22
356_L	359_T	0.562	0.22
400_R	404_A	0.562	0.22
604_P	615_R	0.561	0.22
508_C	519_A	0.561	0.22
457_G	505_D	0.561	0.22
12_L	20_G	0.560	0.22
52_S	60_D	0.559	0.22
376_D	389_H	0.559	0.22
266_L	539_L	0.559	0.22
10_A	33_R	0.559	0.22
107_E	110_A	0.558	0.22
463_A	614_M	0.558	0.22
348_A	356_L	0.558	0.22
459_K	463_A	0.558	0.22
630_Q	638_T	0.557	0.22
587_A	595_L	0.557	0.22
603_P	613_A	0.557	0.22
193_V	323_G	0.557	0.22
382_A	389_H	0.557	0.22
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10_A	108_V	0.556	0.22
356_L	414_G	0.555	0.22
588_F	596_A	0.555	0.22
470_M	475_D	0.555	0.22
376_D	384_A	0.554	0.22
274_D	279_S	0.554	0.22
626_E	639_Q	0.554	0.22
374_P	380_E	0.554	0.22
552_I	580_N	0.553	0.22
184_R	329_E	0.553	0.22
199_V	237_A	0.552	0.21
163_T	167_V	0.552	0.21
385_G	394_E	0.552	0.21
131_S	555_E	0.552	0.21
202_L	245_S	0.552	0.21
39_A	58_E	0.552	0.21
236_L	338_A	0.550	0.21
356_L	360_L	0.550	0.21
436_S	485_M	0.549	0.21
168_L	242_I	0.549	0.21
614_M	617_G	0.549	0.21
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18_G	21_I	0.549	0.21
557_R	563_F	0.548	0.21
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406_S	417_E	0.546	0.21
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466_D	470_M	0.544	0.21
577_G	598_D	0.544	0.21
367_T	389_H	0.544	0.21
373_E	388_F	0.544	0.21
209_V	219_V	0.543	0.21
41_L	49_I	0.543	0.21
284_Y	469_S	0.543	0.21
99_E	481_E	0.543	0.21
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177_D	587_A	0.543	0.21
20_G	109_E	0.543	0.21
54_G	426_T	0.543	0.21
152_M	160_G	0.542	0.21
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456_A	525_S	0.540	0.21
470_M	479_A	0.540	0.21
85_D	298_D	0.539	0.21
92_E	101_K	0.539	0.21
453_L	540_L	0.539	0.21
439_I	443_G	0.538	0.21
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23_E	150_V	0.538	0.21
91_I	158_I	0.537	0.21
537_L	648_F	0.537	0.21
131_S	556_G	0.534	0.21
60_D	67_A	0.534	0.21
484_R	626_E	0.534	0.21
469_S	580_N	0.534	0.21
20_G	598_D	0.534	0.21
432_L	486_G	0.533	0.21
602_G	614_M	0.532	0.21
371_R	374_P	0.532	0.21
286_Y	295_V	0.531	0.20
490_F	505_D	0.531	0.20
505_D	508_C	0.531	0.20
514_E	534_E	0.531	0.20
508_C	513_M	0.529	0.20
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516_A	528_S	0.528	0.20
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479_A	636_M	0.527	0.20
474_A	479_A	0.527	0.20
67_A	70_A	0.527	0.20
58_E	64_E	0.526	0.20
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132_E	528_S	0.525	0.20
38_S	75_S	0.524	0.20
187_K	323_G	0.522	0.20
385_G	391_R	0.522	0.20
522_R	579_I	0.521	0.20
230_P	236_L	0.521	0.20
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189_S	240_V	0.520	0.20
376_D	392_G	0.520	0.20
152_M	305_A	0.520	0.20
223_T	229_L	0.520	0.20
41_L	54_G	0.517	0.20
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412_N	449_R	0.517	0.20
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383_A	386_E	0.515	0.20
377_T	386_E	0.515	0.20
94_V	436_S	0.515	0.20
603_P	615_R	0.514	0.20
460_A	623_A	0.514	0.20
305_A	308_L	0.514	0.20
400_R	406_S	0.514	0.20
50_E	60_D	0.514	0.20
376_D	380_E	0.513	0.20
431_L	434_D	0.513	0.20
201_L	486_G	0.513	0.20
286_Y	291_A	0.512	0.20
386_E	394_E	0.512	0.20
396_A	401_E	0.512	0.20
48_Q	62_L	0.511	0.20
491_G	622_D	0.511	0.20
191_G	236_L	0.511	0.20
62_L	65_A	0.511	0.20
391_R	395_D	0.510	0.20
73_R	542_G	0.510	0.20
147_N	230_P	0.510	0.20
403_D	407_V	0.510	0.20
324_V	330_I	0.510	0.20
113_P	496_A	0.509	0.19
8_S	170_C	0.509	0.19
268_D	575_D	0.508	0.19
405_V	434_D	0.508	0.19
387_S	390_G	0.507	0.19
369_Q	373_E	0.507	0.19
7_H	358_E	0.507	0.19
636_M	646_S	0.506	0.19
44_D	55_K	0.506	0.19
368_G	371_R	0.505	0.19
131_S	142_G	0.505	0.19
75_S	78_V	0.505	0.19
209_V	232_G	0.505	0.19
457_G	506_G	0.505	0.19
380_E	384_A	0.505	0.19
604_P	613_A	0.505	0.19
269_H	334_V	0.504	0.19
603_P	612_R	0.504	0.19
543_W	632_F	0.504	0.19
136_R	312_M	0.503	0.19
205_A	427_I	0.502	0.19
169_E	184_R	0.501	0.19
97_K	103_D	0.501	0.19
254_D	366_A	0.500	0.19
462_S	641_L	0.500	0.19
238_D	282_G	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1wdkA	2	0.5812	100	0.634	Contact Map
2wtbA	1	0.5508	100	0.639	Contact Map
3k6jA	1	0.5615	100	0.646	Contact Map
3zwcA	1	0.5979	100	0.646	Contact Map
1zcjA	1	0.5964	100	0.652	Contact Map
4b3hA	1	0.569	100	0.659	Contact Map
3mogA	3	0.5827	100	0.673	Contact Map
4j0eA	2	0.4325	100	0.727	Contact Map
1f0yA	2	0.431	100	0.737	Contact Map
4r1nA	2	0.4264	100	0.742	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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