GREMLIN Database
Q9HQ53 - Uncharacterized protein
UniProt: Q9HQ53 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 144 (125)
Sequences: 1810 (1369)
Seq/√Len: 122.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_D138_T3.3661.00
28_A62_T3.1081.00
35_L57_A2.7801.00
60_V86_L2.7181.00
122_G126_S2.5381.00
61_L65_L2.5311.00
27_V61_L2.5141.00
17_R135_L2.3921.00
36_L54_A2.3151.00
67_N85_G2.2101.00
32_Q51_A2.1501.00
51_A119_N2.0851.00
20_R69_W2.0241.00
16_T20_R1.9111.00
67_N139_W1.8931.00
36_L115_Y1.8751.00
32_Q54_A1.8051.00
51_A104_L1.7951.00
106_A110_W1.7651.00
56_E90_N1.7551.00
66_N70_T1.7391.00
39_F53_A1.7091.00
32_Q100_Q1.6851.00
107_L118_S1.5941.00
17_R131_F1.5891.00
94_G98_P1.5821.00
62_T93_R1.5321.00
55_I59_I1.5071.00
92_V133_L1.4831.00
31_A61_L1.4821.00
33_M119_N1.4771.00
88_K137_W1.4741.00
63_Y85_G1.4731.00
52_V101_L1.4631.00
32_Q119_N1.4111.00
47_Y108_V1.3871.00
55_I97_I1.3761.00
36_L119_N1.3731.00
39_F50_S1.3651.00
96_A129_Y1.3601.00
41_D115_Y1.3261.00
40_V115_Y1.2951.00
37_W116_L1.2601.00
28_A61_L1.2581.00
99_I129_Y1.2350.99
103_V122_G1.2130.99
14_T17_R1.1940.99
131_F135_L1.1860.99
64_V68_A1.1580.99
120_A124_L1.1560.99
99_I126_S1.1480.99
21_F130_R1.1480.99
36_L40_V1.1330.99
124_L128_G1.0960.99
18_L130_R1.0860.99
26_V30_G1.0810.99
33_M123_I1.0640.98
37_W115_Y1.0620.98
47_Y109_E1.0590.98
35_L39_F1.0560.98
59_I93_R1.0490.98
51_A101_L1.0490.98
24_V65_L1.0460.98
21_F24_V1.0290.98
22_A26_V1.0160.98
29_A32_Q0.9760.97
86_L90_N0.9730.97
59_I90_N0.9640.97
87_V91_V0.9560.97
93_R134_D0.9260.96
37_W41_D0.9250.96
34_A38_V0.9190.96
62_T89_T0.9170.96
78_G83_A0.9050.96
28_A93_R0.8860.95
100_Q118_S0.8820.95
119_N123_I0.8820.95
28_A123_I0.8820.95
48_I101_L0.8740.95
100_Q126_S0.8720.95
36_L104_L0.8700.94
100_Q123_I0.8700.94
98_P102_G0.8640.94
18_L22_A0.8620.94
19_R23_A0.8550.94
60_V90_N0.8520.94
104_L119_N0.8420.93
84_V88_K0.8420.93
71_F89_T0.8280.93
14_T131_F0.8050.92
71_F131_F0.8040.92
128_G132_V0.8020.92
107_L117_L0.8000.92
63_Y82_Y0.7990.92
63_Y67_N0.7870.91
89_T97_I0.7820.91
89_T93_R0.7790.91
47_Y104_L0.7640.90
29_A62_T0.7620.90
32_Q36_L0.7570.89
133_L138_T0.7570.89
55_I93_R0.7480.89
38_V43_V0.7450.88
32_Q58_T0.7390.88
132_V136_R0.7330.88
17_R73_A0.7330.88
45_V50_S0.7240.87
38_V42_A0.7200.87
94_G105_F0.7140.86
15_A19_R0.7140.86
51_A62_T0.7100.86
56_E60_V0.7070.86
54_A119_N0.7070.86
39_F43_V0.7030.85
103_V126_S0.7030.85
23_A69_W0.7020.85
88_K134_D0.6980.85
28_A134_D0.6960.85
39_F45_V0.6880.84
27_V65_L0.6870.84
26_V29_A0.6860.84
63_Y76_N0.6810.84
21_F126_S0.6700.83
29_A127_G0.6700.83
59_I89_T0.6660.82
29_A63_Y0.6650.82
43_V49_P0.6650.82
103_V107_L0.6630.82
40_V47_Y0.6590.82
119_N122_G0.6520.81
129_Y139_W0.6460.80
107_L121_V0.6420.80
55_I130_R0.6400.80
37_W102_G0.6400.80
112_S124_L0.6340.79
29_A33_M0.6310.79
24_V27_V0.6280.78
22_A127_G0.6270.78
62_T66_N0.6240.78
71_F136_R0.6220.78
66_N134_D0.6210.78
97_I104_L0.6180.77
34_A42_A0.6170.77
64_V82_Y0.6110.76
23_A27_V0.6060.76
106_A112_S0.6060.76
137_W140_S0.6030.76
40_V54_A0.6030.76
55_I58_T0.6000.75
113_L118_S0.5980.75
52_V83_A0.5910.74
32_Q62_T0.5890.74
114_P117_L0.5860.73
93_R138_T0.5820.73
48_I52_V0.5820.73
33_M37_W0.5740.72
83_A87_V0.5740.72
28_A70_T0.5620.70
101_L104_L0.5580.70
30_G124_L0.5570.70
104_L108_V0.5550.69
106_A111_Y0.5530.69
108_V118_S0.5510.69
129_Y133_L0.5490.69
28_A65_L0.5440.68
55_I90_N0.5390.67
100_Q104_L0.5360.67
27_V30_G0.5360.67
48_I105_F0.5350.67
133_L137_W0.5340.67
65_L134_D0.5340.67
18_L65_L0.5310.66
21_F127_G0.5300.66
85_G90_N0.5300.66
38_V41_D0.5290.66
107_L113_L0.5270.66
28_A66_N0.5240.65
48_I109_E0.5230.65
97_I101_L0.5190.64
14_T18_L0.5170.64
34_A112_S0.5140.64
24_V70_T0.5140.64
40_V52_V0.5120.63
90_N139_W0.5100.63
21_F134_D0.5080.63
56_E139_W0.5060.62
82_Y86_L0.5010.62
96_A99_I0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tq3A 1 0.8472 7.7 0.933 Contact Map
4od4A 1 0.7708 3.4 0.943 Contact Map
1rh5B 1 0.2917 2.7 0.946 Contact Map
3ixzA 1 0.9236 2.7 0.946 Contact Map
2zxeA 1 0.9653 2.5 0.947 Contact Map
4ytpD 1 0.375 2.4 0.948 Contact Map
4ysxD 1 0.375 2.4 0.948 Contact Map
3mp7B 1 0.2708 2 0.949 Contact Map
4av3A 2 0.6042 1.8 0.951 Contact Map
3mktA 1 0.9167 1.8 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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