GREMLIN Database
THYX - Thymidylate synthase ThyX
UniProt: Q9HQ52 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (192)
Sequences: 1412 (879)
Seq/√Len: 63.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_A225_Q3.9391.00
218_Q221_D3.5011.00
70_S190_T3.3581.00
78_V82_C3.1001.00
84_A96_V2.7741.00
57_L65_P2.7671.00
68_H190_T2.7481.00
83_M96_V2.7341.00
67_E194_R2.5431.00
84_A87_T2.5071.00
218_Q222_A2.4501.00
87_T96_V2.3441.00
85_Q209_Q2.3411.00
149_A153_A2.2921.00
153_A157_R2.2441.00
83_M187_V2.2251.00
67_E192_N2.1791.00
210_W214_E2.0761.00
157_R160_E2.0421.00
8_A226_W2.0321.00
83_M87_T2.0201.00
150_V164_E1.9991.00
23_D95_D1.9801.00
83_M185_V1.9591.00
78_V83_M1.9531.00
148_E152_Q1.9431.00
67_E90_R1.9261.00
86_L187_V1.9251.00
75_I189_I1.8551.00
199_V216_T1.8531.00
55_A232_E1.8481.00
154_S158_A1.7991.00
92_A191_L1.7901.00
72_T190_T1.7581.00
159_V163_Q1.7581.00
195_S198_H1.7130.99
93_S192_N1.7110.99
51_S232_E1.7010.99
82_C215_L1.6880.99
91_H198_H1.6830.99
98_S101_Y1.6240.99
157_R161_D1.5760.99
165_L178_V1.5630.99
224_A235_D1.5550.99
94_F189_I1.5540.99
13_E229_H1.5300.99
208_A212_I1.5240.99
73_F219_L1.4640.98
150_V161_D1.4600.98
154_S161_D1.4540.98
19_S68_H1.4440.98
146_E164_E1.4400.98
156_R160_E1.4400.98
191_L196_L1.3670.97
147_R165_L1.3540.97
98_S176_R1.3200.96
81_S181_I1.3080.96
198_H202_M1.3010.96
164_E168_L1.2840.96
56_Q60_R1.2810.96
79_S211_E1.2760.96
100_R176_R1.2660.95
199_V212_I1.2550.95
145_A149_A1.2490.95
16_I230_T1.2440.95
88_R203_R1.2340.95
196_L223_A1.2150.94
21_R53_L1.2120.94
68_H72_T1.2110.94
152_Q156_R1.2100.94
150_V165_L1.1970.94
11_N14_E1.1860.94
151_F155_V1.1620.93
87_T94_F1.1570.93
197_M230_T1.1480.92
61_G201_D1.1480.92
74_A186_N1.1420.92
87_T187_V1.1060.91
7_E15_L1.0940.91
80_R99_M1.0820.90
91_H195_S1.0760.90
158_A161_D1.0750.90
57_L66_F1.0710.90
158_A180_P1.0700.90
85_Q208_A1.0630.89
5_L71_A1.0620.89
16_I65_P1.0610.89
146_E149_A1.0510.89
147_R161_D1.0500.89
220_L224_A1.0470.89
4_R74_A1.0400.88
220_L231_F1.0350.88
53_L56_Q1.0130.87
5_L226_W1.0080.87
162_Y176_R1.0040.86
90_R192_N0.9910.86
144_M148_E0.9900.86
153_A156_R0.9850.85
92_A195_S0.9640.84
80_R84_A0.9570.84
222_A226_W0.9560.83
120_T152_Q0.9530.83
200_A223_A0.9420.83
62_H101_Y0.9420.83
144_M147_R0.9380.82
104_F179_L0.9180.81
169_G172_P0.9090.80
51_S229_H0.9070.80
71_A226_W0.9050.80
89_H203_R0.9030.80
86_L189_I0.9020.80
23_D80_R0.8970.79
92_A199_V0.8950.79
85_Q203_R0.8810.78
68_H95_D0.8770.78
55_A229_H0.8740.78
23_D96_V0.8700.77
20_A53_L0.8690.77
45_T50_L0.8670.77
5_L73_F0.8650.77
161_D165_L0.8600.76
90_R94_F0.8560.76
67_E88_R0.8550.76
13_E230_T0.8480.75
86_L215_L0.8470.75
86_L195_S0.8450.75
4_R8_A0.8450.75
150_V153_A0.8430.75
147_R168_L0.8400.75
84_A187_V0.8330.74
13_E20_A0.8320.74
22_N188_V0.8260.73
123_S171_P0.8200.73
221_D224_A0.8150.72
88_R94_F0.8090.72
84_A181_I0.8070.72
155_V182_G0.8050.72
71_A227_C0.8020.71
150_V168_L0.8000.71
160_E214_E0.7940.71
221_D225_Q0.7920.70
122_P125_T0.7800.69
154_S165_L0.7790.69
146_E156_R0.7740.69
145_A148_E0.7700.68
48_E51_S0.7600.67
176_R211_E0.7560.67
123_S210_W0.7490.66
146_E168_L0.7380.65
14_E50_L0.7350.65
13_E227_C0.7340.64
70_S191_L0.7310.64
67_E94_F0.7300.64
75_I202_M0.7250.63
165_L168_L0.7230.63
76_E186_N0.7130.62
104_F159_V0.7120.62
176_R180_P0.7090.62
151_F165_L0.7080.62
64_G87_T0.7080.62
90_R194_R0.7070.62
48_E52_N0.7030.61
71_A223_A0.7010.61
64_G95_D0.7010.61
106_D159_V0.6990.61
155_V178_V0.6970.60
92_A198_H0.6950.60
150_V157_R0.6940.60
53_L65_P0.6940.60
89_H202_M0.6930.60
200_A204_A0.6910.60
99_M173_E0.6900.60
73_F196_L0.6860.59
123_S170_M0.6840.59
19_S72_T0.6820.59
160_E163_Q0.6820.59
24_Y95_D0.6810.59
204_A220_L0.6810.59
197_M223_A0.6730.58
62_H98_S0.6700.57
177_F182_G0.6680.57
97_Q104_F0.6670.57
167_G225_Q0.6640.57
161_D164_E0.6640.57
51_S230_T0.6620.57
6_L188_V0.6590.56
197_M233_Y0.6500.55
191_L199_V0.6470.55
17_C50_L0.6460.55
91_H199_V0.6440.54
64_G194_R0.6440.54
51_S55_A0.6420.54
176_R185_V0.6420.54
17_C20_A0.6400.54
78_V187_V0.6380.54
200_A219_L0.6360.54
75_I120_T0.6330.53
63_Y194_R0.6330.53
82_C212_I0.6310.53
99_M104_F0.6310.53
68_H192_N0.6250.52
203_R209_Q0.6230.52
157_R167_G0.6220.52
8_A225_Q0.6220.52
121_P125_T0.6210.52
58_L66_F0.6200.52
203_R208_A0.6200.52
93_S194_R0.6190.52
101_Y176_R0.6190.52
179_L183_T0.6170.51
68_H93_S0.6170.51
196_L219_L0.6170.51
149_A157_R0.6170.51
168_L171_P0.6130.51
126_D148_E0.6120.51
160_E164_E0.6110.51
105_D108_D0.6020.50
89_H208_A0.6000.49
5_L8_A0.5990.49
70_S93_S0.5950.49
46_T229_H0.5930.49
197_M201_D0.5920.48
200_A216_T0.5910.48
100_R180_P0.5900.48
72_T188_V0.5880.48
180_P211_E0.5860.48
79_S84_A0.5830.47
214_E217_E0.5830.47
64_G211_E0.5800.47
144_M165_L0.5790.47
144_M150_V0.5770.47
120_T148_E0.5770.47
149_A160_E0.5760.47
191_L219_L0.5740.46
197_M234_Y0.5720.46
154_S157_R0.5720.46
120_T125_T0.5690.46
163_Q167_G0.5690.46
191_L195_S0.5670.46
146_E152_Q0.5670.46
76_E107_V0.5660.45
9_T15_L0.5640.45
21_R232_E0.5640.45
214_E218_Q0.5620.45
193_P230_T0.5610.45
28_W232_E0.5600.45
174_D186_N0.5600.45
97_Q186_N0.5590.45
205_A235_D0.5570.44
209_Q212_I0.5560.44
23_D64_G0.5550.44
4_R157_R0.5530.44
16_I54_I0.5520.44
148_E151_F0.5510.44
147_R150_V0.5420.43
195_S202_M0.5400.43
96_V187_V0.5380.42
214_E232_E0.5380.42
20_A65_P0.5370.42
52_N55_A0.5370.42
98_S185_V0.5350.42
150_V158_A0.5340.42
144_M151_F0.5330.42
83_M86_L0.5320.42
164_E221_D0.5310.42
19_S73_F0.5300.41
53_L66_F0.5300.41
55_A236_A0.5290.41
85_Q212_I0.5260.41
145_A221_D0.5250.41
164_E167_G0.5250.41
17_C193_P0.5240.41
173_E209_Q0.5240.41
65_P69_P0.5210.40
162_Y179_L0.5200.40
124_A151_F0.5190.40
83_M95_D0.5160.40
148_E160_E0.5160.40
104_F183_T0.5130.40
205_A236_A0.5110.39
147_R178_V0.5110.39
106_D226_W0.5090.39
81_S84_A0.5090.39
5_L9_T0.5090.39
75_I219_L0.5050.39
11_N46_T0.5040.39
62_H68_H0.5010.38
64_G176_R0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gwcA 3 0.8421 100 0.195 Contact Map
2cfaA 3 0.7126 100 0.203 Contact Map
3fnnA 3 0.8138 100 0.211 Contact Map
4gt9A 3 0.83 100 0.22 Contact Map
3n3yA 4 0.8259 100 0.237 Contact Map
4n78F 1 0.4777 7.9 0.961 Contact Map
1oaoA 2 0.2551 6.1 0.963 Contact Map
3pf6A 2 0.2429 5.3 0.964 Contact Map
1vq8X 1 0.251 3.8 0.966 Contact Map
1j27A 2 0.2308 2.7 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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