GREMLIN Database
Q9HQ50 - Flavoprotein
UniProt: Q9HQ50 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (167)
Sequences: 16239 (11388)
Seq/√Len: 881.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_T113_C3.9641.00
23_R47_D3.8151.00
51_I62_L3.2351.00
91_E98_D2.6971.00
93_R98_D2.4601.00
99_Y116_S2.4381.00
91_E100_V2.3921.00
100_V117_P2.3541.00
50_V114_L2.3321.00
101_V112_V2.2941.00
25_V48_A2.2381.00
36_V68_A2.1361.00
121_V167_Y2.0581.00
48_A74_L1.9731.00
79_V110_H1.9091.00
38_A42_H1.8701.00
77_D87_A1.8551.00
101_V114_L1.8501.00
24_D44_V1.8461.00
17_F167_Y1.8171.00
23_R45_T1.7991.00
116_S119_A1.7881.00
143_D146_T1.7631.00
88_D153_R1.7531.00
48_A72_T1.7471.00
27_V123_F1.7191.00
72_T84_R1.7031.00
20_T44_V1.6881.00
66_V83_D1.6401.00
88_D154_L1.5631.00
149_E153_R1.5451.00
74_L84_R1.5141.00
76_F103_H1.4931.00
36_V40_R1.4721.00
20_T24_D1.4691.00
38_A41_D1.4511.00
64_A68_A1.4431.00
87_A90_D1.4391.00
25_V50_V1.4361.00
27_V52_T1.4281.00
120_G164_T1.4191.00
115_Y164_T1.4111.00
46_P71_P1.3801.00
37_A41_D1.3711.00
113_C122_L1.3651.00
36_V69_F1.3461.00
100_V115_Y1.3321.00
176_S179_A1.3241.00
97_D116_S1.3211.00
62_L73_V1.3121.00
46_P69_F1.3021.00
115_Y122_L1.2971.00
39_V46_P1.2951.00
63_D67_D1.2751.00
84_R90_D1.2711.00
74_L86_L1.2681.00
148_V152_D1.2591.00
34_D37_A1.2571.00
108_E111_H1.2441.00
153_R156_D1.2211.00
102_L115_Y1.1991.00
133_S136_R1.1791.00
66_V73_V1.1781.00
63_D66_V1.1681.00
17_F123_F1.1501.00
146_T149_E1.1461.00
88_D103_H1.1411.00
104_T150_S1.1261.00
111_H125_A1.0961.00
120_G163_L1.0961.00
166_L174_V1.0881.00
24_D46_P1.0791.00
102_L154_L1.0761.00
106_G150_S1.0741.00
29_A49_V1.0701.00
37_A40_R1.0641.00
113_C127_L1.0621.00
109_P146_T1.0541.00
40_R68_A1.0421.00
104_T127_L1.0401.00
165_A173_S1.0291.00
26_V46_P1.0291.00
121_V165_A1.0251.00
152_D156_D1.0131.00
78_G103_H1.0021.00
52_T125_A1.0001.00
93_R96_D0.9931.00
127_L147_L0.9911.00
77_D85_A0.9831.00
159_A164_T0.9781.00
122_L158_V0.9771.00
144_R147_L0.9741.00
21_G96_D0.9721.00
76_F112_V0.9661.00
144_R148_V0.9551.00
18_L38_A0.9461.00
145_E149_E0.9271.00
54_P75_G0.9261.00
64_A67_D0.9231.00
115_Y158_V0.9091.00
124_S166_L0.9061.00
127_L154_L0.9021.00
50_V99_Y0.8961.00
26_V29_A0.8911.00
21_G95_G0.8881.00
35_V38_A0.8831.00
140_D143_D0.8801.00
159_A163_L0.8771.00
56_P60_G0.8741.00
162_E180_A0.8651.00
122_L166_L0.8591.00
62_L66_V0.8571.00
14_S30_G0.8491.00
77_D80_A0.8431.00
152_D155_A0.8411.00
25_V94_L0.8381.00
23_R48_A0.8351.00
51_I73_V0.8321.00
104_T111_H0.8311.00
89_G100_V0.8251.00
111_H127_L0.8241.00
82_A85_A0.8221.00
76_F79_V0.8221.00
136_R139_L0.8211.00
97_D119_A0.8111.00
75_G79_V0.8101.00
132_G177_D0.8071.00
18_L24_D0.8011.00
35_V39_V0.7991.00
75_G82_A0.7971.00
49_V71_P0.7911.00
109_P141_G0.7911.00
17_F169_G0.7871.00
94_L97_D0.7851.00
86_L112_V0.7851.00
117_P120_G0.7821.00
132_G178_P0.7751.00
16_V35_V0.7711.00
12_F56_P0.7691.00
129_F135_G0.7681.00
178_P181_D0.7671.00
130_A172_P0.7651.00
72_T83_D0.7651.00
127_L150_S0.7651.00
80_A85_A0.7611.00
86_L101_V0.7611.00
162_E177_D0.7601.00
19_V27_V0.7601.00
91_E117_P0.7551.00
49_V62_L0.7541.00
99_Y114_L0.7541.00
75_G80_A0.7501.00
139_L144_R0.7501.00
132_G135_G0.7471.00
33_Y64_A0.7401.00
20_T38_A0.7401.00
55_H169_G0.7371.00
115_Y159_A0.7341.00
18_L26_V0.7341.00
25_V99_Y0.7331.00
86_L114_L0.7291.00
123_F167_Y0.7271.00
115_Y163_L0.7251.00
128_V166_L0.7241.00
26_V65_L0.7111.00
166_L176_S0.7061.00
103_H112_V0.7011.00
98_D117_P0.6951.00
33_Y61_N0.6951.00
102_L153_R0.6931.00
116_S120_G0.6901.00
124_S168_P0.6891.00
27_V50_V0.6891.00
78_G87_A0.6881.00
102_L113_C0.6871.00
113_C154_L0.6801.00
48_A84_R0.6791.00
15_N169_G0.6791.00
167_Y173_S0.6771.00
24_D47_D0.6771.00
165_A175_T0.6711.00
54_P110_H0.6691.00
149_E152_D0.6691.00
100_V158_V0.6621.00
98_D118_A0.6591.00
29_A62_L0.6571.00
61_N64_A0.6541.00
23_R95_G0.6461.00
20_T42_H0.6441.00
76_F80_A0.6401.00
174_V179_A0.6391.00
15_N172_P0.6391.00
115_Y120_G0.6391.00
32_N60_G0.6391.00
49_V73_V0.6301.00
15_N171_G0.6301.00
177_D181_D0.6221.00
51_I59_V0.6191.00
47_D72_T0.6191.00
86_L92_I0.6181.00
34_D68_A0.6161.00
158_V163_L0.6131.00
21_G97_D0.6131.00
116_S121_V0.6131.00
14_S169_G0.6101.00
16_V30_G0.6081.00
151_I155_A0.6041.00
65_L69_F0.6031.00
105_P150_S0.6001.00
32_N61_N0.5961.00
24_D39_V0.5941.00
26_V39_V0.5891.00
150_S153_R0.5891.00
49_V65_L0.5821.00
155_A176_S0.5821.00
147_L151_I0.5821.00
86_L90_D0.5771.00
50_V112_V0.5761.00
151_I156_D0.5721.00
134_F137_T0.5641.00
19_V116_S0.5591.00
141_G147_L0.5571.00
143_D147_L0.5561.00
54_P79_V0.5511.00
18_L39_V0.5481.00
137_T144_R0.5481.00
87_A103_H0.5481.00
59_V62_L0.5471.00
159_A162_E0.5381.00
66_V70_D0.5381.00
29_A61_N0.5371.00
19_V25_V0.5351.00
176_S180_A0.5311.00
102_L122_L0.5311.00
24_D45_T0.5291.00
46_P65_L0.5261.00
27_V114_L0.5261.00
35_V61_N0.5231.00
40_R43_G0.5181.00
39_V69_F0.5131.00
50_V92_I0.5111.00
26_V35_V0.5071.00
31_A59_V0.5071.00
120_G165_A0.5031.00
102_L158_V0.5031.00
90_D101_V0.5031.00
129_F136_R0.5021.00
175_T178_P0.5001.00
106_G139_L0.5001.00
92_I95_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.9688 100 0.268 Contact Map
3r2uA 4 0.9792 100 0.273 Contact Map
4yslA 2 0.9792 100 0.278 Contact Map
4efzA 2 0.9792 100 0.278 Contact Map
3tp9A 2 0.9792 100 0.283 Contact Map
1xm8A 1 0.9583 100 0.293 Contact Map
2p18A 1 0.9635 100 0.293 Contact Map
1qh5A 1 0.9583 100 0.294 Contact Map
2qedA 1 0.9531 100 0.301 Contact Map
4ad9A 4 0.9531 100 0.306 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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