GREMLIN Database
PHR - Deoxyribodipyrimidine photo-lyase
UniProt: Q9HQ46 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 481 (415)
Sequences: 5446 (4246)
Seq/√Len: 208.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
317_D320_A4.5871.00
246_H251_T4.0911.00
333_I354_I3.8941.00
322_Q326_D3.8101.00
342_R373_W3.5911.00
321_L325_K3.5441.00
321_L369_A3.5011.00
304_N310_H3.2211.00
339_R429_E3.1341.00
216_L257_V3.0941.00
67_R71_R2.9671.00
337_G351_V2.8301.00
101_V131_F2.8171.00
413_G423_I2.8111.00
62_A251_T2.7041.00
99_R129_A2.5601.00
82_G87_V2.5181.00
102_W128_H2.5101.00
102_W130_Q2.4821.00
342_R377_K2.4791.00
67_R76_D2.4771.00
13_T256_T2.4701.00
279_A282_G2.4691.00
65_A210_A2.4201.00
100_V121_L2.3941.00
331_Y358_F2.3831.00
87_V90_A2.3161.00
15_N103_N2.2971.00
209_T256_T2.2671.00
6_H39_A2.2411.00
340_Q344_E2.2411.00
290_Y389_G2.2381.00
351_V422_Y2.2081.00
315_R320_A2.1891.00
209_T213_R2.1881.00
217_D260_A2.1371.00
411_T415_R2.1371.00
4_F17_G2.1261.00
330_G335_D2.0761.00
213_R256_T2.0611.00
343_A426_F2.0611.00
4_F15_N2.0491.00
99_R127_A2.0291.00
62_A208_G2.0221.00
83_D86_A2.0151.00
59_M249_F1.9911.00
90_A94_D1.9751.00
344_E426_F1.9701.00
211_A214_S1.9531.00
373_W377_K1.9451.00
371_Y387_N1.8971.00
260_A263_A1.8951.00
89_P124_A1.8881.00
241_S280_F1.8671.00
322_Q325_K1.8651.00
216_L260_A1.8561.00
410_M413_G1.8301.00
69_R209_T1.8101.00
339_R427_V1.7951.00
408_N412_Q1.7801.00
58_F246_H1.7671.00
157_W285_A1.7391.00
92_A97_A1.7371.00
227_R231_R1.7351.00
80_R94_D1.7171.00
58_F249_F1.7161.00
80_R87_V1.7051.00
290_Y388_G1.7031.00
6_H70_Y1.6791.00
212_A252_I1.6631.00
85_A116_G1.6541.00
340_Q422_Y1.6481.00
85_A89_P1.6461.00
359_L365_V1.6401.00
235_P351_V1.6381.00
325_K376_E1.6331.00
220_R225_I1.6321.00
39_A75_S1.6271.00
258_Y281_I1.6251.00
356_A393_A1.6241.00
156_F292_Q1.6031.00
332_P336_A1.6001.00
366_D369_A1.5991.00
247_L257_V1.5901.00
256_T260_A1.5881.00
19_A23_P1.5861.00
157_W282_G1.5851.00
261_A277_V1.5611.00
118_R130_Q1.5531.00
375_R381_H1.5461.00
331_Y362_D1.5431.00
65_A69_R1.5391.00
234_Y237_E1.5351.00
70_Y75_S1.5301.00
323_A328_E1.5211.00
69_R210_A1.5191.00
71_R76_D1.5161.00
153_Y282_G1.5101.00
13_T213_R1.5091.00
40_V91_V1.4981.00
243_L280_F1.4651.00
8_R105_D1.4611.00
218_A222_S1.4541.00
40_V88_L1.4481.00
61_D207_A1.4331.00
261_A280_F1.4321.00
293_V398_T1.4291.00
20_A23_P1.4271.00
359_L370_G1.4201.00
369_A372_D1.4091.00
3_L97_A1.4021.00
229_E279_A1.3981.00
107_S110_A1.3981.00
261_A281_I1.3901.00
57_A61_D1.3851.00
16_R133_D1.3831.00
44_D47_V1.3811.00
93_N124_A1.3581.00
134_A291_A1.3501.00
111_T295_Y1.3491.00
40_V80_R1.3421.00
337_G422_Y1.3371.00
420_A424_T1.3341.00
316_D369_A1.3241.00
303_E310_H1.3181.00
41_F59_M1.3141.00
160_W285_A1.3111.00
6_H66_L1.3091.00
231_R237_E1.3081.00
194_E197_F1.2951.00
91_V95_L1.2891.00
92_A126_V1.2871.00
157_W161_Q1.2811.00
132_H138_R1.2781.00
421_D424_T1.2731.00
279_A283_Q1.2721.00
300_V387_N1.2721.00
260_A264_A1.2711.00
299_N303_E1.2671.00
321_L365_V1.2671.00
7_R114_D1.2601.00
231_R239_P1.2591.00
283_Q385_N1.2561.00
243_L257_V1.2551.00
174_P177_L1.2481.00
105_D110_A1.2441.00
42_C88_L1.2421.00
100_V128_H1.2321.00
255_R259_E1.2281.00
370_G390_W1.2231.00
208_G211_A1.2211.00
333_I413_G1.2091.00
137_H160_W1.2081.00
325_K373_W1.2001.00
340_Q346_Y1.1981.00
383_T387_N1.1971.00
45_D81_H1.1961.00
41_F63_L1.1941.00
86_A90_A1.1871.00
38_A78_I1.1731.00
341_L378_L1.1711.00
208_G251_T1.1641.00
232_R283_Q1.1611.00
411_T414_E1.1601.00
263_A267_D1.1551.00
5_W117_V1.1511.00
227_R230_D1.1471.00
111_T115_A1.1441.00
334_V354_I1.1391.00
115_A118_R1.1321.00
107_S383_T1.1321.00
262_R281_I1.1311.00
294_L384_A1.1261.00
58_F245_P1.1201.00
389_G393_A1.1181.00
69_R73_L1.1161.00
318_P369_A1.0961.00
42_C87_V1.0941.00
13_T209_T1.0921.00
12_T73_L1.0871.00
60_L64_A1.0841.00
258_Y285_A1.0821.00
334_V338_M1.0811.00
242_R346_Y1.0721.00
227_R276_N1.0711.00
112_D116_G1.0681.00
89_P93_N1.0651.00
321_L359_L1.0611.00
197_F201_E1.0541.00
92_A95_L1.0491.00
208_G212_A1.0461.00
324_W338_M1.0401.00
54_P377_K1.0401.00
136_H160_W1.0321.00
198_A201_E1.0251.00
220_R261_A1.0241.00
285_A288_E1.0201.00
92_A100_V1.0161.00
408_N411_T1.0041.00
207_A211_A1.0021.00
218_A224_D1.0001.00
316_D320_A0.9981.00
319_A323_A0.9901.00
89_P92_A0.9901.00
240_T346_Y0.9891.00
65_A207_A0.9891.00
319_A369_A0.9881.00
330_G421_D0.9871.00
413_G420_A0.9851.00
103_N133_D0.9841.00
217_D221_E0.9791.00
180_D183_L0.9781.00
257_V280_F0.9771.00
115_A119_D0.9761.00
405_R408_N0.9711.00
238_E242_R0.9691.00
89_P120_A0.9671.00
110_A113_R0.9671.00
78_I91_V0.9651.00
43_F48_L0.9641.00
20_A131_F0.9631.00
22_A37_V0.9621.00
51_A55_R0.9601.00
80_R90_A0.9591.00
38_A95_L0.9551.00
148_D151_S0.9520.99
3_L92_A0.9480.99
339_R343_A0.9480.99
405_R412_Q0.9460.99
206_D211_A0.9410.99
108_G112_D0.9380.99
84_P89_P0.9380.99
226_Y264_A0.9370.99
135_V291_A0.9350.99
64_A68_E0.9350.99
423_I427_V0.9330.99
283_Q353_M0.9260.99
104_H132_H0.9210.99
197_F200_P0.9200.99
220_R264_A0.9150.99
54_P205_P0.9140.99
68_E72_D0.9090.99
42_C84_P0.9070.99
102_W118_R0.9070.99
92_A121_L0.9070.99
33_D36_P0.9020.99
187_S192_V0.8980.99
69_R72_D0.8940.99
58_F251_T0.8940.99
214_S218_A0.8930.99
196_G199_E0.8900.99
291_A385_N0.8900.99
82_G86_A0.8890.99
58_F208_G0.8890.99
117_V121_L0.8880.99
229_E276_N0.8830.99
105_D113_R0.8820.99
137_H142_I0.8790.99
46_E83_D0.8770.99
220_R260_A0.8750.99
410_M414_E0.8720.99
307_A310_H0.8710.99
38_A97_A0.8710.99
325_K369_A0.8620.99
58_F62_A0.8580.99
327_G338_M0.8560.99
70_Y77_L0.8520.99
400_A404_F0.8520.99
356_A374_F0.8500.99
148_D400_A0.8490.99
340_Q426_F0.8450.99
144_T148_D0.8440.99
5_W84_P0.8370.99
14_D255_R0.8340.99
407_F412_Q0.8330.99
143_R296_F0.8300.99
211_A215_L0.8270.99
104_H130_Q0.8260.99
396_T401_Q0.8260.99
43_F79_V0.8250.99
335_D339_R0.8240.99
332_P335_D0.8220.99
365_V369_A0.8210.98
350_R412_Q0.8210.98
304_N309_E0.8210.98
401_Q404_F0.8170.98
106_Y135_V0.8170.98
159_K162_D0.8160.98
243_L252_I0.8150.98
245_P379_A0.8140.98
153_Y156_F0.8120.98
104_H138_R0.8070.98
205_P379_A0.8030.98
101_V129_A0.8000.98
225_I261_A0.7960.98
61_D65_A0.7940.98
167_P170_P0.7940.98
252_I257_V0.7920.98
328_E427_V0.7920.98
172_P175_A0.7920.98
88_L92_A0.7910.98
42_C82_G0.7840.98
16_R20_A0.7840.98
140_G296_F0.7840.98
196_G200_P0.7840.98
186_T192_V0.7840.98
233_D283_Q0.7830.98
161_Q278_A0.7830.98
167_P171_E0.7830.98
194_E200_P0.7820.98
164_E167_P0.7820.98
331_Y410_M0.7790.98
161_Q285_A0.7760.98
374_F386_D0.7760.98
137_H285_A0.7750.98
282_G286_W0.7740.98
58_F207_A0.7740.98
196_G201_E0.7690.98
413_G430_L0.7690.98
205_P242_R0.7680.98
51_A56_V0.7670.98
43_F63_L0.7670.98
168_P171_E0.7650.98
205_P245_P0.7650.98
138_R141_E0.7630.98
83_D116_G0.7610.98
304_N396_T0.7570.97
341_L347_M0.7560.97
326_D342_R0.7540.97
264_A268_A0.7520.97
4_F39_A0.7520.97
324_W360_T0.7480.97
301_V383_T0.7480.97
297_N305_F0.7470.97
65_A68_E0.7450.97
121_L126_V0.7430.97
78_I95_L0.7400.97
300_V305_F0.7400.97
121_L128_H0.7390.97
310_H368_R0.7370.97
65_A251_T0.7360.97
78_I94_D0.7350.97
213_R217_D0.7340.97
192_V200_P0.7340.97
278_A282_G0.7320.97
316_D365_V0.7280.97
332_P423_I0.7260.97
216_L220_R0.7230.97
194_E198_A0.7230.97
340_Q343_A0.7210.97
3_L91_V0.7190.97
245_P346_Y0.7190.97
43_F81_H0.7190.97
153_Y157_W0.7170.96
265_K277_V0.7160.96
304_N307_A0.7150.96
306_K309_E0.7140.96
195_L198_A0.7120.96
145_N159_K0.7110.96
191_S194_E0.7110.96
88_L91_V0.7050.96
371_Y390_W0.7050.96
4_F101_V0.7030.96
216_L252_I0.7030.96
258_Y284_L0.7020.96
265_K278_A0.7020.96
187_S190_P0.7020.96
19_A171_E0.7010.96
175_A178_A0.6990.96
20_A129_A0.6990.96
135_V139_P0.6990.96
339_R342_R0.6980.96
136_H258_Y0.6890.96
22_A177_L0.6880.96
422_Y426_F0.6880.96
191_S197_F0.6880.96
80_R91_V0.6860.95
106_Y138_R0.6860.95
119_D123_A0.6850.95
392_W405_R0.6840.95
225_I277_V0.6820.95
265_K274_R0.6820.95
235_P333_I0.6820.95
12_T70_Y0.6820.95
54_P57_A0.6820.95
168_P255_R0.6810.95
6_H12_T0.6810.95
155_Y158_R0.6810.95
181_T184_A0.6780.95
345_A379_A0.6770.95
293_V300_V0.6760.95
112_D115_A0.6740.95
282_G285_A0.6740.95
193_Q196_G0.6720.95
19_A22_A0.6710.95
291_A382_D0.6690.95
141_E159_K0.6680.95
290_Y398_T0.6680.95
385_N389_G0.6680.95
5_W102_W0.6630.95
292_Q296_F0.6600.94
168_P172_P0.6580.94
118_R122_D0.6560.94
193_Q201_E0.6520.94
417_D420_A0.6510.94
109_L113_R0.6490.94
20_A101_V0.6480.94
65_A208_G0.6480.94
209_T212_A0.6470.94
386_D390_W0.6460.94
338_M355_V0.6460.94
368_R371_Y0.6450.94
215_L242_R0.6430.94
164_E171_E0.6420.94
215_L224_D0.6420.94
140_G295_Y0.6400.93
240_T348_H0.6390.93
230_D233_D0.6380.93
333_I351_V0.6360.93
327_G335_D0.6350.93
382_D385_N0.6350.93
236_H340_Q0.6340.93
356_A386_D0.6330.93
132_H135_V0.6320.93
169_A174_P0.6310.93
114_D118_R0.6310.93
195_L200_P0.6310.93
324_W356_A0.6300.93
328_E429_E0.6300.93
39_A42_C0.6280.93
190_P194_E0.6250.93
105_D248_K0.6250.93
192_V195_L0.6250.93
43_F60_L0.6240.93
277_V281_I0.6220.92
261_A264_A0.6220.92
190_P195_L0.6210.92
391_Q405_R0.6190.92
3_L40_V0.6190.92
17_G103_N0.6180.92
253_G256_T0.6170.92
109_L112_D0.6170.92
41_F47_V0.6150.92
350_R405_R0.6140.92
190_P196_G0.6130.92
62_A207_A0.6130.92
337_G347_M0.6130.92
290_Y293_V0.6120.92
192_V197_F0.6120.92
118_R140_G0.6120.92
399_D405_R0.6120.92
44_D84_P0.6110.92
21_A101_V0.6090.92
241_S244_S0.6080.92
361_K405_R0.6080.92
71_R75_S0.6070.92
100_V117_V0.6070.92
189_L192_V0.6060.91
236_H239_P0.6060.91
136_H140_G0.6050.91
151_S297_N0.6040.91
156_F160_W0.6030.91
229_E233_D0.6030.91
230_D276_N0.6020.91
156_F288_E0.5990.91
171_E174_P0.5990.91
294_L301_V0.5980.91
168_P174_P0.5970.91
281_I285_A0.5960.91
316_D321_L0.5960.91
286_W388_G0.5950.91
327_G427_V0.5940.91
257_V260_A0.5930.91
207_A212_A0.5910.90
225_I276_N0.5900.90
3_L88_L0.5900.90
361_K399_D0.5900.90
173_E177_L0.5890.90
391_Q396_T0.5890.90
347_M378_L0.5890.90
176_D181_T0.5890.90
177_L180_D0.5880.90
3_L95_L0.5870.90
170_P259_E0.5870.90
84_P113_R0.5870.90
219_F241_S0.5860.90
353_M407_F0.5850.90
357_A393_A0.5850.90
137_H141_E0.5840.90
224_D238_E0.5840.90
356_A360_T0.5820.90
320_A365_V0.5820.90
90_A93_N0.5810.90
42_C92_A0.5810.90
347_M374_F0.5800.90
324_W365_V0.5780.89
86_A89_P0.5780.89
303_E307_A0.5770.89
314_W317_D0.5770.89
155_Y159_K0.5760.89
392_W397_G0.5750.89
315_R364_L0.5750.89
57_A207_A0.5740.89
289_F398_T0.5740.89
403_Y406_V0.5730.89
67_R77_L0.5720.89
371_Y375_R0.5720.89
170_P173_E0.5710.89
55_R248_K0.5700.89
221_E264_A0.5700.89
161_Q282_G0.5690.89
5_W88_L0.5680.89
143_R147_G0.5680.89
170_P174_P0.5660.89
353_M416_Y0.5650.88
173_E176_D0.5650.88
88_L95_L0.5630.88
118_R128_H0.5630.88
176_D179_A0.5630.88
35_G98_T0.5620.88
204_V242_R0.5620.88
283_Q349_N0.5600.88
375_R383_T0.5600.88
392_W399_D0.5570.88
133_D255_R0.5560.88
63_L67_R0.5550.88
108_G383_T0.5550.88
132_H137_H0.5550.88
23_P33_D0.5550.88
279_A354_I0.5540.87
92_A120_A0.5540.87
79_V189_L0.5530.87
332_P430_L0.5530.87
134_A137_H0.5530.87
349_N353_M0.5520.87
117_V120_A0.5520.87
12_T209_T0.5510.87
195_L201_E0.5510.87
389_G400_A0.5500.87
54_P379_A0.5500.87
361_K404_F0.5480.87
232_R353_M0.5480.87
183_L230_D0.5470.87
283_Q286_W0.5470.87
336_A340_Q0.5460.87
406_V409_P0.5440.86
243_L247_L0.5440.86
84_P87_V0.5420.86
399_D402_P0.5410.86
122_D125_G0.5410.86
61_D206_D0.5400.86
232_R349_N0.5390.86
136_H139_P0.5380.86
274_R277_V0.5380.86
191_S195_L0.5380.86
370_G391_Q0.5370.86
68_E210_A0.5370.86
407_F411_T0.5360.86
324_W374_F0.5350.86
75_S177_L0.5350.86
159_K163_R0.5340.85
317_D369_A0.5330.85
6_H10_L0.5310.85
145_N150_Y0.5300.85
192_V196_G0.5300.85
231_R234_Y0.5290.85
39_A70_Y0.5270.85
337_G355_V0.5270.85
180_D184_A0.5250.85
286_W349_N0.5250.85
347_M355_V0.5230.84
410_M430_L0.5230.84
82_G90_A0.5220.84
44_D48_L0.5220.84
22_A178_A0.5210.84
420_A430_L0.5210.84
387_N398_T0.5200.84
105_D108_G0.5200.84
256_T259_E0.5200.84
390_W397_G0.5200.84
92_A124_A0.5200.84
331_Y413_G0.5200.84
153_Y289_F0.5200.84
340_Q347_M0.5190.84
4_F18_L0.5190.84
358_F361_K0.5170.84
97_A126_V0.5170.84
146_A151_S0.5170.84
291_A384_A0.5160.84
305_F309_E0.5160.84
4_F21_A0.5160.84
174_P180_D0.5150.83
104_H140_G0.5150.83
135_V140_G0.5150.83
338_M341_L0.5140.83
102_W114_D0.5140.83
234_Y239_P0.5140.83
226_Y268_A0.5140.83
342_R376_E0.5130.83
122_D127_A0.5120.83
394_A399_D0.5110.83
318_P322_Q0.5080.83
358_F363_L0.5070.82
424_T430_L0.5070.82
235_P425_E0.5060.82
145_N148_D0.5060.82
178_A181_T0.5050.82
104_H139_P0.5050.82
68_E71_R0.5050.82
132_H139_P0.5050.82
194_E199_E0.5040.82
89_P123_A0.5040.82
150_Y153_Y0.5030.82
64_A67_R0.5030.82
135_V292_Q0.5020.82
304_N366_D0.5020.82
349_N412_Q0.5010.82
19_A172_P0.5010.82
206_D246_H0.5000.82
258_Y262_R0.5000.82
106_Y139_P0.5000.82
177_L181_T0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u63A 1 0.9584 100 0.072 Contact Map
1owlA 1 0.9626 100 0.077 Contact Map
3fy4A 1 0.973 100 0.078 Contact Map
1np7A 1 0.9543 100 0.082 Contact Map
1u3dA 1 0.9667 100 0.082 Contact Map
4gu5A 1 0.9854 100 0.088 Contact Map
1dnpA 1 0.9501 100 0.092 Contact Map
4k0rA 1 0.9293 100 0.095 Contact Map
4mlpC 1 0.9709 100 0.096 Contact Map
2wq7A 1 0.9771 100 0.107 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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