GREMLIN Database
Q9HQ44 - Uncharacterized protein
UniProt: Q9HQ44 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 452 (374)
Sequences: 10767 (8317)
Seq/√Len: 430.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_G255_R4.7441.00
318_D331_S4.5561.00
169_S250_A3.9411.00
36_S294_D3.7261.00
379_R397_A3.5671.00
249_A253_D3.0481.00
250_A254_R3.0141.00
29_T245_G3.0001.00
65_A328_T2.9851.00
39_V302_R2.9491.00
161_E181_Y2.9321.00
379_R395_D2.9301.00
14_V17_L2.7521.00
395_D398_S2.6751.00
413_P416_A2.5971.00
194_H242_T2.5871.00
165_V250_A2.4901.00
23_S31_D2.4651.00
43_A307_V2.4401.00
250_A253_D2.4011.00
192_P196_R2.3511.00
381_T402_E2.3031.00
169_S254_R2.2421.00
163_R166_E2.2331.00
41_E304_S2.2331.00
377_D420_A2.2131.00
84_A322_G2.2091.00
82_A109_D2.2091.00
162_D246_R2.1781.00
38_T303_V2.1631.00
377_D416_A2.1361.00
164_A177_L2.1121.00
307_V332_L2.0761.00
41_E302_R2.0591.00
197_A238_R2.0261.00
9_T320_M2.0201.00
317_L322_G2.0161.00
319_V333_A1.9911.00
248_L260_V1.9691.00
10_V260_V1.9431.00
255_R294_D1.9281.00
198_T238_R1.9201.00
248_L255_R1.9181.00
12_V244_I1.9101.00
17_L262_V1.8521.00
14_V262_V1.8241.00
382_Y391_H1.8211.00
87_R173_E1.7951.00
38_T301_G1.7881.00
407_S414_L1.7881.00
9_T81_L1.7681.00
61_S74_D1.7551.00
318_D333_A1.7531.00
13_T263_A1.7421.00
333_A337_R1.7331.00
314_A329_G1.7291.00
77_L176_F1.7291.00
391_H418_H1.7281.00
298_G301_G1.7251.00
259_M293_V1.7021.00
89_A167_F1.6941.00
166_E170_A1.6851.00
165_V246_R1.6841.00
164_A179_L1.6791.00
406_V410_A1.6731.00
91_V177_L1.6701.00
179_L247_V1.6351.00
75_T83_D1.6171.00
259_M319_V1.6161.00
32_A36_S1.6161.00
29_T32_A1.6141.00
261_V293_V1.5951.00
261_V316_V1.5851.00
243_S246_R1.5831.00
37_G292_L1.5821.00
42_R376_R1.5741.00
33_L292_L1.5731.00
14_V240_V1.5681.00
283_Y392_E1.5631.00
26_E238_R1.5351.00
30_L262_V1.5321.00
90_G178_W1.5081.00
181_Y243_S1.5021.00
414_L418_H1.4941.00
32_A252_G1.4921.00
410_A413_P1.4871.00
33_L244_I1.4751.00
313_P327_F1.4501.00
80_R313_P1.4501.00
10_V175_F1.4471.00
53_S309_L1.4401.00
161_E247_V1.4251.00
259_M295_H1.4251.00
8_G175_F1.4251.00
44_Y287_V1.4181.00
27_T31_D1.4031.00
169_S253_D1.3991.00
11_L261_V1.3981.00
161_E165_V1.3971.00
408_G414_L1.3801.00
392_E405_D1.3731.00
404_T409_T1.3701.00
89_A177_L1.3621.00
43_A291_L1.3591.00
380_W413_P1.3581.00
79_G106_R1.3461.00
10_V251_L1.3451.00
161_E243_S1.3351.00
17_L184_T1.3141.00
17_L237_V1.3081.00
110_T170_A1.2961.00
382_Y418_H1.2801.00
193_R242_T1.2711.00
184_T237_V1.2671.00
29_T249_A1.2641.00
312_V316_V1.2531.00
158_L243_S1.2451.00
5_S257_D1.2421.00
45_A289_V1.2341.00
181_Y240_V1.2211.00
284_D376_R1.2161.00
6_A84_A1.2091.00
33_L294_D1.2051.00
255_R260_V1.2001.00
40_F291_L1.1991.00
11_L263_A1.1981.00
62_H310_S1.1931.00
194_H238_R1.1921.00
19_A288_H1.1841.00
416_A420_A1.1811.00
80_R317_L1.1791.00
13_T57_V1.1761.00
420_A423_Q1.1641.00
375_A420_A1.1611.00
45_A53_S1.1591.00
380_W410_A1.1581.00
406_V409_T1.1471.00
347_I350_V1.1461.00
295_H319_V1.1421.00
12_V247_V1.1251.00
155_T239_Q1.1241.00
419_A423_Q1.1191.00
347_I420_A1.1171.00
160_I179_L1.1071.00
33_L37_G1.1071.00
244_I248_L1.1031.00
391_H407_S1.1021.00
200_D231_T1.0991.00
75_T80_R1.0991.00
415_D419_A1.0971.00
284_D288_H1.0961.00
156_R160_I1.0961.00
120_R123_R1.0911.00
89_A110_T1.0891.00
191_A194_H1.0841.00
34_A39_V1.0831.00
415_D418_H1.0831.00
7_A257_D1.0811.00
251_L255_R1.0791.00
195_L235_A1.0731.00
158_L239_Q1.0681.00
81_L316_V1.0671.00
112_D163_R1.0671.00
411_D415_D1.0651.00
251_L260_V1.0641.00
165_V169_S1.0591.00
8_G258_T1.0511.00
196_R199_T1.0491.00
346_P420_A1.0461.00
238_R242_T1.0451.00
40_F335_E1.0441.00
192_P195_L1.0401.00
23_S27_T1.0391.00
10_V258_T1.0381.00
303_V335_E1.0361.00
36_S255_R1.0351.00
26_E198_T1.0351.00
268_E271_L1.0311.00
381_T396_R1.0261.00
31_D35_D1.0241.00
75_T79_G1.0221.00
191_A239_Q1.0211.00
44_Y284_D1.0091.00
377_D417_L1.0091.00
10_V177_L1.0081.00
268_E272_E1.0061.00
80_R83_D1.0041.00
284_D381_T1.0021.00
157_M183_D1.0011.00
30_L292_L1.0001.00
344_R347_I0.9991.00
91_V110_T0.9961.00
269_E273_H0.9941.00
418_H422_R0.9861.00
70_I76_T0.9841.00
11_L176_F0.9831.00
420_A424_R0.9821.00
291_L312_V0.9791.00
46_H308_G0.9751.00
380_W393_L0.9751.00
9_T316_V0.9681.00
393_L413_P0.9631.00
36_S299_A0.9631.00
199_T231_T0.9611.00
56_S66_A0.9571.00
248_L294_D0.9491.00
25_V234_D0.9481.00
77_L313_P0.9471.00
335_E343_T0.9461.00
239_Q243_S0.9421.00
9_T259_M0.9401.00
90_G180_H0.9371.00
81_L320_M0.9361.00
375_A382_Y0.9361.00
32_A248_L0.9271.00
242_T246_R0.9241.00
56_S63_V0.9201.00
32_A249_A0.9201.00
100_E105_D0.9151.00
391_H414_L0.9131.00
195_L232_L0.9121.00
32_A35_D0.9101.00
44_Y376_R0.9091.00
13_T180_H0.9001.00
240_V262_V0.8981.00
81_L322_G0.8971.00
384_R391_H0.8951.00
376_R379_R0.8941.00
33_L248_L0.8941.00
270_F273_H0.8921.00
348_T351_A0.8891.00
382_Y417_L0.8851.00
393_L414_L0.8841.00
61_S65_A0.8821.00
36_S252_G0.8821.00
56_S310_S0.8801.00
11_L57_V0.8791.00
246_R249_A0.8791.00
26_E197_A0.8781.00
413_P417_L0.8771.00
168_L247_V0.8761.00
161_E246_R0.8751.00
374_S383_I0.8751.00
7_A295_H0.8711.00
373_V384_R0.8691.00
80_R84_A0.8621.00
411_D414_L0.8611.00
17_L22_R0.8601.00
61_S66_A0.8591.00
175_F258_T0.8581.00
171_A254_R0.8571.00
303_V306_A0.8561.00
45_A309_L0.8491.00
196_R235_A0.8481.00
249_A252_G0.8451.00
34_A292_L0.8451.00
380_W406_V0.8431.00
30_L244_I0.8421.00
347_I351_A0.8391.00
87_R167_F0.8361.00
380_W395_D0.8351.00
194_H239_Q0.8321.00
120_R124_T0.8271.00
86_V320_M0.8261.00
282_L374_S0.8251.00
27_T30_L0.8251.00
50_T54_F0.8241.00
61_S326_G0.8221.00
291_L307_V0.8211.00
379_R413_P0.8171.00
252_G294_D0.8171.00
37_G294_D0.8161.00
121_L124_T0.8151.00
43_A309_L0.8141.00
27_T237_V0.8081.00
87_R171_A0.8071.00
42_R288_H0.8031.00
264_G289_V0.8001.00
313_P317_L0.7991.00
168_L250_A0.7971.00
227_G231_T0.7971.00
396_R402_E0.7961.00
384_R418_H0.7961.00
410_A414_L0.7951.00
166_E169_S0.7911.00
55_P66_A0.7891.00
331_S334_P0.7861.00
58_L178_W0.7851.00
40_F336_I0.7851.00
81_L176_F0.7851.00
38_T299_A0.7841.00
11_L316_V0.7831.00
94_A97_F0.7791.00
334_P339_G0.7771.00
46_H56_S0.7761.00
193_R196_R0.7761.00
377_D413_P0.7741.00
373_V421_T0.7711.00
9_T319_V0.7691.00
190_P195_L0.7691.00
382_Y414_L0.7681.00
276_L283_Y0.7661.00
151_R154_A0.7631.00
157_M243_S0.7581.00
76_T79_G0.7561.00
314_A327_F0.7561.00
91_V167_F0.7551.00
162_D166_E0.7531.00
247_V250_A0.7481.00
305_T335_E0.7481.00
159_D163_R0.7471.00
222_S225_T0.7471.00
30_L33_L0.7451.00
154_A159_D0.7451.00
419_A422_R0.7451.00
330_E343_T0.7441.00
248_L252_G0.7421.00
126_A129_P0.7391.00
193_R197_A0.7381.00
21_A233_Y0.7371.00
260_V294_D0.7361.00
16_S266_H0.7341.00
375_A421_T0.7341.00
269_E272_E0.7341.00
154_A162_D0.7331.00
183_D240_V0.7321.00
80_R322_G0.7311.00
46_H309_L0.7301.00
7_A259_M0.7301.00
374_S381_T0.7271.00
12_V260_V0.7241.00
375_A424_R0.7221.00
58_L108_F0.7221.00
393_L417_L0.7211.00
279_Y286_L0.7211.00
25_V238_R0.7201.00
338_A341_E0.7201.00
10_V247_V0.7201.00
398_S404_T0.7191.00
231_T235_A0.7161.00
263_A291_L0.7151.00
87_R109_D0.7131.00
330_E344_R0.7131.00
155_T158_L0.7111.00
263_A309_L0.7081.00
197_A242_T0.7061.00
405_D408_G0.7051.00
190_P235_A0.7051.00
165_V247_V0.7041.00
122_G125_L0.7041.00
228_E231_T0.7001.00
268_E273_H0.6961.00
384_R425_L0.6961.00
349_S352_V0.6951.00
251_L254_R0.6941.00
62_H308_G0.6941.00
11_L312_V0.6931.00
168_L177_L0.6911.00
16_S268_E0.6911.00
406_V413_P0.6901.00
161_E164_A0.6861.00
16_S279_Y0.6851.00
347_I377_D0.6811.00
38_T298_G0.6791.00
282_L383_I0.6771.00
114_F117_T0.6761.00
158_L191_A0.6761.00
40_F303_V0.6761.00
122_G127_A0.6751.00
245_G249_A0.6751.00
302_R305_T0.6741.00
293_V336_I0.6741.00
13_T178_W0.6731.00
7_A86_V0.6731.00
384_R422_R0.6721.00
22_R31_D0.6721.00
83_D88_T0.6721.00
161_E179_L0.6711.00
282_L372_L0.6701.00
124_T128_H0.6691.00
108_F178_W0.6691.00
22_R30_L0.6691.00
287_V374_S0.6691.00
95_N98_L0.6681.00
162_D165_V0.6671.00
78_A81_L0.6631.00
78_A82_A0.6621.00
82_A88_T0.6621.00
64_F351_A0.6611.00
96_G99_T0.6580.99
318_D334_P0.6550.99
24_R234_D0.6550.99
119_S124_T0.6540.99
157_M181_Y0.6510.99
17_L21_A0.6500.99
48_N282_L0.6490.99
393_L406_V0.6480.99
303_V307_V0.6470.99
181_Y244_I0.6460.99
276_L279_Y0.6420.99
316_V320_M0.6400.99
79_G83_D0.6390.99
158_L193_R0.6350.99
58_L78_A0.6330.99
259_M316_V0.6330.99
77_L81_L0.6330.99
190_P232_L0.6320.99
165_V254_R0.6310.99
122_G128_H0.6300.99
111_Y114_F0.6290.99
255_R296_P0.6270.99
43_A289_V0.6270.99
305_T343_T0.6260.99
422_R426_D0.6260.99
58_L96_G0.6230.99
46_H62_H0.6230.99
22_R27_T0.6210.99
39_V292_L0.6200.99
332_L336_I0.6190.99
175_F251_L0.6180.99
158_L246_R0.6160.99
21_A234_D0.6160.99
38_T300_G0.6160.99
124_T127_A0.6150.99
306_A376_R0.6140.99
71_G74_D0.6130.99
102_W105_D0.6130.99
29_T248_L0.6090.99
165_V243_S0.6090.99
284_D396_R0.6080.99
10_V168_L0.6080.99
256_E296_P0.6070.99
183_D236_T0.6060.99
233_Y237_V0.6060.99
91_V164_A0.6050.99
125_L128_H0.6040.99
40_F293_V0.6040.99
289_V309_L0.6030.99
78_A90_G0.6030.99
23_S26_E0.6020.99
184_T233_Y0.6010.99
399_D404_T0.6000.99
306_A348_T0.5990.99
90_G111_Y0.5990.99
330_E335_E0.5980.99
334_P338_A0.5960.99
91_V160_I0.5950.99
376_R396_R0.5940.99
121_L126_A0.5930.99
274_G400_P0.5900.99
120_R126_A0.5900.99
349_S375_A0.5890.99
122_G126_A0.5880.99
333_A336_I0.5870.99
79_G82_A0.5870.99
121_L125_L0.5860.99
62_H328_T0.5850.99
194_H235_A0.5850.99
46_H63_V0.5850.99
13_T309_L0.5830.99
112_D159_D0.5820.99
308_G348_T0.5820.99
277_A281_K0.5810.99
123_R126_A0.5800.99
193_R239_Q0.5780.99
199_T228_E0.5750.99
42_R304_S0.5740.99
36_S248_L0.5740.99
40_F307_V0.5740.99
150_E153_D0.5740.99
25_V237_V0.5720.99
240_V244_I0.5710.99
288_H400_P0.5710.99
293_V332_L0.5700.99
350_V374_S0.5700.99
390_T405_D0.5680.99
383_I392_E0.5670.98
77_L316_V0.5650.98
46_H310_S0.5640.98
375_A417_L0.5630.98
408_G411_D0.5620.98
228_E232_L0.5610.98
5_S172_S0.5610.98
330_E345_G0.5610.98
110_T167_F0.5600.98
78_A108_F0.5600.98
103_G106_R0.5590.98
263_A289_V0.5590.98
190_P236_T0.5580.98
319_V337_R0.5570.98
122_G129_P0.5570.98
423_Q426_D0.5570.98
158_L162_D0.5560.98
72_V106_R0.5540.98
33_L262_V0.5530.98
223_S227_G0.5520.98
10_V179_L0.5520.98
315_T332_L0.5510.98
266_H289_V0.5490.98
244_I262_V0.5480.98
12_V179_L0.5480.98
275_H400_P0.5480.98
232_L236_T0.5470.98
341_E344_R0.5470.98
114_F182_M0.5460.98
157_M239_Q0.5430.98
393_L405_D0.5420.98
194_H197_A0.5420.98
43_A263_A0.5420.98
261_V312_V0.5400.98
5_S256_E0.5400.98
150_E154_A0.5400.98
198_T234_D0.5360.98
13_T53_S0.5350.98
256_E297_A0.5340.98
125_L129_P0.5340.98
47_G63_V0.5330.98
273_H285_E0.5320.98
164_A168_L0.5300.98
168_L254_R0.5290.98
290_P293_V0.5290.98
346_P377_D0.5280.98
157_M161_E0.5280.98
422_R425_L0.5260.98
74_D78_A0.5260.98
120_R128_H0.5250.98
66_A74_D0.5250.98
160_I182_M0.5250.98
49_W52_F0.5250.98
146_S149_R0.5240.97
11_L178_W0.5220.97
167_F177_L0.5220.97
407_S411_D0.5210.97
414_L417_L0.5200.97
87_R110_T0.5180.97
35_D300_G0.5180.97
33_L260_V0.5170.97
32_A255_R0.5150.97
334_P337_R0.5150.97
113_A117_T0.5150.97
127_A163_R0.5140.97
38_T336_I0.5130.97
53_S57_V0.5120.97
340_T343_T0.5120.97
396_R400_P0.5100.97
337_R341_E0.5090.97
159_D162_D0.5080.97
22_R39_V0.5070.97
107_G111_Y0.5060.97
14_V184_T0.5060.97
12_V181_Y0.5050.97
148_G151_R0.5050.97
284_D287_V0.5030.97
111_Y115_T0.5030.97
146_S154_A0.5020.97
57_V312_V0.5010.97
84_A323_S0.5010.97
105_D111_Y0.5010.97
414_L421_T0.5010.97
14_V30_L0.5010.97
197_A235_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uplA 2 0.9912 100 0.257 Contact Map
4upiA 2 0.9801 100 0.257 Contact Map
4uphA 2 0.9735 100 0.26 Contact Map
2vqrA 3 0.9735 100 0.26 Contact Map
4upkA 3 0.9801 100 0.269 Contact Map
3b5qA 1 0.9027 100 0.273 Contact Map
1hdhA 1 0.896 100 0.274 Contact Map
2qzuA 2 0.9027 100 0.279 Contact Map
3ed4A 3 0.927 100 0.289 Contact Map
1p49A 3 0.8938 100 0.293 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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