GREMLIN Database
Q9HQ42 - Uncharacterized protein
UniProt: Q9HQ42 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (241)
Sequences: 3907 (2824)
Seq/√Len: 181.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_L225_G6.2031.00
82_D87_T4.6991.00
165_E169_G4.4971.00
37_D82_D4.2941.00
137_A162_Y3.3731.00
90_W141_S3.2621.00
165_E202_R3.0251.00
263_S266_D2.9621.00
131_A134_D2.7371.00
86_G137_A2.7021.00
160_P199_A2.6911.00
35_G231_E2.5801.00
164_H224_L2.5701.00
86_G136_D2.5571.00
206_Q209_P2.3481.00
87_T135_I2.3031.00
126_A131_A2.2541.00
206_Q210_G2.2381.00
133_S155_A2.2201.00
227_Y236_P2.1991.00
39_H82_D2.1551.00
87_T130_T2.0791.00
217_P270_S2.0641.00
141_S226_L2.0381.00
82_D130_T2.0371.00
223_L241_G2.0331.00
277_L281_T1.9991.00
216_L223_L1.9811.00
90_W226_L1.9341.00
229_E236_P1.9041.00
140_A151_L1.8921.00
211_L228_L1.8851.00
212_D229_E1.8671.00
38_V237_A1.8561.00
36_V83_H1.8211.00
213_L226_L1.8171.00
266_D269_E1.8171.00
214_L227_Y1.7991.00
89_L135_I1.7911.00
137_A160_P1.7871.00
243_E274_V1.7821.00
130_T134_D1.7551.00
81_I90_W1.7111.00
212_D227_Y1.6451.00
188_D191_R1.6341.00
139_V226_L1.6281.00
189_F192_A1.6051.00
41_L80_L1.6011.00
47_T73_E1.5801.00
87_T136_D1.5451.00
276_D280_R1.5411.00
80_L89_L1.5281.00
227_Y238_I1.5191.00
269_E273_R1.4681.00
83_H86_G1.4181.00
227_Y277_L1.4171.00
272_R276_D1.4131.00
41_L124_A1.4021.00
80_L130_T1.4021.00
143_L163_V1.3951.00
133_S156_G1.3841.00
186_S190_D1.3791.00
138_V161_I1.3721.00
151_L161_I1.3611.00
88_V137_A1.3591.00
156_G159_T1.3241.00
80_L135_I1.3181.00
225_G238_I1.3161.00
168_L172_Y1.3101.00
168_L200_V1.3081.00
122_P132_I1.3051.00
141_S241_G1.2951.00
83_H88_V1.2891.00
188_D192_A1.2771.00
278_A283_A1.2701.00
167_E171_A1.2531.00
278_A285_V1.2431.00
230_P233_G1.2161.00
213_L224_L1.2151.00
40_Y77_Y1.2061.00
120_T123_A1.2031.00
126_A132_I1.1981.00
88_V211_L1.1941.00
87_T134_D1.1921.00
35_G230_P1.1891.00
123_A126_A1.1861.00
167_E220_T1.1851.00
201_D204_R1.1681.00
40_Y79_L1.1671.00
83_H210_G1.1641.00
45_T73_E1.1611.00
164_H203_G1.1541.00
268_R272_R1.1531.00
122_P153_H1.1501.00
214_L238_I1.1481.00
170_Y221_P1.1401.00
90_W239_V1.1351.00
240_A285_V1.1201.00
239_V286_F1.1191.00
214_L225_G1.1181.00
79_L239_V1.1061.00
269_E272_R1.0921.00
90_W139_V1.0701.00
203_G215_H1.0651.00
204_R212_D1.0641.00
92_T151_L1.0601.00
277_L283_A1.0551.00
33_P38_V1.0381.00
238_I283_A1.0311.00
143_L148_A1.0301.00
214_L277_L1.0291.00
32_S37_D1.0231.00
80_L87_T1.0160.99
169_G173_R1.0050.99
125_L130_T1.0030.99
143_L171_A1.0010.99
201_D224_L0.9980.99
187_P190_D0.9960.99
57_S60_A0.9840.99
183_A186_S0.9800.99
182_I189_F0.9790.99
138_V151_L0.9760.99
236_P283_A0.9760.99
165_E200_V0.9750.99
216_L270_S0.9740.99
261_L271_R0.9660.99
203_G224_L0.9650.99
276_D279_R0.9580.99
39_H128_A0.9550.99
37_D87_T0.9450.99
81_I211_L0.9340.99
79_L286_F0.9290.99
185_H189_F0.9280.99
89_L138_V0.9270.99
182_I185_H0.9250.99
117_D123_A0.9120.99
62_V65_P0.9090.99
36_V210_G0.9080.99
41_L128_A0.9040.99
166_R169_G0.9020.99
137_A208_Y0.8990.99
135_I159_T0.8970.99
225_G243_E0.8970.99
33_P230_P0.8950.99
89_L92_T0.8900.99
185_H188_D0.8890.99
244_A287_C0.8880.99
62_V66_D0.8860.99
119_H127_D0.8810.98
202_R205_R0.8760.98
240_A287_C0.8740.98
227_Y283_A0.8680.98
229_E232_D0.8660.98
150_G153_H0.8540.98
182_I191_R0.8540.98
138_V154_F0.8490.98
273_R277_L0.8410.98
100_D117_D0.8210.98
190_D193_L0.8180.98
265_A268_R0.8130.97
225_G274_V0.8120.97
264_L268_R0.8110.97
162_Y201_D0.8110.97
181_S185_H0.8040.97
96_P123_A0.7950.97
217_P266_D0.7890.97
135_I160_P0.7850.97
139_V211_L0.7800.97
186_S191_R0.7800.97
163_V198_V0.7780.97
211_L226_L0.7650.96
187_P191_R0.7610.96
36_V228_L0.7540.96
140_A161_I0.7530.96
168_L198_V0.7530.96
204_R215_H0.7510.96
61_T65_P0.7460.96
89_L125_L0.7450.96
187_P192_A0.7430.96
184_Y188_D0.7380.96
124_A127_D0.7370.96
49_D70_A0.7320.95
184_Y189_F0.7310.95
273_R276_D0.7300.95
135_I154_F0.7300.95
239_V288_G0.7290.95
95_H150_G0.7280.95
36_V230_P0.7280.95
50_R54_I0.7270.95
228_L239_V0.7260.95
94_S98_A0.7240.95
238_I278_A0.7230.95
61_T66_D0.7190.95
240_A244_A0.7170.95
210_G229_E0.7160.95
271_R275_R0.7150.95
43_R121_L0.7120.95
42_D124_A0.7110.95
181_S184_Y0.7090.94
44_G93_G0.7050.94
174_S177_T0.7030.94
243_E270_S0.7030.94
207_L213_L0.7030.94
238_I274_V0.6980.94
204_R210_G0.6950.94
42_D119_H0.6940.94
143_L167_E0.6940.94
206_Q212_D0.6930.94
59_M62_V0.6920.94
125_L135_I0.6910.94
197_V200_V0.6880.94
67_P70_A0.6870.93
220_T261_L0.6860.93
236_P281_T0.6830.93
36_V211_L0.6830.93
152_R155_A0.6810.93
40_Y286_F0.6810.93
80_L128_A0.6790.93
47_T71_L0.6790.93
182_I188_D0.6780.93
144_H147_H0.6780.93
88_V139_V0.6770.93
140_A148_A0.6770.93
90_W241_G0.6760.93
43_R78_N0.6710.93
78_N121_L0.6610.92
182_I186_S0.6610.92
169_G172_Y0.6610.92
201_D207_L0.6600.92
139_V207_L0.6590.92
249_N256_M0.6540.92
79_L288_G0.6530.92
139_V224_L0.6460.91
237_A286_F0.6440.91
194_N197_V0.6440.91
166_R217_P0.6440.91
79_L237_A0.6420.91
50_R55_D0.6420.91
241_G288_G0.6380.91
122_P126_A0.6360.91
266_D270_S0.6360.91
51_A57_S0.6350.91
38_V230_P0.6340.90
261_L264_L0.6330.90
112_H115_D0.6330.90
272_R275_R0.6290.90
216_L238_I0.6290.90
33_P36_V0.6280.90
206_Q229_E0.6260.90
162_Y199_A0.6260.90
251_E254_V0.6260.90
92_T148_A0.6240.90
132_I153_H0.6240.90
182_I192_A0.6230.90
253_G275_R0.6190.89
43_R95_H0.6170.89
190_D194_N0.6140.89
56_S59_M0.6130.89
41_L130_T0.6090.89
181_S189_F0.6090.89
233_G284_D0.6060.88
152_R197_V0.6050.88
178_D189_F0.6020.88
201_D213_L0.5980.88
95_H261_L0.5960.88
201_D205_R0.5960.88
249_N255_P0.5950.87
227_Y281_T0.5950.87
240_A288_G0.5940.87
156_G160_P0.5920.87
185_H191_R0.5910.87
91_D289_H0.5890.87
277_L282_T0.5880.87
267_W271_R0.5840.87
214_L273_R0.5810.86
79_L245_Y0.5790.86
218_G242_D0.5760.86
43_R287_C0.5750.86
53_M56_S0.5750.86
81_I88_V0.5730.85
175_A178_D0.5730.85
164_H201_D0.5710.85
93_G140_A0.5690.85
119_H123_A0.5690.85
118_E123_A0.5690.85
194_N198_V0.5670.85
46_I76_V0.5650.85
265_A269_E0.5630.84
97_D100_D0.5620.84
36_V81_I0.5600.84
48_A260_L0.5580.84
96_P117_D0.5580.84
39_H130_T0.5570.84
96_P120_T0.5560.84
87_T125_L0.5550.84
50_R72_V0.5510.83
50_R70_A0.5500.83
162_Y205_R0.5500.83
240_A243_E0.5460.83
183_A192_A0.5460.83
45_T75_P0.5460.83
164_H167_E0.5450.83
61_T64_D0.5450.83
182_I187_P0.5440.82
82_D134_D0.5440.82
76_V118_E0.5430.82
208_Y211_L0.5430.82
48_A52_Y0.5420.82
225_G270_S0.5420.82
204_R214_L0.5390.82
154_F159_T0.5390.82
68_E139_V0.5380.82
257_A268_R0.5370.82
153_H161_I0.5360.82
66_D282_T0.5360.82
181_S186_S0.5330.81
186_S189_F0.5300.81
36_V84_P0.5300.81
132_I159_T0.5300.81
79_L287_C0.5280.81
177_T186_S0.5270.80
145_L149_G0.5260.80
167_E223_L0.5260.80
76_V223_L0.5250.80
62_V67_P0.5240.80
80_L134_D0.5230.80
205_R213_L0.5230.80
266_D273_R0.5200.80
121_L154_F0.5200.80
185_H190_D0.5200.80
225_G239_V0.5200.80
75_P245_Y0.5190.79
98_A145_L0.5190.79
149_G245_Y0.5190.79
56_S72_V0.5180.79
183_A188_D0.5180.79
32_S35_G0.5180.79
42_D120_T0.5180.79
247_R287_C0.5180.79
168_L193_L0.5170.79
42_D77_Y0.5170.79
247_R251_E0.5160.79
163_V168_L0.5150.79
49_D54_I0.5150.79
268_R271_R0.5120.79
240_A283_A0.5110.78
261_L267_W0.5110.78
83_H208_Y0.5110.78
287_C290_D0.5100.78
221_P262_S0.5080.78
49_D52_Y0.5070.78
50_R56_S0.5040.77
274_V278_A0.5040.77
48_A98_A0.5040.77
166_R202_R0.5040.77
246_Q249_N0.5030.77
221_P263_S0.5030.77
38_V256_M0.5030.77
148_A151_L0.5020.77
263_S269_E0.5020.77
95_H98_A0.5020.77
216_L241_G0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4le6A 4 0.7542 100 0.439 Contact Map
2r2dA 5 0.8704 100 0.444 Contact Map
3aj3A 2 0.8206 100 0.453 Contact Map
1p9eA 3 0.8738 100 0.458 Contact Map
4zo2A 2 0.8505 100 0.469 Contact Map
3dhaA 1 0.8239 100 0.487 Contact Map
3eshA 5 0.8472 100 0.491 Contact Map
4d1tA 1 0.7309 100 0.604 Contact Map
1ztcA 4 0.6645 100 0.605 Contact Map
4eybA 2 0.7641 100 0.611 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.