Q9HQ42 - HALSA - GREMLIN Contacts

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Q9HQ42 - Uncharacterized protein

UniProt:	Q9HQ42	Sequences: MVVASPPPRINLCQRLTTTGRFPRPNFGAATSPPGVDVHYLDRGTITADRAYMIDSSTMATVADPDPEHALVECPVYNLLIDHPKGTVLWDTGSHPDAGDGYWPTPLFEAFHHEDADEHTLPAALADAGTAISDIDAVVASHLHLDHAGGLRHFAGTDTPIYVHERELGYAYRSAATDTGSIAYHSPDFDRALNWRVVAVDRGRRQLYPGLDLLHLPGHTPGLLGLYLEPEDGAAPAIVAGDEAYQRENYEDGVPMATSLLSSLADWRESRRRVRDLARRTTADVFCGHDTRDAARLAARF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	301 (241)
Sequences:	3907 (2824)
Seq/√Len:	181.9

BACSU - YTNP
HALSA - Q9HQ42
SULSO - Q97Y13 Q97YH8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
216_L	225_G	6.203	1.00
82_D	87_T	4.699	1.00
165_E	169_G	4.497	1.00
37_D	82_D	4.294	1.00
137_A	162_Y	3.373	1.00
90_W	141_S	3.262	1.00
165_E	202_R	3.025	1.00
263_S	266_D	2.962	1.00
131_A	134_D	2.737	1.00
86_G	137_A	2.702	1.00
160_P	199_A	2.691	1.00
35_G	231_E	2.580	1.00
164_H	224_L	2.570	1.00
86_G	136_D	2.557	1.00
206_Q	209_P	2.348	1.00
87_T	135_I	2.303	1.00
126_A	131_A	2.254	1.00
206_Q	210_G	2.238	1.00
133_S	155_A	2.220	1.00
227_Y	236_P	2.199	1.00
39_H	82_D	2.155	1.00
87_T	130_T	2.079	1.00
217_P	270_S	2.064	1.00
141_S	226_L	2.038	1.00
82_D	130_T	2.037	1.00
223_L	241_G	2.033	1.00
277_L	281_T	1.999	1.00
216_L	223_L	1.981	1.00
90_W	226_L	1.934	1.00
229_E	236_P	1.904	1.00
140_A	151_L	1.892	1.00
211_L	228_L	1.885	1.00
212_D	229_E	1.867	1.00
38_V	237_A	1.856	1.00
36_V	83_H	1.821	1.00
213_L	226_L	1.817	1.00
266_D	269_E	1.817	1.00
214_L	227_Y	1.799	1.00
89_L	135_I	1.791	1.00
137_A	160_P	1.787	1.00
243_E	274_V	1.782	1.00
130_T	134_D	1.755	1.00
81_I	90_W	1.711	1.00
212_D	227_Y	1.645	1.00
188_D	191_R	1.634	1.00
139_V	226_L	1.628	1.00
189_F	192_A	1.605	1.00
41_L	80_L	1.601	1.00
47_T	73_E	1.580	1.00
87_T	136_D	1.545	1.00
276_D	280_R	1.541	1.00
80_L	89_L	1.528	1.00
227_Y	238_I	1.519	1.00
269_E	273_R	1.468	1.00
83_H	86_G	1.418	1.00
227_Y	277_L	1.417	1.00
272_R	276_D	1.413	1.00
41_L	124_A	1.402	1.00
80_L	130_T	1.402	1.00
143_L	163_V	1.395	1.00
133_S	156_G	1.384	1.00
186_S	190_D	1.379	1.00
138_V	161_I	1.372	1.00
151_L	161_I	1.361	1.00
88_V	137_A	1.359	1.00
156_G	159_T	1.324	1.00
80_L	135_I	1.318	1.00
225_G	238_I	1.316	1.00
168_L	172_Y	1.310	1.00
168_L	200_V	1.308	1.00
122_P	132_I	1.305	1.00
141_S	241_G	1.295	1.00
83_H	88_V	1.289	1.00
188_D	192_A	1.277	1.00
278_A	283_A	1.270	1.00
167_E	171_A	1.253	1.00
278_A	285_V	1.243	1.00
230_P	233_G	1.216	1.00
213_L	224_L	1.215	1.00
40_Y	77_Y	1.206	1.00
120_T	123_A	1.203	1.00
126_A	132_I	1.198	1.00
88_V	211_L	1.194	1.00
87_T	134_D	1.192	1.00
35_G	230_P	1.189	1.00
123_A	126_A	1.186	1.00
167_E	220_T	1.185	1.00
201_D	204_R	1.168	1.00
40_Y	79_L	1.167	1.00
83_H	210_G	1.164	1.00
45_T	73_E	1.161	1.00
164_H	203_G	1.154	1.00
268_R	272_R	1.153	1.00
122_P	153_H	1.150	1.00
214_L	238_I	1.148	1.00
170_Y	221_P	1.140	1.00
90_W	239_V	1.135	1.00
240_A	285_V	1.120	1.00
239_V	286_F	1.119	1.00
214_L	225_G	1.118	1.00
79_L	239_V	1.106	1.00
269_E	272_R	1.092	1.00
90_W	139_V	1.070	1.00
203_G	215_H	1.065	1.00
204_R	212_D	1.064	1.00
92_T	151_L	1.060	1.00
277_L	283_A	1.055	1.00
33_P	38_V	1.038	1.00
238_I	283_A	1.031	1.00
143_L	148_A	1.030	1.00
214_L	277_L	1.029	1.00
32_S	37_D	1.023	1.00
80_L	87_T	1.016	0.99
169_G	173_R	1.005	0.99
125_L	130_T	1.003	0.99
143_L	171_A	1.001	0.99
201_D	224_L	0.998	0.99
187_P	190_D	0.996	0.99
57_S	60_A	0.984	0.99
183_A	186_S	0.980	0.99
182_I	189_F	0.979	0.99
138_V	151_L	0.976	0.99
236_P	283_A	0.976	0.99
165_E	200_V	0.975	0.99
216_L	270_S	0.974	0.99
261_L	271_R	0.966	0.99
203_G	224_L	0.965	0.99
276_D	279_R	0.958	0.99
39_H	128_A	0.955	0.99
37_D	87_T	0.945	0.99
81_I	211_L	0.934	0.99
79_L	286_F	0.929	0.99
185_H	189_F	0.928	0.99
89_L	138_V	0.927	0.99
182_I	185_H	0.925	0.99
117_D	123_A	0.912	0.99
62_V	65_P	0.909	0.99
36_V	210_G	0.908	0.99
41_L	128_A	0.904	0.99
166_R	169_G	0.902	0.99
137_A	208_Y	0.899	0.99
135_I	159_T	0.897	0.99
225_G	243_E	0.897	0.99
33_P	230_P	0.895	0.99
89_L	92_T	0.890	0.99
185_H	188_D	0.889	0.99
244_A	287_C	0.888	0.99
62_V	66_D	0.886	0.99
119_H	127_D	0.881	0.98
202_R	205_R	0.876	0.98
240_A	287_C	0.874	0.98
227_Y	283_A	0.868	0.98
229_E	232_D	0.866	0.98
150_G	153_H	0.854	0.98
182_I	191_R	0.854	0.98
138_V	154_F	0.849	0.98
273_R	277_L	0.841	0.98
100_D	117_D	0.821	0.98
190_D	193_L	0.818	0.98
265_A	268_R	0.813	0.97
225_G	274_V	0.812	0.97
264_L	268_R	0.811	0.97
162_Y	201_D	0.811	0.97
181_S	185_H	0.804	0.97
96_P	123_A	0.795	0.97
217_P	266_D	0.789	0.97
135_I	160_P	0.785	0.97
139_V	211_L	0.780	0.97
186_S	191_R	0.780	0.97
163_V	198_V	0.778	0.97
211_L	226_L	0.765	0.96
187_P	191_R	0.761	0.96
36_V	228_L	0.754	0.96
140_A	161_I	0.753	0.96
168_L	198_V	0.753	0.96
204_R	215_H	0.751	0.96
61_T	65_P	0.746	0.96
89_L	125_L	0.745	0.96
187_P	192_A	0.743	0.96
184_Y	188_D	0.738	0.96
124_A	127_D	0.737	0.96
49_D	70_A	0.732	0.95
184_Y	189_F	0.731	0.95
273_R	276_D	0.730	0.95
135_I	154_F	0.730	0.95
239_V	288_G	0.729	0.95
95_H	150_G	0.728	0.95
36_V	230_P	0.728	0.95
50_R	54_I	0.727	0.95
228_L	239_V	0.726	0.95
94_S	98_A	0.724	0.95
238_I	278_A	0.723	0.95
61_T	66_D	0.719	0.95
240_A	244_A	0.717	0.95
210_G	229_E	0.716	0.95
271_R	275_R	0.715	0.95
43_R	121_L	0.712	0.95
42_D	124_A	0.711	0.95
181_S	184_Y	0.709	0.94
44_G	93_G	0.705	0.94
174_S	177_T	0.703	0.94
243_E	270_S	0.703	0.94
207_L	213_L	0.703	0.94
238_I	274_V	0.698	0.94
204_R	210_G	0.695	0.94
42_D	119_H	0.694	0.94
143_L	167_E	0.694	0.94
206_Q	212_D	0.693	0.94
59_M	62_V	0.692	0.94
125_L	135_I	0.691	0.94
197_V	200_V	0.688	0.94
67_P	70_A	0.687	0.93
220_T	261_L	0.686	0.93
236_P	281_T	0.683	0.93
36_V	211_L	0.683	0.93
152_R	155_A	0.681	0.93
40_Y	286_F	0.681	0.93
80_L	128_A	0.679	0.93
47_T	71_L	0.679	0.93
182_I	188_D	0.678	0.93
144_H	147_H	0.678	0.93
88_V	139_V	0.677	0.93
140_A	148_A	0.677	0.93
90_W	241_G	0.676	0.93
43_R	78_N	0.671	0.93
78_N	121_L	0.661	0.92
182_I	186_S	0.661	0.92
169_G	172_Y	0.661	0.92
201_D	207_L	0.660	0.92
139_V	207_L	0.659	0.92
249_N	256_M	0.654	0.92
79_L	288_G	0.653	0.92
139_V	224_L	0.646	0.91
237_A	286_F	0.644	0.91
194_N	197_V	0.644	0.91
166_R	217_P	0.644	0.91
79_L	237_A	0.642	0.91
50_R	55_D	0.642	0.91
241_G	288_G	0.638	0.91
122_P	126_A	0.636	0.91
266_D	270_S	0.636	0.91
51_A	57_S	0.635	0.91
38_V	230_P	0.634	0.90
261_L	264_L	0.633	0.90
112_H	115_D	0.633	0.90
272_R	275_R	0.629	0.90
216_L	238_I	0.629	0.90
33_P	36_V	0.628	0.90
206_Q	229_E	0.626	0.90
162_Y	199_A	0.626	0.90
251_E	254_V	0.626	0.90
92_T	148_A	0.624	0.90
132_I	153_H	0.624	0.90
182_I	192_A	0.623	0.90
253_G	275_R	0.619	0.89
43_R	95_H	0.617	0.89
190_D	194_N	0.614	0.89
56_S	59_M	0.613	0.89
41_L	130_T	0.609	0.89
181_S	189_F	0.609	0.89
233_G	284_D	0.606	0.88
152_R	197_V	0.605	0.88
178_D	189_F	0.602	0.88
201_D	213_L	0.598	0.88
95_H	261_L	0.596	0.88
201_D	205_R	0.596	0.88
249_N	255_P	0.595	0.87
227_Y	281_T	0.595	0.87
240_A	288_G	0.594	0.87
156_G	160_P	0.592	0.87
185_H	191_R	0.591	0.87
91_D	289_H	0.589	0.87
277_L	282_T	0.588	0.87
267_W	271_R	0.584	0.87
214_L	273_R	0.581	0.86
79_L	245_Y	0.579	0.86
218_G	242_D	0.576	0.86
43_R	287_C	0.575	0.86
53_M	56_S	0.575	0.86
81_I	88_V	0.573	0.85
175_A	178_D	0.573	0.85
164_H	201_D	0.571	0.85
93_G	140_A	0.569	0.85
119_H	123_A	0.569	0.85
118_E	123_A	0.569	0.85
194_N	198_V	0.567	0.85
46_I	76_V	0.565	0.85
265_A	269_E	0.563	0.84
97_D	100_D	0.562	0.84
36_V	81_I	0.560	0.84
48_A	260_L	0.558	0.84
96_P	117_D	0.558	0.84
39_H	130_T	0.557	0.84
96_P	120_T	0.556	0.84
87_T	125_L	0.555	0.84
50_R	72_V	0.551	0.83
50_R	70_A	0.550	0.83
162_Y	205_R	0.550	0.83
240_A	243_E	0.546	0.83
183_A	192_A	0.546	0.83
45_T	75_P	0.546	0.83
164_H	167_E	0.545	0.83
61_T	64_D	0.545	0.83
182_I	187_P	0.544	0.82
82_D	134_D	0.544	0.82
76_V	118_E	0.543	0.82
208_Y	211_L	0.543	0.82
48_A	52_Y	0.542	0.82
225_G	270_S	0.542	0.82
204_R	214_L	0.539	0.82
154_F	159_T	0.539	0.82
68_E	139_V	0.538	0.82
257_A	268_R	0.537	0.82
153_H	161_I	0.536	0.82
66_D	282_T	0.536	0.82
181_S	186_S	0.533	0.81
186_S	189_F	0.530	0.81
36_V	84_P	0.530	0.81
132_I	159_T	0.530	0.81
79_L	287_C	0.528	0.81
177_T	186_S	0.527	0.80
145_L	149_G	0.526	0.80
167_E	223_L	0.526	0.80
76_V	223_L	0.525	0.80
62_V	67_P	0.524	0.80
80_L	134_D	0.523	0.80
205_R	213_L	0.523	0.80
266_D	273_R	0.520	0.80
121_L	154_F	0.520	0.80
185_H	190_D	0.520	0.80
225_G	239_V	0.520	0.80
75_P	245_Y	0.519	0.79
98_A	145_L	0.519	0.79
149_G	245_Y	0.519	0.79
56_S	72_V	0.518	0.79
183_A	188_D	0.518	0.79
32_S	35_G	0.518	0.79
42_D	120_T	0.518	0.79
247_R	287_C	0.518	0.79
168_L	193_L	0.517	0.79
42_D	77_Y	0.517	0.79
247_R	251_E	0.516	0.79
163_V	168_L	0.515	0.79
49_D	54_I	0.515	0.79
268_R	271_R	0.512	0.79
240_A	283_A	0.511	0.78
261_L	267_W	0.511	0.78
83_H	208_Y	0.511	0.78
287_C	290_D	0.510	0.78
221_P	262_S	0.508	0.78
49_D	52_Y	0.507	0.78
50_R	56_S	0.504	0.77
274_V	278_A	0.504	0.77
48_A	98_A	0.504	0.77
166_R	202_R	0.504	0.77
246_Q	249_N	0.503	0.77
221_P	263_S	0.503	0.77
38_V	256_M	0.503	0.77
148_A	151_L	0.502	0.77
263_S	269_E	0.502	0.77
95_H	98_A	0.502	0.77
216_L	241_G	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4le6A	4	0.7542	100	0.439	Contact Map
2r2dA	5	0.8704	100	0.444	Contact Map
3aj3A	2	0.8206	100	0.453	Contact Map
1p9eA	3	0.8738	100	0.458	Contact Map
4zo2A	2	0.8505	100	0.469	Contact Map
3dhaA	1	0.8239	100	0.487	Contact Map
3eshA	5	0.8472	100	0.491	Contact Map
4d1tA	1	0.7309	100	0.604	Contact Map
1ztcA	4	0.6645	100	0.605	Contact Map
4eybA	2	0.7641	100	0.611	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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