GREMLIN Database
Q9HQ40 - N5,N10-methylenetetrahydromethanopterin reductase
UniProt: Q9HQ40 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (233)
Sequences: 9707 (6622)
Seq/√Len: 433.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_A200_D5.1081.00
43_D48_Q4.0161.00
25_R80_R2.9291.00
22_R45_D2.8641.00
75_V101_D2.8111.00
204_R207_A2.7571.00
199_A240_A2.6281.00
128_P236_A2.5631.00
206_A210_G2.5571.00
233_T237_V2.5021.00
104_R108_L2.3851.00
76_E105_G2.3591.00
130_A134_R2.3051.00
99_L103_R2.2391.00
19_R45_D2.2371.00
16_S19_R2.2141.00
127_Q132_A2.2061.00
202_R240_A2.2051.00
131_A135_D2.1931.00
130_A197_T2.1171.00
112_D115_A2.1081.00
106_M116_V2.0891.00
96_R100_A2.0311.00
129_D132_A2.0291.00
101_D105_G1.9901.00
197_T200_D1.9811.00
33_A40_V1.9461.00
138_R142_A1.9041.00
76_E108_L1.8521.00
32_R62_A1.8421.00
41_D50_Q1.8411.00
100_A104_R1.8231.00
231_D235_A1.7641.00
7_A11_G1.7501.00
19_R22_R1.7451.00
41_D51_G1.7271.00
22_R46_L1.7231.00
26_E44_G1.7021.00
79_G105_G1.6581.00
207_A211_I1.6111.00
25_R81_F1.5941.00
194_A201_V1.5911.00
29_D42_Y1.5871.00
11_G50_Q1.5871.00
43_D50_Q1.5871.00
80_R109_G1.5761.00
76_E109_G1.5661.00
29_D81_F1.5411.00
232_D236_A1.5321.00
105_G108_L1.5271.00
33_A37_G1.5001.00
206_A209_A1.4971.00
96_R211_I1.4751.00
36_T62_A1.4671.00
26_E45_D1.4601.00
19_R46_L1.4441.00
101_D104_R1.4101.00
106_M111_R1.4101.00
92_A211_I1.4091.00
30_V42_Y1.4031.00
29_D33_A1.4001.00
33_A38_D1.3851.00
176_D179_R1.3781.00
92_A207_A1.3771.00
66_D84_G1.3551.00
33_A42_Y1.3451.00
30_V47_I1.3441.00
136_L232_D1.3361.00
199_A203_D1.3221.00
32_R81_F1.3181.00
76_E80_R1.3101.00
160_G163_A1.3041.00
79_G109_G1.2931.00
132_A136_L1.2891.00
30_V49_T1.2791.00
117_Q215_D1.2701.00
181_V185_T1.2681.00
126_A198_Q1.2651.00
75_V105_G1.2641.00
135_D138_R1.2431.00
236_A240_A1.2401.00
22_R73_K1.2231.00
178_E181_V1.2231.00
200_D203_D1.2081.00
126_A201_V1.2071.00
25_R29_D1.2031.00
105_G109_G1.1971.00
39_P51_G1.1931.00
135_D139_Q1.1761.00
97_E100_A1.1761.00
28_I81_F1.1741.00
34_V40_V1.1731.00
59_P62_A1.1631.00
66_D119_T1.1511.00
127_Q133_A1.1491.00
178_E182_G1.1481.00
126_A237_V1.1481.00
128_P132_A1.1471.00
234_L238_A1.1391.00
230_I234_L1.1381.00
31_V35_L1.1361.00
99_L118_T1.1311.00
72_P101_D1.1091.00
120_L214_V1.1091.00
198_Q232_D1.1081.00
174_D177_H1.1051.00
92_A96_R1.0971.00
91_T94_G1.0881.00
27_Y31_V1.0811.00
137_T141_L1.0741.00
30_V33_A1.0601.00
122_V205_L1.0561.00
18_E73_K1.0551.00
167_D171_A1.0491.00
173_Q176_D1.0431.00
69_G85_W1.0431.00
107_D113_A1.0301.00
172_W175_G1.0201.00
207_A210_G1.0161.00
139_Q142_A1.0121.00
104_R107_D1.0021.00
200_D204_R0.9991.00
72_P105_G0.9911.00
73_K76_E0.9851.00
172_W176_D0.9781.00
131_A134_R0.9781.00
76_E104_R0.9741.00
179_R187_D0.9691.00
228_A232_D0.9621.00
35_L63_P0.9541.00
125_C136_L0.9511.00
134_R138_R0.9471.00
85_W102_L0.9451.00
179_R182_G0.9391.00
128_P232_D0.9371.00
103_R107_D0.9291.00
42_Y45_D0.9221.00
106_M113_A0.9171.00
49_T52_F0.9161.00
32_R83_D0.9091.00
23_R47_I0.8931.00
134_R137_T0.8891.00
59_P63_P0.8861.00
178_E184_V0.8831.00
167_D170_D0.8811.00
93_D96_R0.8801.00
67_V78_A0.8741.00
162_E165_A0.8731.00
42_Y47_I0.8711.00
178_E187_D0.8651.00
37_G57_D0.8621.00
94_G97_E0.8621.00
206_A240_A0.8531.00
228_A231_D0.8491.00
166_T169_Y0.8461.00
203_D207_A0.8431.00
122_V194_A0.8411.00
124_C219_V0.8391.00
25_R73_K0.8381.00
117_Q216_A0.8361.00
206_A241_P0.8341.00
138_R141_L0.8301.00
139_Q143_F0.8211.00
229_V232_D0.8201.00
26_E42_Y0.8181.00
227_N231_D0.8181.00
75_V102_L0.8161.00
163_A166_T0.8121.00
78_A85_W0.8071.00
106_M109_G0.8061.00
196_G201_V0.8051.00
182_G185_T0.8041.00
67_V82_A0.8021.00
102_L116_V0.8011.00
75_V79_G0.8011.00
102_L118_T0.7981.00
170_D173_Q0.7951.00
134_R190_D0.7941.00
172_W177_H0.7911.00
102_L106_M0.7901.00
202_R206_A0.7881.00
77_L81_F0.7871.00
202_R237_V0.7801.00
65_I82_A0.7781.00
80_R108_L0.7721.00
132_A135_D0.7701.00
97_E101_D0.7701.00
87_A98_R0.7691.00
155_S159_Q0.7691.00
41_D52_F0.7651.00
179_R184_V0.7631.00
127_Q136_L0.7621.00
154_D157_A0.7601.00
180_A184_V0.7591.00
73_K77_L0.7571.00
169_Y173_Q0.7561.00
90_F94_G0.7531.00
5_G8_V0.7531.00
103_R113_A0.7511.00
119_T216_A0.7491.00
66_D216_A0.7461.00
180_A185_T0.7451.00
84_G119_T0.7431.00
154_D159_Q0.7421.00
6_P9_I0.7421.00
166_T170_D0.7411.00
79_G106_M0.7371.00
32_R36_T0.7361.00
194_A205_L0.7331.00
155_S158_R0.7261.00
70_M98_R0.7231.00
171_A175_G0.7221.00
168_V171_A0.7201.00
4_S9_I0.7181.00
184_V187_D0.7171.00
21_L71_G0.7161.00
157_A162_E0.7161.00
5_G9_I0.7111.00
39_P53_R0.7071.00
136_L139_Q0.6991.00
126_A197_T0.6991.00
198_Q236_A0.6971.00
129_D133_A0.6961.00
30_V34_V0.6941.00
29_D32_R0.6941.00
29_D80_R0.6931.00
223_R228_A0.6901.00
23_R27_Y0.6891.00
143_F146_G0.6751.00
21_L77_L0.6721.00
181_V187_D0.6721.00
170_D174_D0.6701.00
43_D46_L0.6681.00
203_D206_A0.6661.00
19_R23_R0.6651.00
137_T195_A0.6631.00
104_R113_A0.6631.00
182_G187_D0.6611.00
128_P198_Q0.6601.00
70_M89_L0.6571.00
169_Y172_W0.6550.99
205_L241_P0.6510.99
94_G98_R0.6500.99
23_R46_L0.6490.99
33_A36_T0.6470.99
202_R241_P0.6470.99
103_R106_M0.6460.99
182_G186_D0.6430.99
30_V40_V0.6410.99
192_F204_R0.6400.99
111_R115_A0.6390.99
156_L160_G0.6370.99
173_Q177_H0.6340.99
28_I65_I0.6300.99
124_C233_T0.6290.99
171_A176_D0.6220.99
6_P10_Q0.6220.99
205_L219_V0.6160.99
178_E185_T0.6130.99
76_E101_D0.6130.99
163_A167_D0.6100.99
28_I32_R0.6100.99
164_P167_D0.6070.99
103_R118_T0.6060.99
24_T77_L0.6050.99
128_P228_A0.6040.99
75_V85_W0.6030.99
36_T61_P0.6020.99
137_T193_A0.6020.99
174_D178_E0.6010.99
9_I12_W0.5980.99
93_D211_I0.5970.99
133_A195_A0.5940.99
158_R161_Y0.5910.99
152_Y156_L0.5900.99
5_G10_Q0.5890.99
57_D60_D0.5880.99
155_S161_Y0.5870.99
221_F233_T0.5850.99
34_V54_L0.5840.99
178_E186_D0.5820.99
39_P50_Q0.5740.99
121_V218_A0.5730.99
153_R157_A0.5720.99
112_D116_V0.5700.99
35_L65_I0.5690.99
159_Q163_A0.5690.99
157_A160_G0.5670.99
87_A95_I0.5670.99
126_A232_D0.5660.99
4_S13_H0.5640.98
156_L159_Q0.5640.98
179_R185_T0.5620.98
20_P69_G0.5620.98
121_V220_S0.5600.98
237_V240_A0.5580.98
123_P222_P0.5570.98
179_R183_L0.5570.98
26_E30_V0.5570.98
161_Y164_P0.5560.98
25_R77_L0.5540.98
111_R116_V0.5530.98
208_F213_G0.5500.98
21_L74_A0.5490.98
214_V217_V0.5490.98
38_D57_D0.5470.98
26_E46_L0.5460.98
194_A204_R0.5440.98
180_A186_D0.5430.98
169_Y174_D0.5430.98
171_A177_H0.5430.98
103_R115_A0.5410.98
72_P76_E0.5410.98
127_Q232_D0.5400.98
8_V11_G0.5370.98
142_A146_G0.5360.98
233_T238_A0.5350.98
151_F154_D0.5350.98
106_M115_A0.5330.98
106_M112_D0.5320.98
109_G112_D0.5320.98
100_A103_R0.5320.98
95_I208_F0.5290.98
28_I77_L0.5290.98
89_L95_I0.5280.98
67_V74_A0.5260.98
30_V44_G0.5250.98
130_A133_A0.5230.98
124_C194_A0.5230.98
27_Y47_I0.5220.98
159_Q162_E0.5220.98
12_W52_F0.5200.97
99_L102_L0.5190.97
123_P220_S0.5160.97
183_L186_D0.5140.97
181_V186_D0.5120.97
180_A183_L0.5080.97
84_G117_Q0.5080.97
170_D175_G0.5080.97
124_C201_V0.5070.97
93_D207_A0.5070.97
146_G149_G0.5060.97
7_A10_Q0.5040.97
66_D117_Q0.5030.97
198_Q202_R0.5020.97
150_E153_R0.5010.97
64_A117_Q0.5010.97
154_D158_R0.5010.97
53_R57_D0.5010.97
129_D135_D0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ezwA 3 0.9673 100 0.273 Contact Map
1z69A 4 0.951 100 0.293 Contact Map
1lucA 1 0.8694 100 0.299 Contact Map
3sdoA 2 0.9918 100 0.301 Contact Map
1tvlA 2 0.8612 100 0.302 Contact Map
2wgkA 2 0.9633 100 0.309 Contact Map
2i7gA 2 0.9143 100 0.312 Contact Map
3b9oA 2 0.9796 100 0.314 Contact Map
3c8nA 2 0.9102 100 0.315 Contact Map
1rhcA 2 0.902 100 0.319 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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