GREMLIN Database
Q9HQ39 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
UniProt: Q9HQ39 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (208)
Sequences: 212 (160)
Seq/√Len: 11.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_V122_I6.0451.00
115_V132_Y3.8280.99
14_C143_A3.4570.98
34_H129_V3.3860.97
16_A195_W3.3850.97
23_A26_R3.2410.97
21_Q25_R3.1110.96
82_L87_I2.8880.93
35_A139_A2.6970.91
76_S98_K2.6570.90
163_F199_L2.6460.90
92_M103_A2.6370.90
14_C21_Q2.4510.86
80_D102_T2.4310.85
115_V125_I2.4310.85
31_L129_V2.3440.83
55_G178_W2.2490.80
74_A82_L2.2060.79
14_C25_R2.1280.76
17_F28_R2.1270.76
25_R143_A2.0560.74
94_T161_A2.0220.72
16_A191_R1.9850.71
2_E167_H1.9840.71
92_M98_K1.9270.69
19_Y23_A1.9260.69
197_A201_R1.8870.67
94_T145_P1.8630.66
96_L115_V1.7810.62
77_T98_K1.7570.61
73_F91_L1.7100.59
18_G169_G1.6840.58
77_T106_L1.6710.57
49_T172_A1.6670.57
103_A128_H1.6640.57
58_T178_W1.6340.55
162_A200_L1.6160.54
163_F202_W1.5990.54
10_Y13_V1.5900.53
35_A103_A1.5880.53
19_Y188_E1.5880.53
16_A180_F1.5710.52
162_A207_R1.5520.51
83_A109_Q1.5480.51
6_W10_Y1.5390.51
166_D207_R1.5380.51
57_P199_L1.5180.50
25_R144_A1.5080.49
106_L111_T1.4910.48
93_V164_L1.4760.48
168_C194_A1.4410.46
52_I194_A1.4110.45
45_C73_F1.3910.44
76_S175_F1.3650.42
87_I122_I1.3620.42
2_E5_D1.3610.42
182_D185_V1.3360.41
13_V180_F1.3350.41
103_A132_Y1.3330.41
3_Y7_Q1.3130.40
31_L139_A1.3040.40
53_A77_T1.2990.39
31_L115_V1.2970.39
74_A125_I1.2780.38
180_F191_R1.2680.38
74_A79_V1.2600.38
103_A113_V1.2540.37
56_A81_V1.2500.37
92_M107_T1.2460.37
73_F93_V1.2270.36
32_A148_P1.2070.35
51_A70_D1.2070.35
162_A173_L1.1990.35
50_V86_G1.1660.33
37_P42_R1.1560.33
54_G180_F1.1500.33
76_S92_M1.1490.33
79_V111_T1.1440.32
116_H177_G1.1410.32
15_A127_E1.1230.32
92_M97_D1.1080.31
103_A115_V1.1070.31
133_D198_R1.0950.30
128_H200_L1.0910.30
56_A178_W1.0830.30
89_V98_K1.0730.29
11_D21_Q1.0680.29
92_M101_E1.0620.29
19_Y25_R1.0570.29
92_M113_V1.0530.29
63_R106_L1.0520.29
13_V54_G1.0510.29
4_D64_E1.0490.29
31_L56_A1.0460.28
76_S97_D1.0460.28
52_I169_G1.0390.28
146_T149_V1.0360.28
47_G86_G1.0360.28
140_T150_V1.0330.28
137_V164_L1.0230.28
90_D165_A1.0220.27
1_M6_W1.0200.27
111_T124_A1.0200.27
6_W152_H1.0170.27
70_D138_L1.0050.27
149_V185_V1.0030.27
55_G77_T0.9960.27
33_A126_R0.9930.26
120_D203_L0.9890.26
82_L202_W0.9890.26
59_L82_L0.9840.26
21_Q143_A0.9750.26
52_I83_A0.9630.25
79_V106_L0.9610.25
81_V181_D0.9580.25
3_Y8_P0.9530.25
3_Y21_Q0.9520.25
89_V152_H0.9280.24
57_P163_F0.9140.24
104_R200_L0.9100.23
60_A109_Q0.9020.23
50_V170_A0.9010.23
34_H72_V0.9000.23
90_D129_V0.8930.23
30_V81_V0.8880.23
73_F89_V0.8860.23
132_Y176_P0.8840.23
31_L137_V0.8840.23
15_A105_R0.8820.22
178_W195_W0.8810.22
52_I133_D0.8790.22
60_A186_T0.8650.22
79_V83_A0.8620.22
84_D132_Y0.8450.21
68_A87_I0.8360.21
28_R114_A0.8330.21
116_H132_Y0.8310.21
34_H130_P0.8230.21
20_E23_A0.8230.21
10_Y196_A0.8230.21
53_A72_V0.8180.20
35_A38_F0.8180.20
117_A154_G0.8170.20
108_A174_R0.8060.20
7_Q144_A0.8020.20
149_V152_H0.7890.19
28_R89_V0.7860.19
73_F165_A0.7840.19
94_T115_V0.7840.19
174_R181_D0.7790.19
58_T181_D0.7740.19
14_C140_T0.7690.19
39_D45_C0.7680.19
200_L203_L0.7640.19
24_D154_G0.7640.19
4_D12_D0.7640.19
65_V188_E0.7600.19
205_T208_G0.7590.19
3_Y25_R0.7590.19
2_E144_A0.7520.18
83_A132_Y0.7520.18
100_P181_D0.7510.18
58_T87_I0.7480.18
73_F152_H0.7420.18
34_H111_T0.7390.18
125_I165_A0.7380.18
115_V119_G0.7370.18
199_L203_L0.7370.18
72_V171_A0.7360.18
175_F178_W0.7310.18
12_D195_W0.7310.18
55_G156_T0.7290.18
91_L139_A0.7260.18
80_D99_N0.7240.18
15_A124_A0.7230.18
31_L97_D0.7230.18
128_H136_H0.7220.18
31_L98_K0.7210.17
51_A176_P0.7200.17
34_H167_H0.7200.17
73_F194_A0.7190.17
76_S178_W0.7080.17
14_C17_F0.7050.17
170_A180_F0.7040.17
166_D195_W0.7030.17
108_A164_L0.7030.17
34_H71_R0.6970.17
32_A178_W0.6960.17
6_W13_V0.6910.17
73_F127_E0.6910.17
63_R171_A0.6850.16
99_N102_T0.6840.16
16_A200_L0.6820.16
20_E113_V0.6740.16
108_A125_I0.6710.16
79_V103_A0.6700.16
98_K175_F0.6670.16
6_W197_A0.6660.16
53_A207_R0.6640.16
51_A69_A0.6550.16
19_Y131_T0.6550.16
129_V139_A0.6540.16
6_W89_V0.6480.16
8_P27_A0.6450.15
125_I190_R0.6440.15
28_R88_E0.6340.15
104_R131_T0.6320.15
59_L86_G0.6240.15
27_A145_P0.6220.15
50_V165_A0.6160.15
151_D154_G0.6140.15
115_V199_L0.6120.15
75_A117_A0.6110.15
51_A207_R0.6100.15
173_L178_W0.6080.15
45_C168_C0.6050.14
18_G29_D0.6020.14
113_V173_L0.5950.14
52_I124_A0.5950.14
5_D30_V0.5950.14
74_A86_G0.5920.14
86_G165_A0.5890.14
104_R128_H0.5870.14
37_P111_T0.5870.14
114_A139_A0.5850.14
31_L74_A0.5840.14
113_V143_A0.5830.14
16_A19_Y0.5810.14
44_D140_T0.5810.14
53_A66_A0.5800.14
36_E40_M0.5770.14
62_E186_T0.5710.14
37_P44_D0.5700.14
57_P78_A0.5700.14
40_M92_M0.5690.14
82_L163_F0.5680.14
31_L35_A0.5670.14
63_R176_P0.5650.14
75_A154_G0.5640.14
128_H131_T0.5640.14
110_G113_V0.5620.13
14_C125_I0.5600.13
92_M111_T0.5590.13
86_G101_E0.5560.13
66_A203_L0.5550.13
118_H189_K0.5540.13
121_N158_G0.5540.13
121_N157_D0.5540.13
121_N160_R0.5540.13
118_H192_K0.5540.13
50_V200_L0.5540.13
118_H158_G0.5540.13
118_H157_D0.5540.13
118_H121_N0.5540.13
121_N189_K0.5540.13
121_N192_K0.5540.13
118_H160_R0.5540.13
95_D160_R0.5540.13
95_D121_N0.5540.13
189_K192_K0.5540.13
95_D158_G0.5540.13
95_D157_D0.5540.13
160_R192_K0.5540.13
160_R189_K0.5540.13
158_G192_K0.5540.13
95_D192_K0.5540.13
157_D192_K0.5540.13
157_D189_K0.5540.13
157_D160_R0.5540.13
95_D189_K0.5540.13
158_G189_K0.5540.13
95_D118_H0.5540.13
35_A152_H0.5530.13
140_T199_L0.5530.13
162_A203_L0.5470.13
46_T138_L0.5470.13
29_D52_I0.5460.13
59_L96_L0.5460.13
21_Q141_T0.5440.13
123_A126_R0.5410.13
145_P149_V0.5400.13
92_M137_V0.5370.13
56_A115_V0.5350.13
114_A138_L0.5320.13
203_L207_R0.5310.13
162_A178_W0.5310.13
57_P96_L0.5290.13
64_E127_E0.5280.13
47_G50_V0.5280.13
174_R202_W0.5270.13
52_I107_T0.5260.13
46_T146_T0.5250.13
19_Y200_L0.5230.13
27_A122_I0.5220.13
4_D205_T0.5190.13
83_A111_T0.5180.13
102_T106_L0.5150.12
2_E194_A0.5150.12
56_A91_L0.5130.12
104_R137_V0.5120.12
1_M10_Y0.5100.12
100_P106_L0.5100.12
94_T162_A0.5100.12
73_F164_L0.5070.12
20_E139_A0.5070.12
102_T129_V0.5060.12
75_A151_D0.5060.12
84_D143_A0.5050.12
20_E109_Q0.5030.12
81_V186_T0.5020.12
98_K154_G0.5010.12
17_F193_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ro7A 3 0.72 99.8 0.779 Contact Map
2p2vA 3 0.7733 99.8 0.782 Contact Map
2wqqA 1 0.6889 99.7 0.793 Contact Map
3l8mA 5 0.6267 99.6 0.822 Contact Map
3melA 2 0.6444 99.5 0.833 Contact Map
2omkA 2 0.7067 99.4 0.837 Contact Map
3cq9A 2 0.6489 99.4 0.838 Contact Map
3ihkA 3 0.6222 99.4 0.838 Contact Map
3lm8A 2 0.6444 99.3 0.843 Contact Map
3k94A 2 0.6444 99.2 0.851 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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