GREMLIN Database
Q9HQ36 - Uncharacterized protein
UniProt: Q9HQ36 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 253 (229)
Sequences: 1751 (1163)
Seq/√Len: 76.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_S80_A5.1421.00
79_D141_R4.3541.00
37_K68_D3.9441.00
110_A172_D3.6621.00
146_G166_A3.6101.00
43_E74_R3.2801.00
31_T61_F3.1891.00
85_F124_A3.0911.00
45_L76_L2.9051.00
90_F142_I2.9021.00
22_D129_R2.7951.00
22_D48_D2.6981.00
194_E222_R2.6101.00
192_E232_G2.5071.00
20_I159_L2.4951.00
78_F126_V2.4741.00
18_V167_L2.3791.00
43_E122_P2.2801.00
17_A45_L2.2461.00
82_V88_V2.2411.00
199_H239_H2.2351.00
129_R138_E2.1611.00
127_F163_A2.0481.00
19_A124_A2.0481.00
45_L74_R2.0001.00
90_F139_L1.9721.00
125_L166_A1.9711.00
35_A164_T1.9611.00
196_F225_L1.9451.00
59_Y71_P1.9161.00
17_A43_E1.8881.00
192_E195_Q1.8651.00
58_A70_L1.7691.00
159_L163_A1.7611.00
195_Q239_H1.7591.00
18_V36_M1.7511.00
197_Y226_G1.7311.00
203_F246_E1.6961.00
206_A246_E1.6901.00
188_A235_I1.6681.00
88_V126_V1.6491.00
27_G57_E1.6371.00
202_E246_E1.6071.00
110_A169_E1.6021.00
41_F167_L1.6021.00
87_T144_E1.5550.99
89_G112_L1.5250.99
39_F164_T1.5150.99
204_L241_L1.5040.99
84_E191_A1.4970.99
19_A85_F1.4890.99
32_I163_A1.4510.99
235_I239_H1.4270.99
20_I163_A1.4220.99
21_V134_L1.4220.99
135_T138_E1.4160.99
203_F245_A1.4020.99
36_M41_F1.3890.99
51_Y55_D1.3750.99
189_D192_E1.3500.98
196_F235_I1.3380.98
207_V244_R1.3240.98
48_D77_S1.3150.98
78_F82_V1.3140.98
24_E131_R1.3140.98
67_E71_P1.3120.98
47_V81_L1.3080.98
126_V142_I1.3070.98
207_V245_A1.3020.98
26_A55_D1.2890.98
203_F242_L1.2830.98
143_D190_E1.2630.97
171_R175_M1.2590.97
196_F200_A1.2570.97
115_S144_E1.2560.97
127_F159_L1.2460.97
107_R144_E1.2190.97
88_V190_E1.2140.97
224_M230_P1.2090.97
86_H121_A1.1910.96
37_K65_A1.1880.96
45_L84_E1.1650.96
29_V52_L1.1620.96
18_V125_L1.1540.96
186_H232_G1.1390.95
221_L241_L1.1360.95
46_L49_P1.1350.95
92_A145_V1.1280.95
59_Y67_E1.1270.95
86_H122_P1.1230.95
150_A154_Y1.1180.95
82_V85_F1.1180.95
93_I100_S1.1170.95
205_D214_Q1.1160.95
244_R247_T1.1130.95
191_A195_Q1.1100.95
132_V135_T1.1060.94
61_F161_Q1.0990.94
15_K122_P1.0920.94
243_R247_T1.0820.94
201_S218_M1.0730.94
21_V129_R1.0600.93
107_R115_S1.0540.93
207_V241_L1.0480.93
27_G61_F1.0310.92
62_A67_E1.0270.92
112_L146_G1.0250.92
17_A76_L1.0190.92
31_T38_N1.0190.92
85_F88_V1.0140.91
23_A46_L1.0020.91
89_G146_G0.9960.91
20_I32_I0.9920.91
17_A85_F0.9900.90
110_A173_L0.9880.90
129_R135_T0.9870.90
204_L207_V0.9840.90
26_A52_L0.9550.89
109_P166_A0.9530.89
84_E122_P0.9460.88
211_A215_A0.9360.88
92_A104_F0.9360.88
76_L80_A0.9360.88
42_E72_E0.9320.88
49_P75_E0.9210.87
143_D193_I0.9210.87
19_A76_L0.9180.87
230_P238_V0.9120.86
93_I155_P0.9110.86
21_V47_V0.9100.86
39_F150_A0.8980.86
51_Y54_R0.8970.86
230_P235_I0.8750.84
89_G144_E0.8740.84
115_S118_D0.8730.84
30_G34_R0.8710.84
210_P213_K0.8680.84
232_G236_N0.8600.83
26_A54_R0.8500.82
224_M238_V0.8490.82
157_M164_T0.8420.82
195_Q199_H0.8390.82
196_F238_V0.8270.81
143_D226_G0.8170.80
88_V142_I0.8130.79
74_R80_A0.8130.79
46_L228_T0.8110.79
201_S205_D0.8070.79
194_E198_E0.8060.79
32_I160_G0.8040.79
31_T160_G0.8030.79
38_N61_F0.8010.78
52_L55_D0.7980.78
150_A155_P0.7950.78
117_R173_L0.7950.78
27_G164_T0.7940.78
210_P214_Q0.7920.78
228_T234_E0.7890.77
81_L84_E0.7870.77
25_T61_F0.7850.77
17_A122_P0.7830.77
195_Q198_E0.7780.76
22_D135_T0.7750.76
16_P170_L0.7720.76
196_F242_L0.7720.76
93_I136_N0.7700.76
58_A73_A0.7690.76
28_N34_R0.7690.76
183_V231_T0.7650.75
114_D118_D0.7610.75
19_A81_L0.7590.75
140_A219_R0.7530.74
57_E61_F0.7480.74
95_N101_H0.7450.73
55_D63_G0.7410.73
89_G115_S0.7410.73
54_R59_Y0.7390.73
111_E114_D0.7360.72
29_V32_I0.7330.72
137_D140_A0.7300.72
18_V41_F0.7300.72
197_Y222_R0.7270.71
198_E202_E0.7270.71
33_A136_N0.7200.71
91_T166_A0.7190.71
37_K154_Y0.7180.70
37_K42_E0.7180.70
106_F145_V0.7120.70
210_P215_A0.7080.69
38_N164_T0.7040.69
185_R231_T0.7020.69
116_L125_L0.7010.69
24_E156_V0.6980.68
78_F141_R0.6970.68
46_L75_E0.6960.68
189_D193_I0.6950.68
21_V85_F0.6940.68
41_F160_G0.6940.68
70_L73_A0.6910.68
64_H151_S0.6890.67
100_S103_R0.6890.67
110_A114_D0.6890.67
37_K151_S0.6850.67
83_S191_A0.6790.66
141_R194_E0.6750.66
223_R231_T0.6750.66
39_F171_R0.6740.66
33_A70_L0.6690.65
37_K69_I0.6690.65
52_L59_Y0.6680.65
211_A214_Q0.6680.65
26_A59_Y0.6680.65
183_V186_H0.6660.65
16_P41_F0.6640.64
215_A219_R0.6630.64
186_H189_D0.6610.64
209_Y237_T0.6600.64
109_P168_Y0.6590.64
216_K219_R0.6570.64
118_D178_T0.6570.64
225_L245_A0.6550.63
151_S154_Y0.6500.63
94_T157_M0.6490.63
76_L84_E0.6490.63
219_R226_G0.6480.63
114_D176_S0.6460.62
39_F157_M0.6430.62
213_K237_T0.6420.62
132_V231_T0.6420.62
26_A29_V0.6410.62
92_A215_A0.6360.61
35_A39_F0.6350.61
143_D222_R0.6290.60
169_E172_D0.6280.60
180_L183_V0.6270.60
33_A58_A0.6260.60
123_T198_E0.6240.60
154_Y161_Q0.6240.60
56_S60_G0.6220.59
59_Y62_A0.6220.59
88_V143_D0.6190.59
33_A93_I0.6160.59
70_L90_F0.6130.58
217_T220_M0.6130.58
113_G170_L0.6130.58
18_V163_A0.6080.58
140_A145_V0.6070.58
79_D126_V0.6070.58
92_A141_R0.6060.57
148_I165_V0.6040.57
36_M69_I0.6020.57
193_I235_I0.6020.57
227_R234_E0.6020.57
116_L126_V0.6020.57
45_L85_F0.6000.57
108_T114_D0.5980.56
214_Q218_M0.5980.56
150_A157_M0.5960.56
92_A139_L0.5950.56
72_E119_V0.5940.56
17_A74_R0.5900.55
35_A65_A0.5890.55
80_A137_D0.5890.55
242_L245_A0.5880.55
44_L148_I0.5880.55
32_I167_L0.5850.55
29_V58_A0.5820.54
36_M168_Y0.5820.54
103_R223_R0.5790.54
36_M167_L0.5790.54
31_T59_Y0.5780.54
56_S59_Y0.5770.54
38_N243_R0.5770.54
29_V84_E0.5730.53
213_K217_T0.5730.53
55_D60_G0.5720.53
65_A68_D0.5710.53
200_A241_L0.5710.53
82_V190_E0.5700.53
198_E201_S0.5700.53
40_G151_S0.5690.53
14_S42_E0.5690.53
43_E85_F0.5690.53
169_E240_G0.5670.53
64_H154_Y0.5670.53
190_E226_G0.5660.52
60_G63_G0.5660.52
175_M178_T0.5620.52
205_D211_A0.5600.52
151_S165_V0.5600.52
120_E198_E0.5600.52
131_R135_T0.5510.51
234_E239_H0.5510.51
91_T168_Y0.5510.51
187_R229_H0.5500.50
24_E50_P0.5490.50
42_E151_S0.5480.50
197_Y218_M0.5480.50
110_A176_S0.5470.50
117_R174_A0.5460.50
64_H100_S0.5460.50
112_L116_L0.5460.50
205_D208_D0.5450.50
139_L147_S0.5440.50
150_A171_R0.5420.49
25_T31_T0.5420.49
90_F157_M0.5410.49
104_F145_V0.5360.49
156_V159_L0.5360.49
31_T161_Q0.5350.48
71_P119_V0.5340.48
93_I220_M0.5300.48
72_E179_Q0.5300.48
113_G173_L0.5300.48
113_G117_R0.5280.48
21_V137_D0.5280.48
38_N150_A0.5280.48
224_M228_T0.5250.47
86_H123_T0.5250.47
94_T156_V0.5250.47
21_V138_E0.5250.47
225_L230_P0.5250.47
156_V217_T0.5240.47
24_E159_L0.5220.47
82_V126_V0.5220.47
42_E153_D0.5210.47
244_R248_Q0.5210.47
109_P112_L0.5180.46
39_F167_L0.5170.46
22_D132_V0.5150.46
118_D177_E0.5150.46
176_S179_Q0.5120.46
19_A88_V0.5110.45
92_A101_H0.5100.45
22_D95_N0.5100.45
31_T164_T0.5100.45
113_G235_I0.5080.45
224_M241_L0.5060.45
168_Y197_Y0.5050.45
47_V76_L0.5050.45
209_Y217_T0.5050.45
220_M233_R0.5040.45
109_P149_P0.5030.44
233_R237_T0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3onpA 2 0.6126 100 0.353 Contact Map
4cndA 2 0.6561 100 0.354 Contact Map
3ilkA 2 0.9289 100 0.356 Contact Map
4cngA 2 0.6087 100 0.373 Contact Map
3ic6A 2 0.747 100 0.525 Contact Map
3ktyA 2 0.6522 100 0.577 Contact Map
3dcmX 2 0.6126 100 0.631 Contact Map
1zjrA 2 0.7352 100 0.638 Contact Map
1v2xA 2 0.7036 100 0.643 Contact Map
1x7oA 2 0.6482 100 0.649 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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