Q9HQ36 - HALSA - GREMLIN Contacts

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Q9HQ36 - Uncharacterized protein

UniProt:	Q9HQ36	Sequences: MTWTSTPTTRPAMSKPAVAIVDAETAGNVGTIARAMKNFGFEELLLVDPPYLGRDSEAYGFAGHAREDILPEARELSFDALVSEFHTVGFTAITNEDATSHTRFPFRTPAELGDSLRDVEAPTALVFGRERVGLTNDELARIDEVGSIPASDDYPVMNLGQSATVALYELRDLAMSETQLPDVERHRADEAEIEQFYEHASEFLDAVDYPAEKQAKTMRMLRRMLGRTHPTGREINTVHGLLRRAETQLPEDD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	253 (229)
Sequences:	1751 (1163)
Seq/√Len:	76.8

ECOLI - TRMJ LAST TRMH
HALSA - Q9HQ36
SULSO - Q7LXK8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
77_S	80_A	5.142	1.00
79_D	141_R	4.354	1.00
37_K	68_D	3.944	1.00
110_A	172_D	3.662	1.00
146_G	166_A	3.610	1.00
43_E	74_R	3.280	1.00
31_T	61_F	3.189	1.00
85_F	124_A	3.091	1.00
45_L	76_L	2.905	1.00
90_F	142_I	2.902	1.00
22_D	129_R	2.795	1.00
22_D	48_D	2.698	1.00
194_E	222_R	2.610	1.00
192_E	232_G	2.507	1.00
20_I	159_L	2.495	1.00
78_F	126_V	2.474	1.00
18_V	167_L	2.379	1.00
43_E	122_P	2.280	1.00
17_A	45_L	2.246	1.00
82_V	88_V	2.241	1.00
199_H	239_H	2.235	1.00
129_R	138_E	2.161	1.00
127_F	163_A	2.048	1.00
19_A	124_A	2.048	1.00
45_L	74_R	2.000	1.00
90_F	139_L	1.972	1.00
125_L	166_A	1.971	1.00
35_A	164_T	1.961	1.00
196_F	225_L	1.945	1.00
59_Y	71_P	1.916	1.00
17_A	43_E	1.888	1.00
192_E	195_Q	1.865	1.00
58_A	70_L	1.769	1.00
159_L	163_A	1.761	1.00
195_Q	239_H	1.759	1.00
18_V	36_M	1.751	1.00
197_Y	226_G	1.731	1.00
203_F	246_E	1.696	1.00
206_A	246_E	1.690	1.00
188_A	235_I	1.668	1.00
88_V	126_V	1.649	1.00
27_G	57_E	1.637	1.00
202_E	246_E	1.607	1.00
110_A	169_E	1.602	1.00
41_F	167_L	1.602	1.00
87_T	144_E	1.555	0.99
89_G	112_L	1.525	0.99
39_F	164_T	1.515	0.99
204_L	241_L	1.504	0.99
84_E	191_A	1.497	0.99
19_A	85_F	1.489	0.99
32_I	163_A	1.451	0.99
235_I	239_H	1.427	0.99
20_I	163_A	1.422	0.99
21_V	134_L	1.422	0.99
135_T	138_E	1.416	0.99
203_F	245_A	1.402	0.99
36_M	41_F	1.389	0.99
51_Y	55_D	1.375	0.99
189_D	192_E	1.350	0.98
196_F	235_I	1.338	0.98
207_V	244_R	1.324	0.98
48_D	77_S	1.315	0.98
78_F	82_V	1.314	0.98
24_E	131_R	1.314	0.98
67_E	71_P	1.312	0.98
47_V	81_L	1.308	0.98
126_V	142_I	1.307	0.98
207_V	245_A	1.302	0.98
26_A	55_D	1.289	0.98
203_F	242_L	1.283	0.98
143_D	190_E	1.263	0.97
171_R	175_M	1.259	0.97
196_F	200_A	1.257	0.97
115_S	144_E	1.256	0.97
127_F	159_L	1.246	0.97
107_R	144_E	1.219	0.97
88_V	190_E	1.214	0.97
224_M	230_P	1.209	0.97
86_H	121_A	1.191	0.96
37_K	65_A	1.188	0.96
45_L	84_E	1.165	0.96
29_V	52_L	1.162	0.96
18_V	125_L	1.154	0.96
186_H	232_G	1.139	0.95
221_L	241_L	1.136	0.95
46_L	49_P	1.135	0.95
92_A	145_V	1.128	0.95
59_Y	67_E	1.127	0.95
86_H	122_P	1.123	0.95
150_A	154_Y	1.118	0.95
82_V	85_F	1.118	0.95
93_I	100_S	1.117	0.95
205_D	214_Q	1.116	0.95
244_R	247_T	1.113	0.95
191_A	195_Q	1.110	0.95
132_V	135_T	1.106	0.94
61_F	161_Q	1.099	0.94
15_K	122_P	1.092	0.94
243_R	247_T	1.082	0.94
201_S	218_M	1.073	0.94
21_V	129_R	1.060	0.93
107_R	115_S	1.054	0.93
207_V	241_L	1.048	0.93
27_G	61_F	1.031	0.92
62_A	67_E	1.027	0.92
112_L	146_G	1.025	0.92
17_A	76_L	1.019	0.92
31_T	38_N	1.019	0.92
85_F	88_V	1.014	0.91
23_A	46_L	1.002	0.91
89_G	146_G	0.996	0.91
20_I	32_I	0.992	0.91
17_A	85_F	0.990	0.90
110_A	173_L	0.988	0.90
129_R	135_T	0.987	0.90
204_L	207_V	0.984	0.90
26_A	52_L	0.955	0.89
109_P	166_A	0.953	0.89
84_E	122_P	0.946	0.88
211_A	215_A	0.936	0.88
92_A	104_F	0.936	0.88
76_L	80_A	0.936	0.88
42_E	72_E	0.932	0.88
49_P	75_E	0.921	0.87
143_D	193_I	0.921	0.87
19_A	76_L	0.918	0.87
230_P	238_V	0.912	0.86
93_I	155_P	0.911	0.86
21_V	47_V	0.910	0.86
39_F	150_A	0.898	0.86
51_Y	54_R	0.897	0.86
230_P	235_I	0.875	0.84
89_G	144_E	0.874	0.84
115_S	118_D	0.873	0.84
30_G	34_R	0.871	0.84
210_P	213_K	0.868	0.84
232_G	236_N	0.860	0.83
26_A	54_R	0.850	0.82
224_M	238_V	0.849	0.82
157_M	164_T	0.842	0.82
195_Q	199_H	0.839	0.82
196_F	238_V	0.827	0.81
143_D	226_G	0.817	0.80
88_V	142_I	0.813	0.79
74_R	80_A	0.813	0.79
46_L	228_T	0.811	0.79
201_S	205_D	0.807	0.79
194_E	198_E	0.806	0.79
32_I	160_G	0.804	0.79
31_T	160_G	0.803	0.79
38_N	61_F	0.801	0.78
52_L	55_D	0.798	0.78
150_A	155_P	0.795	0.78
117_R	173_L	0.795	0.78
27_G	164_T	0.794	0.78
210_P	214_Q	0.792	0.78
228_T	234_E	0.789	0.77
81_L	84_E	0.787	0.77
25_T	61_F	0.785	0.77
17_A	122_P	0.783	0.77
195_Q	198_E	0.778	0.76
22_D	135_T	0.775	0.76
16_P	170_L	0.772	0.76
196_F	242_L	0.772	0.76
93_I	136_N	0.770	0.76
58_A	73_A	0.769	0.76
28_N	34_R	0.769	0.76
183_V	231_T	0.765	0.75
114_D	118_D	0.761	0.75
19_A	81_L	0.759	0.75
140_A	219_R	0.753	0.74
57_E	61_F	0.748	0.74
95_N	101_H	0.745	0.73
55_D	63_G	0.741	0.73
89_G	115_S	0.741	0.73
54_R	59_Y	0.739	0.73
111_E	114_D	0.736	0.72
29_V	32_I	0.733	0.72
137_D	140_A	0.730	0.72
18_V	41_F	0.730	0.72
197_Y	222_R	0.727	0.71
198_E	202_E	0.727	0.71
33_A	136_N	0.720	0.71
91_T	166_A	0.719	0.71
37_K	154_Y	0.718	0.70
37_K	42_E	0.718	0.70
106_F	145_V	0.712	0.70
210_P	215_A	0.708	0.69
38_N	164_T	0.704	0.69
185_R	231_T	0.702	0.69
116_L	125_L	0.701	0.69
24_E	156_V	0.698	0.68
78_F	141_R	0.697	0.68
46_L	75_E	0.696	0.68
189_D	193_I	0.695	0.68
21_V	85_F	0.694	0.68
41_F	160_G	0.694	0.68
70_L	73_A	0.691	0.68
64_H	151_S	0.689	0.67
100_S	103_R	0.689	0.67
110_A	114_D	0.689	0.67
37_K	151_S	0.685	0.67
83_S	191_A	0.679	0.66
141_R	194_E	0.675	0.66
223_R	231_T	0.675	0.66
39_F	171_R	0.674	0.66
33_A	70_L	0.669	0.65
37_K	69_I	0.669	0.65
52_L	59_Y	0.668	0.65
211_A	214_Q	0.668	0.65
26_A	59_Y	0.668	0.65
183_V	186_H	0.666	0.65
16_P	41_F	0.664	0.64
215_A	219_R	0.663	0.64
186_H	189_D	0.661	0.64
209_Y	237_T	0.660	0.64
109_P	168_Y	0.659	0.64
216_K	219_R	0.657	0.64
118_D	178_T	0.657	0.64
225_L	245_A	0.655	0.63
151_S	154_Y	0.650	0.63
94_T	157_M	0.649	0.63
76_L	84_E	0.649	0.63
219_R	226_G	0.648	0.63
114_D	176_S	0.646	0.62
39_F	157_M	0.643	0.62
213_K	237_T	0.642	0.62
132_V	231_T	0.642	0.62
26_A	29_V	0.641	0.62
92_A	215_A	0.636	0.61
35_A	39_F	0.635	0.61
143_D	222_R	0.629	0.60
169_E	172_D	0.628	0.60
180_L	183_V	0.627	0.60
33_A	58_A	0.626	0.60
123_T	198_E	0.624	0.60
154_Y	161_Q	0.624	0.60
56_S	60_G	0.622	0.59
59_Y	62_A	0.622	0.59
88_V	143_D	0.619	0.59
33_A	93_I	0.616	0.59
70_L	90_F	0.613	0.58
217_T	220_M	0.613	0.58
113_G	170_L	0.613	0.58
18_V	163_A	0.608	0.58
140_A	145_V	0.607	0.58
79_D	126_V	0.607	0.58
92_A	141_R	0.606	0.57
148_I	165_V	0.604	0.57
36_M	69_I	0.602	0.57
193_I	235_I	0.602	0.57
227_R	234_E	0.602	0.57
116_L	126_V	0.602	0.57
45_L	85_F	0.600	0.57
108_T	114_D	0.598	0.56
214_Q	218_M	0.598	0.56
150_A	157_M	0.596	0.56
92_A	139_L	0.595	0.56
72_E	119_V	0.594	0.56
17_A	74_R	0.590	0.55
35_A	65_A	0.589	0.55
80_A	137_D	0.589	0.55
242_L	245_A	0.588	0.55
44_L	148_I	0.588	0.55
32_I	167_L	0.585	0.55
29_V	58_A	0.582	0.54
36_M	168_Y	0.582	0.54
103_R	223_R	0.579	0.54
36_M	167_L	0.579	0.54
31_T	59_Y	0.578	0.54
56_S	59_Y	0.577	0.54
38_N	243_R	0.577	0.54
29_V	84_E	0.573	0.53
213_K	217_T	0.573	0.53
55_D	60_G	0.572	0.53
65_A	68_D	0.571	0.53
200_A	241_L	0.571	0.53
82_V	190_E	0.570	0.53
198_E	201_S	0.570	0.53
40_G	151_S	0.569	0.53
14_S	42_E	0.569	0.53
43_E	85_F	0.569	0.53
169_E	240_G	0.567	0.53
64_H	154_Y	0.567	0.53
190_E	226_G	0.566	0.52
60_G	63_G	0.566	0.52
175_M	178_T	0.562	0.52
205_D	211_A	0.560	0.52
151_S	165_V	0.560	0.52
120_E	198_E	0.560	0.52
131_R	135_T	0.551	0.51
234_E	239_H	0.551	0.51
91_T	168_Y	0.551	0.51
187_R	229_H	0.550	0.50
24_E	50_P	0.549	0.50
42_E	151_S	0.548	0.50
197_Y	218_M	0.548	0.50
110_A	176_S	0.547	0.50
117_R	174_A	0.546	0.50
64_H	100_S	0.546	0.50
112_L	116_L	0.546	0.50
205_D	208_D	0.545	0.50
139_L	147_S	0.544	0.50
150_A	171_R	0.542	0.49
25_T	31_T	0.542	0.49
90_F	157_M	0.541	0.49
104_F	145_V	0.536	0.49
156_V	159_L	0.536	0.49
31_T	161_Q	0.535	0.48
71_P	119_V	0.534	0.48
93_I	220_M	0.530	0.48
72_E	179_Q	0.530	0.48
113_G	173_L	0.530	0.48
113_G	117_R	0.528	0.48
21_V	137_D	0.528	0.48
38_N	150_A	0.528	0.48
224_M	228_T	0.525	0.47
86_H	123_T	0.525	0.47
94_T	156_V	0.525	0.47
21_V	138_E	0.525	0.47
225_L	230_P	0.525	0.47
156_V	217_T	0.524	0.47
24_E	159_L	0.522	0.47
82_V	126_V	0.522	0.47
42_E	153_D	0.521	0.47
244_R	248_Q	0.521	0.47
109_P	112_L	0.518	0.46
39_F	167_L	0.517	0.46
22_D	132_V	0.515	0.46
118_D	177_E	0.515	0.46
176_S	179_Q	0.512	0.46
19_A	88_V	0.511	0.45
92_A	101_H	0.510	0.45
22_D	95_N	0.510	0.45
31_T	164_T	0.510	0.45
113_G	235_I	0.508	0.45
224_M	241_L	0.506	0.45
168_Y	197_Y	0.505	0.45
47_V	76_L	0.505	0.45
209_Y	217_T	0.505	0.45
220_M	233_R	0.504	0.45
109_P	149_P	0.503	0.44
233_R	237_T	0.500	0.44

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3onpA	2	0.6126	100	0.353	Contact Map
4cndA	2	0.6561	100	0.354	Contact Map
3ilkA	2	0.9289	100	0.356	Contact Map
4cngA	2	0.6087	100	0.373	Contact Map
3ic6A	2	0.747	100	0.525	Contact Map
3ktyA	2	0.6522	100	0.577	Contact Map
3dcmX	2	0.6126	100	0.631	Contact Map
1zjrA	2	0.7352	100	0.638	Contact Map
1v2xA	2	0.7036	100	0.643	Contact Map
1x7oA	2	0.6482	100	0.649	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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