GREMLIN Database
Q9HQ34 - Uncharacterized protein
UniProt: Q9HQ34 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 313 (276)
Sequences: 39057 (28442)
Seq/√Len: 1712.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_G163_V3.4241.00
16_L244_V2.9211.00
103_I160_L2.8331.00
244_V248_R2.7301.00
269_A275_D2.6651.00
94_L162_L2.5241.00
52_G197_L2.4791.00
45_A204_W2.4791.00
135_G291_G2.4311.00
91_A165_L2.4111.00
30_A229_Y2.3251.00
244_V247_E2.2661.00
114_L167_A2.2371.00
126_V178_G2.1501.00
70_G73_E2.1421.00
91_A162_L2.0931.00
118_F175_V2.0871.00
32_K275_D2.0481.00
105_A265_A2.0281.00
17_F245_L2.0201.00
25_G264_G1.9671.00
120_S128_I1.9371.00
31_I93_Y1.9331.00
50_I231_T1.9251.00
87_I169_S1.8821.00
49_S200_S1.8551.00
56_L193_A1.8511.00
99_V160_L1.8301.00
115_T255_N1.7881.00
116_A136_L1.7861.00
221_P225_A1.7771.00
119_A126_V1.7721.00
161_L165_L1.7691.00
110_L114_L1.7461.00
231_T236_A1.7261.00
57_A60_A1.7051.00
201_L205_V1.6961.00
129_D132_Q1.6941.00
99_V159_G1.6921.00
25_G268_V1.6911.00
98_D158_G1.6691.00
250_G253_E1.6531.00
187_P190_T1.6521.00
91_A169_S1.6251.00
26_S229_Y1.5921.00
205_V208_A1.5921.00
52_G200_S1.5851.00
293_A297_H1.5801.00
114_L171_A1.5701.00
22_A264_G1.5641.00
139_G259_Y1.5551.00
73_E185_G1.5491.00
278_S281_A1.5291.00
135_G295_V1.4901.00
58_Y62_T1.4851.00
38_V223_A1.4651.00
104_A163_V1.4401.00
45_A200_S1.4351.00
119_A123_H1.4131.00
20_L245_L1.4121.00
56_L60_A1.4111.00
279_P283_A1.3941.00
114_L168_A1.3911.00
118_F122_L1.3871.00
142_G284_G1.3791.00
177_T243_F1.3601.00
53_L57_A1.3351.00
34_G43_F1.3341.00
75_V79_T1.3211.00
72_R76_L1.3141.00
99_V103_I1.3131.00
101_A269_A1.3111.00
57_A61_H1.3101.00
220_T223_A1.3061.00
145_I287_V1.2981.00
54_I236_A1.2961.00
98_D159_G1.2951.00
94_L98_D1.2931.00
24_W238_G1.2911.00
268_V272_L1.2871.00
51_A196_M1.2851.00
282_L286_A1.2841.00
23_I233_V1.2841.00
33_I226_S1.2831.00
94_L97_H1.2811.00
16_L241_L1.2781.00
264_G268_V1.2761.00
102_P266_S1.2731.00
139_G291_G1.2711.00
100_S103_I1.2701.00
130_G134_A1.2671.00
157_L160_L1.2501.00
286_A290_A1.2421.00
135_G294_L1.2301.00
145_I280_R1.2301.00
76_L176_L1.2301.00
133_A137_L1.2301.00
71_R75_V1.2221.00
131_T294_L1.2141.00
43_F230_L1.2131.00
79_T176_L1.2101.00
260_L264_G1.2101.00
37_D223_A1.2081.00
72_R75_V1.2081.00
137_L141_A1.2001.00
202_A205_V1.1961.00
277_V282_L1.1961.00
71_R74_W1.1911.00
222_T225_A1.1911.00
118_F172_L1.1871.00
29_V268_V1.1841.00
225_A229_Y1.1821.00
14_T257_V1.1821.00
157_L161_L1.1811.00
171_A175_V1.1771.00
98_D162_L1.1731.00
106_I285_F1.1711.00
178_G250_G1.1631.00
115_T251_A1.1521.00
146_V284_G1.1491.00
123_H175_V1.1451.00
32_K36_A1.1341.00
15_V19_L1.1321.00
39_P42_S1.1281.00
45_A49_S1.1231.00
41_L206_G1.1221.00
96_E104_A1.1201.00
221_P224_L1.1121.00
45_A207_A1.0961.00
86_G203_L1.0931.00
86_G202_A1.0931.00
78_A198_I1.0881.00
20_L24_W1.0681.00
158_G162_L1.0651.00
47_R235_G1.0651.00
30_A226_S1.0611.00
142_G288_I1.0601.00
82_L202_A1.0601.00
246_L254_I1.0591.00
20_L241_L1.0531.00
52_G193_A1.0521.00
26_S268_V1.0521.00
131_T298_R1.0471.00
120_S127_T1.0471.00
115_T174_G1.0451.00
128_I133_A1.0411.00
13_T245_L1.0411.00
99_V163_V1.0401.00
107_V167_A1.0381.00
19_L241_L1.0361.00
118_F171_A1.0361.00
98_D156_D1.0351.00
60_A64_D1.0321.00
44_A93_Y1.0301.00
84_V173_G1.0211.00
101_A273_F1.0181.00
224_L228_A1.0171.00
31_I96_E1.0161.00
130_G133_A1.0131.00
178_G251_A1.0131.00
116_A128_I1.0111.00
118_F168_A1.0081.00
24_W242_Y1.0031.00
23_I241_L0.9881.00
225_A228_A0.9881.00
121_K124_E0.9861.00
81_G198_I0.9861.00
179_K184_G0.9711.00
73_E186_L0.9671.00
158_G161_L0.9661.00
279_P282_L0.9611.00
138_A291_G0.9611.00
131_T297_H0.9601.00
92_L96_E0.9561.00
206_G210_R0.9561.00
29_V272_L0.9551.00
76_L180_L0.9541.00
216_A219_W0.9511.00
246_L250_G0.9501.00
41_L90_G0.9461.00
107_V160_L0.9461.00
148_N278_S0.9451.00
101_A275_D0.9431.00
126_V132_Q0.9401.00
34_G223_A0.9381.00
167_A171_A0.9241.00
110_L143_V0.9231.00
159_G163_V0.9231.00
34_G226_S0.9221.00
64_D187_P0.9171.00
40_A44_A0.9171.00
124_E127_T0.9151.00
129_D133_A0.9151.00
60_A63_T0.9151.00
107_V163_V0.9141.00
75_V78_A0.9141.00
250_G254_I0.9121.00
144_V148_N0.9101.00
42_S207_A0.9051.00
13_T248_R0.8991.00
228_A231_T0.8981.00
48_Y199_G0.8911.00
118_F121_K0.8901.00
49_S204_W0.8901.00
73_E76_L0.8891.00
205_V209_V0.8851.00
76_L80_V0.8821.00
83_F172_L0.8801.00
115_T171_A0.8691.00
106_I144_V0.8671.00
127_T131_T0.8661.00
54_I232_L0.8551.00
249_A254_I0.8441.00
21_A264_G0.8421.00
83_F169_S0.8401.00
21_A25_G0.8321.00
127_T130_G0.8311.00
120_S124_E0.8301.00
141_A145_I0.8291.00
206_G209_V0.8241.00
56_L197_L0.8241.00
90_G94_L0.8231.00
249_A253_E0.8131.00
245_L254_I0.8121.00
270_W277_V0.8041.00
208_A211_G0.8031.00
74_W198_I0.8031.00
29_V269_A0.8031.00
59_A63_T0.8021.00
143_V147_A0.7951.00
172_L176_L0.7941.00
263_I285_F0.7921.00
52_G56_L0.7901.00
260_L263_I0.7901.00
76_L179_K0.7891.00
193_A197_L0.7871.00
266_S277_V0.7871.00
141_A287_V0.7871.00
280_R283_A0.7851.00
197_L201_L0.7821.00
44_A203_L0.7761.00
163_V167_A0.7761.00
123_H126_V0.7751.00
156_D160_L0.7721.00
285_F289_F0.7691.00
170_F174_G0.7671.00
142_G291_G0.7651.00
86_G90_G0.7641.00
198_I201_L0.7591.00
222_T226_S0.7581.00
283_A287_V0.7571.00
113_I139_G0.7561.00
233_V237_G0.7561.00
266_S285_F0.7561.00
198_I202_A0.7531.00
18_L264_G0.7501.00
117_G121_K0.7491.00
79_T82_L0.7471.00
145_I283_A0.7471.00
17_F257_V0.7461.00
228_A232_L0.7441.00
81_G86_G0.7431.00
70_G74_W0.7431.00
61_H64_D0.7431.00
227_L231_T0.7421.00
62_T187_P0.7411.00
134_A138_A0.7391.00
37_D220_T0.7391.00
54_I57_A0.7371.00
154_S157_L0.7361.00
74_W78_A0.7351.00
116_A132_Q0.7331.00
186_L191_M0.7291.00
290_A294_L0.7291.00
270_W276_V0.7241.00
88_Y169_S0.7231.00
46_I50_I0.7221.00
114_L164_F0.7211.00
194_W198_I0.7211.00
87_I91_A0.7161.00
58_Y189_E0.7151.00
226_S229_Y0.7091.00
80_V84_V0.7081.00
115_T175_V0.7031.00
76_L79_T0.7031.00
209_V212_E0.7021.00
59_A193_A0.7011.00
31_I35_I0.7001.00
107_V164_F0.6971.00
21_A260_L0.6971.00
29_V101_A0.6961.00
110_L113_I0.6941.00
277_V281_A0.6911.00
128_I132_Q0.6871.00
88_Y173_G0.6861.00
17_F249_A0.6841.00
237_G241_L0.6841.00
291_G295_V0.6821.00
55_V236_A0.6801.00
14_T253_E0.6741.00
223_A226_S0.6721.00
33_I273_F0.6691.00
42_S46_I0.6681.00
197_L200_S0.6641.00
83_F176_L0.6621.00
54_I231_T0.6621.00
77_A186_L0.6601.00
49_S53_L0.6601.00
28_F92_L0.6571.00
181_P184_G0.6561.00
23_I238_G0.6541.00
269_A273_F0.6421.00
81_G84_V0.6401.00
78_A82_L0.6371.00
92_L104_A0.6371.00
99_V104_A0.6351.00
200_S204_W0.6311.00
95_G104_A0.6301.00
190_T194_W0.6291.00
38_V43_F0.6271.00
229_Y233_V0.6271.00
192_E243_F0.6251.00
109_S143_V0.6251.00
170_F242_Y0.6241.00
50_I54_I0.6231.00
199_G203_L0.6191.00
126_V252_T0.6191.00
240_L244_V0.6181.00
138_A294_L0.6181.00
256_L295_V0.6171.00
58_Y61_H0.6161.00
51_A236_A0.6161.00
27_S234_C0.6161.00
112_P259_Y0.6151.00
276_V280_R0.6141.00
19_L23_I0.6131.00
266_S270_W0.6131.00
13_T249_A0.6111.00
194_W197_L0.6081.00
213_N216_A0.6061.00
281_A285_F0.6051.00
92_L166_A0.6041.00
201_L204_W0.6031.00
95_G159_G0.6021.00
28_F105_A0.6001.00
207_A211_G0.5971.00
192_E195_A0.5971.00
220_T224_L0.5961.00
116_A120_S0.5951.00
91_A166_A0.5951.00
35_I96_E0.5951.00
162_L165_L0.5941.00
74_W194_W0.5921.00
110_L167_A0.5821.00
78_A81_G0.5791.00
155_V158_G0.5761.00
267_V271_A0.5741.00
23_I234_C0.5701.00
147_A160_L0.5701.00
174_G242_Y0.5691.00
109_S112_P0.5681.00
219_W224_L0.5681.00
132_Q250_G0.5681.00
86_G206_G0.5661.00
68_P71_R0.5621.00
122_L172_L0.5601.00
268_V271_A0.5601.00
123_H178_G0.5601.00
93_Y97_H0.5581.00
62_T189_E0.5561.00
259_Y292_F0.5541.00
186_L190_T0.5541.00
188_V192_E0.5531.00
74_W77_A0.5521.00
70_G75_V0.5511.00
106_I147_A0.5511.00
59_A190_T0.5461.00
278_S282_L0.5461.00
21_A261_E0.5461.00
38_V42_S0.5451.00
109_S167_A0.5401.00
179_K185_G0.5381.00
106_I146_V0.5361.00
53_L56_L0.5361.00
78_A202_A0.5361.00
46_I227_L0.5361.00
88_Y92_L0.5341.00
204_W208_A0.5341.00
14_T18_L0.5331.00
110_L139_G0.5321.00
119_A252_T0.5301.00
57_A62_T0.5301.00
117_G136_L0.5291.00
258_S261_E0.5281.00
68_P73_E0.5261.00
41_L210_R0.5251.00
173_G243_F0.5241.00
270_W282_L0.5231.00
271_A274_G0.5221.00
129_D298_R0.5201.00
67_R70_G0.5181.00
77_A81_G0.5181.00
18_L21_A0.5171.00
95_G99_V0.5161.00
289_F293_A0.5151.00
292_F295_V0.5151.00
17_F242_Y0.5111.00
59_A62_T0.5111.00
174_G255_N0.5091.00
67_R71_R0.5071.00
267_V270_W0.5071.00
39_P211_G0.5051.00
217_V220_T0.5041.00
105_A109_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.246 98.8 0.762 Contact Map
3b5dA 2 0.3227 98.1 0.806 Contact Map
4he8J 1 0.492 66.9 0.914 Contact Map
1pw4A 1 0.8562 59.6 0.917 Contact Map
4j05A 3 0.9329 52.9 0.921 Contact Map
4pypA 1 0.9042 41.6 0.926 Contact Map
3wdoA 1 0.9265 38.7 0.927 Contact Map
4tphA 2 0.8754 36.1 0.928 Contact Map
2cfqA 1 0.9457 35.6 0.928 Contact Map
1u7gA 3 0.7827 26.6 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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