GREMLIN Database
Q9HQ33 - Transcription regulator
UniProt: Q9HQ33 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (140)
Sequences: 13437 (8852)
Seq/√Len: 748.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_R50_D2.9161.00
11_A26_E2.9151.00
70_L129_R2.5071.00
92_Q105_V2.5061.00
99_E131_N2.4941.00
109_P113_D2.2601.00
20_P38_L2.2581.00
57_D112_D2.1051.00
48_T55_N2.0441.00
11_A18_G2.0311.00
40_N44_D2.0031.00
5_D37_R1.8991.00
72_S128_D1.8911.00
87_V120_D1.8901.00
64_T105_V1.8581.00
91_T107_R1.7971.00
48_T53_D1.7861.00
18_G26_E1.7711.00
66_V94_F1.7561.00
4_R29_I1.6941.00
87_V117_L1.6811.00
29_I33_T1.6721.00
68_E133_T1.6661.00
39_N43_D1.6431.00
11_A14_D1.6411.00
83_E124_L1.6291.00
21_E25_E1.5721.00
110_G113_D1.5721.00
22_A25_E1.5341.00
80_V84_I1.4761.00
21_E31_V1.4721.00
113_D116_R1.4671.00
29_I34_I1.4541.00
89_G113_D1.4511.00
30_P33_T1.4381.00
8_I23_L1.4171.00
27_T34_I1.4161.00
83_E86_A1.4081.00
20_P35_H1.3831.00
69_V104_V1.3741.00
81_A85_S1.3631.00
17_T50_D1.3521.00
68_E100_T1.3491.00
67_L106_A1.3371.00
3_D7_T1.3331.00
138_R141_D1.3251.00
22_A26_E1.3031.00
70_L99_E1.2951.00
116_R119_S1.2841.00
12_I38_L1.2801.00
61_L109_P1.2581.00
89_G120_D1.2551.00
18_G23_L1.2501.00
63_V111_S1.2451.00
70_L128_D1.2191.00
78_E82_D1.2171.00
81_A137_D1.2011.00
18_G22_A1.1911.00
39_N42_R1.1851.00
4_R7_T1.1801.00
15_L26_E1.1791.00
76_G79_D1.1701.00
19_S22_A1.1631.00
115_E137_D1.1431.00
14_D26_E1.1421.00
11_A23_L1.1171.00
71_T80_V1.1081.00
68_E131_N1.1041.00
49_N53_D1.1011.00
4_R27_T1.0961.00
15_L18_G1.0541.00
7_T11_A1.0481.00
64_T107_R1.0321.00
7_T10_K1.0301.00
90_V106_A1.0281.00
108_L114_V1.0061.00
2_D37_R1.0001.00
81_A102_F0.9931.00
16_G50_D0.9911.00
17_T42_R0.9871.00
20_P24_Q0.9851.00
79_D83_E0.9831.00
93_T104_V0.9831.00
7_T27_T0.9751.00
66_V103_V0.9701.00
96_T103_V0.9611.00
108_L113_D0.9601.00
24_Q34_I0.9491.00
94_F105_V0.9421.00
106_A117_L0.9401.00
35_H39_N0.9301.00
10_K14_D0.9251.00
108_L117_L0.9141.00
20_P31_V0.9091.00
99_E129_R0.9081.00
82_D85_S0.9051.00
55_N58_S0.9021.00
62_D110_G0.8981.00
66_V105_V0.8941.00
31_V35_H0.8881.00
24_Q29_I0.8831.00
82_D86_A0.8511.00
41_L46_V0.8471.00
1_M6_I0.8391.00
94_F135_V0.8391.00
16_G52_Y0.8211.00
56_P107_R0.8131.00
90_V93_T0.8081.00
84_I93_T0.8071.00
66_V135_V0.8061.00
90_V104_V0.7941.00
21_E35_H0.7901.00
5_D40_N0.7891.00
32_S36_Y0.7841.00
77_Y102_F0.7771.00
83_E87_V0.7741.00
68_E103_V0.7731.00
94_F138_R0.7721.00
118_I132_S0.7711.00
122_E130_T0.7641.00
23_L38_L0.7601.00
100_T131_N0.7491.00
69_V80_V0.7471.00
6_I10_K0.7441.00
97_M134_F0.7431.00
23_L34_I0.7381.00
72_S126_P0.7341.00
76_G123_A0.7331.00
81_A139_H0.7331.00
68_E99_E0.7291.00
79_D82_D0.7271.00
78_E81_A0.7261.00
116_R120_D0.7251.00
36_Y40_N0.7071.00
8_I34_I0.7021.00
8_I37_R0.6981.00
61_L107_R0.6931.00
46_V58_S0.6921.00
65_V114_V0.6791.00
70_L100_T0.6781.00
84_I104_V0.6781.00
89_G109_P0.6671.00
111_S134_F0.6641.00
95_F102_F0.6561.00
3_D6_I0.6561.00
24_Q31_V0.6551.00
11_A15_L0.6511.00
8_I11_A0.6501.00
67_L130_T0.6501.00
89_G117_L0.6431.00
87_V124_L0.6411.00
79_D125_D0.6401.00
112_D115_E0.6391.00
61_L89_G0.6381.00
65_V134_F0.6381.00
8_I38_L0.6361.00
64_T138_R0.6361.00
80_V102_F0.6221.00
79_D126_P0.6201.00
32_S35_H0.6201.00
96_T100_T0.6161.00
112_D116_R0.6151.00
5_D41_L0.6151.00
9_L41_L0.6151.00
14_D18_G0.6131.00
72_S75_G0.6121.00
118_I130_T0.6121.00
55_N59_I0.6111.00
120_D124_L0.6101.00
8_I18_G0.6071.00
37_R41_L0.6051.00
64_T135_V0.6041.00
16_G49_N0.6021.00
67_L104_V0.5991.00
20_P34_I0.5991.00
54_I59_I0.5981.00
70_L131_N0.5951.00
113_D117_L0.5951.00
83_E125_D0.5801.00
111_S136_I0.5781.00
117_L121_F0.5751.00
36_Y39_N0.5751.00
117_L120_D0.5731.00
78_E123_A0.5731.00
45_G48_T0.5721.00
2_D5_D0.5611.00
96_T135_V0.5591.00
47_I50_D0.5581.00
1_M46_V0.5521.00
95_F122_E0.5461.00
65_V132_S0.5441.00
92_Q141_D0.5441.00
8_I41_L0.5421.00
69_V127_V0.5411.00
64_T94_F0.5381.00
21_E24_Q0.5381.00
69_V130_T0.5311.00
114_V134_F0.5291.00
96_T133_T0.5281.00
10_K13_A0.5221.00
4_R33_T0.5191.00
15_L22_A0.5141.00
97_M136_I0.5111.00
95_F136_I0.5111.00
40_N43_D0.5091.00
13_A51_L0.5091.00
93_T139_H0.5071.00
71_T101_D0.5061.00
122_E129_R0.5061.00
53_D56_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.9503 100 0.158 Contact Map
4un1B 1 0.913 100 0.215 Contact Map
4un1A 1 0.8758 100 0.222 Contact Map
2e1cA 1 0.9068 100 0.232 Contact Map
4pcqA 2 0.8944 100 0.242 Contact Map
2p5vA 5 0.9379 100 0.245 Contact Map
2ia0A 2 0.913 100 0.254 Contact Map
2cg4A 6 0.9068 100 0.264 Contact Map
2pn6A 5 0.913 100 0.27 Contact Map
3i4pA 5 0.9317 100 0.275 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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