GREMLIN Database
Q9HQ31 - Uncharacterized protein
UniProt: Q9HQ31 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 514 (457)
Sequences: 1016 (857)
Seq/√Len: 40.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_A134_D6.9751.00
367_R478_D5.9111.00
62_R81_R4.8761.00
58_A78_V4.8461.00
127_V131_A4.3171.00
92_Q291_Q4.0041.00
74_I122_A3.9011.00
72_L112_V3.8901.00
40_V44_G3.6951.00
451_Q478_D3.5771.00
201_L301_M3.5771.00
480_D483_D3.5581.00
361_Q365_V3.5451.00
297_D430_R3.5441.00
75_A83_E3.3581.00
96_V108_A3.0861.00
194_D337_A3.0371.00
295_V307_A3.0241.00
257_V278_F2.9821.00
189_A263_R2.8831.00
457_T484_A2.7691.00
108_A129_R2.7671.00
207_L210_G2.7561.00
302_R426_G2.7561.00
116_G441_Q2.7531.00
266_R287_L2.6971.00
264_L273_Y2.6001.00
421_V461_I2.5591.00
210_G213_A2.4731.00
99_S102_A2.4331.00
451_Q458_S2.3621.00
314_A441_Q2.3531.00
86_I122_A2.2941.00
361_Q406_R2.2901.00
295_V338_V2.2811.00
302_R430_R2.2711.00
55_Y78_V2.2431.00
483_D486_A2.2181.00
458_S478_D2.1660.99
395_A399_P2.1570.99
102_A126_F2.1510.99
114_T195_L2.1450.99
115_A441_Q2.1230.99
291_Q441_Q2.1000.99
274_E280_R2.0860.99
43_L236_L2.0750.99
407_R427_W2.0740.99
68_T73_D2.0600.99
357_P432_T2.0370.99
77_G331_P2.0150.99
291_Q464_A1.9970.99
375_V385_L1.9960.99
88_L139_V1.9540.99
330_V341_L1.9360.99
264_L271_L1.9220.99
115_A290_L1.9180.99
92_Q115_A1.8940.98
297_D432_T1.8930.98
233_M237_V1.8930.98
76_S82_R1.8680.98
294_S431_K1.8620.98
209_S213_A1.8530.98
84_R262_F1.7870.98
424_Q432_T1.7630.97
246_G374_G1.7440.97
424_Q430_R1.7160.97
2_K195_L1.7150.97
71_S85_E1.7150.97
105_L484_A1.6900.97
479_R484_A1.6890.97
92_Q439_R1.6690.96
248_W426_G1.6540.96
64_D254_V1.6490.96
86_I114_T1.6420.96
133_A136_Q1.6330.96
16_A396_V1.6260.96
294_S433_T1.6180.96
359_R456_L1.5970.95
247_V351_I1.5680.95
200_L465_G1.5580.95
100_L278_F1.5500.95
65_Y131_A1.5440.94
74_I86_I1.5320.94
365_V405_A1.5310.94
306_F333_A1.5170.94
387_V390_P1.5160.94
63_F74_I1.5120.94
374_G378_A1.5060.94
363_R478_D1.4900.93
2_K5_P1.4890.93
141_T238_A1.4810.93
92_Q441_Q1.4760.93
455_A486_A1.4720.93
62_R78_V1.4710.93
115_A291_Q1.4550.92
297_D335_R1.4500.92
58_A218_A1.4460.92
36_A47_V1.4440.92
112_V139_V1.4390.92
87_P103_R1.4030.91
209_S290_L1.4010.91
136_Q140_R1.3980.91
292_T312_E1.3880.91
3_L91_V1.3880.91
238_A249_L1.3870.91
195_L345_I1.3850.90
457_T481_G1.3720.90
59_Y62_R1.3720.90
298_S332_I1.3660.90
96_V110_V1.3630.90
361_Q409_H1.3630.90
234_V238_A1.3610.90
52_V242_A1.3580.90
402_V440_V1.3500.89
94_V132_A1.3450.89
253_A295_V1.3410.89
95_D316_Y1.3380.89
127_V134_D1.3370.89
291_Q439_R1.3280.89
363_R464_A1.3160.88
98_R108_A1.3140.88
65_Y315_G1.2940.87
483_D487_L1.2920.87
440_V461_I1.2890.87
115_A314_A1.2840.87
272_R284_T1.2770.86
298_S302_R1.2690.86
104_L405_A1.2590.86
309_L314_A1.2580.86
98_R291_Q1.2490.85
66_E73_D1.2450.85
115_A121_E1.2300.84
186_L304_Y1.2260.84
111_D123_S1.2160.84
293_V309_L1.2140.84
23_F241_V1.2100.83
193_R252_A1.2080.83
24_L180_V1.2070.83
96_V132_A1.2030.83
362_D366_R1.2020.83
92_Q113_E1.1890.82
300_L304_Y1.1840.82
178_T218_A1.1840.82
92_Q356_P1.1830.82
50_V380_A1.1800.82
131_A216_T1.1790.82
135_L280_R1.1750.81
56_E59_Y1.1740.81
357_P480_D1.1670.81
86_I121_E1.1580.81
423_T476_A1.1580.81
27_G396_V1.1530.80
73_D83_E1.1510.80
196_L199_G1.1460.80
128_S309_L1.1450.80
375_V379_G1.1440.80
455_A481_G1.1420.80
63_F92_Q1.1390.79
37_L440_V1.1380.79
23_F27_G1.1380.79
92_Q114_T1.1350.79
220_P235_V1.1340.79
116_G126_F1.1330.79
112_V225_R1.1250.79
148_D400_L1.1200.78
20_G91_V1.1150.78
423_T453_R1.1140.78
41_A233_M1.1120.78
209_S217_V1.1080.77
271_L330_V1.1050.77
294_S442_T1.1040.77
101_V104_L1.1020.77
364_Y368_Y1.1010.77
198_Y301_M1.0980.77
39_G43_L1.0950.77
262_F331_P1.0830.76
73_D84_R1.0810.76
22_A56_E1.0760.75
271_L329_A1.0730.75
65_Y132_A1.0730.75
36_A42_V1.0730.75
364_Y412_R1.0720.75
405_A439_R1.0720.75
443_V491_V1.0670.75
222_L268_G1.0580.74
21_W24_L1.0580.74
275_R279_E1.0550.74
296_E310_A1.0480.73
237_V242_A1.0430.73
295_V480_D1.0410.73
82_R228_V1.0410.73
47_V51_A1.0360.73
199_G255_R1.0330.72
462_D466_S1.0300.72
104_L212_I1.0230.72
297_D360_A1.0230.72
134_D138_D1.0220.71
128_S131_A1.0220.71
249_L253_A1.0140.71
386_V428_W1.0120.71
92_Q289_K1.0100.71
23_F482_G1.0050.70
8_V12_A1.0010.70
99_S332_I1.0000.70
340_E344_E1.0000.70
264_L363_R0.9960.70
3_L63_F0.9950.69
212_I219_A0.9920.69
185_E211_I0.9920.69
194_D306_F0.9910.69
285_I314_A0.9870.69
109_V450_F0.9870.69
315_G478_D0.9850.69
308_S476_A0.9840.69
65_Y84_R0.9830.68
86_I126_F0.9820.68
184_G440_V0.9720.68
487_L491_V0.9700.67
64_D75_A0.9700.67
78_V303_R0.9600.67
21_W25_I0.9600.67
100_L279_E0.9590.67
193_R463_T0.9570.66
68_T396_V0.9560.66
7_S12_A0.9550.66
31_S72_L0.9540.66
402_V452_R0.9530.66
212_I486_A0.9520.66
271_L368_Y0.9510.66
297_D436_P0.9500.66
362_D454_W0.9470.66
129_R370_L0.9470.66
34_N373_L0.9410.65
267_V272_R0.9370.65
132_A426_G0.9350.65
243_L365_V0.9350.65
121_E441_Q0.9330.64
345_I387_V0.9330.64
271_L287_L0.9330.64
263_R274_E0.9320.64
307_A335_R0.9310.64
315_G451_Q0.9300.64
54_A375_V0.9280.64
43_L47_V0.9250.64
453_R456_L0.9210.63
107_L198_Y0.9180.63
44_G455_A0.9160.63
437_A490_D0.9150.63
193_R355_R0.9120.63
308_S328_A0.9070.62
51_A377_A0.9050.62
260_Y277_L0.9030.62
198_Y332_I0.9000.62
459_V487_L0.8990.61
399_P403_P0.8990.61
285_I447_Q0.8990.61
359_R398_V0.8950.61
181_G240_A0.8930.61
274_E279_E0.8900.61
149_A212_I0.8870.60
297_D307_A0.8860.60
270_D284_T0.8860.60
70_D134_D0.8830.60
260_Y278_F0.8810.60
145_T148_D0.8800.60
269_G288_S0.8730.59
357_P360_A0.8730.59
182_E417_D0.8710.59
463_T484_A0.8690.59
50_V241_V0.8660.59
115_A464_A0.8630.58
215_A365_V0.8610.58
219_A258_Q0.8600.58
79_F185_E0.8560.58
236_L240_A0.8550.58
190_L264_L0.8550.58
366_R369_A0.8550.58
365_V369_A0.8470.57
149_A336_A0.8470.57
373_L376_V0.8450.57
60_Y405_A0.8440.57
186_L263_R0.8430.57
139_V448_T0.8430.57
411_T426_G0.8420.56
141_T191_S0.8420.56
44_G48_A0.8380.56
50_V54_A0.8380.56
337_A340_E0.8380.56
63_F122_A0.8360.56
373_L377_A0.8340.56
148_D355_R0.8340.56
76_S218_A0.8300.55
117_G122_A0.8250.55
83_E273_Y0.8240.55
480_D484_A0.8230.55
407_R411_T0.8220.55
81_R105_L0.8210.55
306_F334_P0.8190.54
8_V110_V0.8180.54
111_D450_F0.8180.54
109_V125_R0.8170.54
46_M376_V0.8150.54
423_T474_A0.8150.54
222_L241_V0.8130.54
186_L189_A0.8120.54
361_Q366_R0.8090.53
388_S391_W0.8090.53
243_L304_Y0.8080.53
24_L211_I0.8070.53
203_F206_R0.8070.53
376_V391_W0.8050.53
122_A312_E0.8040.53
202_S313_T0.8040.53
16_A22_A0.8020.53
413_G424_Q0.8020.53
65_Y107_L0.8010.53
194_D414_V0.8000.53
123_S210_G0.7990.52
14_S416_S0.7980.52
107_L126_F0.7970.52
50_V399_P0.7960.52
96_V279_E0.7940.52
69_E193_R0.7930.52
65_Y331_P0.7890.52
299_V303_R0.7890.52
187_L284_T0.7880.51
246_G278_F0.7840.51
110_V427_W0.7820.51
249_L434_V0.7800.51
126_F306_F0.7800.51
290_L488_A0.7790.51
28_A57_I0.7790.51
135_L225_R0.7770.50
112_V435_V0.7770.50
365_V394_L0.7760.50
332_I439_R0.7760.50
307_A338_V0.7750.50
67_L345_I0.7730.50
53_V379_G0.7710.50
107_L448_T0.7670.50
300_L342_A0.7660.49
102_A198_Y0.7660.49
54_A183_R0.7650.49
135_L292_T0.7640.49
273_Y329_A0.7630.49
20_G370_L0.7610.49
19_F300_L0.7610.49
93_N103_R0.7610.49
239_G379_G0.7580.49
38_T268_G0.7570.49
30_L81_R0.7560.49
365_V447_Q0.7550.48
198_Y255_R0.7530.48
93_N113_E0.7520.48
215_A402_V0.7520.48
185_E344_E0.7520.48
70_D75_A0.7510.48
49_V380_A0.7490.48
44_G479_R0.7490.48
239_G243_L0.7480.48
104_L448_T0.7470.48
284_T413_G0.7460.48
369_A401_A0.7450.48
113_E299_V0.7440.47
259_F328_A0.7440.47
295_V434_V0.7430.47
54_A249_L0.7420.47
279_E329_A0.7420.47
100_L141_T0.7390.47
357_P363_R0.7330.46
421_V476_A0.7330.46
358_E361_Q0.7330.46
118_G261_G0.7290.46
40_V396_V0.7290.46
122_A441_Q0.7290.46
25_I278_F0.7280.46
67_L479_R0.7250.46
146_P242_A0.7250.46
342_A440_V0.7240.46
184_G418_S0.7230.46
58_A103_R0.7190.45
240_A396_V0.7180.45
98_R129_R0.7180.45
37_L249_L0.7180.45
449_V453_R0.7180.45
147_G481_G0.7170.45
404_A427_W0.7150.45
488_A493_D0.7150.45
58_A79_F0.7140.45
268_G300_L0.7130.45
237_V340_E0.7130.45
366_R454_W0.7130.45
105_L396_V0.7130.45
115_A313_T0.7110.44
290_L377_A0.7110.44
435_V461_I0.7110.44
212_I493_D0.7100.44
423_T461_I0.7090.44
395_A398_V0.7080.44
85_E272_R0.7060.44
295_V346_E0.7060.44
51_A54_A0.7060.44
198_Y260_Y0.7060.44
91_V477_I0.7050.44
140_R188_F0.7030.44
305_G335_R0.7030.44
289_K413_G0.7020.44
297_D302_R0.7020.44
273_Y283_G0.7020.44
225_R379_G0.7010.44
237_V422_V0.6970.43
299_V407_R0.6960.43
147_G243_L0.6960.43
89_R260_Y0.6950.43
200_L248_W0.6940.43
67_L72_L0.6930.43
301_M304_Y0.6930.43
93_N283_G0.6930.43
3_L124_L0.6930.43
102_A306_F0.6910.43
360_A451_Q0.6890.42
107_L404_A0.6890.42
386_V396_V0.6890.42
106_G461_I0.6880.42
237_V278_F0.6870.42
2_K66_E0.6840.42
65_Y307_A0.6840.42
295_V337_A0.6830.42
314_A330_V0.6820.42
46_M184_G0.6810.42
92_Q464_A0.6800.42
198_Y262_F0.6780.41
48_A127_V0.6780.41
68_T142_R0.6770.41
292_T462_D0.6770.41
191_S194_D0.6770.41
119_S330_V0.6760.41
278_F395_A0.6750.41
189_A489_D0.6750.41
302_R411_T0.6750.41
193_R357_P0.6750.41
246_G377_A0.6740.41
64_D420_H0.6740.41
22_A25_I0.6710.41
40_V56_E0.6710.41
110_V311_V0.6700.41
49_V61_R0.6700.41
264_L348_V0.6660.40
254_V257_V0.6660.40
106_G357_P0.6650.40
251_S301_M0.6650.40
60_Y342_A0.6640.40
92_Q436_P0.6600.40
18_G209_S0.6570.40
198_Y308_S0.6570.40
82_R421_V0.6560.40
150_A181_G0.6560.40
29_A323_S0.6560.40
261_G275_R0.6540.39
32_G79_F0.6460.39
104_L137_A0.6460.39
291_Q314_A0.6450.39
184_G265_R0.6450.39
120_T131_A0.6430.38
466_S493_D0.6410.38
96_V136_Q0.6400.38
26_G105_L0.6400.38
142_R489_D0.6390.38
150_A455_A0.6380.38
183_R390_P0.6380.38
278_F350_D0.6370.38
314_A442_T0.6360.38
236_L303_R0.6360.38
359_R362_D0.6340.38
81_R218_A0.6340.38
211_I290_L0.6340.38
385_L403_P0.6330.38
58_A386_V0.6330.38
79_F305_G0.6320.37
7_S21_W0.6310.37
112_V488_A0.6290.37
41_A76_S0.6290.37
98_R478_D0.6270.37
26_G239_G0.6270.37
121_E463_T0.6240.37
197_L465_G0.6230.37
194_D291_Q0.6220.37
44_G47_V0.6210.36
106_G350_D0.6200.36
195_L256_V0.6190.36
146_P249_L0.6170.36
74_I201_L0.6170.36
203_F301_M0.6160.36
18_G428_W0.6160.36
264_L330_V0.6160.36
8_V19_F0.6150.36
63_F441_Q0.6150.36
297_D426_G0.6130.36
7_S11_R0.6110.36
446_K460_V0.6110.36
52_V296_E0.6110.36
16_A373_L0.6100.36
202_S205_P0.6100.36
291_Q466_S0.6090.35
267_V421_V0.6090.35
217_V220_P0.6080.35
24_L106_G0.6080.35
205_P459_V0.6080.35
69_E218_A0.6070.35
63_F314_A0.6070.35
215_A218_A0.6050.35
274_E435_V0.6050.35
447_Q481_G0.6050.35
418_S486_A0.6050.35
95_D456_L0.6050.35
347_P490_D0.6040.35
81_R384_R0.6040.35
93_N312_E0.6030.35
126_F281_R0.6030.35
14_S18_G0.6020.35
130_E445_R0.6020.35
399_P420_H0.6020.35
8_V25_I0.6010.35
241_V489_D0.6010.35
308_S332_I0.6000.35
208_F394_L0.6000.35
289_K433_T0.5990.35
267_V270_D0.5980.35
356_P360_A0.5980.35
102_A107_L0.5970.34
15_R87_P0.5970.34
130_E309_L0.5970.34
103_R274_E0.5970.34
187_L196_L0.5960.34
89_R406_R0.5960.34
259_F478_D0.5950.34
40_V191_S0.5940.34
363_R450_F0.5930.34
194_D413_G0.5930.34
94_V264_L0.5920.34
374_G384_R0.5910.34
245_L390_P0.5890.34
57_I290_L0.5890.34
113_E117_G0.5890.34
150_A179_P0.5890.34
108_A132_A0.5890.34
113_E291_Q0.5890.34
86_I429_R0.5880.34
216_T222_L0.5870.34
65_Y92_Q0.5870.34
458_S477_I0.5870.34
212_I241_V0.5850.33
306_F338_V0.5850.33
194_D363_R0.5850.33
90_R115_A0.5830.33
253_A344_E0.5820.33
22_A214_V0.5810.33
65_Y437_A0.5800.33
122_A483_D0.5760.33
24_L369_A0.5750.33
96_V102_A0.5730.33
68_T123_S0.5720.32
316_Y439_R0.5710.32
240_A374_G0.5710.32
57_I112_V0.5700.32
95_D281_R0.5700.32
82_R93_N0.5690.32
290_L311_V0.5690.32
242_A354_S0.5690.32
104_L236_L0.5680.32
65_Y90_R0.5680.32
84_R107_L0.5680.32
188_F291_Q0.5680.32
5_P9_P0.5680.32
273_Y463_T0.5680.32
72_L209_S0.5670.32
243_L406_R0.5670.32
371_A375_V0.5670.32
62_R132_A0.5670.32
103_R331_P0.5660.32
101_V127_V0.5660.32
218_A221_S0.5660.32
208_F211_I0.5660.32
60_Y85_E0.5620.32
12_A16_A0.5620.32
113_E314_A0.5610.32
368_Y405_A0.5610.32
183_R218_A0.5610.32
60_Y110_V0.5600.31
103_R315_G0.5600.31
223_G463_T0.5600.31
342_A434_V0.5600.31
353_L360_A0.5590.31
91_V119_S0.5590.31
71_S255_R0.5580.31
275_R281_R0.5580.31
195_L296_E0.5570.31
214_V489_D0.5560.31
230_D238_A0.5550.31
183_R379_G0.5550.31
357_P456_L0.5550.31
218_A226_M0.5550.31
146_P377_A0.5550.31
379_G387_V0.5540.31
58_A62_R0.5540.31
78_V399_P0.5530.31
88_L194_D0.5530.31
215_A245_L0.5520.31
65_Y77_G0.5520.31
24_L222_L0.5520.31
445_R485_D0.5510.31
38_T44_G0.5510.31
241_V460_V0.5500.31
23_F30_L0.5490.31
60_Y121_E0.5490.31
205_P210_G0.5480.31
184_G374_G0.5450.30
369_A444_L0.5430.30
133_A357_P0.5420.30
450_F453_R0.5400.30
292_T493_D0.5390.30
101_V297_D0.5390.30
208_F215_A0.5390.30
28_A91_V0.5390.30
27_G144_T0.5390.30
240_A380_A0.5380.30
63_F113_E0.5370.30
204_N258_Q0.5360.30
77_G115_A0.5350.30
193_R334_P0.5350.30
93_N204_N0.5340.29
291_Q414_V0.5320.29
11_R18_G0.5320.29
223_G239_G0.5310.29
91_V191_S0.5310.29
284_T330_V0.5310.29
44_G52_V0.5300.29
91_V135_L0.5280.29
180_V215_A0.5280.29
200_L337_A0.5260.29
110_V215_A0.5250.29
178_T245_L0.5240.29
329_A451_Q0.5240.29
10_V227_A0.5230.29
336_A486_A0.5210.28
210_G303_R0.5210.28
298_S301_M0.5210.28
222_L227_A0.5210.28
237_V375_V0.5210.28
199_G465_G0.5200.28
20_G376_V0.5200.28
110_V279_E0.5190.28
110_V313_T0.5190.28
450_F454_W0.5170.28
97_T487_L0.5160.28
95_D313_T0.5160.28
12_A56_E0.5140.28
84_R131_A0.5130.28
198_Y478_D0.5130.28
65_Y124_L0.5130.28
246_G486_A0.5130.28
115_A232_G0.5130.28
50_V237_V0.5130.28
204_N251_S0.5110.28
80_S210_G0.5110.28
124_L439_R0.5110.28
86_I99_S0.5100.28
198_Y313_T0.5090.28
47_V127_V0.5080.28
309_L330_V0.5070.27
183_R362_D0.5070.27
79_F88_L0.5060.27
119_S319_G0.5060.27
47_V237_V0.5050.27
195_L259_F0.5040.27
252_A460_V0.5040.27
92_Q466_S0.5030.27
78_V185_E0.5030.27
63_F115_A0.5020.27
199_G256_V0.5020.27
240_A461_I0.5020.27
219_A224_G0.5010.27
146_P181_G0.5010.27
451_Q465_G0.5010.27
208_F494_C0.5010.27
74_I212_I0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fssA 1 0.2004 17.1 0.974 Contact Map
4ifsA 1 0.2296 13.3 0.975 Contact Map
3ixzA 1 0.144 5.4 0.979 Contact Map
3hsaA 3 0.214 5.1 0.979 Contact Map
2kogA 1 0.2121 4.4 0.98 Contact Map
4pq0A 1 0.2198 4.3 0.98 Contact Map
3rlfF 1 0.2821 4.3 0.98 Contact Map
2zxeA 1 0.144 4.1 0.98 Contact Map
2l8sA 1 0.0875 3.3 0.981 Contact Map
3ar4A 1 0.1284 3.1 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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