GREMLIN Database
Q9HQ30 - Uncharacterized protein
UniProt: Q9HQ30 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 159 (141)
Sequences: 4392 (3667)
Seq/√Len: 308.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_R137_D3.6041.00
101_R132_R3.0431.00
99_S111_G2.9851.00
131_S134_R2.8041.00
111_G135_A2.7081.00
7_R10_V2.6861.00
78_E86_R2.5431.00
28_G32_G2.2561.00
137_D141_T2.2351.00
105_E129_G2.1781.00
132_R136_A2.0941.00
76_Y86_R2.0261.00
95_Q118_A2.0131.00
30_G34_L1.9431.00
71_R76_Y1.9341.00
96_H116_Y1.9191.00
109_G132_R1.8251.00
71_R74_T1.8201.00
100_R114_V1.7721.00
101_R106_R1.7221.00
94_V115_V1.7191.00
37_G40_S1.6561.00
69_D76_Y1.6551.00
58_H62_R1.6451.00
70_V91_Y1.6361.00
111_G132_R1.6211.00
57_T61_L1.6191.00
58_H81_V1.5541.00
60_L64_R1.5331.00
75_L115_V1.4971.00
102_G105_E1.4901.00
101_R111_G1.4881.00
61_L81_V1.4861.00
43_A47_V1.4631.00
66_W128_P1.4541.00
105_E112_R1.4271.00
8_V12_W1.4111.00
66_W77_I1.4041.00
130_L135_A1.3931.00
65_I84_R1.3901.00
99_S139_Q1.3821.00
67_R78_E1.3601.00
46_A50_V1.3461.00
9_V13_L1.3361.00
8_V11_V1.3311.00
141_T145_L1.3301.00
112_R126_T1.3281.00
6_A9_V1.3041.00
38_V41_A1.2901.00
56_A60_L1.2821.00
38_V42_A1.2801.00
61_L65_I1.2711.00
74_T88_T1.2461.00
112_R128_P1.2271.00
19_F22_V1.1881.00
77_I125_V1.1691.00
36_V40_S1.1661.00
10_V13_L1.1621.00
10_V18_V1.1561.00
12_W16_V1.1401.00
89_V117_T1.1391.00
18_V22_V1.1291.00
42_A45_V1.1131.00
20_A24_A1.1071.00
89_V125_V1.0781.00
100_R112_R1.0631.00
99_S135_A1.0571.00
65_I81_V1.0561.00
70_V138_A1.0171.00
133_E137_D0.9901.00
79_H87_T0.9841.00
116_Y120_S0.9811.00
29_I33_A0.9791.00
49_G53_L0.9791.00
78_E84_R0.9761.00
99_S136_A0.9731.00
27_A31_S0.9641.00
87_T96_H0.9631.00
32_G35_D0.9611.00
139_Q143_R0.9611.00
91_Y142_L0.9361.00
28_G31_S0.9311.00
98_D114_V0.9271.00
76_Y88_T0.9251.00
110_L129_G0.9121.00
23_L31_S0.9091.00
103_P107_V0.9001.00
63_Y79_H0.8931.00
90_P93_R0.8921.00
50_V54_L0.8911.00
98_D116_Y0.8821.00
134_R141_T0.8811.00
8_V13_L0.8751.00
42_A46_A0.8581.00
104_L107_V0.8561.00
39_S43_A0.8511.00
61_L82_L0.8441.00
79_H85_V0.8381.00
39_S48_F0.8341.00
23_L26_A0.8281.00
94_V125_V0.8271.00
30_G33_A0.8221.00
94_V142_L0.8151.00
32_G36_V0.8111.00
139_Q144_A0.8071.00
136_A139_Q0.8071.00
13_L16_V0.8061.00
70_V75_L0.8031.00
138_A142_L0.7881.00
26_A30_G0.7871.00
53_L57_T0.7841.00
6_A10_V0.7831.00
97_V139_Q0.7811.00
11_V15_R0.7790.99
29_I32_G0.7730.99
72_E91_Y0.7700.99
25_G29_I0.7670.99
70_V141_T0.7660.99
8_V129_G0.7600.99
45_V49_G0.7590.99
19_F24_A0.7580.99
74_T93_R0.7550.99
105_E110_L0.7530.99
136_A140_E0.7510.99
58_H61_L0.7490.99
36_V42_A0.7390.99
9_V16_V0.7350.99
25_G37_G0.7340.99
66_W106_R0.7330.99
22_V26_A0.7210.99
13_L55_G0.7180.99
118_A127_I0.7170.99
91_Y145_L0.7140.99
127_I130_L0.7100.99
22_V29_I0.7080.99
37_G41_A0.7050.99
68_F81_V0.7050.99
31_S35_D0.7040.99
97_V135_A0.6970.99
22_V25_G0.6940.99
94_V146_A0.6930.99
8_V15_R0.6810.99
9_V60_L0.6780.99
20_A27_A0.6760.99
19_F27_A0.6740.99
13_L60_L0.6720.98
37_G133_E0.6640.98
142_L145_L0.6580.98
113_V135_A0.6560.98
68_F77_I0.6520.98
116_Y124_D0.6460.98
101_R105_E0.6370.98
119_G125_V0.6330.98
62_R66_W0.6330.98
75_L127_I0.6300.98
62_R89_V0.6240.98
80_G142_L0.6220.98
64_R67_R0.6190.97
68_F110_L0.6170.97
22_V31_S0.6130.97
27_A32_G0.6080.97
120_S124_D0.6060.97
141_T144_A0.6040.97
19_F26_A0.6000.97
21_V25_G0.5980.97
12_W62_R0.5950.97
80_G118_A0.5930.97
74_T91_Y0.5900.97
23_L38_V0.5810.96
62_R79_H0.5790.96
35_D47_V0.5790.96
18_V21_V0.5790.96
20_A36_V0.5780.96
98_D139_Q0.5750.96
40_S43_A0.5750.96
55_G59_A0.5750.96
7_R131_S0.5720.96
11_V104_L0.5690.96
110_L130_L0.5690.96
36_V46_A0.5650.96
59_A62_R0.5650.96
119_G123_A0.5570.95
97_V142_L0.5550.95
68_F95_Q0.5520.95
36_V41_A0.5520.95
140_E144_A0.5510.95
91_Y125_V0.5500.95
14_W104_L0.5490.95
43_A46_A0.5450.95
39_S42_A0.5440.95
40_S44_A0.5430.95
73_D90_P0.5400.94
65_I68_F0.5370.94
94_V108_L0.5350.94
54_L57_T0.5330.94
105_E128_P0.5280.94
34_L147_I0.5260.94
39_S45_V0.5250.94
40_S48_F0.5230.93
144_A147_I0.5230.93
96_H115_V0.5220.93
8_V63_Y0.5200.93
19_F45_V0.5180.93
19_F23_L0.5130.93
41_A44_A0.5130.93
90_P102_G0.5090.93
31_S34_L0.5080.92
68_F130_L0.5080.92
123_A127_I0.5080.92
10_V14_W0.5070.92
22_V28_G0.5000.92
95_Q130_L0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.3962 11.5 0.909 Contact Map
4i0uA 4 0.3836 10.9 0.91 Contact Map
3aqpA 1 0.761 5.8 0.92 Contact Map
2zxeA 1 0.4843 5 0.923 Contact Map
2a65A 2 0.4403 4.5 0.925 Contact Map
3ixzA 1 0.4843 4.3 0.925 Contact Map
2kogA 1 0.2516 3.8 0.927 Contact Map
2kncA 1 0.3396 3 0.931 Contact Map
3ar4A 1 0.434 2.9 0.931 Contact Map
2k1aA 1 0.2642 2.8 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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