Q9HQ30 - HALSA - GREMLIN Contacts

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Q9HQ30 - Uncharacterized protein

UniProt:	Q9HQ30	Sequences: MERLDARVVVVWLWRVLVFAVVLAGAAGIGSGALDVGVSSAAAAVAVFGVVALLGATHALLRYRIWRFDVREDTLYIEHGVLVRVRTTVPYVRVQHVDSRRGPLERVLGLGRVVVYTAGSRGADVTIPGLSRERAADAQETLRALAIESEPESGEGDAV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	159 (141)
Sequences:	4392 (3667)
Seq/√Len:	308.8

BACSU - YDBT YDBS
HALSA - Q9HQ30 Q9HQ31

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
134_R	137_D	3.604	1.00
101_R	132_R	3.043	1.00
99_S	111_G	2.985	1.00
131_S	134_R	2.804	1.00
111_G	135_A	2.708	1.00
7_R	10_V	2.686	1.00
78_E	86_R	2.543	1.00
28_G	32_G	2.256	1.00
137_D	141_T	2.235	1.00
105_E	129_G	2.178	1.00
132_R	136_A	2.094	1.00
76_Y	86_R	2.026	1.00
95_Q	118_A	2.013	1.00
30_G	34_L	1.943	1.00
71_R	76_Y	1.934	1.00
96_H	116_Y	1.919	1.00
109_G	132_R	1.825	1.00
71_R	74_T	1.820	1.00
100_R	114_V	1.772	1.00
101_R	106_R	1.722	1.00
94_V	115_V	1.719	1.00
37_G	40_S	1.656	1.00
69_D	76_Y	1.655	1.00
58_H	62_R	1.645	1.00
70_V	91_Y	1.636	1.00
111_G	132_R	1.621	1.00
57_T	61_L	1.619	1.00
58_H	81_V	1.554	1.00
60_L	64_R	1.533	1.00
75_L	115_V	1.497	1.00
102_G	105_E	1.490	1.00
101_R	111_G	1.488	1.00
61_L	81_V	1.486	1.00
43_A	47_V	1.463	1.00
66_W	128_P	1.454	1.00
105_E	112_R	1.427	1.00
8_V	12_W	1.411	1.00
66_W	77_I	1.404	1.00
130_L	135_A	1.393	1.00
65_I	84_R	1.390	1.00
99_S	139_Q	1.382	1.00
67_R	78_E	1.360	1.00
46_A	50_V	1.346	1.00
9_V	13_L	1.336	1.00
8_V	11_V	1.331	1.00
141_T	145_L	1.330	1.00
112_R	126_T	1.328	1.00
6_A	9_V	1.304	1.00
38_V	41_A	1.290	1.00
56_A	60_L	1.282	1.00
38_V	42_A	1.280	1.00
61_L	65_I	1.271	1.00
74_T	88_T	1.246	1.00
112_R	128_P	1.227	1.00
19_F	22_V	1.188	1.00
77_I	125_V	1.169	1.00
36_V	40_S	1.166	1.00
10_V	13_L	1.162	1.00
10_V	18_V	1.156	1.00
12_W	16_V	1.140	1.00
89_V	117_T	1.139	1.00
18_V	22_V	1.129	1.00
42_A	45_V	1.113	1.00
20_A	24_A	1.107	1.00
89_V	125_V	1.078	1.00
100_R	112_R	1.063	1.00
99_S	135_A	1.057	1.00
65_I	81_V	1.056	1.00
70_V	138_A	1.017	1.00
133_E	137_D	0.990	1.00
79_H	87_T	0.984	1.00
116_Y	120_S	0.981	1.00
29_I	33_A	0.979	1.00
49_G	53_L	0.979	1.00
78_E	84_R	0.976	1.00
99_S	136_A	0.973	1.00
27_A	31_S	0.964	1.00
87_T	96_H	0.963	1.00
32_G	35_D	0.961	1.00
139_Q	143_R	0.961	1.00
91_Y	142_L	0.936	1.00
28_G	31_S	0.931	1.00
98_D	114_V	0.927	1.00
76_Y	88_T	0.925	1.00
110_L	129_G	0.912	1.00
23_L	31_S	0.909	1.00
103_P	107_V	0.900	1.00
63_Y	79_H	0.893	1.00
90_P	93_R	0.892	1.00
50_V	54_L	0.891	1.00
98_D	116_Y	0.882	1.00
134_R	141_T	0.881	1.00
8_V	13_L	0.875	1.00
42_A	46_A	0.858	1.00
104_L	107_V	0.856	1.00
39_S	43_A	0.851	1.00
61_L	82_L	0.844	1.00
79_H	85_V	0.838	1.00
39_S	48_F	0.834	1.00
23_L	26_A	0.828	1.00
94_V	125_V	0.827	1.00
30_G	33_A	0.822	1.00
94_V	142_L	0.815	1.00
32_G	36_V	0.811	1.00
139_Q	144_A	0.807	1.00
136_A	139_Q	0.807	1.00
13_L	16_V	0.806	1.00
70_V	75_L	0.803	1.00
138_A	142_L	0.788	1.00
26_A	30_G	0.787	1.00
53_L	57_T	0.784	1.00
6_A	10_V	0.783	1.00
97_V	139_Q	0.781	1.00
11_V	15_R	0.779	0.99
29_I	32_G	0.773	0.99
72_E	91_Y	0.770	0.99
25_G	29_I	0.767	0.99
70_V	141_T	0.766	0.99
8_V	129_G	0.760	0.99
45_V	49_G	0.759	0.99
19_F	24_A	0.758	0.99
74_T	93_R	0.755	0.99
105_E	110_L	0.753	0.99
136_A	140_E	0.751	0.99
58_H	61_L	0.749	0.99
36_V	42_A	0.739	0.99
9_V	16_V	0.735	0.99
25_G	37_G	0.734	0.99
66_W	106_R	0.733	0.99
22_V	26_A	0.721	0.99
13_L	55_G	0.718	0.99
118_A	127_I	0.717	0.99
91_Y	145_L	0.714	0.99
127_I	130_L	0.710	0.99
22_V	29_I	0.708	0.99
37_G	41_A	0.705	0.99
68_F	81_V	0.705	0.99
31_S	35_D	0.704	0.99
97_V	135_A	0.697	0.99
22_V	25_G	0.694	0.99
94_V	146_A	0.693	0.99
8_V	15_R	0.681	0.99
9_V	60_L	0.678	0.99
20_A	27_A	0.676	0.99
19_F	27_A	0.674	0.99
13_L	60_L	0.672	0.98
37_G	133_E	0.664	0.98
142_L	145_L	0.658	0.98
113_V	135_A	0.656	0.98
68_F	77_I	0.652	0.98
116_Y	124_D	0.646	0.98
101_R	105_E	0.637	0.98
119_G	125_V	0.633	0.98
62_R	66_W	0.633	0.98
75_L	127_I	0.630	0.98
62_R	89_V	0.624	0.98
80_G	142_L	0.622	0.98
64_R	67_R	0.619	0.97
68_F	110_L	0.617	0.97
22_V	31_S	0.613	0.97
27_A	32_G	0.608	0.97
120_S	124_D	0.606	0.97
141_T	144_A	0.604	0.97
19_F	26_A	0.600	0.97
21_V	25_G	0.598	0.97
12_W	62_R	0.595	0.97
80_G	118_A	0.593	0.97
74_T	91_Y	0.590	0.97
23_L	38_V	0.581	0.96
62_R	79_H	0.579	0.96
35_D	47_V	0.579	0.96
18_V	21_V	0.579	0.96
20_A	36_V	0.578	0.96
98_D	139_Q	0.575	0.96
40_S	43_A	0.575	0.96
55_G	59_A	0.575	0.96
7_R	131_S	0.572	0.96
11_V	104_L	0.569	0.96
110_L	130_L	0.569	0.96
36_V	46_A	0.565	0.96
59_A	62_R	0.565	0.96
119_G	123_A	0.557	0.95
97_V	142_L	0.555	0.95
68_F	95_Q	0.552	0.95
36_V	41_A	0.552	0.95
140_E	144_A	0.551	0.95
91_Y	125_V	0.550	0.95
14_W	104_L	0.549	0.95
43_A	46_A	0.545	0.95
39_S	42_A	0.544	0.95
40_S	44_A	0.543	0.95
73_D	90_P	0.540	0.94
65_I	68_F	0.537	0.94
94_V	108_L	0.535	0.94
54_L	57_T	0.533	0.94
105_E	128_P	0.528	0.94
34_L	147_I	0.526	0.94
39_S	45_V	0.525	0.94
40_S	48_F	0.523	0.93
144_A	147_I	0.523	0.93
96_H	115_V	0.522	0.93
8_V	63_Y	0.520	0.93
19_F	45_V	0.518	0.93
19_F	23_L	0.513	0.93
41_A	44_A	0.513	0.93
90_P	102_G	0.509	0.93
31_S	34_L	0.508	0.92
68_F	130_L	0.508	0.92
123_A	127_I	0.508	0.92
10_V	14_W	0.507	0.92
22_V	28_G	0.500	0.92
95_Q	130_L	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ev6A	3	0.3962	11.5	0.909	Contact Map
4i0uA	4	0.3836	10.9	0.91	Contact Map
3aqpA	1	0.761	5.8	0.92	Contact Map
2zxeA	1	0.4843	5	0.923	Contact Map
2a65A	2	0.4403	4.5	0.925	Contact Map
3ixzA	1	0.4843	4.3	0.925	Contact Map
2kogA	1	0.2516	3.8	0.927	Contact Map
2kncA	1	0.3396	3	0.931	Contact Map
3ar4A	1	0.434	2.9	0.931	Contact Map
2k1aA	1	0.2642	2.8	0.932	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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