GREMLIN Database
Q9HQ28 - Uncharacterized protein
UniProt: Q9HQ28 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 82 (72)
Sequences: 677 (342)
Seq/√Len: 40.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_P44_E3.8211.00
46_V50_D3.8181.00
22_V34_L2.6081.00
7_E11_E2.5821.00
46_V54_M2.4261.00
24_R27_G2.4231.00
62_A66_E2.2671.00
47_S50_D2.2060.99
56_Y63_M2.0670.99
4_A7_E2.0550.99
49_V53_D1.8510.98
17_D40_S1.6910.97
42_A54_M1.6030.96
38_V72_L1.5520.95
21_T37_V1.5430.95
11_E20_A1.5390.94
23_S35_E1.4590.93
6_I67_I1.4270.92
27_G32_D1.3930.91
12_A60_G1.3690.90
10_I14_F1.3380.89
44_E78_S1.2620.86
37_V75_R1.2420.85
37_V73_T1.1730.82
13_G58_A1.1670.81
22_V31_D1.1660.81
53_D57_D1.1450.80
9_R62_A1.1400.80
24_R32_D1.1310.79
8_A12_A1.1070.78
3_L34_L1.0440.73
51_Q75_R1.0260.72
24_R30_D1.0080.71
6_I34_L1.0060.70
31_D71_E1.0050.70
4_A8_A0.9880.69
61_D64_T0.9760.68
31_D34_L0.9680.67
39_V76_P0.9520.66
5_D9_R0.9400.65
60_G64_T0.9220.64
10_I20_A0.9200.63
5_D8_A0.9200.63
23_S37_V0.9140.63
24_R34_L0.8920.61
48_L64_T0.8840.60
48_L51_Q0.8300.55
51_Q74_T0.8190.54
35_E73_T0.8160.54
34_L67_I0.8050.53
39_V77_R0.8050.53
17_D42_A0.7930.52
8_A19_S0.7860.51
8_A78_S0.7790.51
42_A52_H0.7750.50
5_D35_E0.7610.49
54_M57_D0.7560.49
9_R20_A0.7560.49
27_G63_M0.7480.48
17_D20_A0.7440.48
11_E17_D0.6870.42
11_E41_P0.6790.42
40_S76_P0.6780.42
23_S73_T0.6680.41
51_Q72_L0.6680.41
63_M66_E0.6660.41
57_D66_E0.6620.40
56_Y61_D0.6480.39
24_R31_D0.6320.38
10_I38_V0.6280.37
8_A45_G0.6270.37
16_A41_P0.6250.37
60_G63_M0.6160.36
50_D53_D0.6130.36
21_T39_V0.6130.36
51_Q58_A0.6120.36
5_D50_D0.6080.36
59_L63_M0.6060.35
59_L75_R0.6020.35
48_L53_D0.5930.34
40_S52_H0.5900.34
19_S47_S0.5860.34
34_L61_D0.5820.33
44_E76_P0.5810.33
8_A42_A0.5800.33
56_Y67_I0.5770.33
56_Y60_G0.5750.33
17_D41_P0.5750.33
38_V58_A0.5730.33
16_A42_A0.5720.33
18_C58_A0.5710.32
2_D8_A0.5650.32
3_L39_V0.5640.32
2_D5_D0.5630.32
2_D31_D0.5500.31
40_S53_D0.5380.30
32_D66_E0.5360.30
41_P77_R0.5340.30
6_I14_F0.5320.29
56_Y65_T0.5240.29
7_E19_S0.5220.29
34_L70_L0.5200.28
39_V44_E0.5180.28
14_F37_V0.5150.28
56_Y70_L0.5140.28
40_S54_M0.5040.27
48_L65_T0.5000.27
60_G75_R0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tr3A 2 0.939 99.9 0.307 Contact Map
3o2eA 2 0.9634 99.9 0.308 Contact Map
2kdnA 1 0.9634 99.9 0.309 Contact Map
1xs3A 1 0.9146 99.9 0.312 Contact Map
2dhmA 1 0.9634 99.9 0.313 Contact Map
2mm9A 1 0.9634 99.9 0.315 Contact Map
1v9jA 1 0.9756 99.9 0.316 Contact Map
1ny8A 1 0.9268 99.9 0.318 Contact Map
1v60A 1 0.9634 99.9 0.33 Contact Map
2mcqA 1 0.9146 99.9 0.334 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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