GREMLIN Database
FEN - Flap endonuclease 1
UniProt: Q9HQ27 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (284)
Sequences: 1467 (988)
Seq/√Len: 58.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_A169_V6.1891.00
218_D267_R4.2901.00
163_T169_V4.2261.00
174_S179_C4.1631.00
214_E271_L3.9791.00
163_T185_P3.9021.00
288_A291_A3.7841.00
115_D118_E3.7501.00
25_V171_Y3.7081.00
109_D113_A3.1881.00
217_V271_L3.0421.00
294_A298_D2.9111.00
20_L199_L2.8841.00
143_L291_A2.8251.00
138_R150_E2.7331.00
161_Y165_T2.6711.00
260_V263_G2.6341.00
268_E272_N2.5321.00
24_V169_V2.4921.00
251_D254_A2.4761.00
238_T241_D2.4381.00
25_V173_G2.2081.00
71_F146_I2.1821.00
143_L295_F2.1671.00
63_A137_T2.1251.00
212_T215_Q2.0991.00
248_D251_D2.0981.00
219_V223_C2.0451.00
33_L137_T2.0271.00
13_E204_A2.0081.00
284_D287_P1.9441.00
186_V201_D1.8831.00
78_V169_V1.8561.00
104_E108_D1.8441.00
215_Q247_G1.8361.00
180_L187_T1.8291.00
220_G230_G1.8020.99
59_N136_T1.7990.99
106_Q109_D1.7980.99
202_F213_W1.7950.99
101_E105_E1.7750.99
255_A258_E1.7250.99
172_A184_S1.7200.99
26_A159_A1.7140.99
210_D244_G1.7110.99
211_L219_V1.6700.99
259_H262_H1.6440.99
161_Y277_D1.6250.99
200_M205_T1.6160.99
216_L220_G1.6120.99
36_Y62_G1.6080.99
97_R101_E1.5910.99
248_D252_V1.5840.99
225_T270_F1.5710.98
203_D207_A1.5640.98
35_K62_G1.5530.98
252_V255_A1.5340.98
23_S170_D1.5180.98
293_R298_D1.5150.98
27_V79_F1.4860.98
142_D148_Q1.4760.98
107_L119_A1.4690.98
158_Q275_V1.4630.98
60_L140_L1.4570.98
174_S187_T1.4000.97
107_L123_D1.3960.97
223_C236_P1.3880.97
15_T20_L1.3860.97
88_L269_L1.3810.97
23_S186_V1.3800.97
86_T227_F1.3690.96
94_A98_E1.3540.96
91_D94_A1.3480.96
33_L118_E1.3360.96
185_P203_D1.2930.95
241_D245_E1.2920.95
175_D190_Q1.2860.95
30_H134_H1.2790.95
181_L220_G1.2680.94
156_E159_A1.2650.94
234_F239_A1.2460.94
18_A21_E1.2300.93
289_I293_R1.2150.93
277_D280_V1.2020.93
153_A269_L1.1980.93
183_G202_F1.1840.92
291_A294_A1.1810.92
290_D293_R1.1790.92
225_T266_I1.1660.91
222_L239_A1.1630.91
67_L146_I1.1630.91
218_D249_L1.1570.91
186_V199_L1.1560.91
164_R213_W1.1470.91
159_A169_V1.1330.90
213_W271_L1.1330.90
252_V258_E1.1300.90
234_F238_T1.1300.90
139_E291_A1.1200.90
242_A252_V1.1170.90
9_L12_I1.1170.90
76_T147_P1.1130.89
114_G119_A1.0990.89
226_D235_G1.0980.89
20_L188_L1.0970.89
93_I128_R1.0950.89
172_A179_C1.0750.88
242_A246_H1.0730.88
178_D226_D1.0650.87
160_A172_A1.0590.87
276_T279_Y1.0520.87
188_L197_P1.0520.87
15_T19_D1.0520.87
181_L216_L1.0460.86
64_V67_L1.0450.86
32_W66_G1.0440.86
76_T284_D1.0390.86
216_L230_G1.0310.86
225_T228_N1.0300.85
182_L269_L1.0260.85
78_V232_D1.0250.85
268_E271_L1.0240.85
163_T171_Y1.0180.85
111_R119_A1.0160.85
219_V240_L1.0160.85
118_E122_L1.0130.84
218_D243_I1.0130.84
161_Y278_D1.0110.84
98_E102_R1.0100.84
130_T133_I1.0090.84
180_L200_M0.9940.83
25_V75_L0.9930.83
217_V267_R0.9860.83
21_E74_G0.9750.82
24_V147_P0.9720.82
132_T142_D0.9680.82
171_Y188_L0.9640.81
182_L273_P0.9630.81
106_Q118_E0.9620.81
68_P144_L0.9600.81
7_R10_A0.9600.81
292_A295_F0.9590.81
201_D204_A0.9570.81
95_D99_Q0.9560.81
135_E138_R0.9510.81
67_L79_F0.9500.80
102_R106_Q0.9480.80
29_A79_F0.9450.80
25_V188_L0.9440.80
107_L111_R0.9390.80
63_A79_F0.9390.80
152_P275_V0.9340.79
286_S289_I0.9330.79
24_V76_T0.9320.79
285_V292_A0.9300.79
107_L126_T0.9220.78
37_L129_L0.9150.78
155_G177_Y0.9130.78
211_L240_L0.9130.78
176_D226_D0.9080.77
143_L292_A0.9070.77
259_H263_G0.9050.77
163_T220_G0.9020.77
92_E95_D0.8890.76
68_P72_E0.8830.75
126_T174_S0.8790.75
30_H66_G0.8770.75
135_E139_E0.8730.75
31_N35_K0.8600.73
110_A115_D0.8570.73
82_D89_K0.8510.73
213_W217_V0.8470.72
291_A296_V0.8470.72
183_G230_G0.8430.72
108_D111_R0.8410.72
80_V149_V0.8390.72
154_E178_D0.8390.72
123_D137_T0.8350.71
151_A182_L0.8340.71
95_D98_E0.8320.71
61_V240_L0.8260.70
82_D235_G0.8240.70
18_A73_H0.8230.70
33_L37_L0.8220.70
58_A61_V0.8220.70
64_V68_P0.8200.70
243_I248_D0.8180.70
290_D294_A0.8160.69
181_L217_V0.8140.69
264_D268_E0.8120.69
86_T273_P0.8110.69
221_I269_L0.8110.69
265_R290_D0.8070.69
154_E176_D0.7910.67
34_Y40_T0.7900.67
35_K66_G0.7880.67
158_Q273_P0.7870.67
7_R12_I0.7840.66
83_G89_K0.7830.66
211_L215_Q0.7830.66
230_G249_L0.7830.66
157_A160_A0.7830.66
248_D254_A0.7810.66
96_R178_D0.7800.66
111_R123_D0.7790.66
152_P158_Q0.7790.66
161_Y276_T0.7750.65
110_A114_G0.7690.65
154_E226_D0.7690.65
246_H255_A0.7680.65
218_D221_I0.7680.65
192_T196_H0.7670.65
119_A123_D0.7650.64
29_A81_W0.7630.64
69_K73_H0.7600.64
96_R154_E0.7590.64
145_D250_W0.7580.64
71_F144_L0.7570.64
182_L215_Q0.7510.63
29_A36_Y0.7500.63
159_A189_R0.7490.63
132_T288_A0.7490.63
257_G260_V0.7480.63
32_W70_F0.7450.62
10_A15_T0.7450.62
19_D193_S0.7400.62
60_L66_G0.7370.62
52_S210_D0.7370.62
160_A179_C0.7340.61
188_L191_L0.7340.61
15_T197_P0.7330.61
78_V147_P0.7330.61
142_D278_D0.7300.61
179_C184_S0.7270.60
17_F73_H0.7270.60
79_F141_F0.7240.60
204_A208_E0.7240.60
204_A207_A0.7230.60
140_L145_D0.7230.60
247_G251_D0.7220.60
37_L100_R0.7190.60
91_D229_P0.7140.59
64_V144_L0.7110.59
26_A162_M0.7100.59
160_A163_T0.7090.59
156_E189_R0.7090.59
82_D226_D0.7070.58
33_L158_Q0.7070.58
81_W182_L0.7060.58
234_F253_L0.7020.58
129_L133_I0.7010.58
158_Q161_Y0.7000.58
237_T241_D0.6980.57
29_A216_L0.6970.57
177_Y225_T0.6970.57
96_R270_F0.6970.57
25_V165_T0.6970.57
142_D204_A0.6950.57
91_D98_E0.6940.57
37_L68_P0.6920.57
286_S290_D0.6910.57
35_K175_D0.6910.57
30_H155_G0.6900.56
21_E24_V0.6880.56
243_I259_H0.6870.56
48_V151_A0.6850.56
52_S111_R0.6840.56
136_T145_D0.6840.56
242_A245_E0.6820.56
190_Q198_E0.6770.55
170_D186_V0.6770.55
221_I243_I0.6770.55
96_R100_R0.6760.55
99_Q102_R0.6740.55
86_T269_L0.6730.55
90_D94_A0.6730.55
82_D176_D0.6710.54
8_Q12_I0.6700.54
78_V149_V0.6690.54
25_V163_T0.6670.54
113_A119_A0.6660.54
59_N62_G0.6660.54
74_G141_F0.6550.53
153_A159_A0.6550.53
89_K176_D0.6540.53
89_K154_E0.6540.53
169_V172_A0.6540.53
226_D233_G0.6510.52
30_H93_I0.6480.52
69_K72_E0.6470.52
47_D52_S0.6460.52
92_E96_R0.6450.52
141_F148_Q0.6430.51
142_D150_E0.6430.51
153_A274_D0.6420.51
85_V93_I0.6410.51
71_F259_H0.6400.51
247_G258_E0.6380.51
34_Y296_V0.6370.51
215_Q243_I0.6360.51
280_V283_P0.6360.51
265_R268_E0.6320.50
38_T187_T0.6310.50
42_Q47_D0.6300.50
40_T58_A0.6300.50
89_K226_D0.6290.50
231_I261_A0.6280.50
165_T278_D0.6280.50
110_A118_E0.6270.50
222_L231_I0.6260.49
278_D294_A0.6250.49
140_L174_S0.6210.49
105_E109_D0.6210.49
111_R277_D0.6190.49
17_F25_V0.6190.49
221_I225_T0.6180.49
249_L267_R0.6140.48
109_D203_D0.6130.48
6_L11_A0.6130.48
156_E226_D0.6120.48
36_Y39_T0.6110.48
231_I245_E0.6100.48
177_Y230_G0.6070.47
180_L216_L0.6030.47
115_D271_L0.6030.47
69_K133_I0.6020.47
88_L287_P0.6010.47
54_G57_V0.5990.46
182_L257_G0.5990.46
243_I267_R0.5970.46
243_I252_V0.5970.46
165_T276_T0.5960.46
285_V289_I0.5950.46
33_L119_A0.5940.46
103_Y126_T0.5920.46
28_D178_D0.5900.45
140_L144_L0.5880.45
176_D235_G0.5840.45
267_R271_L0.5840.45
288_A297_T0.5830.45
74_G164_R0.5830.45
53_D186_V0.5820.45
281_I285_V0.5810.44
273_P277_D0.5800.44
155_G225_T0.5790.44
36_Y41_V0.5790.44
31_N159_A0.5780.44
217_V273_P0.5760.44
174_S189_R0.5730.44
231_I289_I0.5730.44
81_W158_Q0.5730.44
56_E75_L0.5720.43
203_D232_D0.5700.43
111_R174_S0.5680.43
164_R266_I0.5680.43
156_E273_P0.5680.43
100_R180_L0.5680.43
86_T93_I0.5670.43
178_D235_G0.5660.43
31_N174_S0.5660.43
30_H182_L0.5640.43
67_L144_L0.5630.42
132_T136_T0.5630.42
60_L181_L0.5620.42
272_N294_A0.5610.42
243_I271_L0.5590.42
53_D187_T0.5570.42
251_D255_A0.5510.41
131_P150_E0.5510.41
182_L213_W0.5510.41
122_L125_R0.5510.41
156_E179_C0.5500.41
152_P228_N0.5490.41
170_D219_V0.5480.41
181_L213_W0.5470.41
33_L63_A0.5460.41
163_T172_A0.5460.41
140_L143_L0.5460.41
22_G234_F0.5450.41
216_L221_I0.5440.40
253_L256_E0.5440.40
89_K155_G0.5430.40
82_D178_D0.5420.40
220_G227_F0.5420.40
90_D105_E0.5410.40
14_E85_V0.5400.40
31_N57_V0.5400.40
92_E161_Y0.5380.40
14_E198_E0.5370.40
228_N266_I0.5330.39
276_T281_I0.5330.39
102_R105_E0.5320.39
140_L211_L0.5320.39
102_R232_D0.5300.39
175_D266_I0.5300.39
32_W79_F0.5280.39
14_E73_H0.5280.39
38_T41_V0.5260.39
147_P159_A0.5250.38
165_T279_Y0.5250.38
142_D291_A0.5240.38
184_S277_D0.5230.38
155_G220_G0.5230.38
76_T146_I0.5210.38
29_A33_L0.5200.38
156_E178_D0.5150.37
28_D96_R0.5130.37
33_L123_D0.5130.37
11_A33_L0.5120.37
149_V257_G0.5110.37
202_F205_T0.5110.37
103_Y122_L0.5100.37
164_R172_A0.5100.37
105_E283_P0.5100.37
8_Q11_A0.5100.37
89_K235_G0.5090.37
104_E107_L0.5080.37
149_V203_D0.5070.37
221_I267_R0.5050.36
27_V32_W0.5040.36
112_E277_D0.5030.36
149_V165_T0.5030.36
34_Y93_I0.5030.36
34_Y37_L0.5030.36
111_R148_Q0.5000.36
258_E261_A0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ul1X 1 0.8624 100 0.303 Contact Map
1b43A 2 0.9725 100 0.303 Contact Map
1a76A 1 0.9511 100 0.311 Contact Map
3oryA 3 0.9694 100 0.315 Contact Map
2izoA 1 0.7829 100 0.315 Contact Map
3q8kA 1 0.9908 100 0.316 Contact Map
1rxwA 1 0.9235 100 0.32 Contact Map
4q0wA 1 0.8685 100 0.323 Contact Map
4wa8A 1 0.844 100 0.335 Contact Map
3qe9Y 1 0.9664 100 0.368 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.