FEN - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

FEN - Flap endonuclease 1

UniProt:	Q9HQ27	Sequences: MGNADLRQLAAIEETPFADLEGSVVAVDAHNWLYKYLTTTVQWTGADVYTTSDGTEVANLVGAVQGLPKFFEHGLTPVFVWDGGVTELKDDEIADRREQRERYEEQLDDAREAGDAAEAARLDARTQRLTPTIHETTRELFDLLDIPQVEAPAEGEAQAAYMTRTDDAVDYAGSDDYDCLLLGSPVTLRQLTSSGHPELMDFDATLAEHDLTWEQLVDVGILCGTDFNPGIDGFGPTTALDAIGEHGDLWDVLAAEGEHVAHGDRIRELFLNPDVTDDYVIDPDVSPAIDAARAFVTDEWEVDADAVARGFERIDAAAAQTGLDRWT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	327 (284)
Sequences:	1467 (988)
Seq/√Len:	58.6

HALSA - FEN
SULSO - FEN

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
26_A	169_V	6.189	1.00
218_D	267_R	4.290	1.00
163_T	169_V	4.226	1.00
174_S	179_C	4.163	1.00
214_E	271_L	3.979	1.00
163_T	185_P	3.902	1.00
288_A	291_A	3.784	1.00
115_D	118_E	3.750	1.00
25_V	171_Y	3.708	1.00
109_D	113_A	3.188	1.00
217_V	271_L	3.042	1.00
294_A	298_D	2.911	1.00
20_L	199_L	2.884	1.00
143_L	291_A	2.825	1.00
138_R	150_E	2.733	1.00
161_Y	165_T	2.671	1.00
260_V	263_G	2.634	1.00
268_E	272_N	2.532	1.00
24_V	169_V	2.492	1.00
251_D	254_A	2.476	1.00
238_T	241_D	2.438	1.00
25_V	173_G	2.208	1.00
71_F	146_I	2.182	1.00
143_L	295_F	2.167	1.00
63_A	137_T	2.125	1.00
212_T	215_Q	2.099	1.00
248_D	251_D	2.098	1.00
219_V	223_C	2.045	1.00
33_L	137_T	2.027	1.00
13_E	204_A	2.008	1.00
284_D	287_P	1.944	1.00
186_V	201_D	1.883	1.00
78_V	169_V	1.856	1.00
104_E	108_D	1.844	1.00
215_Q	247_G	1.836	1.00
180_L	187_T	1.829	1.00
220_G	230_G	1.802	0.99
59_N	136_T	1.799	0.99
106_Q	109_D	1.798	0.99
202_F	213_W	1.795	0.99
101_E	105_E	1.775	0.99
255_A	258_E	1.725	0.99
172_A	184_S	1.720	0.99
26_A	159_A	1.714	0.99
210_D	244_G	1.711	0.99
211_L	219_V	1.670	0.99
259_H	262_H	1.644	0.99
161_Y	277_D	1.625	0.99
200_M	205_T	1.616	0.99
216_L	220_G	1.612	0.99
36_Y	62_G	1.608	0.99
97_R	101_E	1.591	0.99
248_D	252_V	1.584	0.99
225_T	270_F	1.571	0.98
203_D	207_A	1.564	0.98
35_K	62_G	1.553	0.98
252_V	255_A	1.534	0.98
23_S	170_D	1.518	0.98
293_R	298_D	1.515	0.98
27_V	79_F	1.486	0.98
142_D	148_Q	1.476	0.98
107_L	119_A	1.469	0.98
158_Q	275_V	1.463	0.98
60_L	140_L	1.457	0.98
174_S	187_T	1.400	0.97
107_L	123_D	1.396	0.97
223_C	236_P	1.388	0.97
15_T	20_L	1.386	0.97
88_L	269_L	1.381	0.97
23_S	186_V	1.380	0.97
86_T	227_F	1.369	0.96
94_A	98_E	1.354	0.96
91_D	94_A	1.348	0.96
33_L	118_E	1.336	0.96
185_P	203_D	1.293	0.95
241_D	245_E	1.292	0.95
175_D	190_Q	1.286	0.95
30_H	134_H	1.279	0.95
181_L	220_G	1.268	0.94
156_E	159_A	1.265	0.94
234_F	239_A	1.246	0.94
18_A	21_E	1.230	0.93
289_I	293_R	1.215	0.93
277_D	280_V	1.202	0.93
153_A	269_L	1.198	0.93
183_G	202_F	1.184	0.92
291_A	294_A	1.181	0.92
290_D	293_R	1.179	0.92
225_T	266_I	1.166	0.91
222_L	239_A	1.163	0.91
67_L	146_I	1.163	0.91
218_D	249_L	1.157	0.91
186_V	199_L	1.156	0.91
164_R	213_W	1.147	0.91
159_A	169_V	1.133	0.90
213_W	271_L	1.133	0.90
252_V	258_E	1.130	0.90
234_F	238_T	1.130	0.90
139_E	291_A	1.120	0.90
242_A	252_V	1.117	0.90
9_L	12_I	1.117	0.90
76_T	147_P	1.113	0.89
114_G	119_A	1.099	0.89
226_D	235_G	1.098	0.89
20_L	188_L	1.097	0.89
93_I	128_R	1.095	0.89
172_A	179_C	1.075	0.88
242_A	246_H	1.073	0.88
178_D	226_D	1.065	0.87
160_A	172_A	1.059	0.87
276_T	279_Y	1.052	0.87
188_L	197_P	1.052	0.87
15_T	19_D	1.052	0.87
181_L	216_L	1.046	0.86
64_V	67_L	1.045	0.86
32_W	66_G	1.044	0.86
76_T	284_D	1.039	0.86
216_L	230_G	1.031	0.86
225_T	228_N	1.030	0.85
182_L	269_L	1.026	0.85
78_V	232_D	1.025	0.85
268_E	271_L	1.024	0.85
163_T	171_Y	1.018	0.85
111_R	119_A	1.016	0.85
219_V	240_L	1.016	0.85
118_E	122_L	1.013	0.84
218_D	243_I	1.013	0.84
161_Y	278_D	1.011	0.84
98_E	102_R	1.010	0.84
130_T	133_I	1.009	0.84
180_L	200_M	0.994	0.83
25_V	75_L	0.993	0.83
217_V	267_R	0.986	0.83
21_E	74_G	0.975	0.82
24_V	147_P	0.972	0.82
132_T	142_D	0.968	0.82
171_Y	188_L	0.964	0.81
182_L	273_P	0.963	0.81
106_Q	118_E	0.962	0.81
68_P	144_L	0.960	0.81
7_R	10_A	0.960	0.81
292_A	295_F	0.959	0.81
201_D	204_A	0.957	0.81
95_D	99_Q	0.956	0.81
135_E	138_R	0.951	0.81
67_L	79_F	0.950	0.80
102_R	106_Q	0.948	0.80
29_A	79_F	0.945	0.80
25_V	188_L	0.944	0.80
107_L	111_R	0.939	0.80
63_A	79_F	0.939	0.80
152_P	275_V	0.934	0.79
286_S	289_I	0.933	0.79
24_V	76_T	0.932	0.79
285_V	292_A	0.930	0.79
107_L	126_T	0.922	0.78
37_L	129_L	0.915	0.78
155_G	177_Y	0.913	0.78
211_L	240_L	0.913	0.78
176_D	226_D	0.908	0.77
143_L	292_A	0.907	0.77
259_H	263_G	0.905	0.77
163_T	220_G	0.902	0.77
92_E	95_D	0.889	0.76
68_P	72_E	0.883	0.75
126_T	174_S	0.879	0.75
30_H	66_G	0.877	0.75
135_E	139_E	0.873	0.75
31_N	35_K	0.860	0.73
110_A	115_D	0.857	0.73
82_D	89_K	0.851	0.73
213_W	217_V	0.847	0.72
291_A	296_V	0.847	0.72
183_G	230_G	0.843	0.72
108_D	111_R	0.841	0.72
80_V	149_V	0.839	0.72
154_E	178_D	0.839	0.72
123_D	137_T	0.835	0.71
151_A	182_L	0.834	0.71
95_D	98_E	0.832	0.71
61_V	240_L	0.826	0.70
82_D	235_G	0.824	0.70
18_A	73_H	0.823	0.70
33_L	37_L	0.822	0.70
58_A	61_V	0.822	0.70
64_V	68_P	0.820	0.70
243_I	248_D	0.818	0.70
290_D	294_A	0.816	0.69
181_L	217_V	0.814	0.69
264_D	268_E	0.812	0.69
86_T	273_P	0.811	0.69
221_I	269_L	0.811	0.69
265_R	290_D	0.807	0.69
154_E	176_D	0.791	0.67
34_Y	40_T	0.790	0.67
35_K	66_G	0.788	0.67
158_Q	273_P	0.787	0.67
7_R	12_I	0.784	0.66
83_G	89_K	0.783	0.66
211_L	215_Q	0.783	0.66
230_G	249_L	0.783	0.66
157_A	160_A	0.783	0.66
248_D	254_A	0.781	0.66
96_R	178_D	0.780	0.66
111_R	123_D	0.779	0.66
152_P	158_Q	0.779	0.66
161_Y	276_T	0.775	0.65
110_A	114_G	0.769	0.65
154_E	226_D	0.769	0.65
246_H	255_A	0.768	0.65
218_D	221_I	0.768	0.65
192_T	196_H	0.767	0.65
119_A	123_D	0.765	0.64
29_A	81_W	0.763	0.64
69_K	73_H	0.760	0.64
96_R	154_E	0.759	0.64
145_D	250_W	0.758	0.64
71_F	144_L	0.757	0.64
182_L	215_Q	0.751	0.63
29_A	36_Y	0.750	0.63
159_A	189_R	0.749	0.63
132_T	288_A	0.749	0.63
257_G	260_V	0.748	0.63
32_W	70_F	0.745	0.62
10_A	15_T	0.745	0.62
19_D	193_S	0.740	0.62
60_L	66_G	0.737	0.62
52_S	210_D	0.737	0.62
160_A	179_C	0.734	0.61
188_L	191_L	0.734	0.61
15_T	197_P	0.733	0.61
78_V	147_P	0.733	0.61
142_D	278_D	0.730	0.61
179_C	184_S	0.727	0.60
17_F	73_H	0.727	0.60
79_F	141_F	0.724	0.60
204_A	208_E	0.724	0.60
204_A	207_A	0.723	0.60
140_L	145_D	0.723	0.60
247_G	251_D	0.722	0.60
37_L	100_R	0.719	0.60
91_D	229_P	0.714	0.59
64_V	144_L	0.711	0.59
26_A	162_M	0.710	0.59
160_A	163_T	0.709	0.59
156_E	189_R	0.709	0.59
82_D	226_D	0.707	0.58
33_L	158_Q	0.707	0.58
81_W	182_L	0.706	0.58
234_F	253_L	0.702	0.58
129_L	133_I	0.701	0.58
158_Q	161_Y	0.700	0.58
237_T	241_D	0.698	0.57
29_A	216_L	0.697	0.57
177_Y	225_T	0.697	0.57
96_R	270_F	0.697	0.57
25_V	165_T	0.697	0.57
142_D	204_A	0.695	0.57
91_D	98_E	0.694	0.57
37_L	68_P	0.692	0.57
286_S	290_D	0.691	0.57
35_K	175_D	0.691	0.57
30_H	155_G	0.690	0.56
21_E	24_V	0.688	0.56
243_I	259_H	0.687	0.56
48_V	151_A	0.685	0.56
52_S	111_R	0.684	0.56
136_T	145_D	0.684	0.56
242_A	245_E	0.682	0.56
190_Q	198_E	0.677	0.55
170_D	186_V	0.677	0.55
221_I	243_I	0.677	0.55
96_R	100_R	0.676	0.55
99_Q	102_R	0.674	0.55
86_T	269_L	0.673	0.55
90_D	94_A	0.673	0.55
82_D	176_D	0.671	0.54
8_Q	12_I	0.670	0.54
78_V	149_V	0.669	0.54
25_V	163_T	0.667	0.54
113_A	119_A	0.666	0.54
59_N	62_G	0.666	0.54
74_G	141_F	0.655	0.53
153_A	159_A	0.655	0.53
89_K	176_D	0.654	0.53
89_K	154_E	0.654	0.53
169_V	172_A	0.654	0.53
226_D	233_G	0.651	0.52
30_H	93_I	0.648	0.52
69_K	72_E	0.647	0.52
47_D	52_S	0.646	0.52
92_E	96_R	0.645	0.52
141_F	148_Q	0.643	0.51
142_D	150_E	0.643	0.51
153_A	274_D	0.642	0.51
85_V	93_I	0.641	0.51
71_F	259_H	0.640	0.51
247_G	258_E	0.638	0.51
34_Y	296_V	0.637	0.51
215_Q	243_I	0.636	0.51
280_V	283_P	0.636	0.51
265_R	268_E	0.632	0.50
38_T	187_T	0.631	0.50
42_Q	47_D	0.630	0.50
40_T	58_A	0.630	0.50
89_K	226_D	0.629	0.50
231_I	261_A	0.628	0.50
165_T	278_D	0.628	0.50
110_A	118_E	0.627	0.50
222_L	231_I	0.626	0.49
278_D	294_A	0.625	0.49
140_L	174_S	0.621	0.49
105_E	109_D	0.621	0.49
111_R	277_D	0.619	0.49
17_F	25_V	0.619	0.49
221_I	225_T	0.618	0.49
249_L	267_R	0.614	0.48
109_D	203_D	0.613	0.48
6_L	11_A	0.613	0.48
156_E	226_D	0.612	0.48
36_Y	39_T	0.611	0.48
231_I	245_E	0.610	0.48
177_Y	230_G	0.607	0.47
180_L	216_L	0.603	0.47
115_D	271_L	0.603	0.47
69_K	133_I	0.602	0.47
88_L	287_P	0.601	0.47
54_G	57_V	0.599	0.46
182_L	257_G	0.599	0.46
243_I	267_R	0.597	0.46
243_I	252_V	0.597	0.46
165_T	276_T	0.596	0.46
285_V	289_I	0.595	0.46
33_L	119_A	0.594	0.46
103_Y	126_T	0.592	0.46
28_D	178_D	0.590	0.45
140_L	144_L	0.588	0.45
176_D	235_G	0.584	0.45
267_R	271_L	0.584	0.45
288_A	297_T	0.583	0.45
74_G	164_R	0.583	0.45
53_D	186_V	0.582	0.45
281_I	285_V	0.581	0.44
273_P	277_D	0.580	0.44
155_G	225_T	0.579	0.44
36_Y	41_V	0.579	0.44
31_N	159_A	0.578	0.44
217_V	273_P	0.576	0.44
174_S	189_R	0.573	0.44
231_I	289_I	0.573	0.44
81_W	158_Q	0.573	0.44
56_E	75_L	0.572	0.43
203_D	232_D	0.570	0.43
111_R	174_S	0.568	0.43
164_R	266_I	0.568	0.43
156_E	273_P	0.568	0.43
100_R	180_L	0.568	0.43
86_T	93_I	0.567	0.43
178_D	235_G	0.566	0.43
31_N	174_S	0.566	0.43
30_H	182_L	0.564	0.43
67_L	144_L	0.563	0.42
132_T	136_T	0.563	0.42
60_L	181_L	0.562	0.42
272_N	294_A	0.561	0.42
243_I	271_L	0.559	0.42
53_D	187_T	0.557	0.42
251_D	255_A	0.551	0.41
131_P	150_E	0.551	0.41
182_L	213_W	0.551	0.41
122_L	125_R	0.551	0.41
156_E	179_C	0.550	0.41
152_P	228_N	0.549	0.41
170_D	219_V	0.548	0.41
181_L	213_W	0.547	0.41
33_L	63_A	0.546	0.41
163_T	172_A	0.546	0.41
140_L	143_L	0.546	0.41
22_G	234_F	0.545	0.41
216_L	221_I	0.544	0.40
253_L	256_E	0.544	0.40
89_K	155_G	0.543	0.40
82_D	178_D	0.542	0.40
220_G	227_F	0.542	0.40
90_D	105_E	0.541	0.40
14_E	85_V	0.540	0.40
31_N	57_V	0.540	0.40
92_E	161_Y	0.538	0.40
14_E	198_E	0.537	0.40
228_N	266_I	0.533	0.39
276_T	281_I	0.533	0.39
102_R	105_E	0.532	0.39
140_L	211_L	0.532	0.39
102_R	232_D	0.530	0.39
175_D	266_I	0.530	0.39
32_W	79_F	0.528	0.39
14_E	73_H	0.528	0.39
38_T	41_V	0.526	0.39
147_P	159_A	0.525	0.38
165_T	279_Y	0.525	0.38
142_D	291_A	0.524	0.38
184_S	277_D	0.523	0.38
155_G	220_G	0.523	0.38
76_T	146_I	0.521	0.38
29_A	33_L	0.520	0.38
156_E	178_D	0.515	0.37
28_D	96_R	0.513	0.37
33_L	123_D	0.513	0.37
11_A	33_L	0.512	0.37
149_V	257_G	0.511	0.37
202_F	205_T	0.511	0.37
103_Y	122_L	0.510	0.37
164_R	172_A	0.510	0.37
105_E	283_P	0.510	0.37
8_Q	11_A	0.510	0.37
89_K	235_G	0.509	0.37
104_E	107_L	0.508	0.37
149_V	203_D	0.507	0.37
221_I	267_R	0.505	0.36
27_V	32_W	0.504	0.36
112_E	277_D	0.503	0.36
149_V	165_T	0.503	0.36
34_Y	93_I	0.503	0.36
34_Y	37_L	0.503	0.36
111_R	148_Q	0.500	0.36
258_E	261_A	0.500	0.36

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ul1X	1	0.8624	100	0.303	Contact Map
1b43A	2	0.9725	100	0.303	Contact Map
1a76A	1	0.9511	100	0.311	Contact Map
3oryA	3	0.9694	100	0.315	Contact Map
2izoA	1	0.7829	100	0.315	Contact Map
3q8kA	1	0.9908	100	0.316	Contact Map
1rxwA	1	0.9235	100	0.32	Contact Map
4q0wA	1	0.8685	100	0.323	Contact Map
4wa8A	1	0.844	100	0.335	Contact Map
3qe9Y	1	0.9664	100	0.368	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.