GREMLIN Database
Q9HQ24 - Ornithine cyclodeaminase
UniProt: Q9HQ24 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (303)
Sequences: 3959 (2917)
Seq/√Len: 167.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_S146_D4.0731.00
22_R113_D3.9561.00
128_S152_S3.4571.00
133_H164_D3.1571.00
147_T174_S2.8931.00
122_E149_H2.8911.00
180_A184_T2.8471.00
60_G66_T2.8131.00
114_E271_V2.8061.00
210_H285_T2.7971.00
180_A204_N2.6961.00
205_L228_A2.6661.00
4_S7_E2.6081.00
233_T283_E2.6021.00
137_Q168_D2.5691.00
147_T172_S2.4501.00
178_S181_A2.4301.00
60_G65_Y2.3651.00
124_A182_A2.2971.00
60_G63_G2.2481.00
125_V136_V2.2191.00
16_D306_R2.2141.00
63_G66_T2.1841.00
122_E147_T2.1831.00
124_A186_A2.1801.00
269_D274_T2.1501.00
155_P159_E2.0091.00
136_V165_L1.9901.00
224_L286_V1.9481.00
301_N305_E1.9461.00
136_V148_I1.9291.00
91_L304_Y1.9041.00
158_R162_A1.9021.00
265_A275_A1.8941.00
208_G283_E1.8591.00
202_S231_R1.8471.00
154_T157_S1.8031.00
201_D204_N1.7791.00
112_V139_T1.7671.00
13_T16_D1.7631.00
206_D209_T1.7591.00
202_S225_D1.7441.00
279_Q283_E1.7111.00
82_L304_Y1.6781.00
152_S157_S1.6491.00
3_L307_A1.6231.00
183_V204_N1.5751.00
80_T300_A1.5721.00
149_H185_G1.5591.00
201_D225_D1.5451.00
112_V212_T1.5421.00
60_G67_Y1.5411.00
269_D275_A1.5341.00
22_R114_E1.5271.00
63_G67_Y1.5271.00
229_I286_V1.5201.00
62_M66_T1.5161.00
123_L145_L1.5031.00
128_S150_V1.4981.00
24_G298_A1.4951.00
80_T99_M1.4791.00
19_D113_D1.4751.00
159_E163_A1.4751.00
84_D91_L1.4701.00
226_T255_A1.4591.00
123_L139_T1.4571.00
22_R26_R1.4441.00
222_R226_T1.4441.00
156_E159_E1.4211.00
304_Y308_V1.4211.00
62_M65_Y1.4141.00
68_S73_S1.4091.00
227_A230_E1.4021.00
233_T279_Q1.3931.00
117_R187_D1.3881.00
9_A98_S1.3881.00
8_I303_L1.3861.00
150_V161_F1.3811.00
80_T96_G1.3791.00
185_G206_D1.3741.00
217_Y221_K1.3731.00
15_A141_T1.3611.00
8_I94_L1.3471.00
92_A304_Y1.3381.00
213_A224_L1.3261.00
17_Y299_A1.3151.00
145_L188_I1.3131.00
113_D143_R1.3111.00
26_R271_V1.3091.00
158_R175_A1.3071.00
232_A286_V1.2921.00
71_F86_D1.2901.00
207_A282_D1.2791.00
278_R283_E1.2781.00
82_L300_A1.2771.00
68_S71_F1.2751.00
280_S283_E1.2611.00
112_V210_H1.2571.00
107_A295_E1.2521.00
239_R269_D1.2511.00
108_G135_Q1.2461.00
259_D262_H1.2451.00
84_D87_S1.2421.00
117_R120_A1.2421.00
155_P177_E1.2281.00
121_S187_D1.2241.00
162_A166_D1.2161.00
68_S72_G1.2101.00
170_D173_V1.2091.00
123_L148_I1.2071.00
21_V110_V1.2061.00
177_E181_A1.2011.00
5_A95_D1.1981.00
234_Y258_V1.1851.00
126_I179_S1.1761.00
20_A302_M1.1741.00
7_E10_G1.1641.00
118_A281_A1.1631.00
162_A173_V1.1551.00
149_H176_V1.1471.00
238_L241_R1.1451.00
235_V270_V1.1431.00
231_R284_I1.1331.00
84_D89_A1.1301.00
243_T260_S1.1301.00
183_V189_V1.1281.00
126_I151_Y1.1181.00
109_A142_V1.1071.00
3_L7_E1.1031.00
306_R309_E1.1021.00
187_D206_D1.0981.00
126_I200_F1.0971.00
124_A149_H1.0931.00
25_Y295_E1.0921.00
110_V114_E1.0911.00
182_A186_A1.0861.00
23_S27_Q1.0821.00
26_R30_E1.0781.00
147_T185_G1.0761.00
152_S158_R1.0741.00
120_A143_R1.0711.00
115_L235_V1.0701.00
120_A188_I1.0691.00
191_T213_A1.0681.00
18_V142_V1.0640.99
112_V188_I1.0620.99
302_M306_R1.0610.99
11_L307_A1.0540.99
160_S164_D1.0450.99
120_A187_D1.0430.99
225_D228_A1.0410.99
161_F165_L1.0400.99
162_A175_A1.0350.99
239_R266_E1.0310.99
14_P138_A1.0260.99
163_A166_D1.0230.99
78_F96_G1.0220.99
163_A167_A1.0070.99
260_S263_I1.0060.99
109_A139_T1.0030.99
32_A57_P0.9980.99
190_I212_T0.9940.99
135_Q192_A0.9910.99
239_R260_S0.9860.99
105_G135_Q0.9770.99
149_H174_S0.9760.99
25_Y107_A0.9730.99
131_Q135_Q0.9730.99
116_A120_A0.9620.99
136_V161_F0.9600.99
73_S87_S0.9590.99
132_A152_S0.9570.99
122_E185_G0.9560.99
61_V66_T0.9520.99
15_A19_D0.9520.99
3_L94_L0.9510.99
128_S157_S0.9500.99
160_S163_A0.9490.99
78_F97_A0.9490.99
94_L303_L0.9460.99
81_P93_L0.9340.99
258_V262_H0.9290.99
248_S288_D0.9270.99
124_A176_V0.9210.99
205_L209_T0.9170.98
128_S161_F0.9150.98
27_Q58_D0.9110.98
196_S220_E0.9110.98
111_G289_S0.9070.98
5_A9_A0.9060.98
215_G223_E0.9050.98
73_S89_A0.9050.98
222_R251_A0.8990.98
239_R243_T0.8990.98
107_A287_F0.8970.98
132_A161_F0.8950.98
19_D23_S0.8950.98
81_P90_P0.8950.98
23_S26_R0.8940.98
189_V205_L0.8920.98
28_R238_L0.8920.98
128_S132_A0.8910.98
139_T190_I0.8900.98
212_T285_T0.8880.98
208_G284_I0.8830.98
159_E162_A0.8820.98
276_P279_Q0.8820.98
157_S160_S0.8810.98
180_A201_D0.8760.98
277_G283_E0.8680.98
124_A179_S0.8680.98
236_P249_F0.8630.98
77_W89_A0.8590.98
150_V175_A0.8540.98
113_D142_V0.8520.98
30_E272_A0.8500.98
112_V143_R0.8470.97
63_G297_V0.8460.97
181_A185_G0.8450.97
112_V190_I0.8430.97
18_V109_A0.8430.97
27_Q32_A0.8400.97
134_G137_Q0.8390.97
235_V265_A0.8380.97
123_L190_I0.8360.97
124_A189_V0.8350.97
114_E270_V0.8250.97
135_Q214_M0.8240.97
17_Y102_L0.8240.97
54_A293_G0.8210.97
203_D227_A0.8180.97
140_A145_L0.8180.97
122_E187_D0.8120.97
126_I199_V0.8090.97
179_S183_V0.8090.97
22_R110_V0.8050.97
265_A269_D0.8050.97
112_V116_A0.8050.97
305_E309_E0.8030.96
209_T284_I0.8020.96
217_Y288_D0.8000.96
226_T252_A0.7970.96
249_F263_I0.7940.96
38_T52_Y0.7900.96
146_D172_S0.7900.96
101_P130_A0.7890.96
140_A171_A0.7870.96
99_M303_L0.7850.96
230_E257_V0.7850.96
153_P157_S0.7830.96
238_L266_E0.7800.96
116_A143_R0.7790.96
237_D242_T0.7790.96
109_A143_R0.7780.96
109_A141_T0.7750.96
16_D19_D0.7740.96
202_S228_A0.7740.96
218_H221_K0.7720.96
124_A178_S0.7670.95
75_D100_N0.7660.95
184_T204_N0.7630.95
50_T217_Y0.7620.95
94_L300_A0.7600.95
251_A255_A0.7540.95
26_R272_A0.7510.95
20_A24_G0.7490.95
191_T200_F0.7490.95
76_A100_N0.7480.95
6_D10_G0.7470.95
111_G212_T0.7450.95
159_E175_A0.7440.95
273_G278_R0.7400.94
117_R281_A0.7390.94
180_A203_D0.7370.94
36_P41_L0.7360.94
221_K288_D0.7290.94
98_S102_L0.7280.94
233_T275_A0.7260.94
266_E269_D0.7260.94
29_G269_D0.7210.94
101_P134_G0.7190.94
6_D9_A0.7190.94
108_G212_T0.7180.94
241_R290_G0.7110.93
211_V228_A0.7090.93
83_Y90_P0.7080.93
116_A188_I0.7070.93
11_L306_R0.7030.93
112_V285_T0.7030.93
36_P39_A0.7010.93
233_T285_T0.6980.93
132_A192_A0.6950.92
50_T76_A0.6940.92
140_A169_L0.6940.92
176_V182_A0.6920.92
50_T221_K0.6870.92
8_I12_A0.6860.92
108_G214_M0.6860.92
200_F211_V0.6850.92
208_G278_R0.6830.92
236_P242_T0.6810.92
246_A250_I0.6780.91
124_A151_Y0.6760.91
226_T230_E0.6740.91
118_A143_R0.6740.91
246_A288_D0.6730.91
27_Q30_E0.6690.91
105_G134_G0.6690.91
149_H182_A0.6670.91
273_G277_G0.6660.91
208_G280_S0.6660.91
14_P105_G0.6650.91
150_V162_A0.6640.91
60_G86_D0.6640.91
29_G266_E0.6620.91
82_L297_V0.6580.90
133_H165_L0.6470.89
203_D231_R0.6460.89
119_D281_A0.6430.89
14_P109_A0.6430.89
151_Y200_F0.6420.89
241_R288_D0.6410.89
217_Y241_R0.6410.89
111_G267_L0.6390.89
79_M93_L0.6370.89
38_T290_G0.6350.89
165_L173_V0.6340.89
184_T206_D0.6340.89
56_L59_D0.6340.89
161_F173_V0.6290.88
278_R281_A0.6280.88
78_F100_N0.6230.88
126_I178_S0.6220.88
228_A286_V0.6210.88
19_D22_R0.6190.87
109_A123_L0.6180.87
151_Y179_S0.6180.87
235_V277_G0.6170.87
248_S251_A0.6150.87
214_M289_S0.6150.87
36_P40_L0.6140.87
143_R188_I0.6130.87
145_L148_I0.6130.87
189_V209_T0.6130.87
205_L284_I0.6130.87
61_V65_Y0.6130.87
91_L308_V0.6100.87
12_A303_L0.6100.87
200_F225_D0.6080.86
211_V224_L0.6040.86
90_P93_L0.6030.86
305_E308_V0.6020.86
111_G287_F0.6010.86
23_S59_D0.6000.86
193_T223_E0.6000.86
14_P141_T0.5990.86
217_Y290_G0.5970.85
302_M305_E0.5950.85
201_D227_A0.5940.85
122_E186_A0.5910.85
240_G244_Q0.5870.84
236_P239_R0.5860.84
184_T203_D0.5860.84
21_V299_A0.5840.84
192_A214_M0.5840.84
176_V181_A0.5830.84
66_T83_Y0.5820.84
128_S158_R0.5810.84
122_E146_D0.5790.84
234_Y262_H0.5770.83
195_A198_P0.5760.83
48_M221_K0.5740.83
56_L298_A0.5740.83
20_A299_A0.5740.83
48_M218_H0.5730.83
152_S289_S0.5720.83
40_L293_G0.5710.83
37_R241_R0.5700.83
54_A297_V0.5690.83
67_Y76_A0.5690.83
5_A96_G0.5660.82
52_Y290_G0.5660.82
205_L211_V0.5650.82
148_I171_A0.5650.82
274_T277_G0.5650.82
28_R294_I0.5640.82
137_Q169_L0.5630.82
36_P53_S0.5620.82
79_M90_P0.5610.82
18_V141_T0.5610.82
17_Y138_A0.5570.81
207_A284_I0.5570.81
108_G139_T0.5560.81
273_G276_P0.5560.81
3_L303_L0.5540.81
11_L303_L0.5540.81
202_S227_A0.5540.81
38_T41_L0.5530.81
25_Y28_R0.5520.81
243_T263_I0.5520.81
155_P158_R0.5490.80
17_Y21_V0.5490.80
241_R292_T0.5480.80
149_H186_A0.5480.80
268_G271_V0.5460.80
148_I173_V0.5450.80
61_V301_N0.5430.80
41_L51_D0.5430.80
137_Q165_L0.5420.79
122_E206_D0.5410.79
155_P175_A0.5390.79
242_T290_G0.5380.79
182_A185_G0.5370.79
121_S144_D0.5370.79
35_E40_L0.5370.79
50_T241_R0.5360.79
21_V295_E0.5360.79
67_Y78_F0.5360.79
269_D273_G0.5350.79
21_V106_A0.5330.78
107_A292_T0.5320.78
156_E160_S0.5320.78
249_F258_V0.5320.78
159_E166_D0.5310.78
213_A248_S0.5310.78
29_G268_G0.5310.78
234_Y249_F0.5310.78
95_D100_N0.5270.78
238_L292_T0.5270.78
124_A183_V0.5270.78
52_Y246_A0.5260.77
153_P289_S0.5260.77
79_M83_Y0.5250.77
131_Q190_I0.5250.77
103_K290_G0.5240.77
105_G151_Y0.5240.77
34_A41_L0.5220.77
246_A290_G0.5180.76
189_V211_V0.5170.76
104_T296_T0.5170.76
105_G138_A0.5170.76
219_P250_I0.5170.76
196_S221_K0.5120.76
150_V165_L0.5080.75
7_E11_L0.5070.75
151_Y199_V0.5060.75
38_T288_D0.5060.75
247_G252_A0.5050.75
35_E54_A0.5040.74
123_L136_V0.5040.74
51_D54_A0.5030.74
61_V91_L0.5020.74
248_S252_A0.5010.74
209_T228_A0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1omoA 2 0.9512 100 0.287 Contact Map
4mp8A 2 0.9573 100 0.297 Contact Map
3hdjA 2 0.939 100 0.31 Contact Map
4bvaA 2 0.8872 100 0.333 Contact Map
1x7dA 2 0.9634 100 0.378 Contact Map
3oj0A 1 0.4207 99.4 0.833 Contact Map
4ppmA 2 0.0274 99.3 0.847 Contact Map
3pwzA 1 0.7165 99.1 0.856 Contact Map
3donA 1 0.7073 98.9 0.868 Contact Map
2hk9A 1 0.6951 98.8 0.872 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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