Q9HQ24 - HALSA - GREMLIN Contacts

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Q9HQ24 - Ornithine cyclodeaminase

UniProt:	Q9HQ24	Sequences: MFLSADEIAGLATPADYVDAVRSGYRQRGEGAPAEPRTALLREDPAGMFTDYSALLPDDGVMGGYTYSAGFGSGDAWFMTPLYDADSGAPLALLDGASMNPLKTGAAGAVGVDELARADASELAVIGSSAQAHGQVQATATVRDLDTIHVYSPTPESRESFAADLDADLDASVSAVESSAAAVTGADIVITATSASEPVFDSDNLDAGTHVTAMGQYHPEKRELDTAAIERATYVPDLRGRTTQDAGSFIAAVDAGVVDSDHIHAELGDVVAGTAPGRQSADEITVFDSGGTGIETVAAANMLYERAVEQDLGSELDFAPASEALYGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	328 (303)
Sequences:	3959 (2917)
Seq/√Len:	167.6

HALSA - Q9HQ24 Q9HN71
SULSO - Q97TY8 Q980D6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
121_S	146_D	4.073	1.00
22_R	113_D	3.956	1.00
128_S	152_S	3.457	1.00
133_H	164_D	3.157	1.00
147_T	174_S	2.893	1.00
122_E	149_H	2.891	1.00
180_A	184_T	2.847	1.00
60_G	66_T	2.813	1.00
114_E	271_V	2.806	1.00
210_H	285_T	2.797	1.00
180_A	204_N	2.696	1.00
205_L	228_A	2.666	1.00
4_S	7_E	2.608	1.00
233_T	283_E	2.602	1.00
137_Q	168_D	2.569	1.00
147_T	172_S	2.450	1.00
178_S	181_A	2.430	1.00
60_G	65_Y	2.365	1.00
124_A	182_A	2.297	1.00
60_G	63_G	2.248	1.00
125_V	136_V	2.219	1.00
16_D	306_R	2.214	1.00
63_G	66_T	2.184	1.00
122_E	147_T	2.183	1.00
124_A	186_A	2.180	1.00
269_D	274_T	2.150	1.00
155_P	159_E	2.009	1.00
136_V	165_L	1.990	1.00
224_L	286_V	1.948	1.00
301_N	305_E	1.946	1.00
136_V	148_I	1.929	1.00
91_L	304_Y	1.904	1.00
158_R	162_A	1.902	1.00
265_A	275_A	1.894	1.00
208_G	283_E	1.859	1.00
202_S	231_R	1.847	1.00
154_T	157_S	1.803	1.00
201_D	204_N	1.779	1.00
112_V	139_T	1.767	1.00
13_T	16_D	1.763	1.00
206_D	209_T	1.759	1.00
202_S	225_D	1.744	1.00
279_Q	283_E	1.711	1.00
82_L	304_Y	1.678	1.00
152_S	157_S	1.649	1.00
3_L	307_A	1.623	1.00
183_V	204_N	1.575	1.00
80_T	300_A	1.572	1.00
149_H	185_G	1.559	1.00
201_D	225_D	1.545	1.00
112_V	212_T	1.542	1.00
60_G	67_Y	1.541	1.00
269_D	275_A	1.534	1.00
22_R	114_E	1.527	1.00
63_G	67_Y	1.527	1.00
229_I	286_V	1.520	1.00
62_M	66_T	1.516	1.00
123_L	145_L	1.503	1.00
128_S	150_V	1.498	1.00
24_G	298_A	1.495	1.00
80_T	99_M	1.479	1.00
19_D	113_D	1.475	1.00
159_E	163_A	1.475	1.00
84_D	91_L	1.470	1.00
226_T	255_A	1.459	1.00
123_L	139_T	1.457	1.00
22_R	26_R	1.444	1.00
222_R	226_T	1.444	1.00
156_E	159_E	1.421	1.00
304_Y	308_V	1.421	1.00
62_M	65_Y	1.414	1.00
68_S	73_S	1.409	1.00
227_A	230_E	1.402	1.00
233_T	279_Q	1.393	1.00
117_R	187_D	1.388	1.00
9_A	98_S	1.388	1.00
8_I	303_L	1.386	1.00
150_V	161_F	1.381	1.00
80_T	96_G	1.379	1.00
185_G	206_D	1.374	1.00
217_Y	221_K	1.373	1.00
15_A	141_T	1.361	1.00
8_I	94_L	1.347	1.00
92_A	304_Y	1.338	1.00
213_A	224_L	1.326	1.00
17_Y	299_A	1.315	1.00
145_L	188_I	1.313	1.00
113_D	143_R	1.311	1.00
26_R	271_V	1.309	1.00
158_R	175_A	1.307	1.00
232_A	286_V	1.292	1.00
71_F	86_D	1.290	1.00
207_A	282_D	1.279	1.00
278_R	283_E	1.278	1.00
82_L	300_A	1.277	1.00
68_S	71_F	1.275	1.00
280_S	283_E	1.261	1.00
112_V	210_H	1.257	1.00
107_A	295_E	1.252	1.00
239_R	269_D	1.251	1.00
108_G	135_Q	1.246	1.00
259_D	262_H	1.245	1.00
84_D	87_S	1.242	1.00
117_R	120_A	1.242	1.00
155_P	177_E	1.228	1.00
121_S	187_D	1.224	1.00
162_A	166_D	1.216	1.00
68_S	72_G	1.210	1.00
170_D	173_V	1.209	1.00
123_L	148_I	1.207	1.00
21_V	110_V	1.206	1.00
177_E	181_A	1.201	1.00
5_A	95_D	1.198	1.00
234_Y	258_V	1.185	1.00
126_I	179_S	1.176	1.00
20_A	302_M	1.174	1.00
7_E	10_G	1.164	1.00
118_A	281_A	1.163	1.00
162_A	173_V	1.155	1.00
149_H	176_V	1.147	1.00
238_L	241_R	1.145	1.00
235_V	270_V	1.143	1.00
231_R	284_I	1.133	1.00
84_D	89_A	1.130	1.00
243_T	260_S	1.130	1.00
183_V	189_V	1.128	1.00
126_I	151_Y	1.118	1.00
109_A	142_V	1.107	1.00
3_L	7_E	1.103	1.00
306_R	309_E	1.102	1.00
187_D	206_D	1.098	1.00
126_I	200_F	1.097	1.00
124_A	149_H	1.093	1.00
25_Y	295_E	1.092	1.00
110_V	114_E	1.091	1.00
182_A	186_A	1.086	1.00
23_S	27_Q	1.082	1.00
26_R	30_E	1.078	1.00
147_T	185_G	1.076	1.00
152_S	158_R	1.074	1.00
120_A	143_R	1.071	1.00
115_L	235_V	1.070	1.00
120_A	188_I	1.069	1.00
191_T	213_A	1.068	1.00
18_V	142_V	1.064	0.99
112_V	188_I	1.062	0.99
302_M	306_R	1.061	0.99
11_L	307_A	1.054	0.99
160_S	164_D	1.045	0.99
120_A	187_D	1.043	0.99
225_D	228_A	1.041	0.99
161_F	165_L	1.040	0.99
162_A	175_A	1.035	0.99
239_R	266_E	1.031	0.99
14_P	138_A	1.026	0.99
163_A	166_D	1.023	0.99
78_F	96_G	1.022	0.99
163_A	167_A	1.007	0.99
260_S	263_I	1.006	0.99
109_A	139_T	1.003	0.99
32_A	57_P	0.998	0.99
190_I	212_T	0.994	0.99
135_Q	192_A	0.991	0.99
239_R	260_S	0.986	0.99
105_G	135_Q	0.977	0.99
149_H	174_S	0.976	0.99
25_Y	107_A	0.973	0.99
131_Q	135_Q	0.973	0.99
116_A	120_A	0.962	0.99
136_V	161_F	0.960	0.99
73_S	87_S	0.959	0.99
132_A	152_S	0.957	0.99
122_E	185_G	0.956	0.99
61_V	66_T	0.952	0.99
15_A	19_D	0.952	0.99
3_L	94_L	0.951	0.99
128_S	157_S	0.950	0.99
160_S	163_A	0.949	0.99
78_F	97_A	0.949	0.99
94_L	303_L	0.946	0.99
81_P	93_L	0.934	0.99
258_V	262_H	0.929	0.99
248_S	288_D	0.927	0.99
124_A	176_V	0.921	0.99
205_L	209_T	0.917	0.98
128_S	161_F	0.915	0.98
27_Q	58_D	0.911	0.98
196_S	220_E	0.911	0.98
111_G	289_S	0.907	0.98
5_A	9_A	0.906	0.98
215_G	223_E	0.905	0.98
73_S	89_A	0.905	0.98
222_R	251_A	0.899	0.98
239_R	243_T	0.899	0.98
107_A	287_F	0.897	0.98
132_A	161_F	0.895	0.98
19_D	23_S	0.895	0.98
81_P	90_P	0.895	0.98
23_S	26_R	0.894	0.98
189_V	205_L	0.892	0.98
28_R	238_L	0.892	0.98
128_S	132_A	0.891	0.98
139_T	190_I	0.890	0.98
212_T	285_T	0.888	0.98
208_G	284_I	0.883	0.98
159_E	162_A	0.882	0.98
276_P	279_Q	0.882	0.98
157_S	160_S	0.881	0.98
180_A	201_D	0.876	0.98
277_G	283_E	0.868	0.98
124_A	179_S	0.868	0.98
236_P	249_F	0.863	0.98
77_W	89_A	0.859	0.98
150_V	175_A	0.854	0.98
113_D	142_V	0.852	0.98
30_E	272_A	0.850	0.98
112_V	143_R	0.847	0.97
63_G	297_V	0.846	0.97
181_A	185_G	0.845	0.97
112_V	190_I	0.843	0.97
18_V	109_A	0.843	0.97
27_Q	32_A	0.840	0.97
134_G	137_Q	0.839	0.97
235_V	265_A	0.838	0.97
123_L	190_I	0.836	0.97
124_A	189_V	0.835	0.97
114_E	270_V	0.825	0.97
135_Q	214_M	0.824	0.97
17_Y	102_L	0.824	0.97
54_A	293_G	0.821	0.97
203_D	227_A	0.818	0.97
140_A	145_L	0.818	0.97
122_E	187_D	0.812	0.97
126_I	199_V	0.809	0.97
179_S	183_V	0.809	0.97
22_R	110_V	0.805	0.97
265_A	269_D	0.805	0.97
112_V	116_A	0.805	0.97
305_E	309_E	0.803	0.96
209_T	284_I	0.802	0.96
217_Y	288_D	0.800	0.96
226_T	252_A	0.797	0.96
249_F	263_I	0.794	0.96
38_T	52_Y	0.790	0.96
146_D	172_S	0.790	0.96
101_P	130_A	0.789	0.96
140_A	171_A	0.787	0.96
99_M	303_L	0.785	0.96
230_E	257_V	0.785	0.96
153_P	157_S	0.783	0.96
238_L	266_E	0.780	0.96
116_A	143_R	0.779	0.96
237_D	242_T	0.779	0.96
109_A	143_R	0.778	0.96
109_A	141_T	0.775	0.96
16_D	19_D	0.774	0.96
202_S	228_A	0.774	0.96
218_H	221_K	0.772	0.96
124_A	178_S	0.767	0.95
75_D	100_N	0.766	0.95
184_T	204_N	0.763	0.95
50_T	217_Y	0.762	0.95
94_L	300_A	0.760	0.95
251_A	255_A	0.754	0.95
26_R	272_A	0.751	0.95
20_A	24_G	0.749	0.95
191_T	200_F	0.749	0.95
76_A	100_N	0.748	0.95
6_D	10_G	0.747	0.95
111_G	212_T	0.745	0.95
159_E	175_A	0.744	0.95
273_G	278_R	0.740	0.94
117_R	281_A	0.739	0.94
180_A	203_D	0.737	0.94
36_P	41_L	0.736	0.94
221_K	288_D	0.729	0.94
98_S	102_L	0.728	0.94
233_T	275_A	0.726	0.94
266_E	269_D	0.726	0.94
29_G	269_D	0.721	0.94
101_P	134_G	0.719	0.94
6_D	9_A	0.719	0.94
108_G	212_T	0.718	0.94
241_R	290_G	0.711	0.93
211_V	228_A	0.709	0.93
83_Y	90_P	0.708	0.93
116_A	188_I	0.707	0.93
11_L	306_R	0.703	0.93
112_V	285_T	0.703	0.93
36_P	39_A	0.701	0.93
233_T	285_T	0.698	0.93
132_A	192_A	0.695	0.92
50_T	76_A	0.694	0.92
140_A	169_L	0.694	0.92
176_V	182_A	0.692	0.92
50_T	221_K	0.687	0.92
8_I	12_A	0.686	0.92
108_G	214_M	0.686	0.92
200_F	211_V	0.685	0.92
208_G	278_R	0.683	0.92
236_P	242_T	0.681	0.92
246_A	250_I	0.678	0.91
124_A	151_Y	0.676	0.91
226_T	230_E	0.674	0.91
118_A	143_R	0.674	0.91
246_A	288_D	0.673	0.91
27_Q	30_E	0.669	0.91
105_G	134_G	0.669	0.91
149_H	182_A	0.667	0.91
273_G	277_G	0.666	0.91
208_G	280_S	0.666	0.91
14_P	105_G	0.665	0.91
150_V	162_A	0.664	0.91
60_G	86_D	0.664	0.91
29_G	266_E	0.662	0.91
82_L	297_V	0.658	0.90
133_H	165_L	0.647	0.89
203_D	231_R	0.646	0.89
119_D	281_A	0.643	0.89
14_P	109_A	0.643	0.89
151_Y	200_F	0.642	0.89
241_R	288_D	0.641	0.89
217_Y	241_R	0.641	0.89
111_G	267_L	0.639	0.89
79_M	93_L	0.637	0.89
38_T	290_G	0.635	0.89
165_L	173_V	0.634	0.89
184_T	206_D	0.634	0.89
56_L	59_D	0.634	0.89
161_F	173_V	0.629	0.88
278_R	281_A	0.628	0.88
78_F	100_N	0.623	0.88
126_I	178_S	0.622	0.88
228_A	286_V	0.621	0.88
19_D	22_R	0.619	0.87
109_A	123_L	0.618	0.87
151_Y	179_S	0.618	0.87
235_V	277_G	0.617	0.87
248_S	251_A	0.615	0.87
214_M	289_S	0.615	0.87
36_P	40_L	0.614	0.87
143_R	188_I	0.613	0.87
145_L	148_I	0.613	0.87
189_V	209_T	0.613	0.87
205_L	284_I	0.613	0.87
61_V	65_Y	0.613	0.87
91_L	308_V	0.610	0.87
12_A	303_L	0.610	0.87
200_F	225_D	0.608	0.86
211_V	224_L	0.604	0.86
90_P	93_L	0.603	0.86
305_E	308_V	0.602	0.86
111_G	287_F	0.601	0.86
23_S	59_D	0.600	0.86
193_T	223_E	0.600	0.86
14_P	141_T	0.599	0.86
217_Y	290_G	0.597	0.85
302_M	305_E	0.595	0.85
201_D	227_A	0.594	0.85
122_E	186_A	0.591	0.85
240_G	244_Q	0.587	0.84
236_P	239_R	0.586	0.84
184_T	203_D	0.586	0.84
21_V	299_A	0.584	0.84
192_A	214_M	0.584	0.84
176_V	181_A	0.583	0.84
66_T	83_Y	0.582	0.84
128_S	158_R	0.581	0.84
122_E	146_D	0.579	0.84
234_Y	262_H	0.577	0.83
195_A	198_P	0.576	0.83
48_M	221_K	0.574	0.83
56_L	298_A	0.574	0.83
20_A	299_A	0.574	0.83
48_M	218_H	0.573	0.83
152_S	289_S	0.572	0.83
40_L	293_G	0.571	0.83
37_R	241_R	0.570	0.83
54_A	297_V	0.569	0.83
67_Y	76_A	0.569	0.83
5_A	96_G	0.566	0.82
52_Y	290_G	0.566	0.82
205_L	211_V	0.565	0.82
148_I	171_A	0.565	0.82
274_T	277_G	0.565	0.82
28_R	294_I	0.564	0.82
137_Q	169_L	0.563	0.82
36_P	53_S	0.562	0.82
79_M	90_P	0.561	0.82
18_V	141_T	0.561	0.82
17_Y	138_A	0.557	0.81
207_A	284_I	0.557	0.81
108_G	139_T	0.556	0.81
273_G	276_P	0.556	0.81
3_L	303_L	0.554	0.81
11_L	303_L	0.554	0.81
202_S	227_A	0.554	0.81
38_T	41_L	0.553	0.81
25_Y	28_R	0.552	0.81
243_T	263_I	0.552	0.81
155_P	158_R	0.549	0.80
17_Y	21_V	0.549	0.80
241_R	292_T	0.548	0.80
149_H	186_A	0.548	0.80
268_G	271_V	0.546	0.80
148_I	173_V	0.545	0.80
61_V	301_N	0.543	0.80
41_L	51_D	0.543	0.80
137_Q	165_L	0.542	0.79
122_E	206_D	0.541	0.79
155_P	175_A	0.539	0.79
242_T	290_G	0.538	0.79
182_A	185_G	0.537	0.79
121_S	144_D	0.537	0.79
35_E	40_L	0.537	0.79
50_T	241_R	0.536	0.79
21_V	295_E	0.536	0.79
67_Y	78_F	0.536	0.79
269_D	273_G	0.535	0.79
21_V	106_A	0.533	0.78
107_A	292_T	0.532	0.78
156_E	160_S	0.532	0.78
249_F	258_V	0.532	0.78
159_E	166_D	0.531	0.78
213_A	248_S	0.531	0.78
29_G	268_G	0.531	0.78
234_Y	249_F	0.531	0.78
95_D	100_N	0.527	0.78
238_L	292_T	0.527	0.78
124_A	183_V	0.527	0.78
52_Y	246_A	0.526	0.77
153_P	289_S	0.526	0.77
79_M	83_Y	0.525	0.77
131_Q	190_I	0.525	0.77
103_K	290_G	0.524	0.77
105_G	151_Y	0.524	0.77
34_A	41_L	0.522	0.77
246_A	290_G	0.518	0.76
189_V	211_V	0.517	0.76
104_T	296_T	0.517	0.76
105_G	138_A	0.517	0.76
219_P	250_I	0.517	0.76
196_S	221_K	0.512	0.76
150_V	165_L	0.508	0.75
7_E	11_L	0.507	0.75
151_Y	199_V	0.506	0.75
38_T	288_D	0.506	0.75
247_G	252_A	0.505	0.75
35_E	54_A	0.504	0.74
123_L	136_V	0.504	0.74
51_D	54_A	0.503	0.74
61_V	91_L	0.502	0.74
248_S	252_A	0.501	0.74
209_T	228_A	0.500	0.74

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1omoA	2	0.9512	100	0.287	Contact Map
4mp8A	2	0.9573	100	0.297	Contact Map
3hdjA	2	0.939	100	0.31	Contact Map
4bvaA	2	0.8872	100	0.333	Contact Map
1x7dA	2	0.9634	100	0.378	Contact Map
3oj0A	1	0.4207	99.4	0.833	Contact Map
4ppmA	2	0.0274	99.3	0.847	Contact Map
3pwzA	1	0.7165	99.1	0.856	Contact Map
3donA	1	0.7073	98.9	0.868	Contact Map
2hk9A	1	0.6951	98.8	0.872	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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