GREMLIN Database
Q9HQ23 - Uncharacterized protein
UniProt: Q9HQ23 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (279)
Sequences: 333 (222)
Seq/√Len: 13.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_L154_L2.9840.97
245_F300_G2.9400.96
232_A266_T2.9200.96
134_M186_I2.9190.96
83_S86_V2.8420.96
53_V157_A2.7640.95
269_G285_G2.5670.92
82_T237_I2.4450.90
295_A306_I2.3370.88
268_V288_L2.3220.88
25_A28_L2.3030.87
209_A212_G2.3030.87
206_A211_A2.2040.85
265_G287_P2.1850.84
35_A50_V2.1450.83
233_V239_V2.1180.82
162_D166_V2.0990.82
133_I219_P2.0720.81
170_E281_R2.0690.81
266_T269_G2.0620.81
120_A140_A2.0520.80
208_E211_A2.0230.79
155_L186_I2.0190.79
107_V259_P2.0070.79
56_L268_V1.9910.78
296_G300_G1.9140.75
152_I234_M1.9070.75
138_A272_V1.8980.75
203_A271_L1.8930.74
86_V138_A1.8880.74
87_A229_L1.8620.73
148_V300_G1.8600.73
105_L200_E1.8600.73
202_A212_G1.8340.72
113_A302_V1.8340.72
81_V304_A1.8210.71
169_T172_M1.8080.71
266_T285_G1.7890.70
87_A186_I1.7830.70
139_A270_L1.7820.70
151_A186_I1.7750.69
57_L161_Y1.7650.69
206_A210_E1.7630.69
236_S266_T1.7440.68
265_G286_L1.7400.68
59_A90_V1.7380.68
167_Y172_M1.7210.67
226_F229_L1.7080.66
82_T108_W1.6880.65
114_L184_L1.6840.65
23_V156_T1.6780.65
226_F232_A1.6580.64
83_S87_A1.6500.64
123_E275_R1.6370.63
49_S151_A1.6010.61
269_G284_A1.5990.61
30_E94_A1.5920.61
26_L30_E1.5780.60
171_H235_P1.5690.60
266_T284_A1.5510.59
40_T43_P1.5370.58
20_V23_V1.5340.58
52_Y154_L1.5220.57
173_L234_M1.5210.57
68_K185_P1.5100.57
150_P240_A1.5010.56
77_G81_V1.4940.56
135_G185_P1.4740.55
110_P130_A1.4670.54
74_I207_D1.4580.54
124_W191_P1.4530.54
262_A299_V1.4420.53
54_A263_M1.4330.52
114_L226_F1.4300.52
53_V154_L1.4280.52
35_A45_N1.4270.52
206_A212_G1.4030.51
135_G168_G1.3880.50
191_P224_A1.3850.50
68_K132_A1.3830.50
126_V129_A1.3780.50
38_Q135_G1.3570.48
206_A209_A1.3560.48
82_T184_L1.3530.48
98_V151_A1.3530.48
272_V291_G1.3490.48
208_E212_G1.3480.48
49_S134_M1.3330.47
177_S184_L1.3260.47
75_L237_I1.3110.46
53_V160_V1.3100.46
228_G231_D1.2700.44
119_Y187_V1.2650.44
169_T266_T1.2530.43
269_G283_H1.2520.43
50_V62_G1.2450.43
167_Y190_V1.2320.42
89_Y246_L1.2320.42
43_P161_Y1.2310.42
124_W127_I1.2290.42
179_V182_L1.2140.41
53_V161_Y1.2090.41
167_Y171_H1.2000.40
109_G272_V1.1880.40
146_F223_P1.1860.40
207_D211_A1.1860.40
154_L164_I1.1750.39
138_A281_R1.1720.39
78_V234_M1.1680.39
232_A235_P1.1650.39
56_L264_A1.1610.38
132_A140_A1.1500.38
265_G273_L1.1430.37
163_A172_M1.1430.37
172_M235_P1.1380.37
45_N49_S1.1330.37
68_K168_G1.1310.37
59_A69_Y1.1260.37
92_A267_L1.1130.36
176_A282_A1.1100.36
142_F189_V1.1090.36
108_W260_L1.1080.36
180_M281_R1.1080.36
199_V207_D1.1030.35
110_P295_A1.0960.35
33_Q107_V1.0950.35
161_Y273_L1.0920.35
273_L287_P1.0840.35
97_A101_A1.0830.35
208_E213_E1.0820.34
177_S236_S1.0750.34
142_F270_L1.0730.34
56_L229_L1.0710.34
239_V257_L1.0690.34
66_V233_V1.0680.34
88_S91_F1.0660.34
174_T186_I1.0520.33
265_G284_A1.0420.33
111_A223_P1.0360.32
232_A236_S1.0340.32
18_F46_P1.0320.32
196_Y200_E1.0270.32
159_A294_I1.0220.32
21_V113_A1.0180.31
183_R189_V1.0180.31
173_L188_L1.0120.31
105_L294_I1.0070.31
123_E224_A1.0070.31
221_D281_R1.0020.31
210_E213_E1.0000.31
204_E210_E1.0000.31
284_A287_P0.9980.31
39_S306_I0.9900.30
82_T236_S0.9870.30
28_L144_I0.9830.30
78_V191_P0.9830.30
237_I272_V0.9830.30
204_E207_D0.9800.30
48_N55_F0.9780.30
39_S56_L0.9770.30
116_G268_V0.9760.30
44_Q148_V0.9710.29
80_L133_I0.9670.29
156_T293_A0.9660.29
184_L233_V0.9650.29
56_L129_A0.9630.29
121_Y225_Y0.9610.29
163_A176_A0.9590.29
81_V152_I0.9570.29
61_G65_L0.9510.28
118_L139_A0.9460.28
177_S240_A0.9420.28
164_I213_E0.9330.28
135_G180_M0.9310.28
78_V152_I0.9290.28
109_G152_I0.9270.27
42_N151_A0.9260.27
78_V168_G0.9260.27
239_V272_V0.9250.27
75_L86_V0.9240.27
204_E213_E0.9220.27
235_P285_G0.9140.27
37_L161_Y0.9140.27
137_G176_A0.9050.27
29_V132_A0.9010.26
74_I104_N0.9010.26
85_L112_L0.8990.26
81_V160_V0.8960.26
114_L130_A0.8770.25
190_V234_M0.8750.25
173_L187_V0.8720.25
62_G65_L0.8720.25
89_Y185_P0.8710.25
89_Y281_R0.8690.25
171_H285_G0.8670.25
153_V160_V0.8660.25
289_L297_Y0.8660.25
99_V106_A0.8560.25
157_A245_F0.8520.24
25_A260_L0.8500.24
121_Y141_L0.8480.24
48_N68_K0.8420.24
207_D210_E0.8400.24
18_F151_A0.8360.24
180_M224_A0.8340.24
126_V153_V0.8340.24
112_L219_P0.8330.24
124_W136_M0.8300.24
73_W266_T0.8290.24
174_T177_S0.8270.23
104_N156_T0.8230.23
53_V276_M0.8200.23
43_P174_T0.8180.23
108_W181_E0.8150.23
122_P224_A0.8150.23
58_V112_L0.8110.23
134_M281_R0.8100.23
79_V179_V0.8070.23
56_L158_L0.7990.22
18_F24_G0.7990.22
233_V257_L0.7940.22
128_D152_I0.7890.22
122_P191_P0.7810.22
165_S172_M0.7760.22
203_A207_D0.7760.22
118_L163_A0.7750.22
39_S106_A0.7740.22
136_M294_I0.7700.21
114_L232_A0.7660.21
74_I95_I0.7650.21
167_Y173_L0.7650.21
40_T161_Y0.7640.21
60_T175_L0.7620.21
40_T55_F0.7610.21
59_A233_V0.7610.21
105_L210_E0.7600.21
98_V103_V0.7560.21
70_D117_A0.7540.21
142_F237_I0.7530.21
57_L156_T0.7530.21
83_S175_L0.7520.21
26_L29_V0.7520.21
117_A159_A0.7470.21
147_G182_L0.7470.21
97_A142_F0.7460.21
79_V111_A0.7450.20
155_L240_A0.7400.20
295_A299_V0.7400.20
158_L164_I0.7390.20
148_V241_S0.7390.20
270_L274_M0.7390.20
66_V232_A0.7390.20
269_G290_N0.7370.20
56_L276_M0.7340.20
60_T142_F0.7320.20
105_L212_G0.7240.20
108_W116_G0.7210.20
288_L305_G0.7210.20
126_V291_G0.7190.20
37_L190_V0.7180.20
111_A119_Y0.7170.20
137_G159_A0.7140.19
142_F175_L0.7140.19
92_A103_V0.7110.19
147_G151_A0.7110.19
181_E294_I0.7090.19
109_G229_L0.7080.19
167_Y285_G0.7070.19
199_V233_V0.7040.19
65_L71_K0.7030.19
105_L206_A0.7010.19
167_Y235_P0.7010.19
58_V102_G0.7000.19
32_F47_L0.6980.19
26_L145_S0.6970.19
44_Q47_L0.6970.19
128_D169_T0.6970.19
92_A281_R0.6960.19
95_I104_N0.6960.19
97_A153_V0.6950.19
23_V154_L0.6930.19
187_V241_S0.6930.19
72_Q127_I0.6900.19
269_G291_G0.6880.19
275_R288_L0.6850.19
207_D212_G0.6850.19
88_S111_A0.6850.19
131_G140_A0.6830.18
52_Y84_G0.6800.18
180_M185_P0.6770.18
241_S244_F0.6750.18
223_P289_L0.6720.18
76_R139_A0.6720.18
28_L54_A0.6710.18
171_H232_A0.6710.18
67_I234_M0.6690.18
152_I235_P0.6690.18
205_T210_E0.6640.18
55_F145_S0.6620.18
139_A188_L0.6620.18
186_I276_M0.6590.18
69_Y212_G0.6550.18
180_M260_L0.6550.18
131_G283_H0.6550.18
70_D95_I0.6490.17
18_F73_W0.6480.17
88_S187_V0.6480.17
117_A157_A0.6420.17
273_L282_A0.6390.17
91_F110_P0.6380.17
63_I142_F0.6370.17
91_F178_G0.6350.17
51_V236_S0.6330.17
82_T267_L0.6310.17
75_L79_V0.6310.17
154_L161_Y0.6300.17
81_V294_I0.6280.17
186_I199_V0.6280.17
290_N307_P0.6240.17
212_G219_P0.6230.17
152_I266_T0.6230.17
104_N134_M0.6220.17
18_F139_A0.6220.17
45_N60_T0.6210.17
202_A210_E0.6170.16
109_G187_V0.6160.16
128_D150_P0.6120.16
131_G235_P0.6070.16
128_D235_P0.6050.16
56_L160_V0.6020.16
233_V255_I0.6010.16
62_G105_L0.6010.16
48_N118_L0.5990.16
132_A302_V0.5960.16
206_A213_E0.5960.16
152_I171_H0.5960.16
242_A262_A0.5940.16
130_A288_L0.5940.16
235_P269_G0.5930.16
203_A210_E0.5930.16
28_L161_Y0.5920.16
67_I178_G0.5910.16
169_T235_P0.5910.16
265_G285_G0.5900.16
41_E138_A0.5890.16
285_G296_G0.5890.16
57_L62_G0.5880.16
98_V205_T0.5870.16
52_Y302_V0.5870.16
35_A112_L0.5860.16
110_P115_V0.5850.16
147_G240_A0.5830.15
177_S301_A0.5820.15
125_W148_V0.5810.15
96_P141_L0.5800.15
75_L97_A0.5790.15
173_L283_H0.5780.15
69_Y296_G0.5750.15
51_V108_W0.5750.15
78_V115_V0.5730.15
130_A226_F0.5730.15
75_L159_A0.5700.15
176_A235_P0.5700.15
60_T283_H0.5670.15
273_L286_L0.5610.15
169_T190_V0.5590.15
242_A258_A0.5570.15
28_L32_F0.5550.15
148_V307_P0.5520.15
191_P196_Y0.5520.15
56_L292_G0.5510.15
20_V303_A0.5500.15
36_G209_A0.5490.15
58_V264_A0.5490.15
134_M142_F0.5480.15
227_I266_T0.5460.14
116_G197_S0.5460.14
128_D171_H0.5440.14
131_G171_H0.5440.14
200_E209_A0.5430.14
94_A192_T0.5410.14
204_E302_V0.5410.14
172_M176_A0.5410.14
84_G113_A0.5400.14
61_G82_T0.5390.14
29_V244_F0.5390.14
153_V305_G0.5380.14
20_V302_V0.5370.14
171_H269_G0.5370.14
98_V113_A0.5360.14
146_F276_M0.5330.14
266_T283_H0.5320.14
171_H190_V0.5280.14
68_K299_V0.5240.14
157_A208_E0.5210.14
63_I156_T0.5210.14
171_H176_A0.5200.14
82_T112_L0.5180.14
166_V230_G0.5170.14
137_G191_P0.5160.14
78_V99_V0.5150.14
52_Y106_A0.5150.14
47_L247_D0.5140.14
195_A198_F0.5130.14
80_L94_A0.5120.14
162_D230_G0.5110.14
172_M190_V0.5100.14
49_S272_V0.5090.14
114_L227_I0.5090.14
128_D167_Y0.5070.13
172_M285_G0.5060.13
191_P298_L0.5060.13
115_V238_M0.5050.13
173_L288_L0.5050.13
41_E112_L0.5040.13
95_I100_V0.5030.13
47_L69_Y0.5010.13
284_A289_L0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5a63B 1 0.6101 100 0.154 Contact Map
4hygA 3 0.7767 100 0.495 Contact Map
4uisB 1 0.3208 100 0.536 Contact Map
4pypA 1 0.5252 35.5 0.964 Contact Map
4px7A 1 0.6006 31.2 0.965 Contact Map
4m64A 1 0.5629 30.4 0.965 Contact Map
4zw9A 1 0.5755 26.7 0.966 Contact Map
3wdoA 1 0.6855 19.2 0.969 Contact Map
4j05A 3 0.8019 18.6 0.969 Contact Map
4i0uA 4 0.1981 14.7 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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