Q9HQ23 - HALSA - GREMLIN Contacts

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Q9HQ23 - Uncharacterized protein

UniProt:	Q9HQ23	Sequences: MNDSTRVAAVLAGVVALFVVVQVGALALVEPFQSAGLQSTENPQNPLNSVVYVAFLLVATGGILLVIKYDKQWILRGVVLVTSGLVASYVFAVAIPAVVVAGVNLAVWGPALALVGALYAYPEWWVIDAAGAIMGMGAAALFGISFGVLPAIVLLTALAVYDAISVYGTEHMLTLASGVMELRLPIVLVVPTTLAYSFVEDAAETADEAEAGEREAAAPADRPAYFIGLGDAVMPSIMVASAAFFLDTPPVVAGIELAPLTAMAGTLVGLLVLMRMVFAGRAHAGLPLLNGGAIAGYLVGAVAAGIPILDALGVAAYL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	318 (279)
Sequences:	333 (222)
Seq/√Len:	13.3

HALSA - Q9HQ23

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
64_L	154_L	2.984	0.97
245_F	300_G	2.940	0.96
232_A	266_T	2.920	0.96
134_M	186_I	2.919	0.96
83_S	86_V	2.842	0.96
53_V	157_A	2.764	0.95
269_G	285_G	2.567	0.92
82_T	237_I	2.445	0.90
295_A	306_I	2.337	0.88
268_V	288_L	2.322	0.88
25_A	28_L	2.303	0.87
209_A	212_G	2.303	0.87
206_A	211_A	2.204	0.85
265_G	287_P	2.185	0.84
35_A	50_V	2.145	0.83
233_V	239_V	2.118	0.82
162_D	166_V	2.099	0.82
133_I	219_P	2.072	0.81
170_E	281_R	2.069	0.81
266_T	269_G	2.062	0.81
120_A	140_A	2.052	0.80
208_E	211_A	2.023	0.79
155_L	186_I	2.019	0.79
107_V	259_P	2.007	0.79
56_L	268_V	1.991	0.78
296_G	300_G	1.914	0.75
152_I	234_M	1.907	0.75
138_A	272_V	1.898	0.75
203_A	271_L	1.893	0.74
86_V	138_A	1.888	0.74
87_A	229_L	1.862	0.73
148_V	300_G	1.860	0.73
105_L	200_E	1.860	0.73
202_A	212_G	1.834	0.72
113_A	302_V	1.834	0.72
81_V	304_A	1.821	0.71
169_T	172_M	1.808	0.71
266_T	285_G	1.789	0.70
87_A	186_I	1.783	0.70
139_A	270_L	1.782	0.70
151_A	186_I	1.775	0.69
57_L	161_Y	1.765	0.69
206_A	210_E	1.763	0.69
236_S	266_T	1.744	0.68
265_G	286_L	1.740	0.68
59_A	90_V	1.738	0.68
167_Y	172_M	1.721	0.67
226_F	229_L	1.708	0.66
82_T	108_W	1.688	0.65
114_L	184_L	1.684	0.65
23_V	156_T	1.678	0.65
226_F	232_A	1.658	0.64
83_S	87_A	1.650	0.64
123_E	275_R	1.637	0.63
49_S	151_A	1.601	0.61
269_G	284_A	1.599	0.61
30_E	94_A	1.592	0.61
26_L	30_E	1.578	0.60
171_H	235_P	1.569	0.60
266_T	284_A	1.551	0.59
40_T	43_P	1.537	0.58
20_V	23_V	1.534	0.58
52_Y	154_L	1.522	0.57
173_L	234_M	1.521	0.57
68_K	185_P	1.510	0.57
150_P	240_A	1.501	0.56
77_G	81_V	1.494	0.56
135_G	185_P	1.474	0.55
110_P	130_A	1.467	0.54
74_I	207_D	1.458	0.54
124_W	191_P	1.453	0.54
262_A	299_V	1.442	0.53
54_A	263_M	1.433	0.52
114_L	226_F	1.430	0.52
53_V	154_L	1.428	0.52
35_A	45_N	1.427	0.52
206_A	212_G	1.403	0.51
135_G	168_G	1.388	0.50
191_P	224_A	1.385	0.50
68_K	132_A	1.383	0.50
126_V	129_A	1.378	0.50
38_Q	135_G	1.357	0.48
206_A	209_A	1.356	0.48
82_T	184_L	1.353	0.48
98_V	151_A	1.353	0.48
272_V	291_G	1.349	0.48
208_E	212_G	1.348	0.48
49_S	134_M	1.333	0.47
177_S	184_L	1.326	0.47
75_L	237_I	1.311	0.46
53_V	160_V	1.310	0.46
228_G	231_D	1.270	0.44
119_Y	187_V	1.265	0.44
169_T	266_T	1.253	0.43
269_G	283_H	1.252	0.43
50_V	62_G	1.245	0.43
167_Y	190_V	1.232	0.42
89_Y	246_L	1.232	0.42
43_P	161_Y	1.231	0.42
124_W	127_I	1.229	0.42
179_V	182_L	1.214	0.41
53_V	161_Y	1.209	0.41
167_Y	171_H	1.200	0.40
109_G	272_V	1.188	0.40
146_F	223_P	1.186	0.40
207_D	211_A	1.186	0.40
154_L	164_I	1.175	0.39
138_A	281_R	1.172	0.39
78_V	234_M	1.168	0.39
232_A	235_P	1.165	0.39
56_L	264_A	1.161	0.38
132_A	140_A	1.150	0.38
265_G	273_L	1.143	0.37
163_A	172_M	1.143	0.37
172_M	235_P	1.138	0.37
45_N	49_S	1.133	0.37
68_K	168_G	1.131	0.37
59_A	69_Y	1.126	0.37
92_A	267_L	1.113	0.36
176_A	282_A	1.110	0.36
142_F	189_V	1.109	0.36
108_W	260_L	1.108	0.36
180_M	281_R	1.108	0.36
199_V	207_D	1.103	0.35
110_P	295_A	1.096	0.35
33_Q	107_V	1.095	0.35
161_Y	273_L	1.092	0.35
273_L	287_P	1.084	0.35
97_A	101_A	1.083	0.35
208_E	213_E	1.082	0.34
177_S	236_S	1.075	0.34
142_F	270_L	1.073	0.34
56_L	229_L	1.071	0.34
239_V	257_L	1.069	0.34
66_V	233_V	1.068	0.34
88_S	91_F	1.066	0.34
174_T	186_I	1.052	0.33
265_G	284_A	1.042	0.33
111_A	223_P	1.036	0.32
232_A	236_S	1.034	0.32
18_F	46_P	1.032	0.32
196_Y	200_E	1.027	0.32
159_A	294_I	1.022	0.32
21_V	113_A	1.018	0.31
183_R	189_V	1.018	0.31
173_L	188_L	1.012	0.31
105_L	294_I	1.007	0.31
123_E	224_A	1.007	0.31
221_D	281_R	1.002	0.31
210_E	213_E	1.000	0.31
204_E	210_E	1.000	0.31
284_A	287_P	0.998	0.31
39_S	306_I	0.990	0.30
82_T	236_S	0.987	0.30
28_L	144_I	0.983	0.30
78_V	191_P	0.983	0.30
237_I	272_V	0.983	0.30
204_E	207_D	0.980	0.30
48_N	55_F	0.978	0.30
39_S	56_L	0.977	0.30
116_G	268_V	0.976	0.30
44_Q	148_V	0.971	0.29
80_L	133_I	0.967	0.29
156_T	293_A	0.966	0.29
184_L	233_V	0.965	0.29
56_L	129_A	0.963	0.29
121_Y	225_Y	0.961	0.29
163_A	176_A	0.959	0.29
81_V	152_I	0.957	0.29
61_G	65_L	0.951	0.28
118_L	139_A	0.946	0.28
177_S	240_A	0.942	0.28
164_I	213_E	0.933	0.28
135_G	180_M	0.931	0.28
78_V	152_I	0.929	0.28
109_G	152_I	0.927	0.27
42_N	151_A	0.926	0.27
78_V	168_G	0.926	0.27
239_V	272_V	0.925	0.27
75_L	86_V	0.924	0.27
204_E	213_E	0.922	0.27
235_P	285_G	0.914	0.27
37_L	161_Y	0.914	0.27
137_G	176_A	0.905	0.27
29_V	132_A	0.901	0.26
74_I	104_N	0.901	0.26
85_L	112_L	0.899	0.26
81_V	160_V	0.896	0.26
114_L	130_A	0.877	0.25
190_V	234_M	0.875	0.25
173_L	187_V	0.872	0.25
62_G	65_L	0.872	0.25
89_Y	185_P	0.871	0.25
89_Y	281_R	0.869	0.25
171_H	285_G	0.867	0.25
153_V	160_V	0.866	0.25
289_L	297_Y	0.866	0.25
99_V	106_A	0.856	0.25
157_A	245_F	0.852	0.24
25_A	260_L	0.850	0.24
121_Y	141_L	0.848	0.24
48_N	68_K	0.842	0.24
207_D	210_E	0.840	0.24
18_F	151_A	0.836	0.24
180_M	224_A	0.834	0.24
126_V	153_V	0.834	0.24
112_L	219_P	0.833	0.24
124_W	136_M	0.830	0.24
73_W	266_T	0.829	0.24
174_T	177_S	0.827	0.23
104_N	156_T	0.823	0.23
53_V	276_M	0.820	0.23
43_P	174_T	0.818	0.23
108_W	181_E	0.815	0.23
122_P	224_A	0.815	0.23
58_V	112_L	0.811	0.23
134_M	281_R	0.810	0.23
79_V	179_V	0.807	0.23
56_L	158_L	0.799	0.22
18_F	24_G	0.799	0.22
233_V	257_L	0.794	0.22
128_D	152_I	0.789	0.22
122_P	191_P	0.781	0.22
165_S	172_M	0.776	0.22
203_A	207_D	0.776	0.22
118_L	163_A	0.775	0.22
39_S	106_A	0.774	0.22
136_M	294_I	0.770	0.21
114_L	232_A	0.766	0.21
74_I	95_I	0.765	0.21
167_Y	173_L	0.765	0.21
40_T	161_Y	0.764	0.21
60_T	175_L	0.762	0.21
40_T	55_F	0.761	0.21
59_A	233_V	0.761	0.21
105_L	210_E	0.760	0.21
98_V	103_V	0.756	0.21
70_D	117_A	0.754	0.21
142_F	237_I	0.753	0.21
57_L	156_T	0.753	0.21
83_S	175_L	0.752	0.21
26_L	29_V	0.752	0.21
117_A	159_A	0.747	0.21
147_G	182_L	0.747	0.21
97_A	142_F	0.746	0.21
79_V	111_A	0.745	0.20
155_L	240_A	0.740	0.20
295_A	299_V	0.740	0.20
158_L	164_I	0.739	0.20
148_V	241_S	0.739	0.20
270_L	274_M	0.739	0.20
66_V	232_A	0.739	0.20
269_G	290_N	0.737	0.20
56_L	276_M	0.734	0.20
60_T	142_F	0.732	0.20
105_L	212_G	0.724	0.20
108_W	116_G	0.721	0.20
288_L	305_G	0.721	0.20
126_V	291_G	0.719	0.20
37_L	190_V	0.718	0.20
111_A	119_Y	0.717	0.20
137_G	159_A	0.714	0.19
142_F	175_L	0.714	0.19
92_A	103_V	0.711	0.19
147_G	151_A	0.711	0.19
181_E	294_I	0.709	0.19
109_G	229_L	0.708	0.19
167_Y	285_G	0.707	0.19
199_V	233_V	0.704	0.19
65_L	71_K	0.703	0.19
105_L	206_A	0.701	0.19
167_Y	235_P	0.701	0.19
58_V	102_G	0.700	0.19
32_F	47_L	0.698	0.19
26_L	145_S	0.697	0.19
44_Q	47_L	0.697	0.19
128_D	169_T	0.697	0.19
92_A	281_R	0.696	0.19
95_I	104_N	0.696	0.19
97_A	153_V	0.695	0.19
23_V	154_L	0.693	0.19
187_V	241_S	0.693	0.19
72_Q	127_I	0.690	0.19
269_G	291_G	0.688	0.19
275_R	288_L	0.685	0.19
207_D	212_G	0.685	0.19
88_S	111_A	0.685	0.19
131_G	140_A	0.683	0.18
52_Y	84_G	0.680	0.18
180_M	185_P	0.677	0.18
241_S	244_F	0.675	0.18
223_P	289_L	0.672	0.18
76_R	139_A	0.672	0.18
28_L	54_A	0.671	0.18
171_H	232_A	0.671	0.18
67_I	234_M	0.669	0.18
152_I	235_P	0.669	0.18
205_T	210_E	0.664	0.18
55_F	145_S	0.662	0.18
139_A	188_L	0.662	0.18
186_I	276_M	0.659	0.18
69_Y	212_G	0.655	0.18
180_M	260_L	0.655	0.18
131_G	283_H	0.655	0.18
70_D	95_I	0.649	0.17
18_F	73_W	0.648	0.17
88_S	187_V	0.648	0.17
117_A	157_A	0.642	0.17
273_L	282_A	0.639	0.17
91_F	110_P	0.638	0.17
63_I	142_F	0.637	0.17
91_F	178_G	0.635	0.17
51_V	236_S	0.633	0.17
82_T	267_L	0.631	0.17
75_L	79_V	0.631	0.17
154_L	161_Y	0.630	0.17
81_V	294_I	0.628	0.17
186_I	199_V	0.628	0.17
290_N	307_P	0.624	0.17
212_G	219_P	0.623	0.17
152_I	266_T	0.623	0.17
104_N	134_M	0.622	0.17
18_F	139_A	0.622	0.17
45_N	60_T	0.621	0.17
202_A	210_E	0.617	0.16
109_G	187_V	0.616	0.16
128_D	150_P	0.612	0.16
131_G	235_P	0.607	0.16
128_D	235_P	0.605	0.16
56_L	160_V	0.602	0.16
233_V	255_I	0.601	0.16
62_G	105_L	0.601	0.16
48_N	118_L	0.599	0.16
132_A	302_V	0.596	0.16
206_A	213_E	0.596	0.16
152_I	171_H	0.596	0.16
242_A	262_A	0.594	0.16
130_A	288_L	0.594	0.16
235_P	269_G	0.593	0.16
203_A	210_E	0.593	0.16
28_L	161_Y	0.592	0.16
67_I	178_G	0.591	0.16
169_T	235_P	0.591	0.16
265_G	285_G	0.590	0.16
41_E	138_A	0.589	0.16
285_G	296_G	0.589	0.16
57_L	62_G	0.588	0.16
98_V	205_T	0.587	0.16
52_Y	302_V	0.587	0.16
35_A	112_L	0.586	0.16
110_P	115_V	0.585	0.16
147_G	240_A	0.583	0.15
177_S	301_A	0.582	0.15
125_W	148_V	0.581	0.15
96_P	141_L	0.580	0.15
75_L	97_A	0.579	0.15
173_L	283_H	0.578	0.15
69_Y	296_G	0.575	0.15
51_V	108_W	0.575	0.15
78_V	115_V	0.573	0.15
130_A	226_F	0.573	0.15
75_L	159_A	0.570	0.15
176_A	235_P	0.570	0.15
60_T	283_H	0.567	0.15
273_L	286_L	0.561	0.15
169_T	190_V	0.559	0.15
242_A	258_A	0.557	0.15
28_L	32_F	0.555	0.15
148_V	307_P	0.552	0.15
191_P	196_Y	0.552	0.15
56_L	292_G	0.551	0.15
20_V	303_A	0.550	0.15
36_G	209_A	0.549	0.15
58_V	264_A	0.549	0.15
134_M	142_F	0.548	0.15
227_I	266_T	0.546	0.14
116_G	197_S	0.546	0.14
128_D	171_H	0.544	0.14
131_G	171_H	0.544	0.14
200_E	209_A	0.543	0.14
94_A	192_T	0.541	0.14
204_E	302_V	0.541	0.14
172_M	176_A	0.541	0.14
84_G	113_A	0.540	0.14
61_G	82_T	0.539	0.14
29_V	244_F	0.539	0.14
153_V	305_G	0.538	0.14
20_V	302_V	0.537	0.14
171_H	269_G	0.537	0.14
98_V	113_A	0.536	0.14
146_F	276_M	0.533	0.14
266_T	283_H	0.532	0.14
171_H	190_V	0.528	0.14
68_K	299_V	0.524	0.14
157_A	208_E	0.521	0.14
63_I	156_T	0.521	0.14
171_H	176_A	0.520	0.14
82_T	112_L	0.518	0.14
166_V	230_G	0.517	0.14
137_G	191_P	0.516	0.14
78_V	99_V	0.515	0.14
52_Y	106_A	0.515	0.14
47_L	247_D	0.514	0.14
195_A	198_F	0.513	0.14
80_L	94_A	0.512	0.14
162_D	230_G	0.511	0.14
172_M	190_V	0.510	0.14
49_S	272_V	0.509	0.14
114_L	227_I	0.509	0.14
128_D	167_Y	0.507	0.13
172_M	285_G	0.506	0.13
191_P	298_L	0.506	0.13
115_V	238_M	0.505	0.13
173_L	288_L	0.505	0.13
41_E	112_L	0.504	0.13
95_I	100_V	0.503	0.13
47_L	69_Y	0.501	0.13
284_A	289_L	0.500	0.13

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
5a63B	1	0.6101	100	0.154	Contact Map
4hygA	3	0.7767	100	0.495	Contact Map
4uisB	1	0.3208	100	0.536	Contact Map
4pypA	1	0.5252	35.5	0.964	Contact Map
4px7A	1	0.6006	31.2	0.965	Contact Map
4m64A	1	0.5629	30.4	0.965	Contact Map
4zw9A	1	0.5755	26.7	0.966	Contact Map
3wdoA	1	0.6855	19.2	0.969	Contact Map
4j05A	3	0.8019	18.6	0.969	Contact Map
4i0uA	4	0.1981	14.7	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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