GREMLIN Database
BTUCA - Cobalamin import system permease protein BtuC
UniProt: Q9HQ19 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 369 (318)
Sequences: 13695 (9826)
Seq/√Len: 551.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
254_N313_D5.0571.00
110_A322_A3.7451.00
59_T331_A3.6811.00
146_A160_A3.6731.00
118_V246_L3.6201.00
60_H102_I3.4141.00
269_D272_R3.2651.00
111_S239_V3.2611.00
118_V277_L3.1261.00
106_A326_G3.1231.00
105_G224_L3.0071.00
306_V324_T2.9551.00
104_L227_S2.7331.00
75_T90_A2.7181.00
111_S288_A2.6181.00
111_S284_V2.6141.00
60_H106_A2.4771.00
114_I322_A2.4441.00
260_E274_K2.4041.00
141_V201_V2.3851.00
56_T327_A2.3601.00
55_V327_A2.3411.00
114_I243_S2.2871.00
108_V288_A2.2571.00
141_V198_L2.2291.00
117_A321_S2.1991.00
65_V73_A2.1871.00
108_V292_A2.0991.00
254_N314_H2.0931.00
310_V320_V2.0771.00
63_P102_I2.0641.00
101_R333_D2.0611.00
106_A330_V2.0301.00
87_P90_A2.0161.00
238_V287_A1.9801.00
72_P75_T1.9771.00
56_T106_A1.9701.00
107_T236_L1.9531.00
121_G314_H1.8991.00
59_T327_A1.8821.00
252_E273_T1.8691.00
119_L281_A1.8491.00
145_A149_L1.8211.00
144_V202_T1.8211.00
227_S231_D1.7631.00
49_V320_V1.7451.00
249_Y252_E1.7431.00
255_V268_V1.7221.00
165_A286_A1.6951.00
245_V280_V1.6671.00
298_V329_L1.6361.00
56_T323_L1.6211.00
335_V339_T1.6111.00
242_G284_V1.5651.00
336_A345_V1.5481.00
103_V232_V1.5461.00
91_Q95_G1.5421.00
272_R276_L1.5381.00
249_Y276_L1.5371.00
62_V65_V1.5351.00
52_G323_L1.5331.00
88_E91_Q1.5251.00
143_A161_A1.5191.00
169_A282_S1.5091.00
59_T330_V1.4881.00
242_G283_V1.4851.00
48_A320_V1.4751.00
142_G160_A1.4701.00
335_V348_I1.4501.00
115_S284_V1.4471.00
117_A317_L1.4351.00
62_V66_S1.4031.00
306_V317_L1.4011.00
228_R231_D1.3911.00
140_A202_T1.3911.00
249_Y273_T1.3891.00
104_L291_F1.3861.00
233_E237_P1.3841.00
52_G320_V1.3771.00
224_L329_L1.3711.00
233_E236_L1.3671.00
197_L354_A1.3441.00
242_G280_V1.3341.00
80_A84_F1.3201.00
113_A302_V1.3121.00
45_T316_V1.3051.00
316_V319_P1.2961.00
63_P334_T1.2951.00
306_V320_V1.2941.00
237_P241_V1.2891.00
302_V328_F1.2851.00
80_A83_Q1.2791.00
142_G164_G1.2561.00
337_R342_E1.2531.00
245_V249_Y1.2501.00
136_S285_T1.2481.00
249_Y277_L1.2421.00
81_P84_F1.2331.00
117_A314_H1.2251.00
168_A198_L1.2111.00
107_T232_V1.2101.00
144_V216_A1.2011.00
140_A220_L1.1971.00
122_F277_L1.1951.00
52_G324_T1.1921.00
273_T276_L1.1861.00
56_T326_G1.1821.00
272_R275_R1.1701.00
264_H271_D1.1591.00
314_H317_L1.1581.00
302_V324_T1.1471.00
271_D274_K1.1461.00
172_V194_V1.1441.00
92_V96_T1.1371.00
295_I329_L1.1361.00
259_G263_A1.1361.00
52_G327_A1.1331.00
141_V145_A1.1321.00
170_F174_A1.1301.00
292_A295_I1.1301.00
49_V316_V1.1271.00
117_A318_L1.1181.00
138_G164_G1.1171.00
162_F283_V1.1161.00
69_L93_I1.1151.00
70_P73_A1.0991.00
107_T235_A1.0941.00
95_G99_L1.0881.00
262_D265_T1.0871.00
148_T205_L1.0871.00
105_G329_L1.0831.00
83_Q86_V1.0831.00
110_A113_A1.0791.00
104_L232_V1.0761.00
159_P163_A1.0711.00
235_A291_F1.0711.00
333_D337_R1.0661.00
103_V229_W1.0651.00
255_V266_L1.0631.00
60_H330_V1.0561.00
246_L280_V1.0441.00
160_A164_G1.0431.00
89_T92_V1.0411.00
335_V338_A1.0391.00
167_I171_T1.0391.00
105_G330_V1.0381.00
86_V91_Q1.0321.00
327_A331_A1.0291.00
350_A355_P1.0271.00
66_S338_A1.0241.00
245_V276_L1.0191.00
102_I334_T1.0161.00
110_A326_G1.0131.00
235_A239_V1.0131.00
138_G168_A1.0081.00
244_A248_A0.9981.00
242_G287_A0.9951.00
76_I94_V0.9871.00
153_V156_G0.9871.00
64_V102_I0.9841.00
47_L50_P0.9811.00
59_T334_T0.9791.00
229_W232_V0.9711.00
145_A205_L0.9691.00
314_H319_P0.9681.00
45_T49_V0.9641.00
271_D275_R0.9641.00
54_S58_H0.9621.00
67_G98_R0.9601.00
81_P86_V0.9601.00
241_V244_A0.9551.00
302_V306_V0.9531.00
46_E49_V0.9511.00
177_T271_D0.9501.00
195_Q199_G0.9441.00
136_S294_A0.9421.00
234_A237_P0.9391.00
75_T80_A0.9381.00
53_A57_M0.9351.00
143_A157_V0.9321.00
319_P322_A0.9311.00
268_V273_T0.9211.00
137_S198_L0.9211.00
317_L321_S0.9181.00
141_V205_L0.9171.00
288_A292_A0.9141.00
310_V316_V0.9131.00
46_E50_P0.9131.00
261_E264_H0.9091.00
141_V202_T0.9071.00
336_A348_I0.9001.00
273_T277_L0.8971.00
65_V76_I0.8921.00
331_A335_V0.8921.00
237_P240_V0.8901.00
47_L51_V0.8861.00
336_A344_P0.8841.00
173_Y271_D0.8841.00
253_M277_L0.8811.00
82_L86_V0.8771.00
111_S115_S0.8771.00
135_V165_A0.8751.00
316_V320_V0.8731.00
204_F208_N0.8711.00
61_A65_V0.8671.00
71_W94_V0.8671.00
116_G303_P0.8661.00
216_A220_L0.8661.00
61_A73_A0.8661.00
91_Q96_T0.8651.00
152_V156_G0.8651.00
254_N315_R0.8591.00
139_A165_A0.8581.00
131_S136_S0.8541.00
110_A243_S0.8531.00
309_V324_T0.8511.00
147_I157_V0.8491.00
107_T239_V0.8471.00
356_F359_Y0.8451.00
177_T180_G0.8451.00
48_A52_G0.8441.00
148_T209_S0.8431.00
137_S140_A0.8401.00
71_W90_A0.8341.00
115_S281_A0.8291.00
48_A51_V0.8281.00
209_S212_E0.8281.00
250_A315_R0.8281.00
146_A157_V0.8261.00
123_F188_L0.8211.00
63_P337_R0.8161.00
53_A323_L0.8131.00
245_V248_A0.8121.00
246_L277_L0.8101.00
166_L286_A0.8101.00
101_R342_E0.8071.00
240_V244_A0.8061.00
102_I330_V0.8061.00
355_P359_Y0.8001.00
85_G88_E0.7971.00
101_R337_R0.7931.00
313_D316_V0.7931.00
306_V310_V0.7901.00
263_A270_V0.7861.00
57_M61_A0.7851.00
275_R279_A0.7791.00
173_Y275_R0.7781.00
307_R317_L0.7761.00
56_T60_H0.7761.00
238_V242_G0.7761.00
329_L349_T0.7761.00
254_N319_P0.7741.00
165_A282_S0.7721.00
145_A150_P0.7701.00
214_R217_M0.7691.00
163_A167_I0.7691.00
260_E264_H0.7681.00
278_L282_S0.7681.00
144_V206_V0.7651.00
86_V90_A0.7601.00
113_A117_A0.7591.00
249_Y280_V0.7571.00
113_A322_A0.7561.00
351_L355_P0.7511.00
178_K181_H0.7491.00
58_H61_A0.7461.00
110_A239_V0.7431.00
57_M60_H0.7421.00
69_L73_A0.7421.00
178_K183_P0.7411.00
119_L133_V0.7411.00
162_F166_L0.7401.00
306_V309_V0.7371.00
295_I345_V0.7301.00
140_A294_A0.7291.00
231_D291_F0.7251.00
81_P85_G0.7231.00
211_R215_P0.7221.00
235_A287_A0.7201.00
114_I246_L0.7191.00
56_T330_V0.7181.00
129_D132_I0.7161.00
260_E270_V0.7141.00
305_A324_T0.7141.00
113_A325_G0.7131.00
99_L229_W0.7111.00
64_V94_V0.7091.00
323_L327_A0.7071.00
135_V169_A0.7031.00
298_V349_T0.7021.00
65_V70_P0.7021.00
236_L240_V0.7011.00
69_L72_P0.7011.00
84_F87_P0.7001.00
270_V274_K0.7001.00
169_A278_L0.7001.00
121_G257_L0.6981.00
92_V97_I0.6961.00
230_H233_E0.6951.00
48_A309_V0.6941.00
287_A291_F0.6931.00
287_A290_S0.6931.00
108_V224_L0.6911.00
112_L298_V0.6901.00
328_F332_A0.6871.00
103_V107_T0.6861.00
239_V288_A0.6841.00
84_F91_Q0.6841.00
114_I318_L0.6821.00
217_M220_L0.6781.00
145_A201_V0.6741.00
308_L360_L0.6711.00
333_D342_E0.6701.00
80_A85_G0.6691.00
264_H270_V0.6661.00
82_L85_G0.6661.00
332_A348_I0.6661.00
176_A190_S0.6661.00
328_F352_I0.6641.00
147_I215_P0.6641.00
156_G159_P0.6631.00
92_V95_G0.6611.00
88_E92_V0.6611.00
168_A172_V0.6611.00
254_N257_L0.6581.00
209_S213_I0.6571.00
74_L77_A0.6561.00
166_L282_S0.6561.00
87_P91_Q0.6531.00
80_A91_Q0.6521.00
85_G91_Q0.6521.00
68_G340_A0.6501.00
58_H62_V0.6491.00
174_A177_T0.6471.00
129_D299_G0.6471.00
177_T181_H0.6471.00
175_I190_S0.6461.00
118_V280_V0.6441.00
315_R319_P0.6431.00
66_S70_P0.6421.00
84_F88_E0.6421.00
322_A326_G0.6411.00
147_I216_A0.6381.00
119_L128_A0.6371.00
119_L135_V0.6341.00
110_A114_I0.6341.00
142_G146_A0.6311.00
60_H64_V0.6311.00
157_V160_A0.6301.00
247_L250_A0.6301.00
248_A252_E0.6281.00
138_G198_L0.6271.00
252_E268_V0.6241.00
99_L103_V0.6241.00
242_G246_L0.6191.00
115_S285_T0.6181.00
238_V283_V0.6171.00
359_Y363_D0.6161.00
136_S139_A0.6161.00
123_F126_P0.6151.00
80_A86_V0.6151.00
52_G56_T0.6151.00
326_G330_V0.6151.00
235_A238_V0.6121.00
185_A188_L0.6091.00
285_T289_V0.6081.00
105_G345_V0.6071.00
64_V99_L0.6051.00
256_L270_V0.6051.00
305_A308_L0.6031.00
51_V55_V0.6031.00
66_S334_T0.6021.00
305_A328_F0.6021.00
172_V176_A0.6021.00
229_W233_E0.6011.00
301_I357_F0.6001.00
155_I159_P0.5991.00
300_L360_L0.5981.00
104_L235_A0.5981.00
206_V217_M0.5981.00
200_A301_I0.5971.00
281_A286_A0.5971.00
206_V220_L0.5961.00
286_A290_S0.5951.00
65_V77_A0.5951.00
169_A173_Y0.5931.00
77_A83_Q0.5931.00
212_E215_P0.5901.00
331_A334_T0.5891.00
300_L303_P0.5881.00
190_S193_A0.5871.00
135_V223_T0.5851.00
252_E255_V0.5851.00
303_P321_S0.5831.00
336_A342_E0.5810.99
336_A340_A0.5810.99
56_T102_I0.5800.99
73_A76_I0.5790.99
173_Y177_T0.5780.99
241_V245_V0.5750.99
311_G319_P0.5740.99
122_F281_A0.5700.99
301_I356_F0.5700.99
330_V334_T0.5700.99
243_S247_L0.5690.99
167_I170_F0.5680.99
139_A161_A0.5680.99
213_I216_A0.5680.99
61_A77_A0.5650.99
137_S199_G0.5650.99
128_A135_V0.5630.99
253_M314_H0.5630.99
306_V321_S0.5620.99
72_P90_A0.5600.99
94_V99_L0.5590.99
164_G168_A0.5590.99
146_A150_P0.5590.99
254_N317_L0.5590.99
282_S286_A0.5540.99
103_V236_L0.5530.99
104_L108_V0.5520.99
60_H103_V0.5500.99
232_V236_L0.5500.99
49_V319_P0.5490.99
334_T338_A0.5490.99
276_L280_V0.5480.99
135_V172_V0.5460.99
224_L345_V0.5460.99
301_I305_A0.5450.99
199_G220_L0.5440.99
239_V244_A0.5430.99
129_D349_T0.5430.99
362_R365_E0.5430.99
329_L345_V0.5410.99
269_D276_L0.5410.99
336_A339_T0.5400.99
50_P54_S0.5390.99
63_P330_V0.5390.99
203_S219_W0.5370.99
199_G203_S0.5370.99
206_V213_I0.5370.99
234_A287_A0.5360.99
277_L281_A0.5360.99
171_T194_V0.5340.99
204_F347_I0.5330.99
114_I239_V0.5330.99
295_I349_T0.5330.99
305_A356_F0.5320.99
248_A251_R0.5320.99
137_S195_Q0.5290.99
129_D294_A0.5290.99
49_V53_A0.5280.99
123_F186_T0.5250.99
117_A306_V0.5240.99
171_T174_A0.5230.99
51_V54_S0.5190.99
302_V332_A0.5190.99
75_T86_V0.5190.99
176_A187_L0.5180.99
143_A147_I0.5170.99
163_A166_L0.5160.99
190_S194_V0.5160.99
203_S207_V0.5140.99
45_T48_A0.5140.99
296_G301_I0.5140.99
143_A160_A0.5120.99
298_V328_F0.5120.99
73_A77_A0.5100.99
53_A56_T0.5090.99
224_L292_A0.5090.99
48_A310_V0.5070.99
138_G194_V0.5070.99
232_V235_A0.5050.99
62_V334_T0.5040.99
71_W95_G0.5020.99
178_K182_T0.5000.99
305_A309_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.7913 100 0.256 Contact Map
2nq2A 2 0.8293 100 0.257 Contact Map
2qi9A 2 0.8645 100 0.274 Contact Map
3d31C 2 0.6423 44.1 0.962 Contact Map
2m8rA 1 0.1816 40.2 0.963 Contact Map
3wajA 1 0.7236 24.9 0.967 Contact Map
3rlbA 1 0.458 21.7 0.968 Contact Map
4z7fA 2 0.439 21.3 0.968 Contact Map
3o7qA 1 0.8184 18.4 0.969 Contact Map
3fymA 1 0.065 11.5 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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