GREMLIN Database
BTUDA - Cobalamin import ATP-binding protein BtuD
UniProt: Q9HQ18 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (308)
Sequences: 5734 (4900)
Seq/√Len: 279.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_G20_D4.4161.00
285_A309_C4.1821.00
271_G323_T3.5871.00
5_V8_L3.4271.00
90_E135_T3.2871.00
201_A222_R3.0771.00
16_R19_D2.9601.00
6_T58_T2.8711.00
91_F99_M2.7771.00
10_V47_A2.6061.00
29_H206_E2.5041.00
312_T316_P2.4981.00
278_V316_P2.4931.00
10_V55_T2.4651.00
321_E325_A2.4421.00
314_V318_T2.3511.00
88_S91_F2.2871.00
286_G313_S2.2411.00
8_L54_P2.2401.00
45_L193_A2.2201.00
318_T322_D2.0931.00
288_S292_G2.0931.00
9_D56_A2.0461.00
278_V320_L2.0311.00
19_D214_R2.0281.00
274_S278_V2.0041.00
285_A288_S1.9691.00
11_E55_T1.9431.00
47_A54_P1.9361.00
290_S310_P1.9151.00
269_V273_D1.8581.00
290_S314_V1.8441.00
25_I31_V1.8441.00
7_G22_H1.8331.00
282_L320_L1.8221.00
275_A320_L1.8161.00
96_V134_V1.7951.00
278_V281_R1.7411.00
305_R309_C1.7391.00
32_G200_A1.7391.00
292_G295_V1.7381.00
49_N159_L1.6621.00
270_G274_S1.6541.00
309_C312_T1.6361.00
32_G204_C1.6241.00
134_V145_V1.5911.00
31_V208_V1.5761.00
310_P314_V1.5681.00
5_V23_A1.5551.00
47_A59_V1.5491.00
281_R285_A1.5471.00
11_E16_R1.5201.00
92_T95_Q1.5171.00
316_P320_L1.5161.00
280_R284_S1.5061.00
284_S288_S1.4961.00
282_L313_S1.4921.00
270_G273_D1.4851.00
252_T255_P1.4791.00
4_D24_S1.4771.00
305_R308_G1.4741.00
5_V48_M1.4701.00
277_P280_R1.4641.00
301_H304_A1.4541.00
96_V149_R1.4451.00
287_A291_V1.4421.00
322_D325_A1.4331.00
285_A313_S1.4321.00
308_G312_T1.4301.00
286_G310_P1.4271.00
172_Q176_L1.4141.00
289_V306_R1.4121.00
220_A223_S1.4051.00
109_G114_T1.3801.00
316_P319_R1.3771.00
26_R29_H1.3741.00
231_R234_F1.3691.00
261_A264_T1.3621.00
10_V52_I1.3541.00
46_R51_L1.3521.00
89_F135_T1.3331.00
279_V283_V1.3241.00
295_V298_D1.3231.00
23_A208_V1.3231.00
285_A292_G1.3201.00
323_T326_A1.3191.00
109_G112_T1.3151.00
292_G306_R1.3131.00
253_P256_D1.3121.00
279_V317_F1.3091.00
286_G314_V1.3071.00
255_P258_T1.3051.00
259_S262_A1.3041.00
272_G276_T1.2981.00
18_L47_A1.2941.00
323_T327_S1.2941.00
307_V311_C1.2911.00
9_D20_D1.2881.00
132_R136_S1.2841.00
91_F95_Q1.2831.00
266_V270_G1.2811.00
6_T22_H1.2671.00
313_S316_P1.2621.00
296_E299_T1.2581.00
272_G327_S1.2431.00
319_R322_D1.2291.00
79_A155_A1.2251.00
4_D60_L1.2181.00
315_A319_R1.2161.00
11_E14_G1.2151.00
286_G290_S1.2101.00
260_A264_T1.2091.00
289_V313_S1.2081.00
318_T321_E1.2061.00
110_T113_D1.2021.00
31_V191_V1.1961.00
79_A150_A1.1911.00
13_A16_R1.1901.00
45_L159_L1.1751.00
271_G275_A1.1741.00
262_A265_S1.1691.00
100_G149_R1.1641.00
46_R52_I1.1611.00
8_L47_A1.1581.00
47_A55_T1.1491.00
267_H271_G1.1461.00
91_F96_V1.1371.00
257_R260_A1.1301.00
308_G311_C1.1271.00
219_G223_S1.1181.00
94_R98_E1.1141.00
266_V269_V1.1131.00
179_V190_V1.1051.00
232_A236_A1.0981.00
302_E305_R1.0981.00
36_P39_A1.0861.00
309_C313_S1.0841.00
299_T302_E1.0841.00
112_T116_V1.0811.00
254_L257_R1.0781.00
159_L191_V1.0721.00
319_R323_T1.0711.00
325_A329_T1.0631.00
256_D260_A1.0531.00
299_T303_T1.0511.00
311_C315_A1.0481.00
12_L17_I1.0471.00
61_V64_D1.0461.00
267_H270_G1.0451.00
317_F320_L1.0451.00
278_V282_L1.0431.00
115_A119_R1.0431.00
290_S294_V1.0431.00
268_V271_G1.0411.00
256_D259_S1.0391.00
77_R153_Q1.0391.00
297_G300_D1.0311.00
295_V299_T1.0221.00
291_V295_V1.0211.00
180_R202_R1.0181.00
322_D326_A1.0101.00
113_D116_V1.0021.00
236_A239_A1.0011.00
192_A204_C1.0011.00
176_L180_R1.0011.00
254_L258_T0.9961.00
293_P298_D0.9941.00
286_G317_F0.9911.00
251_V258_T0.9871.00
306_R309_C0.9851.00
5_V59_V0.9841.00
322_D329_T0.9821.00
120_A152_A0.9791.00
192_A203_Y0.9771.00
248_A252_T0.9751.00
282_L317_F0.9741.00
92_T96_V0.9651.00
200_A204_C0.9631.00
209_V224_V0.9591.00
95_Q98_E0.9571.00
282_L286_G0.9501.00
315_A318_T0.9501.00
93_V145_V0.9481.00
108_F111_D0.9471.00
18_L21_V0.9451.00
21_V208_V0.9451.00
288_S291_V0.9391.00
39_A210_V0.9381.00
7_G56_A0.9351.00
289_V310_P0.9351.00
116_V119_R0.9291.00
255_P259_S0.9251.00
251_V255_P0.9241.00
239_A242_T0.9211.00
28_G189_A0.9181.00
275_A279_V0.9161.00
231_R235_D0.9121.00
307_V310_P0.9071.00
88_S96_V0.9051.00
272_G328_A0.9051.00
9_D19_D0.9011.00
90_E133_D0.8981.00
234_F237_R0.8951.00
223_S227_P0.8951.00
275_A327_S0.8891.00
206_E217_D0.8811.00
10_V43_T0.8801.00
11_E56_A0.8761.00
192_A200_A0.8761.00
298_D301_H0.8731.00
54_P59_V0.8721.00
280_R283_V0.8701.00
230_I233_A0.8691.00
51_L86_S0.8671.00
274_S277_P0.8641.00
6_T60_L0.8631.00
272_G275_A0.8631.00
25_I189_A0.8591.00
112_T115_A0.8571.00
222_R226_T0.8571.00
87_V96_V0.8561.00
251_V254_L0.8551.00
12_L52_I0.8541.00
9_D16_R0.8501.00
268_V327_S0.8461.00
321_E324_T0.8451.00
169_V173_I0.8421.00
179_V203_Y0.8421.00
282_L316_P0.8391.00
34_V209_V0.8361.00
313_S317_F0.8351.00
236_A241_G0.8331.00
8_L59_V0.8251.00
261_A265_S0.8251.00
271_G274_S0.8251.00
223_S226_T0.8241.00
283_V317_F0.8200.99
175_T178_V0.8150.99
284_S287_A0.8150.99
225_L228_D0.8130.99
277_P281_R0.8070.99
293_P307_V0.8040.99
210_V215_V0.8040.99
93_V99_M0.8010.99
64_D76_R0.8000.99
93_V134_V0.8000.99
290_S293_P0.7990.99
98_E117_V0.7990.99
268_V272_G0.7960.99
194_I200_A0.7950.99
225_L229_T0.7950.99
279_V321_E0.7910.99
172_Q196_D0.7910.99
312_T315_A0.7890.99
133_D136_S0.7870.99
252_T258_T0.7860.99
49_N80_T0.7840.99
306_R310_P0.7770.99
230_I234_F0.7750.99
209_V228_D0.7750.99
318_T325_A0.7740.99
233_A237_R0.7700.99
276_T280_R0.7700.99
273_D277_P0.7690.99
177_E180_R0.7660.99
283_V287_A0.7660.99
120_A148_A0.7640.99
276_T328_A0.7590.99
251_V259_S0.7570.99
48_M191_V0.7510.99
260_A263_D0.7500.99
285_A289_V0.7490.99
254_L259_S0.7460.99
266_V272_G0.7460.99
97_V117_V0.7450.99
253_P260_A0.7440.99
317_F321_E0.7400.99
95_Q131_A0.7380.99
300_D304_A0.7370.99
50_G61_V0.7360.99
109_G113_D0.7360.99
293_P299_T0.7340.99
177_E181_D0.7330.99
8_L18_L0.7310.99
300_D303_T0.7260.99
98_E102_H0.7250.99
311_C314_V0.7240.99
221_P225_L0.7240.99
10_V18_L0.7220.99
49_N78_I0.7200.99
232_A235_D0.7190.99
276_T279_V0.7160.99
34_V207_L0.7150.99
47_A53_T0.7130.99
192_A199_L0.7110.99
42_S46_R0.7080.99
247_G250_T0.7060.98
266_V273_D0.7020.98
235_D238_V0.7000.98
268_V276_T0.6920.98
174_R178_V0.6910.98
269_V272_G0.6870.98
160_L190_V0.6820.98
262_A266_V0.6820.98
155_A186_E0.6810.98
60_L63_G0.6810.98
249_V253_P0.6790.98
296_E300_D0.6790.98
94_R131_A0.6780.98
213_G216_H0.6780.98
3_L61_V0.6760.98
29_H205_D0.6760.98
252_T259_S0.6760.98
259_S265_S0.6740.98
81_V143_Q0.6740.98
198_D202_R0.6730.98
270_G276_T0.6730.98
78_I157_V0.6700.98
194_I199_L0.6670.98
318_T324_T0.6650.98
121_M124_T0.6640.98
94_R130_A0.6640.98
226_T229_T0.6640.98
236_A240_V0.6640.98
111_D114_T0.6630.98
245_A249_V0.6630.98
248_A253_P0.6620.98
173_I176_L0.6620.98
101_R152_A0.6620.98
89_F142_R0.6610.98
120_A123_R0.6610.98
234_F238_V0.6610.98
81_V150_A0.6600.98
108_F113_D0.6600.98
25_I191_V0.6590.98
252_T256_D0.6570.98
265_S269_V0.6540.98
266_V276_T0.6540.98
118_D122_A0.6530.97
286_G289_V0.6490.97
157_V191_V0.6480.97
246_T249_V0.6440.97
243_D246_T0.6440.97
124_T148_A0.6410.97
264_T268_V0.6400.97
25_I157_V0.6400.97
253_P259_S0.6390.97
289_V292_G0.6390.97
246_T250_T0.6380.97
294_V299_T0.6370.97
162_E195_H0.6360.97
296_E303_T0.6350.97
298_D302_E0.6330.97
119_R123_R0.6330.97
298_D304_A0.6300.97
7_G10_V0.6290.97
231_R237_R0.6270.97
296_E306_R0.6270.97
94_R117_V0.6250.97
237_R240_V0.6220.97
146_L151_L0.6210.97
243_D247_G0.6210.97
258_T262_A0.6200.97
250_T253_P0.6200.97
282_L285_A0.6180.96
292_G309_C0.6170.96
291_V294_V0.6160.96
238_V244_P0.6110.96
124_T141_E0.6110.96
10_V13_A0.6100.96
211_A214_R0.6070.96
264_T267_H0.6070.96
243_D248_A0.6060.96
145_V171_H0.6050.96
165_A197_L0.6050.96
271_G278_V0.5980.96
231_R238_V0.5960.96
296_E302_E0.5950.96
301_H305_R0.5940.96
289_V309_C0.5910.95
253_P257_R0.5910.95
224_V228_D0.5890.95
252_T260_A0.5880.95
125_G128_Q0.5880.95
242_T246_T0.5870.95
293_P296_E0.5860.95
296_E301_H0.5850.95
228_D231_R0.5840.95
118_D130_A0.5820.95
272_G279_V0.5820.95
97_V148_A0.5770.95
258_T261_A0.5760.95
248_A255_P0.5750.95
61_V76_R0.5740.95
304_A308_G0.5740.95
118_D126_V0.5730.95
211_A216_H0.5730.95
292_G302_E0.5680.94
233_A240_V0.5660.94
259_S263_D0.5640.94
283_V321_E0.5610.94
286_G293_P0.5590.94
281_R284_S0.5590.94
310_P313_S0.5580.94
265_S268_V0.5570.94
240_V247_G0.5550.94
250_T259_S0.5540.94
172_Q180_R0.5530.94
51_L82_P0.5490.93
287_A290_S0.5470.93
37_N165_A0.5460.93
233_A236_A0.5450.93
244_P247_G0.5450.93
260_A265_S0.5450.93
41_K162_E0.5440.93
29_H189_A0.5440.93
96_V100_G0.5430.93
279_V282_L0.5420.93
130_A133_D0.5420.93
283_V286_G0.5410.93
247_G252_T0.5410.93
268_V273_D0.5380.93
93_V137_L0.5370.93
229_T233_A0.5360.93
113_D118_D0.5350.92
172_Q175_T0.5350.92
50_G53_T0.5350.92
263_D266_V0.5330.92
93_V210_V0.5320.92
204_C207_L0.5310.92
251_V315_A0.5310.92
156_P188_R0.5300.92
325_A328_A0.5300.92
288_S309_C0.5290.92
238_V241_G0.5240.92
19_D212_D0.5220.92
8_L56_A0.5220.92
324_T328_A0.5220.92
81_V146_L0.5190.91
144_R167_L0.5190.91
117_V120_A0.5190.91
163_P195_H0.5180.91
119_R122_A0.5170.91
114_T118_D0.5170.91
253_P258_T0.5130.91
247_G251_V0.5130.91
173_I177_E0.5120.91
233_A242_T0.5100.91
146_L149_R0.5100.91
247_G257_R0.5060.90
108_F112_T0.5060.90
92_T131_A0.5060.90
21_V215_V0.5060.90
244_P249_V0.5050.90
96_V99_M0.5030.90
213_G218_A0.5030.90
97_V101_R0.5020.90
244_P248_A0.5020.90
116_V154_A0.5010.90
93_V96_V0.5010.90
255_P262_A0.5000.90
31_V215_V0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ry2A 2 0.5955 100 0.291 Contact Map
4f4cA 1 0.5628 100 0.296 Contact Map
3tuiC 2 0.8191 100 0.316 Contact Map
4mrsA 2 0.6156 100 0.316 Contact Map
4q9hA 1 0.5955 100 0.318 Contact Map
4yerA 2 0.706 100 0.321 Contact Map
4a82A 2 0.593 100 0.321 Contact Map
3b5xA 2 0.593 100 0.322 Contact Map
4mkiB 2 0.6859 100 0.325 Contact Map
3b60A 2 0.593 100 0.327 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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