GREMLIN Database
Q9HQ16 - Signal-transducing histidine kinase homolog
UniProt: Q9HQ16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 606 (470)
Sequences: 6029 (5289)
Seq/√Len: 243.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_A373_V4.5111.00
414_A432_V4.2061.00
587_T599_S3.5081.00
154_V250_R3.4511.00
281_L370_S3.0921.00
591_N594_T2.9431.00
541_A597_V2.8931.00
157_F247_G2.8881.00
340_V379_A2.7491.00
552_K588_V2.7351.00
548_P551_Q2.7081.00
266_A270_R2.7041.00
379_A382_E2.6801.00
199_A219_E2.6341.00
131_V135_A2.6291.00
362_L366_T2.6221.00
588_V598_F2.6201.00
576_D580_D2.5631.00
505_V579_V2.5611.00
345_L349_E2.5361.00
217_E256_R2.5121.00
303_Y346_A2.4631.00
179_A223_L2.4491.00
378_R382_E2.4101.00
279_P300_F2.3901.00
256_R259_E2.3541.00
255_R259_E2.3071.00
517_N543_N2.2981.00
142_W146_E2.2811.00
575_V586_V2.2801.00
461_H499_N2.2731.00
273_F292_N2.2591.00
296_A299_A2.2511.00
411_L436_A2.2461.00
155_G176_F2.2381.00
160_R163_D2.2301.00
279_P372_V2.2151.00
172_E175_A2.1811.00
538_I600_V2.1751.00
236_T243_T2.1621.00
537_T601_T2.1361.00
131_V134_A2.1161.00
537_T599_S2.1001.00
527_S539_H2.0711.00
354_E378_R2.0481.00
362_L365_D2.0441.00
463_M497_H2.0401.00
307_E346_A2.0391.00
222_T228_V2.0331.00
489_G492_P2.0251.00
231_T250_R2.0191.00
222_T226_N2.0001.00
215_E231_T1.9961.00
239_H242_T1.9501.00
418_A433_L1.9361.00
318_T321_S1.9261.00
525_T541_A1.8951.00
270_R274_K1.8901.00
284_D289_G1.8811.00
547_V551_Q1.8781.00
539_H597_V1.8391.00
149_L168_G1.8271.00
505_V578_L1.8271.00
464_S467_A1.8251.00
354_E373_V1.8181.00
155_G249_I1.8161.00
516_H561_T1.8151.00
152_L156_S1.8001.00
359_P367_V1.7961.00
221_E227_T1.7931.00
321_S342_E1.7911.00
238_T243_T1.7671.00
418_A430_E1.7661.00
579_V600_V1.7561.00
304_S307_E1.7491.00
184_A223_L1.7411.00
145_H149_L1.7311.00
171_D175_A1.7301.00
295_D299_A1.7171.00
146_E150_D1.7011.00
386_E389_R1.6961.00
462_V496_V1.6951.00
497_H582_V1.6791.00
219_E229_W1.6511.00
338_H354_E1.6481.00
342_E350_R1.6461.00
345_L351_R1.6331.00
417_L425_H1.6241.00
590_D596_A1.6111.00
542_D546_G1.6061.00
281_L290_I1.5991.00
169_V173_L1.5951.00
548_P592_D1.5881.00
269_F273_F1.5851.00
342_E352_T1.5811.00
466_R528_A1.5671.00
355_I372_V1.5671.00
135_A139_G1.5591.00
527_S541_A1.5581.00
341_F355_I1.5541.00
311_M315_D1.5431.00
303_Y307_E1.5311.00
281_L297_A1.5281.00
276_H280_M1.5251.00
259_E263_R1.5121.00
488_D525_T1.5071.00
160_R165_V1.4981.00
579_V584_G1.4871.00
539_H599_S1.4841.00
417_L429_I1.4821.00
422_D425_H1.4801.00
196_T199_A1.4801.00
535_T601_T1.4791.00
389_R392_L1.4781.00
556_F586_V1.4741.00
232_L249_I1.4641.00
505_V575_V1.4551.00
377_E380_D1.4541.00
196_T219_E1.4531.00
169_V174_V1.4491.00
531_T537_T1.4321.00
218_L232_L1.4281.00
529_D537_T1.4261.00
180_P184_A1.4251.00
589_S597_V1.4251.00
274_K295_D1.4191.00
471_A503_D1.4071.00
177_A220_L1.4041.00
265_R268_R1.4001.00
380_D384_R1.3961.00
298_A305_V1.3941.00
409_L435_S1.3931.00
219_E227_T1.3731.00
578_L582_V1.3721.00
580_D585_R1.3671.00
201_E205_A1.3491.00
329_G333_E1.3481.00
549_D552_K1.3461.00
399_L446_A1.3401.00
344_E350_R1.3361.00
217_E231_T1.3351.00
153_P170_N1.3351.00
382_E385_L1.3321.00
529_D539_H1.3311.00
229_W256_R1.3281.00
231_T255_R1.3211.00
506_F538_I1.3131.00
413_Y428_Y1.3121.00
381_Y385_L1.3051.00
585_R601_T1.2801.00
141_E144_H1.2761.00
418_A426_A1.2701.00
536_A604_T1.2641.00
158_R246_D1.2631.00
557_G560_E1.2621.00
501_M504_S1.2561.00
551_Q554_A1.2561.00
545_P565_S1.2351.00
505_V600_V1.2341.00
149_L156_S1.2321.00
282_L369_F1.2291.00
340_V354_E1.2291.00
174_V182_K1.2281.00
293_A297_A1.2231.00
189_P192_E1.2201.00
138_S141_E1.2201.00
269_F272_M1.2041.00
252_V256_R1.2031.00
440_V444_K1.1981.00
157_F173_L1.1981.00
476_V507_R1.1981.00
504_S578_L1.1801.00
549_D591_N1.1721.00
590_D593_P1.1711.00
158_R170_N1.1691.00
297_A301_Y1.1631.00
517_N524_V1.1571.00
397_Q402_D1.1521.00
352_T379_A1.1521.00
480_F514_I1.1501.00
361_E367_V1.1491.00
150_D171_D1.1491.00
415_D433_L1.1461.00
157_F234_A1.1421.00
157_F166_L1.1411.00
479_S482_S1.1381.00
554_A560_E1.1371.00
196_T227_T1.1311.00
173_L177_A1.1311.00
509_L540_V1.1261.00
318_T342_E1.1251.00
145_H148_I1.1251.00
171_D174_V1.1191.00
427_D431_R1.1161.00
295_D298_A1.1141.00
328_R332_E1.1091.00
357_S368_L1.1071.00
390_D394_V1.1071.00
486_T523_D1.1051.00
239_H244_V1.1031.00
410_V436_A1.0981.00
488_D523_D1.0971.00
266_A269_F1.0971.00
228_V251_D1.0951.00
547_V555_I1.0941.00
262_L265_R1.0931.00
215_E233_T1.0891.00
588_V596_A1.0891.00
159_T164_G1.0891.00
510_L526_V1.0881.00
556_F598_F1.0881.00
282_L291_Q1.0861.00
476_V510_L1.0851.00
498_G501_M1.0851.00
561_T565_S1.0781.00
143_A147_R1.0771.00
547_V552_K1.0711.00
265_R269_F1.0611.00
409_L413_Y1.0551.00
352_T376_T1.0541.00
282_L294_N1.0521.00
522_P543_N1.0511.00
293_A298_A1.0501.00
144_H158_R1.0411.00
260_T263_R1.0401.00
517_N522_P1.0371.00
294_N297_A1.0371.00
138_S142_W1.0211.00
139_G142_W1.0201.00
318_T350_R1.0201.00
268_R282_L1.0161.00
261_E264_Q1.0151.00
156_S170_N1.0121.00
170_N173_L1.0111.00
286_D289_G1.0101.00
464_S493_D1.0041.00
330_Q335_E1.0031.00
421_L425_H1.0031.00
518_D522_P0.9971.00
469_L506_F0.9971.00
220_L228_V0.9951.00
494_V497_H0.9901.00
413_Y435_S0.9881.00
283_I313_V0.9871.00
459_A582_V0.9831.00
229_W253_T0.9821.00
282_L292_N0.9791.00
230_G249_I0.9781.00
159_T234_A0.9761.00
471_A499_N0.9751.00
531_T601_T0.9741.00
414_A418_A0.9711.00
547_V553_D0.9701.00
130_L133_V0.9691.00
149_L170_N0.9691.00
445_T501_M0.9651.00
412_A416_M0.9621.00
380_D383_A0.9581.00
404_R439_A0.9471.00
202_E206_T0.9461.00
173_L249_I0.9451.00
132_V135_A0.9441.00
404_R440_V0.9431.00
590_D594_T0.9431.00
554_A557_G0.9391.00
403_I442_L0.9381.00
258_L261_E0.9381.00
260_T264_Q0.9381.00
180_P183_A0.9381.00
480_F524_V0.9371.00
325_D329_G0.9361.00
552_K590_D0.9361.00
523_D543_N0.9361.00
563_L566_D0.9331.00
178_D222_T0.9321.00
413_Y431_R0.9321.00
283_I357_S0.9321.00
587_T600_V0.9301.00
263_R267_R0.9281.00
501_M578_L0.9271.00
388_Q392_L0.9241.00
386_E390_D0.9231.00
402_D406_D0.9231.00
579_V586_V0.9221.00
280_M294_N0.9221.00
134_A138_S0.9221.00
263_R266_A0.9211.00
463_M468_T0.9181.00
589_S599_S0.9171.00
293_A308_L0.9161.00
253_T257_Q0.9151.00
351_R374_D0.9131.00
515_Q561_T0.9121.00
388_Q391_N0.9121.00
283_I370_S0.9121.00
387_T391_N0.9091.00
477_R481_P0.9081.00
402_D405_N0.9071.00
301_Y343_H0.9041.00
188_R192_E0.9041.00
148_I153_P0.9031.00
261_E265_R0.9031.00
402_D442_L0.8961.00
289_G312_T0.8961.00
509_L586_V0.8961.00
432_V436_A0.8961.00
414_A436_A0.8891.00
273_F294_N0.8841.00
171_D182_K0.8811.00
506_F510_L0.8790.99
451_D568_T0.8790.99
414_A433_L0.8780.99
459_A581_S0.8780.99
497_H502_L0.8770.99
283_I290_I0.8730.99
378_R381_Y0.8720.99
220_L230_G0.8710.99
410_V432_V0.8700.99
483_A517_N0.8660.99
142_W145_H0.8660.99
555_I588_V0.8620.99
157_F249_I0.8610.99
135_A138_S0.8610.99
169_V177_A0.8510.99
155_G173_L0.8500.99
535_T585_R0.8490.99
465_L536_A0.8490.99
214_T234_A0.8470.99
204_V208_S0.8450.99
475_E507_R0.8450.99
431_R435_S0.8430.99
234_A245_V0.8430.99
295_D305_V0.8410.99
357_S370_S0.8410.99
158_R247_G0.8410.99
556_F588_V0.8330.99
201_E204_V0.8300.99
385_L388_Q0.8280.99
375_V379_A0.8280.99
159_T166_L0.8220.99
298_A308_L0.8220.99
402_D504_S0.8200.99
343_H351_R0.8170.99
177_A249_I0.8160.99
217_E255_R0.8140.99
510_L524_V0.8120.99
480_F485_V0.8120.99
302_G345_L0.8110.99
411_L437_D0.8110.99
148_I158_R0.8100.99
137_E140_M0.8090.99
154_V172_E0.8010.99
267_R271_R0.8000.99
414_A429_I0.8000.99
547_V588_V0.7980.99
409_L431_R0.7970.99
476_V514_I0.7970.99
151_A246_D0.7950.99
298_A304_S0.7950.99
155_G172_E0.7950.99
217_E252_V0.7940.99
179_A185_L0.7920.99
279_P297_A0.7920.99
428_Y432_V0.7900.99
229_W252_V0.7880.99
324_L327_H0.7880.99
134_A137_E0.7880.99
381_Y384_R0.7850.99
301_Y372_V0.7840.99
159_T247_G0.7840.99
447_R451_D0.7830.99
317_N321_S0.7820.99
520_D543_N0.7810.99
278_A296_A0.7810.99
403_I407_L0.7790.99
182_K186_R0.7740.99
413_Y432_V0.7720.99
179_A184_A0.7690.99
490_S527_S0.7680.99
402_D435_S0.7620.99
338_H356_H0.7620.99
158_R167_L0.7540.98
272_M369_F0.7540.98
292_N305_V0.7530.98
324_L328_R0.7530.98
256_R260_T0.7510.98
288_G294_N0.7510.98
558_K577_T0.7500.98
148_I152_L0.7470.98
278_A371_I0.7470.98
526_V538_I0.7440.98
485_V522_P0.7430.98
509_L598_F0.7430.98
511_K515_Q0.7420.98
234_A247_G0.7420.98
523_D541_A0.7390.98
559_G573_Y0.7360.98
170_N251_D0.7350.98
356_H373_V0.7350.98
159_T245_V0.7350.98
139_G143_A0.7330.98
156_S246_D0.7330.98
393_D449_I0.7330.98
317_N341_F0.7320.98
395_L400_R0.7320.98
408_Q412_A0.7320.98
405_N412_A0.7320.98
312_T315_D0.7310.98
294_N374_D0.7300.98
294_N298_A0.7280.98
281_L357_S0.7260.98
392_L396_N0.7250.98
297_A308_L0.7250.98
198_A219_E0.7240.98
555_I598_F0.7220.98
357_S372_V0.7190.98
136_P139_G0.7190.98
276_H371_I0.7180.98
516_H565_S0.7150.98
283_I288_G0.7150.98
236_T245_V0.7110.98
174_V180_P0.7090.98
187_G193_F0.7090.98
411_L414_A0.7080.98
290_I294_N0.7070.98
400_R405_N0.7060.98
360_I369_F0.7060.98
273_F280_M0.7050.98
491_I528_A0.7050.98
503_D507_R0.7040.98
155_G170_N0.7030.98
202_E205_A0.7020.98
176_F230_G0.7020.98
398_V405_N0.7020.98
448_D501_M0.7000.97
466_R491_I0.6990.97
292_N295_D0.6980.97
537_T587_T0.6970.97
272_M282_L0.6970.97
282_L288_G0.6950.97
279_P355_I0.6900.97
353_V372_V0.6900.97
330_Q333_E0.6890.97
469_L526_V0.6890.97
411_L440_V0.6870.97
281_L293_A0.6850.97
150_D170_N0.6850.97
227_T253_T0.6840.97
157_F169_V0.6820.97
283_I327_H0.6810.97
155_G232_L0.6800.97
545_P596_A0.6800.97
155_G169_V0.6770.97
341_F357_S0.6760.97
570_M574_L0.6730.97
403_I439_A0.6720.97
483_A514_I0.6720.97
297_A372_V0.6700.97
502_L582_V0.6690.97
305_V309_T0.6680.97
383_A386_E0.6680.97
203_I218_L0.6680.97
148_I246_D0.6670.97
528_A538_I0.6650.97
547_V596_A0.6650.97
558_K573_Y0.6640.97
277_S373_V0.6630.97
403_I406_D0.6610.96
284_D291_Q0.6590.96
343_H355_I0.6580.96
177_A228_V0.6570.96
517_N520_D0.6570.96
466_R493_D0.6540.96
457_P501_M0.6530.96
427_D474_A0.6530.96
155_G174_V0.6520.96
468_T472_E0.6500.96
509_L600_V0.6500.96
195_A219_E0.6500.96
174_V185_L0.6500.96
547_V572_L0.6490.96
158_R168_G0.6490.96
153_P250_R0.6480.96
504_S574_L0.6480.96
272_M276_H0.6470.96
264_Q268_R0.6460.96
279_P353_V0.6450.96
405_N409_L0.6450.96
472_E510_L0.6440.96
550_A592_D0.6430.96
162_G242_T0.6410.96
410_V414_A0.6410.96
169_V185_L0.6410.96
155_G177_A0.6370.96
547_V590_D0.6360.96
272_M280_M0.6360.96
509_L575_V0.6350.96
237_V246_D0.6350.96
321_S350_R0.6330.95
257_Q261_E0.6320.95
445_T504_S0.6310.95
404_R445_T0.6310.95
157_F246_D0.6290.95
147_R246_D0.6280.95
407_L443_T0.6270.95
136_P140_M0.6270.95
144_H148_I0.6270.95
168_G182_K0.6240.95
145_H151_A0.6230.95
530_C604_T0.6200.95
280_M371_I0.6200.95
303_Y308_L0.6190.95
430_E434_E0.6180.95
327_H357_S0.6170.95
402_D575_V0.6170.95
417_L432_V0.6150.95
473_L487_V0.6140.95
313_V357_S0.6130.95
302_G347_D0.6130.95
143_A146_E0.6110.95
465_L538_I0.6110.95
278_A354_E0.6110.95
333_E336_R0.6100.94
433_L437_D0.6100.94
411_L433_L0.6090.94
168_G229_W0.6080.94
447_R568_T0.6070.94
149_L155_G0.6070.94
149_L172_E0.6060.94
285_P367_V0.6060.94
469_L472_E0.6030.94
435_S438_H0.6030.94
151_A156_S0.6020.94
223_L227_T0.6000.94
294_N370_S0.5990.94
313_V372_V0.5980.94
268_R292_N0.5980.94
328_R331_A0.5980.94
290_I310_G0.5970.94
154_V248_A0.5960.94
149_L152_L0.5950.94
402_D559_G0.5940.94
423_G426_A0.5940.94
441_E500_N0.5930.94
505_V582_V0.5930.94
402_D439_A0.5930.94
320_P342_E0.5930.94
254_E257_Q0.5930.94
137_E141_E0.5920.94
303_Y351_R0.5920.94
466_R470_E0.5900.93
196_T221_E0.5890.93
279_P301_Y0.5890.93
205_A209_A0.5880.93
586_V600_V0.5870.93
282_L360_I0.5870.93
399_L405_N0.5860.93
239_H243_T0.5860.93
387_T390_D0.5860.93
205_A208_S0.5860.93
137_E142_W0.5860.93
463_M502_L0.5850.93
416_M428_Y0.5850.93
257_Q260_T0.5840.93
327_H331_A0.5810.93
159_T190_A0.5810.93
169_V186_R0.5800.93
281_L372_V0.5800.93
279_P294_N0.5790.93
355_I370_S0.5790.93
255_R258_L0.5790.93
152_L168_G0.5780.93
405_N440_V0.5780.93
447_R450_A0.5770.93
258_L262_L0.5760.93
326_T329_G0.5760.93
415_D437_D0.5760.93
575_V579_V0.5760.93
542_D595_G0.5740.93
415_D418_A0.5720.92
265_R270_R0.5720.92
417_L431_R0.5720.92
210_D213_V0.5700.92
587_T601_T0.5690.92
283_I368_L0.5680.92
156_S168_G0.5680.92
476_V511_K0.5680.92
485_V514_I0.5640.92
326_T330_Q0.5630.92
141_E146_E0.5630.92
195_A218_L0.5600.92
525_T543_N0.5600.92
399_L403_I0.5600.92
290_I313_V0.5590.92
352_T375_V0.5550.91
293_A301_Y0.5550.91
132_V136_P0.5540.91
409_L414_A0.5540.91
343_H353_V0.5530.91
159_T168_G0.5530.91
395_L439_A0.5520.91
438_H507_R0.5510.91
281_L341_F0.5510.91
159_T207_L0.5510.91
290_I297_A0.5510.91
362_L367_V0.5500.91
153_P156_S0.5490.91
144_H168_G0.5490.91
233_T250_R0.5480.91
340_V378_R0.5480.91
472_E503_D0.5470.91
515_Q566_D0.5470.91
513_A524_V0.5470.91
199_A227_T0.5470.91
397_Q403_I0.5470.91
293_A305_V0.5460.91
382_E386_E0.5460.91
212_V216_T0.5450.90
552_K558_K0.5450.90
280_M292_N0.5450.90
277_S369_F0.5440.90
341_F372_V0.5440.90
447_R498_G0.5430.90
140_M144_H0.5430.90
472_E476_V0.5430.90
358_S369_F0.5410.90
351_R376_T0.5410.90
438_H503_D0.5410.90
350_R376_T0.5410.90
396_N399_L0.5390.90
148_I170_N0.5390.90
446_A450_A0.5390.90
545_P590_D0.5370.90
501_M582_V0.5370.90
467_A471_A0.5360.90
459_A498_G0.5350.90
148_I156_S0.5340.90
155_G158_R0.5330.90
393_D561_T0.5310.89
448_D452_V0.5310.89
228_V253_T0.5300.89
500_N503_D0.5300.89
269_F369_F0.5300.89
195_A199_A0.5290.89
341_F353_V0.5280.89
279_P296_A0.5270.89
488_D492_P0.5260.89
274_K292_N0.5250.89
392_L405_N0.5250.89
404_R452_V0.5250.89
449_I573_Y0.5240.89
404_R444_K0.5240.89
469_L528_A0.5240.89
396_N498_G0.5240.89
195_A200_R0.5230.89
343_H372_V0.5220.89
464_S494_V0.5220.89
324_L331_A0.5220.89
195_A203_I0.5220.89
241_G247_G0.5210.88
441_E445_T0.5210.88
397_Q406_D0.5200.88
561_T566_D0.5190.88
218_L234_A0.5190.88
166_L169_V0.5190.88
288_G313_V0.5180.88
232_L247_G0.5180.88
166_L187_G0.5180.88
396_N448_D0.5170.88
207_L245_V0.5170.88
277_S292_N0.5160.88
409_L412_A0.5150.88
584_G603_R0.5150.88
504_S508_N0.5150.88
279_P373_V0.5150.88
281_L355_I0.5150.88
130_L134_A0.5150.88
460_D566_D0.5140.88
436_A440_V0.5130.88
397_Q405_N0.5130.88
158_R169_V0.5110.87
353_V376_T0.5100.87
148_I155_G0.5090.87
296_A373_V0.5090.87
379_A383_A0.5080.87
176_F249_I0.5080.87
404_R447_R0.5080.87
272_M277_S0.5080.87
403_I446_A0.5070.87
297_A351_R0.5060.87
154_V233_T0.5060.87
245_V249_I0.5060.87
395_L515_Q0.5040.87
402_D507_R0.5040.87
505_V538_I0.5030.87
273_F276_H0.5030.87
393_D397_Q0.5030.87
468_T503_D0.5020.87
448_D504_S0.5010.86
162_G243_T0.5010.86
512_N571_G0.5010.86
406_D439_A0.5000.86
147_R158_R0.5000.86
395_L561_T0.5000.86
444_K448_D0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gczA 2 0.571 100 0.51 Contact Map
3a0rA 2 0.5281 100 0.545 Contact Map
4i5sA 2 0.6304 100 0.545 Contact Map
4r3aA 1 0.5033 100 0.602 Contact Map
4mpcA 2 0.4769 100 0.659 Contact Map
2q8gA 2 0.4835 100 0.662 Contact Map
2c2aA 2 0.3779 100 0.665 Contact Map
4q20A 2 0.368 100 0.665 Contact Map
4e01A 3 0.4736 100 0.668 Contact Map
3d36A 2 0.3597 100 0.671 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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