GREMLIN Database
Q9HQ15 - Uncharacterized protein
UniProt: Q9HQ15 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 444 (360)
Sequences: 28651 (24086)
Seq/√Len: 1269.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
377_D381_G3.7991.00
376_S432_V3.7391.00
370_H436_R3.4051.00
411_Y415_T3.3561.00
247_A265_I3.1331.00
422_D434_T2.9651.00
295_L328_A2.9631.00
374_T432_V2.8921.00
426_N429_Q2.6011.00
348_A378_H2.5771.00
374_T434_T2.5421.00
372_R436_R2.5131.00
358_S374_T2.4271.00
361_E439_A2.4191.00
328_A417_S2.4151.00
320_D356_S2.4081.00
383_P386_E2.4021.00
423_F433_V2.3911.00
387_R425_D2.3881.00
356_S376_S2.3801.00
424_E432_V2.3471.00
372_R434_T2.3461.00
360_S372_R2.3411.00
244_R270_D2.3261.00
251_A263_A2.3151.00
354_Q378_H2.3151.00
294_P327_A2.2841.00
336_A414_V2.2751.00
251_A266_I2.2331.00
358_S376_S2.2061.00
195_D198_E2.2061.00
360_S374_T2.1941.00
424_E434_T2.1791.00
414_V419_G2.1601.00
387_R423_F2.1301.00
410_V421_L2.1221.00
425_D431_S2.0701.00
296_D299_R2.0421.00
414_V435_I2.0161.00
322_P358_S1.9941.00
293_E330_V1.9761.00
255_T258_A1.9621.00
348_A353_P1.9101.00
318_T354_Q1.9081.00
320_D354_Q1.8971.00
336_A413_A1.8901.00
391_N421_L1.8791.00
386_E389_V1.8661.00
93_T97_A1.8591.00
382_I390_L1.8531.00
303_T334_G1.8301.00
215_V219_R1.8231.00
244_R269_C1.8081.00
420_D436_R1.7951.00
193_G198_E1.7921.00
353_P378_H1.7571.00
179_A184_A1.7451.00
222_A225_L1.7081.00
389_V392_G1.7051.00
336_A410_V1.7041.00
308_A338_Q1.6801.00
382_I386_E1.6721.00
367_G372_R1.6691.00
384_R387_R1.6661.00
223_R227_V1.6591.00
227_V231_V1.6491.00
382_I431_S1.6301.00
294_P325_A1.6131.00
413_A417_S1.6121.00
337_I373_I1.5851.00
211_I214_S1.5721.00
322_P356_S1.5641.00
248_E266_I1.5631.00
415_T420_D1.5531.00
244_R273_V1.5501.00
377_D430_G1.5451.00
348_A355_V1.5291.00
386_E395_A1.5211.00
273_V277_D1.5171.00
332_Q335_T1.5121.00
298_A359_V1.5041.00
312_A345_I1.5031.00
180_L208_S1.4961.00
425_D429_Q1.4911.00
194_A198_E1.4791.00
159_G163_Y1.4711.00
422_D436_R1.4701.00
373_I435_I1.4691.00
247_A266_I1.4441.00
292_P327_A1.4411.00
221_R225_L1.4351.00
383_P427_T1.4301.00
329_A332_Q1.4081.00
298_A302_E1.4051.00
251_A259_A1.4031.00
225_L229_D1.3921.00
215_V218_N1.3921.00
387_R391_N1.3901.00
389_V395_A1.3851.00
174_I178_R1.3801.00
312_A315_A1.3731.00
336_A435_I1.3721.00
328_A333_I1.3621.00
204_F208_S1.3621.00
214_S218_N1.3561.00
371_V439_A1.3511.00
210_T213_Q1.3471.00
174_I199_R1.3421.00
250_V262_A1.3391.00
188_H209_D1.3121.00
356_S378_H1.3001.00
204_F207_M1.2911.00
347_H396_I1.2871.00
425_D428_P1.2871.00
339_E410_V1.2821.00
222_A226_H1.2731.00
250_V258_A1.2731.00
163_Y167_L1.2601.00
205_N208_S1.2551.00
342_T346_Q1.2551.00
253_H258_A1.2411.00
246_R261_H1.2391.00
212_D216_A1.2251.00
419_G437_L1.2231.00
414_V421_L1.2181.00
177_F203_G1.2071.00
303_T330_V1.2041.00
398_A401_H1.1981.00
243_V269_C1.1891.00
177_F204_F1.1851.00
309_Q313_P1.1801.00
360_S367_G1.1781.00
280_R283_S1.1751.00
177_F180_L1.1731.00
92_T125_S1.1671.00
201_G205_N1.1661.00
412_W415_T1.1631.00
201_G204_F1.1581.00
391_N423_F1.1561.00
332_Q416_H1.1551.00
177_F181_R1.1311.00
88_G101_H1.1231.00
266_I270_D1.1171.00
296_D325_A1.1171.00
332_Q413_A1.1151.00
235_T335_T1.1121.00
300_I304_V1.1101.00
231_V393_D1.1091.00
307_R334_G1.1091.00
92_T98_D1.1061.00
213_Q217_E1.1021.00
243_V265_I1.1021.00
113_H116_P1.1011.00
220_E224_Q1.1001.00
176_G189_V1.0891.00
247_A251_A1.0851.00
312_A317_L1.0811.00
164_R168_A1.0801.00
186_G212_D1.0721.00
370_H420_D1.0701.00
242_V246_R1.0681.00
423_F431_S1.0651.00
392_G395_A1.0611.00
244_R266_I1.0591.00
391_N433_V1.0581.00
88_G127_S1.0571.00
73_T76_F1.0541.00
188_H205_N1.0491.00
184_A187_T1.0441.00
171_E174_I1.0421.00
228_L232_L1.0401.00
200_I204_F1.0371.00
330_V334_G1.0301.00
396_I400_H1.0261.00
179_A187_T1.0251.00
214_S217_E1.0231.00
301_T359_V1.0181.00
292_P417_S1.0171.00
263_A267_S1.0151.00
246_R264_H1.0131.00
242_V268_R1.0091.00
390_L423_F0.9911.00
247_A269_C0.9871.00
274_E331_P0.9841.00
255_T259_A0.9821.00
340_V421_L0.9771.00
200_I207_M0.9751.00
119_E122_W0.9751.00
314_N317_L0.9711.00
304_V308_A0.9641.00
260_A264_H0.9621.00
247_A262_A0.9591.00
116_P123_V0.9581.00
241_N245_G0.9531.00
142_L146_G0.9521.00
245_G249_L0.9521.00
304_V341_V0.9431.00
340_V433_V0.9421.00
166_N169_Q0.9421.00
174_I203_G0.9411.00
302_E321_T0.9391.00
178_R199_R0.9381.00
376_S426_N0.9321.00
340_V410_V0.9271.00
337_I375_V0.9261.00
193_G201_G0.9251.00
197_W201_G0.9221.00
313_P316_D0.9221.00
138_Q142_L0.9191.00
304_V334_G0.9181.00
203_G206_E0.9181.00
377_D431_S0.9161.00
277_D281_A0.9111.00
367_G370_H0.9101.00
207_M211_I0.9101.00
130_R134_G0.9081.00
311_D314_N0.9081.00
259_A263_A0.9051.00
221_R224_Q0.9051.00
210_T214_S0.9041.00
414_V437_L0.8951.00
333_I417_S0.8931.00
191_V202_T0.8931.00
211_I215_V0.8911.00
181_R206_E0.8901.00
114_T123_V0.8851.00
312_A319_V0.8841.00
305_V321_T0.8791.00
344_A355_V0.8791.00
197_W200_I0.8791.00
110_V127_S0.8721.00
190_D205_N0.8671.00
382_I423_F0.8651.00
297_V373_I0.8641.00
312_A316_D0.8591.00
229_D232_L0.8591.00
382_I388_R0.8591.00
254_A258_A0.8551.00
339_E342_T0.8531.00
90_T125_S0.8531.00
295_L300_I0.8531.00
384_R425_D0.8451.00
391_N411_Y0.8411.00
297_V371_V0.8341.00
200_I203_G0.8331.00
156_A160_W0.8331.00
268_R271_S0.8301.00
267_S303_T0.8241.00
305_V309_Q0.8221.00
337_I341_V0.8211.00
340_V435_I0.8191.00
141_T145_T0.8191.00
174_I177_F0.8181.00
331_P334_G0.8181.00
370_H438_P0.8141.00
405_L409_L0.8131.00
161_W165_R0.8121.00
220_E223_R0.8091.00
90_T98_D0.8091.00
412_W416_H0.8061.00
180_L207_M0.8051.00
382_I387_R0.8031.00
235_T239_E0.8021.00
212_D215_V0.7991.00
313_P317_L0.7991.00
341_V357_V0.7991.00
278_K332_Q0.7971.00
173_L177_F0.7921.00
299_R303_T0.7901.00
216_A219_R0.7901.00
244_R248_E0.7891.00
369_D439_A0.7891.00
265_I269_C0.7871.00
198_E202_T0.7861.00
300_I328_A0.7851.00
304_V338_Q0.7821.00
76_F79_L0.7791.00
264_H268_R0.7791.00
311_D342_T0.7791.00
301_T337_I0.7791.00
381_G431_S0.7771.00
382_I425_D0.7761.00
157_V161_W0.7761.00
76_F80_Q0.7761.00
188_H212_D0.7751.00
393_D412_W0.7741.00
123_V127_S0.7721.00
224_Q227_V0.7711.00
302_E305_V0.7711.00
200_I205_N0.7681.00
256_G259_A0.7671.00
298_A324_T0.7671.00
176_G187_T0.7651.00
367_G436_R0.7611.00
188_H208_S0.7601.00
242_V245_G0.7591.00
274_E278_K0.7571.00
191_V201_G0.7571.00
178_R182_D0.7571.00
308_A341_V0.7561.00
177_F200_I0.7531.00
396_I402_S0.7521.00
334_G338_Q0.7511.00
201_G208_S0.7501.00
390_L433_V0.7481.00
384_R388_R0.7471.00
410_V414_V0.7471.00
269_C273_V0.7461.00
409_L413_A0.7451.00
292_P418_D0.7431.00
226_H286_L0.7421.00
170_V200_I0.7421.00
338_Q342_T0.7411.00
98_D101_H0.7401.00
307_R338_Q0.7381.00
118_S121_D0.7361.00
235_T339_E0.7351.00
237_R273_V0.7341.00
306_E309_Q0.7321.00
114_T117_L0.7261.00
304_V307_R0.7261.00
227_V393_D0.7251.00
296_D324_T0.7251.00
357_V375_V0.7251.00
377_D380_P0.7241.00
308_A342_T0.7241.00
316_D352_A0.7231.00
302_E306_E0.7211.00
138_Q141_T0.7201.00
280_R284_A0.7191.00
223_R226_H0.7181.00
165_R168_A0.7141.00
419_G435_I0.7131.00
229_D233_R0.7131.00
391_N394_D0.7121.00
258_A261_H0.7101.00
241_N244_R0.7051.00
145_T149_I0.7041.00
178_R181_R0.7001.00
242_V264_H0.7001.00
90_T127_S0.6991.00
228_L233_R0.6981.00
77_D80_Q0.6981.00
189_V205_N0.6971.00
103_P106_P0.6941.00
179_A182_D0.6941.00
237_R277_D0.6921.00
198_E201_G0.6921.00
232_L279_E0.6911.00
261_H265_I0.6901.00
312_A355_V0.6901.00
335_T413_A0.6901.00
238_N242_V0.6901.00
175_D179_A0.6881.00
263_A266_I0.6881.00
213_Q216_A0.6871.00
189_V201_G0.6861.00
251_A262_A0.6841.00
142_L145_T0.6831.00
228_L231_V0.6831.00
260_A263_A0.6781.00
74_G77_D0.6771.00
307_R311_D0.6771.00
169_Q173_L0.6771.00
155_I159_G0.6741.00
347_H380_P0.6731.00
336_A417_S0.6721.00
359_V371_V0.6711.00
168_A172_A0.6691.00
178_R203_G0.6671.00
187_T190_D0.6641.00
344_A348_A0.6621.00
176_G205_N0.6611.00
419_G438_P0.6601.00
306_E310_A0.6601.00
322_P360_S0.6601.00
193_G197_W0.6591.00
181_R210_T0.6581.00
199_R202_T0.6581.00
301_T357_V0.6571.00
160_W164_R0.6571.00
179_A183_G0.6561.00
163_Y166_N0.6551.00
344_A375_V0.6531.00
230_R233_R0.6531.00
246_R268_R0.6521.00
300_I307_R0.6491.00
381_G430_G0.6491.00
110_V116_P0.6491.00
176_G179_A0.6481.00
88_G102_R0.6471.00
380_P400_H0.6401.00
187_T191_V0.6401.00
291_T329_A0.6381.00
384_R426_N0.6371.00
203_G207_M0.6361.00
272_L276_A0.6341.00
346_Q400_H0.6331.00
281_A335_T0.6301.00
185_Y208_S0.6281.00
249_L254_A0.6281.00
249_L253_H0.6261.00
112_T115_A0.6251.00
310_A313_P0.6251.00
143_L146_G0.6231.00
108_R112_T0.6201.00
173_L201_G0.6191.00
359_V373_I0.6191.00
236_L272_L0.6191.00
137_I141_T0.6181.00
370_H439_A0.6151.00
170_V174_I0.6151.00
94_D121_D0.6141.00
422_D435_I0.6141.00
290_T332_Q0.6131.00
104_P107_N0.6111.00
200_I208_S0.6081.00
86_S132_V0.6071.00
315_A345_I0.6061.00
374_T424_E0.6051.00
73_T77_D0.6051.00
408_W412_W0.6021.00
246_R250_V0.6011.00
122_W126_V0.6001.00
332_Q417_S0.5991.00
180_L183_G0.5971.00
139_R143_L0.5971.00
282_I393_D0.5951.00
114_T125_S0.5951.00
110_V113_H0.5951.00
281_A284_A0.5931.00
387_R424_E0.5921.00
246_R265_I0.5921.00
257_E261_H0.5891.00
396_I399_L0.5881.00
376_S428_P0.5861.00
184_A188_H0.5861.00
209_D213_Q0.5841.00
110_V114_T0.5831.00
89_V126_V0.5831.00
172_A176_G0.5821.00
235_T275_T0.5811.00
89_V93_T0.5801.00
234_H238_N0.5791.00
248_E252_S0.5791.00
307_R310_A0.5781.00
205_N209_D0.5771.00
98_D102_R0.5761.00
111_T114_T0.5731.00
262_A266_I0.5731.00
208_S211_I0.5721.00
217_E220_E0.5711.00
103_P107_N0.5711.00
282_I408_W0.5701.00
90_T101_H0.5691.00
340_V407_L0.5681.00
278_K335_T0.5661.00
411_Y421_L0.5631.00
264_H267_S0.5601.00
303_T307_R0.5591.00
249_L261_H0.5591.00
192_G195_D0.5581.00
221_R226_H0.5571.00
311_D315_A0.5551.00
206_E210_T0.5521.00
299_R330_V0.5501.00
112_T127_S0.5501.00
173_L204_F0.5491.00
341_V355_V0.5481.00
236_L239_E0.5481.00
305_V357_V0.5481.00
196_E200_I0.5471.00
340_V375_V0.5471.00
168_A171_E0.5471.00
295_L330_V0.5461.00
250_V261_H0.5461.00
317_L348_A0.5461.00
93_T99_I0.5451.00
346_Q402_S0.5441.00
234_H339_E0.5441.00
340_V414_V0.5431.00
281_A332_Q0.5431.00
235_T268_R0.5431.00
169_Q195_D0.5421.00
310_A314_N0.5411.00
235_T409_L0.5401.00
113_H117_L0.5401.00
421_L435_I0.5401.00
201_G207_M0.5391.00
390_L408_W0.5381.00
372_R422_D0.5381.00
195_D201_G0.5381.00
388_R392_G0.5371.00
240_L276_A0.5371.00
397_D400_H0.5361.00
272_L279_E0.5361.00
356_S359_V0.5351.00
301_T304_V0.5351.00
411_Y420_D0.5341.00
348_A352_A0.5331.00
134_G138_Q0.5321.00
361_E367_G0.5321.00
149_I153_A0.5321.00
261_H264_H0.5311.00
266_I269_C0.5311.00
430_G433_V0.5291.00
174_I197_W0.5291.00
238_N245_G0.5281.00
382_I433_V0.5271.00
171_E175_D0.5271.00
279_E283_S0.5271.00
175_D178_R0.5251.00
349_D353_P0.5231.00
208_S212_D0.5231.00
186_G208_S0.5221.00
130_R133_I0.5191.00
172_A175_D0.5191.00
421_L433_V0.5181.00
295_L333_I0.5181.00
243_V247_A0.5101.00
85_D88_G0.5101.00
82_D85_D0.5081.00
195_D199_R0.5081.00
361_E368_T0.5081.00
315_A348_A0.5071.00
101_H104_P0.5061.00
202_T206_E0.5061.00
81_S87_S0.5051.00
85_D89_V0.5051.00
332_Q336_A0.5051.00
173_L176_G0.5041.00
141_T144_Q0.5041.00
271_S334_G0.5041.00
139_R142_L0.5041.00
143_L147_S0.5041.00
300_I334_G0.5031.00
282_I412_W0.5031.00
169_Q177_F0.5011.00
92_T123_V0.5011.00
93_T96_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.6104 100 0.406 Contact Map
4bixA 2 0.5045 100 0.456 Contact Map
4ctiA 2 0.5135 100 0.467 Contact Map
4mpcA 2 0.6689 100 0.523 Contact Map
2q8gA 2 0.6689 100 0.528 Contact Map
4q20A 2 0.5045 100 0.531 Contact Map
4gczA 2 0.8086 100 0.532 Contact Map
3d36A 2 0.4887 100 0.536 Contact Map
3a0rA 2 0.7342 100 0.537 Contact Map
4e01A 3 0.6509 100 0.538 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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