GREMLIN Database
Q9HQ13 - Transcription regulator
UniProt: Q9HQ13 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 149 (139)
Sequences: 13624 (8857)
Seq/√Len: 751.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_A28_E2.9411.00
44_E52_Y2.8891.00
93_E106_R2.5921.00
100_E133_Q2.5741.00
72_R131_R2.5521.00
22_F40_V2.3091.00
110_E114_H2.3061.00
59_K113_D2.1321.00
13_A20_K2.0801.00
7_D39_R2.0701.00
42_R46_A2.0241.00
50_R57_D2.0041.00
74_E130_A1.9311.00
50_R55_D1.8171.00
88_I122_E1.8131.00
66_T106_R1.8061.00
68_F95_N1.8041.00
92_R108_V1.7671.00
6_T31_M1.7451.00
88_I118_L1.7281.00
41_S45_E1.6971.00
13_A16_A1.6721.00
31_M35_T1.6681.00
23_S27_R1.6171.00
70_G135_M1.5791.00
114_H117_A1.5501.00
20_K28_E1.5491.00
111_D114_H1.5401.00
84_R87_G1.5131.00
23_S33_S1.5041.00
90_G114_H1.4991.00
84_R126_M1.4941.00
24_E27_R1.4901.00
31_M36_V1.4861.00
32_S35_T1.4531.00
22_F37_H1.4341.00
81_T85_L1.4221.00
19_R52_Y1.3891.00
71_L105_L1.3861.00
10_I25_I1.3851.00
82_L86_T1.3681.00
72_R100_E1.3581.00
77_R80_E1.3541.00
29_I36_V1.3281.00
117_A121_E1.3251.00
70_G101_W1.3151.00
79_D83_D1.3011.00
20_K25_I1.2791.00
65_T112_T1.2711.00
69_V107_L1.2711.00
14_L40_V1.2591.00
5_D9_E1.2571.00
72_R130_A1.2561.00
116_R139_G1.2491.00
63_L110_E1.2491.00
82_L139_G1.2241.00
73_V81_T1.2191.00
24_E28_E1.2151.00
16_A28_E1.1931.00
41_S44_E1.1841.00
6_T9_E1.1601.00
21_P24_E1.1561.00
4_D39_R1.1431.00
17_D28_E1.1251.00
90_G122_E1.1151.00
70_G133_Q1.0961.00
13_A25_I1.0871.00
22_F26_A1.0781.00
66_T108_V1.0641.00
6_T29_I1.0551.00
51_G55_D1.0381.00
9_E12_R1.0341.00
9_E13_A1.0341.00
94_V105_L1.0301.00
91_V107_L1.0201.00
80_E84_R1.0061.00
109_A114_H0.9981.00
20_K24_E0.9941.00
26_A36_V0.9871.00
18_A52_Y0.9811.00
57_D60_A0.9791.00
82_L103_V0.9781.00
12_R16_A0.9731.00
3_V8_R0.9671.00
68_F104_I0.9561.00
109_A115_L0.9471.00
83_D86_T0.9471.00
37_H41_S0.9441.00
33_S37_H0.9331.00
97_T104_I0.9311.00
68_F106_R0.9241.00
64_G111_D0.9201.00
107_L118_L0.9201.00
22_F33_S0.9171.00
95_N106_R0.9131.00
19_R44_E0.9071.00
109_A118_L0.9021.00
26_A31_M0.8981.00
9_E29_I0.8921.00
23_S37_H0.8731.00
83_D87_G0.8671.00
58_P108_V0.8531.00
100_E131_R0.8471.00
91_V94_V0.8461.00
68_F137_V0.8391.00
18_A24_E0.8261.00
43_L48_V0.8231.00
91_V105_L0.8101.00
7_D42_R0.8061.00
95_N137_V0.7951.00
8_R12_R0.7921.00
74_E77_R0.7891.00
119_M134_T0.7881.00
117_A122_E0.7831.00
95_N140_T0.7801.00
79_D82_L0.7741.00
85_L94_V0.7621.00
70_G104_I0.7571.00
18_A54_A0.7521.00
84_R88_I0.7521.00
71_L81_T0.7501.00
25_I36_V0.7361.00
34_A38_D0.7331.00
10_I36_V0.7291.00
80_E83_D0.7261.00
72_R101_W0.7071.00
25_I40_V0.7061.00
78_E121_E0.7021.00
10_I39_R0.6981.00
63_L90_G0.6971.00
78_E125_D0.6971.00
10_I20_K0.6851.00
69_V132_S0.6841.00
48_V60_A0.6771.00
101_W133_Q0.6771.00
4_D7_D0.6771.00
63_L108_V0.6731.00
82_L141_E0.6711.00
17_D20_K0.6691.00
13_A17_D0.6691.00
90_G118_L0.6671.00
124_A132_S0.6641.00
96_L103_V0.6621.00
80_E128_G0.6591.00
70_G100_E0.6591.00
38_D42_R0.6591.00
112_T136_V0.6581.00
113_D116_R0.6501.00
98_T136_V0.6381.00
26_A33_S0.6371.00
69_V105_L0.6331.00
67_A115_L0.6331.00
34_A37_H0.6311.00
5_D8_R0.6311.00
3_V48_V0.6271.00
66_T137_V0.6231.00
81_T103_V0.6231.00
67_A136_V0.6221.00
47_G50_R0.6191.00
11_L43_L0.6161.00
10_I13_A0.6161.00
74_E128_G0.6151.00
119_M132_S0.6131.00
85_L105_L0.6121.00
113_D117_A0.6101.00
18_A51_G0.6081.00
38_D41_S0.6081.00
22_F36_V0.6031.00
90_G110_E0.5981.00
39_R43_L0.5971.00
114_H118_L0.5951.00
10_I40_V0.5811.00
97_T101_W0.5801.00
71_L129_F0.5761.00
84_R127_D0.5741.00
67_A134_T0.5701.00
10_I43_L0.5691.00
122_E126_M0.5681.00
70_G97_T0.5661.00
88_I126_M0.5651.00
96_L102_D0.5651.00
7_D43_L0.5641.00
49_I52_Y0.5641.00
57_D61_V0.5631.00
66_T95_N0.5611.00
56_V61_V0.5601.00
71_L132_S0.5581.00
66_T140_T0.5431.00
118_L122_E0.5421.00
55_D58_P0.5361.00
112_T138_L0.5351.00
15_Q53_H0.5331.00
6_T35_T0.5321.00
84_R128_G0.5261.00
97_T135_M0.5261.00
118_L123_I0.5241.00
97_T137_V0.5181.00
72_R133_Q0.5171.00
79_D125_D0.5161.00
115_L136_V0.5131.00
73_V102_D0.5121.00
96_L124_A0.5111.00
23_S26_A0.5111.00
42_R45_E0.5111.00
92_R106_R0.5061.00
4_D42_R0.5051.00
78_E103_V0.5031.00
100_E135_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.9128 100 0.13 Contact Map
4un1A 1 0.953 100 0.156 Contact Map
2e1cA 1 0.9866 100 0.164 Contact Map
2p5vA 5 1 100 0.174 Contact Map
4pcqA 2 0.9799 100 0.175 Contact Map
4un1B 1 0.9933 100 0.176 Contact Map
3i4pA 5 0.9799 100 0.202 Contact Map
2ia0A 2 0.9664 100 0.202 Contact Map
2pn6A 5 0.9799 100 0.212 Contact Map
2cg4A 6 0.9933 100 0.214 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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