GREMLIN Database
Q9HQ12 - Extragenic suppressor homolog
UniProt: Q9HQ12 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 266 (243)
Sequences: 10177 (7267)
Seq/√Len: 466.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_V226_G4.0771.00
119_R126_T3.5771.00
81_A109_V3.3031.00
80_G110_D3.1161.00
229_T251_H3.1141.00
218_V222_R2.9221.00
120_F123_L2.7881.00
133_G223_Q2.7641.00
13_A55_V2.6991.00
16_T55_V2.6051.00
155_A200_L2.5911.00
32_E46_R2.4291.00
20_V51_R2.3861.00
18_G119_R2.2641.00
230_D234_T2.1701.00
202_A254_V2.1621.00
101_W122_A2.1271.00
82_A108_V2.0981.00
43_E47_T2.0771.00
81_A107_A2.0641.00
128_I135_T2.0021.00
50_R54_D1.9651.00
49_Q67_G1.9501.00
24_A44_A1.9441.00
55_V58_A1.9441.00
21_A48_A1.9371.00
60_Y63_D1.8991.00
84_V108_V1.8931.00
109_V114_V1.8811.00
108_V113_P1.8221.00
136_L197_S1.8061.00
135_T140_P1.8031.00
53_V57_D1.7921.00
116_A219_H1.7851.00
129_A223_Q1.7581.00
127_Y197_S1.7461.00
219_H223_Q1.7271.00
14_A105_V1.7211.00
63_D81_A1.7041.00
53_V65_I1.7011.00
22_L122_A1.6791.00
51_R55_V1.6381.00
125_D136_L1.6111.00
10_A83_W1.6101.00
9_V60_Y1.6091.00
120_F190_A1.5891.00
11_E128_I1.5841.00
118_N193_S1.5831.00
9_V59_V1.5641.00
102_A189_Q1.5621.00
148_D151_T1.5441.00
193_S220_L1.5351.00
9_V13_A1.5251.00
125_D199_Q1.5171.00
131_A223_Q1.5061.00
246_S251_H1.4911.00
106_A215_V1.4831.00
104_A189_Q1.4741.00
25_F101_W1.4571.00
42_T95_V1.4551.00
12_R59_V1.4511.00
63_D83_W1.4241.00
14_A117_C1.4111.00
21_A88_I1.4101.00
80_G109_V1.4091.00
85_I105_V1.3831.00
20_V23_D1.3791.00
134_A141_I1.3691.00
54_D58_A1.3651.00
125_D197_S1.3631.00
15_R126_T1.3401.00
55_V59_V1.3331.00
52_V85_I1.3301.00
170_A173_A1.3051.00
83_W107_A1.3011.00
22_L101_W1.3001.00
21_A101_W1.2831.00
169_A173_A1.2811.00
192_L217_G1.2781.00
11_E15_R1.2481.00
11_E126_T1.2461.00
7_V128_I1.2371.00
98_T185_Y1.2371.00
47_T50_R1.2341.00
16_T51_R1.2301.00
12_R16_T1.2201.00
40_V95_V1.2161.00
52_V105_V1.2141.00
53_V67_G1.2111.00
50_R70_A1.2051.00
40_V92_N1.2051.00
6_R63_D1.1911.00
21_A44_A1.1741.00
154_V202_A1.1691.00
227_V252_D1.1651.00
112_T222_R1.1591.00
56_I63_D1.1561.00
49_Q53_V1.1521.00
194_M199_Q1.1491.00
49_Q70_A1.1311.00
252_D256_A1.1271.00
218_V228_V1.1261.00
222_R235_R1.1131.00
166_D173_A1.1021.00
129_A219_H1.1001.00
152_F250_A1.0971.00
84_V215_V1.0971.00
20_V47_T1.0921.00
166_D170_A1.0771.00
192_L245_A1.0761.00
46_R50_R1.0671.00
19_A23_D1.0661.00
119_R124_E1.0631.00
113_P219_H1.0621.00
66_V84_V1.0601.00
13_A51_R1.0591.00
170_A174_A1.0421.00
13_A52_V1.0401.00
76_V79_A1.0401.00
20_V24_A1.0331.00
144_S201_E1.0281.00
23_D27_T1.0251.00
16_T19_A1.0241.00
106_A113_P1.0191.00
153_V157_T1.0191.00
12_R55_V1.0001.00
45_D69_E1.0001.00
24_A47_T0.9961.00
253_A256_A0.9921.00
107_A115_A0.9881.00
9_V56_I0.9881.00
53_V70_A0.9851.00
6_R107_A0.9841.00
48_A52_V0.9811.00
192_L221_V0.9761.00
190_A194_M0.9741.00
227_V248_G0.9721.00
6_R60_Y0.9651.00
221_V245_A0.9631.00
251_H255_L0.9591.00
173_A177_E0.9591.00
113_P218_V0.9441.00
66_V82_A0.9271.00
10_A117_C0.9261.00
188_A209_A0.9251.00
141_I197_S0.9201.00
25_F122_A0.9151.00
48_A88_I0.9121.00
36_G39_D0.9081.00
24_A43_E0.9071.00
168_Y171_A0.9061.00
15_R124_E0.9051.00
118_N220_L0.8991.00
8_S12_R0.8981.00
134_A223_Q0.8981.00
227_V251_H0.8961.00
107_A114_V0.8921.00
247_N250_A0.8911.00
93_N183_R0.8851.00
100_L194_M0.8731.00
42_T91_T0.8721.00
34_K41_V0.8721.00
7_V130_G0.8671.00
136_L139_T0.8651.00
81_A114_V0.8601.00
118_N217_G0.8561.00
134_A220_L0.8531.00
56_I60_Y0.8461.00
25_F97_D0.8451.00
22_L124_E0.8391.00
115_A130_G0.8371.00
69_E91_T0.8371.00
66_V212_W0.8301.00
149_P152_F0.8261.00
68_E91_T0.8221.00
230_D233_G0.8171.00
15_R119_R0.8121.00
8_S11_E0.8101.00
67_G70_A0.8091.00
104_A118_N0.8091.00
30_D43_E0.8051.00
209_A214_S0.8051.00
127_Y193_S0.8011.00
7_V117_C0.7981.00
152_F201_E0.7961.00
104_A216_A0.7851.00
11_E117_C0.7851.00
106_A219_H0.7821.00
175_I254_V0.7811.00
64_T82_A0.7801.00
60_Y83_W0.7761.00
147_T249_T0.7751.00
20_V48_A0.7731.00
133_G140_P0.7681.00
6_R81_A0.7681.00
29_I43_E0.7651.00
146_K152_F0.7651.00
15_R19_A0.7641.00
152_F157_T0.7631.00
45_D91_T0.7541.00
102_A187_C0.7471.00
17_G51_R0.7421.00
155_A191_V0.7421.00
217_G220_L0.7411.00
56_I107_A0.7381.00
17_G48_A0.7331.00
48_A103_T0.7301.00
195_V200_L0.7291.00
112_T235_R0.7271.00
130_G223_Q0.7211.00
31_V95_V0.7191.00
14_A103_T0.7161.00
148_D253_A0.7141.00
221_V228_V0.7101.00
109_V112_T0.7101.00
34_K42_T0.7091.00
154_V157_T0.7061.00
96_R180_G0.7061.00
244_V255_L0.7031.00
104_A217_G0.6991.00
106_A116_A0.6941.00
152_F155_A0.6941.00
132_D223_Q0.6911.00
102_A190_A0.6911.00
17_G103_T0.6911.00
43_E46_R0.6901.00
246_S250_A0.6901.00
187_C190_A0.6891.00
250_A253_A0.6871.00
184_R191_V0.6871.00
142_S145_E0.6861.00
102_A120_F0.6851.00
171_A174_A0.6831.00
86_D91_T0.6811.00
7_V115_A0.6791.00
129_A220_L0.6781.00
144_S147_T0.6781.00
24_A27_T0.6741.00
192_L228_V0.6731.00
108_V215_V0.6731.00
7_V11_E0.6731.00
152_F156_P0.6701.00
47_T51_R0.6701.00
21_A94_F0.6671.00
45_D68_E0.6641.00
125_D137_N0.6641.00
222_R227_V0.6621.00
120_F127_Y0.6621.00
162_F165_R0.6611.00
153_V181_D0.6601.00
164_R168_Y0.6591.00
51_R54_D0.6591.00
183_R186_G0.6571.00
10_A63_D0.6571.00
44_A94_F0.6561.00
15_R18_G0.6521.00
20_V44_A0.6511.00
129_A134_A0.6501.00
69_E86_D0.6501.00
44_A48_A0.6501.00
143_V226_G0.6501.00
105_V117_C0.6481.00
12_R15_R0.6471.00
15_R137_N0.6461.00
49_Q71_D0.6441.00
45_D86_D0.6431.00
168_Y172_C0.6421.00
149_P253_A0.6381.00
136_L199_Q0.6371.00
143_V224_A0.6361.00
218_V238_P0.6320.99
196_A220_L0.6300.99
125_D194_M0.6200.99
167_E171_A0.6200.99
171_A175_I0.6180.99
248_G252_D0.6140.99
128_I137_N0.6130.99
92_N96_R0.6130.99
23_D26_R0.6110.99
128_I138_G0.6110.99
130_G133_G0.6060.99
57_D73_L0.6050.99
56_I83_W0.6040.99
120_F125_D0.6040.99
10_A115_A0.5990.99
13_A59_V0.5970.99
214_S236_W0.5960.99
14_A119_R0.5950.99
70_A73_L0.5930.99
146_K201_E0.5920.99
84_V106_A0.5890.99
13_A17_G0.5880.99
24_A88_I0.5880.99
203_T209_A0.5840.99
118_N216_A0.5830.99
68_E86_D0.5820.99
84_V113_P0.5810.99
68_E213_D0.5790.99
192_L195_V0.5760.99
27_T43_E0.5750.99
53_V71_D0.5740.99
64_T79_A0.5730.99
100_L190_A0.5720.99
214_S218_V0.5700.99
167_E170_A0.5690.99
10_A14_A0.5670.99
17_G21_A0.5660.99
171_A207_V0.5660.99
238_P241_T0.5640.99
141_I224_A0.5630.99
184_R206_N0.5630.99
48_A51_R0.5630.99
222_R228_V0.5630.99
191_V203_T0.5620.99
65_I85_I0.5620.99
68_E87_P0.5620.99
41_V49_Q0.5610.99
237_T240_A0.5600.99
108_V211_P0.5570.99
135_T138_G0.5570.99
92_N153_V0.5560.99
187_C191_V0.5550.99
117_C126_T0.5500.99
145_E249_T0.5500.99
102_A118_N0.5440.98
66_V72_A0.5440.98
221_V224_A0.5380.98
233_G255_L0.5370.98
9_V55_V0.5370.98
249_T252_D0.5350.98
18_G126_T0.5330.98
19_A22_L0.5300.98
69_E213_D0.5290.98
45_D213_D0.5290.98
82_A111_G0.5290.98
83_W115_A0.5280.98
129_A133_G0.5280.98
229_T233_G0.5280.98
191_V200_L0.5280.98
248_G251_H0.5270.98
66_V211_P0.5250.98
18_G22_L0.5250.98
57_D62_E0.5230.98
144_S247_N0.5210.98
67_G73_L0.5190.98
219_H222_R0.5170.98
41_V46_R0.5160.98
206_N209_A0.5150.98
244_V254_V0.5140.98
16_T20_V0.5130.98
100_L185_Y0.5130.98
93_N186_G0.5130.98
69_E87_P0.5120.98
161_D164_R0.5100.98
211_P239_G0.5090.98
172_C175_I0.5070.98
89_D213_D0.5060.98
33_T37_K0.5060.98
108_V111_G0.5050.98
134_A224_A0.5040.98
40_V180_G0.5040.98
165_R168_Y0.5020.97
22_L121_P0.5000.97
24_A94_F0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n81A 2 0.9361 100 0.12 Contact Map
3lv0A 2 0.9549 100 0.127 Contact Map
2q74A 2 0.8835 100 0.131 Contact Map
2p3nA 4 0.9511 100 0.134 Contact Map
2pcrA 3 0.9023 100 0.135 Contact Map
2bjiA 2 0.9962 100 0.139 Contact Map
2fvzA 2 0.8947 100 0.14 Contact Map
2qflA 1 0.9699 100 0.14 Contact Map
4i3yA 2 0.9662 100 0.143 Contact Map
3t0jA 3 0.9624 100 0.149 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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