Q9HQ12 - HALSA - GREMLIN Contacts

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Q9HQ12 - Extragenic suppressor homolog

UniProt:	Q9HQ12	Sequences: MHDTDRVSVAERAARTGGAVALDAFRTGIDVETKSGKTDVVTEADRTAQRRVVDVIDAVYDEDTIVGEEADALKTVPDAGAAWVIDPIDGTNNFVRDTQLWATAVAAVVDGTPVAACNRFPALEDTYIAGADGATLNGTPISVSEKTDPETFVVAPTIWWDFDRRDEYAAACAAIVERFGDMRRYGCAQAVLSMVASGQLEATITNVVANPWDSVAGVHLVRQAGGVVTDIDGTRWTPGATGLVASNGTAHDAVLAAAQEIRAAAE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	266 (243)
Sequences:	10177 (7267)
Seq/√Len:	466.2

ECOLI - SUHB CYSQ
BACSU - SUHB
HALSA - Q9HQ12
SULSO - Q97W26

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
221_V	226_G	4.077	1.00
119_R	126_T	3.577	1.00
81_A	109_V	3.303	1.00
80_G	110_D	3.116	1.00
229_T	251_H	3.114	1.00
218_V	222_R	2.922	1.00
120_F	123_L	2.788	1.00
133_G	223_Q	2.764	1.00
13_A	55_V	2.699	1.00
16_T	55_V	2.605	1.00
155_A	200_L	2.591	1.00
32_E	46_R	2.429	1.00
20_V	51_R	2.386	1.00
18_G	119_R	2.264	1.00
230_D	234_T	2.170	1.00
202_A	254_V	2.162	1.00
101_W	122_A	2.127	1.00
82_A	108_V	2.098	1.00
43_E	47_T	2.077	1.00
81_A	107_A	2.064	1.00
128_I	135_T	2.002	1.00
50_R	54_D	1.965	1.00
49_Q	67_G	1.950	1.00
24_A	44_A	1.944	1.00
55_V	58_A	1.944	1.00
21_A	48_A	1.937	1.00
60_Y	63_D	1.899	1.00
84_V	108_V	1.893	1.00
109_V	114_V	1.881	1.00
108_V	113_P	1.822	1.00
136_L	197_S	1.806	1.00
135_T	140_P	1.803	1.00
53_V	57_D	1.792	1.00
116_A	219_H	1.785	1.00
129_A	223_Q	1.758	1.00
127_Y	197_S	1.746	1.00
219_H	223_Q	1.727	1.00
14_A	105_V	1.721	1.00
63_D	81_A	1.704	1.00
53_V	65_I	1.701	1.00
22_L	122_A	1.679	1.00
51_R	55_V	1.638	1.00
125_D	136_L	1.611	1.00
10_A	83_W	1.610	1.00
9_V	60_Y	1.609	1.00
120_F	190_A	1.589	1.00
11_E	128_I	1.584	1.00
118_N	193_S	1.583	1.00
9_V	59_V	1.564	1.00
102_A	189_Q	1.562	1.00
148_D	151_T	1.544	1.00
193_S	220_L	1.535	1.00
9_V	13_A	1.525	1.00
125_D	199_Q	1.517	1.00
131_A	223_Q	1.506	1.00
246_S	251_H	1.491	1.00
106_A	215_V	1.483	1.00
104_A	189_Q	1.474	1.00
25_F	101_W	1.457	1.00
42_T	95_V	1.455	1.00
12_R	59_V	1.451	1.00
63_D	83_W	1.424	1.00
14_A	117_C	1.411	1.00
21_A	88_I	1.410	1.00
80_G	109_V	1.409	1.00
85_I	105_V	1.383	1.00
20_V	23_D	1.379	1.00
134_A	141_I	1.369	1.00
54_D	58_A	1.365	1.00
125_D	197_S	1.363	1.00
15_R	126_T	1.340	1.00
55_V	59_V	1.333	1.00
52_V	85_I	1.330	1.00
170_A	173_A	1.305	1.00
83_W	107_A	1.301	1.00
22_L	101_W	1.300	1.00
21_A	101_W	1.283	1.00
169_A	173_A	1.281	1.00
192_L	217_G	1.278	1.00
11_E	15_R	1.248	1.00
11_E	126_T	1.246	1.00
7_V	128_I	1.237	1.00
98_T	185_Y	1.237	1.00
47_T	50_R	1.234	1.00
16_T	51_R	1.230	1.00
12_R	16_T	1.220	1.00
40_V	95_V	1.216	1.00
52_V	105_V	1.214	1.00
53_V	67_G	1.211	1.00
50_R	70_A	1.205	1.00
40_V	92_N	1.205	1.00
6_R	63_D	1.191	1.00
21_A	44_A	1.174	1.00
154_V	202_A	1.169	1.00
227_V	252_D	1.165	1.00
112_T	222_R	1.159	1.00
56_I	63_D	1.156	1.00
49_Q	53_V	1.152	1.00
194_M	199_Q	1.149	1.00
49_Q	70_A	1.131	1.00
252_D	256_A	1.127	1.00
218_V	228_V	1.126	1.00
222_R	235_R	1.113	1.00
166_D	173_A	1.102	1.00
129_A	219_H	1.100	1.00
152_F	250_A	1.097	1.00
84_V	215_V	1.097	1.00
20_V	47_T	1.092	1.00
166_D	170_A	1.077	1.00
192_L	245_A	1.076	1.00
46_R	50_R	1.067	1.00
19_A	23_D	1.066	1.00
119_R	124_E	1.063	1.00
113_P	219_H	1.062	1.00
66_V	84_V	1.060	1.00
13_A	51_R	1.059	1.00
170_A	174_A	1.042	1.00
13_A	52_V	1.040	1.00
76_V	79_A	1.040	1.00
20_V	24_A	1.033	1.00
144_S	201_E	1.028	1.00
23_D	27_T	1.025	1.00
16_T	19_A	1.024	1.00
106_A	113_P	1.019	1.00
153_V	157_T	1.019	1.00
12_R	55_V	1.000	1.00
45_D	69_E	1.000	1.00
24_A	47_T	0.996	1.00
253_A	256_A	0.992	1.00
107_A	115_A	0.988	1.00
9_V	56_I	0.988	1.00
53_V	70_A	0.985	1.00
6_R	107_A	0.984	1.00
48_A	52_V	0.981	1.00
192_L	221_V	0.976	1.00
190_A	194_M	0.974	1.00
227_V	248_G	0.972	1.00
6_R	60_Y	0.965	1.00
221_V	245_A	0.963	1.00
251_H	255_L	0.959	1.00
173_A	177_E	0.959	1.00
113_P	218_V	0.944	1.00
66_V	82_A	0.927	1.00
10_A	117_C	0.926	1.00
188_A	209_A	0.925	1.00
141_I	197_S	0.920	1.00
25_F	122_A	0.915	1.00
48_A	88_I	0.912	1.00
36_G	39_D	0.908	1.00
24_A	43_E	0.907	1.00
168_Y	171_A	0.906	1.00
15_R	124_E	0.905	1.00
118_N	220_L	0.899	1.00
8_S	12_R	0.898	1.00
134_A	223_Q	0.898	1.00
227_V	251_H	0.896	1.00
107_A	114_V	0.892	1.00
247_N	250_A	0.891	1.00
93_N	183_R	0.885	1.00
100_L	194_M	0.873	1.00
42_T	91_T	0.872	1.00
34_K	41_V	0.872	1.00
7_V	130_G	0.867	1.00
136_L	139_T	0.865	1.00
81_A	114_V	0.860	1.00
118_N	217_G	0.856	1.00
134_A	220_L	0.853	1.00
56_I	60_Y	0.846	1.00
25_F	97_D	0.845	1.00
22_L	124_E	0.839	1.00
115_A	130_G	0.837	1.00
69_E	91_T	0.837	1.00
66_V	212_W	0.830	1.00
149_P	152_F	0.826	1.00
68_E	91_T	0.822	1.00
230_D	233_G	0.817	1.00
15_R	119_R	0.812	1.00
8_S	11_E	0.810	1.00
67_G	70_A	0.809	1.00
104_A	118_N	0.809	1.00
30_D	43_E	0.805	1.00
209_A	214_S	0.805	1.00
127_Y	193_S	0.801	1.00
7_V	117_C	0.798	1.00
152_F	201_E	0.796	1.00
104_A	216_A	0.785	1.00
11_E	117_C	0.785	1.00
106_A	219_H	0.782	1.00
175_I	254_V	0.781	1.00
64_T	82_A	0.780	1.00
60_Y	83_W	0.776	1.00
147_T	249_T	0.775	1.00
20_V	48_A	0.773	1.00
133_G	140_P	0.768	1.00
6_R	81_A	0.768	1.00
29_I	43_E	0.765	1.00
146_K	152_F	0.765	1.00
15_R	19_A	0.764	1.00
152_F	157_T	0.763	1.00
45_D	91_T	0.754	1.00
102_A	187_C	0.747	1.00
17_G	51_R	0.742	1.00
155_A	191_V	0.742	1.00
217_G	220_L	0.741	1.00
56_I	107_A	0.738	1.00
17_G	48_A	0.733	1.00
48_A	103_T	0.730	1.00
195_V	200_L	0.729	1.00
112_T	235_R	0.727	1.00
130_G	223_Q	0.721	1.00
31_V	95_V	0.719	1.00
14_A	103_T	0.716	1.00
148_D	253_A	0.714	1.00
221_V	228_V	0.710	1.00
109_V	112_T	0.710	1.00
34_K	42_T	0.709	1.00
154_V	157_T	0.706	1.00
96_R	180_G	0.706	1.00
244_V	255_L	0.703	1.00
104_A	217_G	0.699	1.00
106_A	116_A	0.694	1.00
152_F	155_A	0.694	1.00
132_D	223_Q	0.691	1.00
102_A	190_A	0.691	1.00
17_G	103_T	0.691	1.00
43_E	46_R	0.690	1.00
246_S	250_A	0.690	1.00
187_C	190_A	0.689	1.00
250_A	253_A	0.687	1.00
184_R	191_V	0.687	1.00
142_S	145_E	0.686	1.00
102_A	120_F	0.685	1.00
171_A	174_A	0.683	1.00
86_D	91_T	0.681	1.00
7_V	115_A	0.679	1.00
129_A	220_L	0.678	1.00
144_S	147_T	0.678	1.00
24_A	27_T	0.674	1.00
192_L	228_V	0.673	1.00
108_V	215_V	0.673	1.00
7_V	11_E	0.673	1.00
152_F	156_P	0.670	1.00
47_T	51_R	0.670	1.00
21_A	94_F	0.667	1.00
45_D	68_E	0.664	1.00
125_D	137_N	0.664	1.00
222_R	227_V	0.662	1.00
120_F	127_Y	0.662	1.00
162_F	165_R	0.661	1.00
153_V	181_D	0.660	1.00
164_R	168_Y	0.659	1.00
51_R	54_D	0.659	1.00
183_R	186_G	0.657	1.00
10_A	63_D	0.657	1.00
44_A	94_F	0.656	1.00
15_R	18_G	0.652	1.00
20_V	44_A	0.651	1.00
129_A	134_A	0.650	1.00
69_E	86_D	0.650	1.00
44_A	48_A	0.650	1.00
143_V	226_G	0.650	1.00
105_V	117_C	0.648	1.00
12_R	15_R	0.647	1.00
15_R	137_N	0.646	1.00
49_Q	71_D	0.644	1.00
45_D	86_D	0.643	1.00
168_Y	172_C	0.642	1.00
149_P	253_A	0.638	1.00
136_L	199_Q	0.637	1.00
143_V	224_A	0.636	1.00
218_V	238_P	0.632	0.99
196_A	220_L	0.630	0.99
125_D	194_M	0.620	0.99
167_E	171_A	0.620	0.99
171_A	175_I	0.618	0.99
248_G	252_D	0.614	0.99
128_I	137_N	0.613	0.99
92_N	96_R	0.613	0.99
23_D	26_R	0.611	0.99
128_I	138_G	0.611	0.99
130_G	133_G	0.606	0.99
57_D	73_L	0.605	0.99
56_I	83_W	0.604	0.99
120_F	125_D	0.604	0.99
10_A	115_A	0.599	0.99
13_A	59_V	0.597	0.99
214_S	236_W	0.596	0.99
14_A	119_R	0.595	0.99
70_A	73_L	0.593	0.99
146_K	201_E	0.592	0.99
84_V	106_A	0.589	0.99
13_A	17_G	0.588	0.99
24_A	88_I	0.588	0.99
203_T	209_A	0.584	0.99
118_N	216_A	0.583	0.99
68_E	86_D	0.582	0.99
84_V	113_P	0.581	0.99
68_E	213_D	0.579	0.99
192_L	195_V	0.576	0.99
27_T	43_E	0.575	0.99
53_V	71_D	0.574	0.99
64_T	79_A	0.573	0.99
100_L	190_A	0.572	0.99
214_S	218_V	0.570	0.99
167_E	170_A	0.569	0.99
10_A	14_A	0.567	0.99
17_G	21_A	0.566	0.99
171_A	207_V	0.566	0.99
238_P	241_T	0.564	0.99
141_I	224_A	0.563	0.99
184_R	206_N	0.563	0.99
48_A	51_R	0.563	0.99
222_R	228_V	0.563	0.99
191_V	203_T	0.562	0.99
65_I	85_I	0.562	0.99
68_E	87_P	0.562	0.99
41_V	49_Q	0.561	0.99
237_T	240_A	0.560	0.99
108_V	211_P	0.557	0.99
135_T	138_G	0.557	0.99
92_N	153_V	0.556	0.99
187_C	191_V	0.555	0.99
117_C	126_T	0.550	0.99
145_E	249_T	0.550	0.99
102_A	118_N	0.544	0.98
66_V	72_A	0.544	0.98
221_V	224_A	0.538	0.98
233_G	255_L	0.537	0.98
9_V	55_V	0.537	0.98
249_T	252_D	0.535	0.98
18_G	126_T	0.533	0.98
19_A	22_L	0.530	0.98
69_E	213_D	0.529	0.98
45_D	213_D	0.529	0.98
82_A	111_G	0.529	0.98
83_W	115_A	0.528	0.98
129_A	133_G	0.528	0.98
229_T	233_G	0.528	0.98
191_V	200_L	0.528	0.98
248_G	251_H	0.527	0.98
66_V	211_P	0.525	0.98
18_G	22_L	0.525	0.98
57_D	62_E	0.523	0.98
144_S	247_N	0.521	0.98
67_G	73_L	0.519	0.98
219_H	222_R	0.517	0.98
41_V	46_R	0.516	0.98
206_N	209_A	0.515	0.98
244_V	254_V	0.514	0.98
16_T	20_V	0.513	0.98
100_L	185_Y	0.513	0.98
93_N	186_G	0.513	0.98
69_E	87_P	0.512	0.98
161_D	164_R	0.510	0.98
211_P	239_G	0.509	0.98
172_C	175_I	0.507	0.98
89_D	213_D	0.506	0.98
33_T	37_K	0.506	0.98
108_V	111_G	0.505	0.98
134_A	224_A	0.504	0.98
40_V	180_G	0.504	0.98
165_R	168_Y	0.502	0.97
22_L	121_P	0.500	0.97
24_A	94_F	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4n81A	2	0.9361	100	0.12	Contact Map
3lv0A	2	0.9549	100	0.127	Contact Map
2q74A	2	0.8835	100	0.131	Contact Map
2p3nA	4	0.9511	100	0.134	Contact Map
2pcrA	3	0.9023	100	0.135	Contact Map
2bjiA	2	0.9962	100	0.139	Contact Map
2fvzA	2	0.8947	100	0.14	Contact Map
2qflA	1	0.9699	100	0.14	Contact Map
4i3yA	2	0.9662	100	0.143	Contact Map
3t0jA	3	0.9624	100	0.149	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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