GREMLIN Database
Q9HQ06 - Acetyltransferase homolog
UniProt: Q9HQ06 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (147)
Sequences: 5084 (3686)
Seq/√Len: 304.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_P91_V3.3371.00
143_D159_G3.1451.00
105_L120_V3.0291.00
123_E142_A2.9031.00
74_G96_D2.8141.00
156_V162_V2.5041.00
125_R143_D2.4961.00
142_A158_P2.4901.00
70_T92_T2.4841.00
147_A163_A2.4621.00
80_E102_D2.4061.00
163_A170_T2.3621.00
124_D142_A2.3231.00
52_R70_T2.2871.00
135_L148_A2.2481.00
73_D95_D2.0791.00
92_T121_V2.0771.00
30_W34_D1.9961.00
106_L130_A1.9461.00
144_A160_E1.8751.00
144_A158_P1.8261.00
115_Y118_G1.7791.00
128_I134_V1.7591.00
54_S73_D1.7121.00
96_D125_R1.7101.00
150_S167_A1.6951.00
162_V167_A1.6911.00
38_P41_V1.6641.00
121_V139_T1.6471.00
43_L47_V1.6241.00
72_G95_D1.5351.00
160_E169_P1.5031.00
144_A156_V1.4481.00
71_V75_V1.4411.00
146_V156_V1.4331.00
53_I57_L1.4301.00
95_D124_D1.4291.00
123_E139_T1.4101.00
24_N28_S1.3931.00
75_V95_D1.3881.00
128_I132_A1.3851.00
99_I105_L1.3821.00
70_T90_L1.3491.00
27_N37_H1.3311.00
162_V169_P1.3151.00
105_L122_V1.3091.00
30_W36_K1.2501.00
77_W81_S1.2421.00
31_R36_K1.2381.00
88_P117_T1.2371.00
27_N36_K1.2251.00
104_T131_G1.1731.00
56_S74_G1.1721.00
89_E117_T1.1521.00
139_T155_D1.1511.00
126_A144_A1.1431.00
146_V162_V1.1351.00
102_D131_G1.1291.00
94_G124_D1.1251.00
25_A29_L1.1231.00
82_T102_D1.1111.00
157_P162_V1.1111.00
97_A142_A1.1071.00
135_L153_T1.1021.00
110_F161_T1.1011.00
28_S48_I1.0871.00
157_P169_P1.0871.00
111_L114_E1.0821.00
97_A124_D1.0471.00
93_V99_I1.0421.00
122_V128_I1.0361.00
41_V44_N1.0151.00
132_A150_S1.0081.00
110_F145_Q0.9911.00
126_A158_P0.9851.00
75_V97_A0.9811.00
77_W83_P0.9801.00
71_V77_W0.9741.00
142_A159_G0.9731.00
138_V155_D0.9681.00
99_I128_I0.9611.00
75_V124_D0.9591.00
25_A49_V0.9571.00
157_P160_E0.9491.00
93_V97_A0.9341.00
55_P73_D0.9241.00
104_T130_A0.9131.00
126_A142_A0.9021.00
103_A132_A0.8991.00
23_P26_R0.8941.00
123_E158_P0.8891.00
45_Y49_V0.8771.00
104_T133_V0.8701.00
60_K76_A0.8671.00
93_V105_L0.8621.00
146_V152_V0.8571.00
133_V149_N0.8501.00
77_W99_I0.8461.00
151_L165_V0.8451.00
150_S165_V0.8431.00
27_N30_W0.8391.00
149_N165_V0.8391.00
65_A69_V0.8301.00
105_L134_V0.8301.00
99_I103_A0.8291.00
71_V93_V0.8241.00
123_E144_A0.8191.00
140_I146_V0.8171.00
57_L75_V0.8061.00
122_V126_A0.8031.00
120_V136_P0.8001.00
47_V53_I0.7951.00
28_S31_R0.7891.00
28_S49_V0.7770.99
134_V140_I0.7770.99
145_Q161_T0.7600.99
155_D162_V0.7590.99
50_L53_I0.7590.99
93_V122_V0.7540.99
63_L69_V0.7460.99
138_V154_A0.7400.99
69_V83_P0.7360.99
160_E163_A0.7310.99
27_N31_R0.7270.99
26_R60_K0.7250.99
32_W46_V0.7230.99
66_R88_P0.7220.99
94_G121_V0.7200.99
23_P39_L0.7140.99
40_R44_N0.7130.99
64_L79_L0.7100.99
39_L43_L0.7000.99
28_S45_Y0.7000.99
25_A28_S0.6850.99
24_N27_N0.6730.98
97_A126_A0.6710.98
26_R79_L0.6700.98
26_R30_W0.6670.98
109_E114_E0.6650.98
44_N48_I0.6650.98
56_S73_D0.6640.98
62_W66_R0.6570.98
131_G149_N0.6570.98
23_P37_H0.6480.98
53_I73_D0.6460.98
163_A167_A0.6460.98
23_P27_N0.6450.98
140_I156_V0.6440.98
75_V93_V0.6430.98
51_A54_S0.6410.98
103_A128_I0.6330.98
57_L71_V0.6310.98
118_G137_G0.6270.98
28_S32_W0.6260.97
92_T119_A0.6230.97
81_S103_A0.6230.97
31_R35_A0.6230.97
30_W37_H0.6230.97
163_A168_A0.6170.97
147_A161_T0.6160.97
47_V51_A0.6120.97
35_A45_Y0.6080.97
31_R34_D0.6060.97
94_G97_A0.6030.97
140_I155_D0.5970.97
125_R142_A0.5960.97
69_V85_V0.5950.97
42_A47_V0.5950.97
25_A33_T0.5930.97
101_Y130_A0.5880.96
32_W45_Y0.5870.96
27_N34_D0.5870.96
23_P30_W0.5850.96
140_I152_V0.5810.96
90_L119_A0.5800.96
141_G158_P0.5790.96
30_W35_A0.5790.96
31_R48_I0.5780.96
78_G127_M0.5770.96
62_W65_A0.5750.96
130_A133_V0.5710.96
143_D158_P0.5690.96
36_K39_L0.5660.96
94_G123_E0.5650.95
161_T171_G0.5640.95
32_W61_N0.5620.95
48_I51_A0.5610.95
63_L81_S0.5580.95
35_A38_P0.5560.95
25_A32_W0.5550.95
51_A70_T0.5550.95
72_G75_V0.5510.95
140_I144_A0.5490.95
32_W35_A0.5490.95
47_V55_P0.5470.95
108_H112_H0.5420.94
29_L65_A0.5390.94
39_L42_A0.5380.94
42_A61_N0.5370.94
35_A41_V0.5370.94
75_V99_I0.5360.94
140_I162_V0.5340.94
84_D101_Y0.5330.94
42_A45_Y0.5280.94
54_S57_L0.5260.93
83_P105_L0.5250.93
109_E112_H0.5250.93
133_V151_L0.5230.93
24_N48_I0.5230.93
79_L84_D0.5210.93
89_E107_C0.5170.93
46_V50_L0.5130.93
106_L133_V0.5090.92
90_L121_V0.5090.92
32_W42_A0.5080.92
156_V167_A0.5080.92
64_L80_E0.5070.92
133_V165_V0.5060.92
99_I122_V0.5010.92
29_L36_K0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3srtA 3 0.9826 100 0.3 Contact Map
3fttA 3 0.9884 100 0.304 Contact Map
2p2oA 3 0.9826 100 0.319 Contact Map
1krrA 3 0.9884 100 0.319 Contact Map
3hjjA 3 0.9826 100 0.32 Contact Map
3nz2A 4 0.9767 100 0.323 Contact Map
1ocxA 3 0.9767 100 0.332 Contact Map
3vbiA 3 0.7733 99.9 0.421 Contact Map
4mzuA 5 0.7442 99.9 0.442 Contact Map
2v0hA 3 0.9709 99.9 0.445 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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