Q9HQ04 - HALSA - GREMLIN Contacts

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Q9HQ04 - Uncharacterized protein

UniProt:	Q9HQ04	Sequences: MTDVLRTLVGPHFEYGLATLVLLCGAVAGYLVGWIHRRVMLAAGVDEIVEGTTVERLARRSGTTTVDLTARFVSTVVYIVAVLVALDAAQFSIQKPLWRLLGSILPSVLAAVVVVVVGVLVGDKVEVFVTERLRSVKFPEASVVAVAARYTVVLAAGLVALSQLGVAVAALLVVFGVYLASVVVFALVATRQLLASAAAGVYLLLRQPYGIGDQVAIGSREGVVQEVDVFVTRIEADSREYVIPNHLVFRDGIVIVHHQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	259 (227)
Sequences:	5008 (3941)
Seq/√Len:	261.6

ECOLI - YBIO MSCM MSCK YNAI YBDG MSCS
BACSU - YHDY YFKC YKUT
HALSA - Q9HQ04 Q9HQH2 Q9HNG6
SULSO - Q97V46 Q7LXV0 Q97V08 Q97V66

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
118_G	156_A	7.188	1.00
225_Q	235_E	4.621	1.00
216_A	221_E	4.210	1.00
214_Q	237_D	3.707	1.00
206_R	230_F	3.458	1.00
191_R	195_A	3.430	1.00
215_V	224_V	3.208	1.00
214_Q	221_E	3.100	1.00
216_A	254_V	3.007	1.00
232_T	245_N	2.822	1.00
247_L	251_D	2.733	1.00
236_A	242_V	2.697	1.00
225_Q	241_Y	2.600	1.00
216_A	219_S	2.479	1.00
192_Q	195_A	2.465	1.00
214_Q	223_V	2.440	1.00
226_E	233_R	2.434	1.00
111_A	160_A	2.305	1.00
126_E	149_R	2.221	1.00
26_A	30_Y	2.221	1.00
222_G	234_I	2.181	1.00
189_A	194_L	2.156	1.00
216_A	256_V	2.151	1.00
111_A	164_L	2.120	1.00
193_L	199_A	2.009	1.00
180_A	187_L	1.930	1.00
218_G	252_G	1.878	1.00
240_E	254_V	1.874	1.00
30_Y	34_W	1.843	1.00
170_A	173_V	1.647	1.00
177_V	181_S	1.639	1.00
25_G	29_G	1.568	1.00
85_A	89_A	1.554	1.00
35_I	39_V	1.549	1.00
22_L	25_G	1.529	1.00
221_E	237_D	1.507	1.00
31_L	35_I	1.497	1.00
236_A	240_E	1.479	1.00
178_Y	189_A	1.474	1.00
34_W	38_R	1.435	1.00
177_V	190_T	1.417	1.00
247_L	252_G	1.399	1.00
48_I	52_T	1.381	1.00
52_T	62_G	1.347	1.00
190_T	198_A	1.331	1.00
182_V	194_L	1.330	1.00
218_G	251_D	1.328	1.00
215_V	248_V	1.315	1.00
18_A	30_Y	1.314	1.00
203_L	228_D	1.313	1.00
30_Y	33_G	1.306	1.00
206_R	231_V	1.283	1.00
25_G	81_A	1.272	1.00
114_V	156_A	1.271	1.00
38_R	41_L	1.266	1.00
16_G	20_L	1.263	1.00
33_G	37_R	1.260	1.00
208_P	233_R	1.257	1.00
48_I	51_G	1.254	1.00
175_F	178_Y	1.243	1.00
104_I	108_V	1.225	1.00
208_P	231_V	1.222	1.00
209_Y	232_T	1.221	1.00
68_L	72_F	1.214	1.00
237_D	256_V	1.208	1.00
178_Y	181_S	1.200	1.00
137_K	141_A	1.200	1.00
71_R	74_S	1.199	1.00
18_A	22_L	1.193	1.00
242_V	254_V	1.189	1.00
29_G	33_G	1.178	1.00
200_G	254_V	1.170	1.00
153_V	157_G	1.167	1.00
178_Y	182_V	1.160	1.00
66_V	72_F	1.156	1.00
220_R	242_V	1.149	1.00
34_W	37_R	1.138	1.00
180_A	192_Q	1.133	1.00
84_V	87_D	1.123	1.00
77_V	81_A	1.117	1.00
20_L	23_L	1.117	1.00
215_V	234_I	1.114	1.00
161_L	166_V	1.107	1.00
207_Q	210_G	1.106	1.00
202_Y	230_F	1.103	1.00
172_L	181_S	1.102	1.00
196_S	246_H	1.099	1.00
15_Y	19_T	1.093	1.00
193_L	249_F	1.090	1.00
70_A	74_S	1.069	1.00
195_A	246_H	1.065	1.00
83_L	87_D	1.062	1.00
65_T	68_L	1.050	1.00
72_F	76_V	1.048	1.00
23_L	28_A	1.043	1.00
118_G	152_V	1.032	1.00
115_V	119_V	1.026	1.00
74_S	78_Y	1.021	1.00
21_V	38_R	1.014	1.00
158_L	168_V	1.002	1.00
192_Q	246_H	0.998	1.00
49_V	54_V	0.996	1.00
240_E	256_V	0.996	1.00
130_T	145_A	0.996	1.00
247_L	250_R	0.995	1.00
177_V	180_A	0.994	1.00
214_Q	256_V	0.993	1.00
174_V	190_T	0.988	1.00
192_Q	196_S	0.977	1.00
144_V	148_A	0.975	1.00
238_S	256_V	0.963	1.00
198_A	249_F	0.956	1.00
208_P	227_V	0.953	1.00
218_G	247_L	0.948	1.00
154_L	158_L	0.946	1.00
23_L	27_V	0.945	1.00
195_A	250_R	0.944	1.00
27_V	30_Y	0.935	1.00
17_L	20_L	0.917	1.00
107_S	110_A	0.917	1.00
196_S	248_V	0.916	1.00
20_L	24_C	0.910	1.00
101_L	106_P	0.908	1.00
137_K	140_E	0.903	1.00
175_F	229_V	0.898	1.00
37_R	42_A	0.898	1.00
234_I	239_R	0.896	1.00
209_Y	215_V	0.892	1.00
52_T	63_T	0.882	1.00
103_S	106_P	0.878	1.00
152_V	156_A	0.869	1.00
167_A	170_A	0.868	1.00
189_A	198_A	0.867	1.00
181_S	187_L	0.866	1.00
51_G	54_V	0.865	1.00
72_F	75_T	0.863	1.00
180_A	190_T	0.862	1.00
133_L	136_V	0.859	1.00
69_T	73_V	0.859	1.00
235_E	239_R	0.859	1.00
202_Y	249_F	0.859	1.00
87_D	90_Q	0.858	1.00
134_R	138_F	0.853	1.00
150_Y	154_L	0.852	1.00
172_L	177_V	0.852	1.00
62_G	75_T	0.847	0.99
193_L	239_R	0.842	0.99
178_Y	187_L	0.840	0.99
203_L	245_N	0.840	0.99
102_G	106_P	0.839	0.99
196_S	199_A	0.833	0.99
49_V	52_T	0.830	0.99
39_V	43_A	0.830	0.99
26_A	29_G	0.829	0.99
33_G	36_H	0.828	0.99
182_V	198_A	0.827	0.99
146_V	149_R	0.826	0.99
231_V	240_E	0.818	0.99
37_R	41_L	0.816	0.99
236_A	257_H	0.815	0.99
22_L	29_G	0.814	0.99
28_A	43_A	0.813	0.99
166_V	170_A	0.812	0.99
221_E	256_V	0.807	0.99
17_L	29_G	0.805	0.99
18_A	26_A	0.803	0.99
50_E	54_V	0.803	0.99
136_V	141_A	0.802	0.99
212_G	223_V	0.797	0.99
34_W	39_V	0.793	0.99
173_V	176_G	0.792	0.99
224_V	234_I	0.788	0.99
142_S	146_V	0.788	0.99
174_V	179_L	0.786	0.99
191_R	246_H	0.785	0.99
18_A	29_G	0.785	0.99
50_E	53_T	0.782	0.99
246_H	250_R	0.782	0.99
220_R	254_V	0.782	0.99
234_I	243_I	0.780	0.99
223_V	237_D	0.778	0.99
231_V	257_H	0.778	0.99
81_A	85_A	0.777	0.99
47_E	50_E	0.776	0.99
122_G	153_V	0.775	0.99
147_A	151_T	0.773	0.99
36_H	39_V	0.769	0.99
22_L	26_A	0.767	0.99
220_R	252_G	0.767	0.99
203_L	248_V	0.758	0.99
195_A	240_E	0.756	0.99
203_L	209_Y	0.756	0.99
182_V	187_L	0.756	0.99
206_R	228_D	0.753	0.99
209_Y	253_I	0.753	0.99
125_V	152_V	0.747	0.99
104_I	107_S	0.746	0.99
145_A	149_R	0.745	0.99
106_P	110_A	0.743	0.99
142_S	226_E	0.742	0.99
209_Y	248_V	0.741	0.99
182_V	188_V	0.740	0.99
111_A	118_G	0.740	0.99
160_A	164_L	0.739	0.99
38_R	42_A	0.738	0.99
234_I	237_D	0.738	0.99
21_V	37_R	0.735	0.99
196_S	244_P	0.735	0.99
216_A	236_A	0.733	0.99
192_Q	250_R	0.730	0.98
27_V	31_L	0.729	0.98
33_G	43_A	0.725	0.98
144_V	150_Y	0.723	0.98
228_D	245_N	0.721	0.98
233_R	241_Y	0.720	0.98
113_V	117_V	0.719	0.98
77_V	80_V	0.711	0.98
228_D	231_V	0.708	0.98
236_A	254_V	0.707	0.98
159_V	162_S	0.700	0.98
232_T	253_I	0.700	0.98
82_V	86_L	0.700	0.98
119_V	122_G	0.698	0.98
71_R	75_T	0.696	0.98
196_S	230_F	0.695	0.98
125_V	149_R	0.694	0.98
203_L	235_E	0.691	0.98
190_T	229_V	0.686	0.98
39_V	42_A	0.683	0.98
188_V	193_L	0.682	0.98
143_V	198_A	0.677	0.98
208_P	245_N	0.674	0.97
170_A	208_P	0.674	0.97
118_G	122_G	0.672	0.97
174_V	257_H	0.672	0.97
119_V	153_V	0.672	0.97
173_V	180_A	0.670	0.97
181_S	230_F	0.667	0.97
80_V	84_V	0.664	0.97
114_V	159_V	0.662	0.97
173_V	201_V	0.661	0.97
174_V	181_S	0.660	0.97
116_V	120_L	0.657	0.97
162_S	167_A	0.655	0.97
62_G	69_T	0.651	0.97
101_L	104_I	0.650	0.97
217_I	220_R	0.646	0.97
150_Y	193_L	0.641	0.97
15_Y	40_M	0.641	0.97
232_T	256_V	0.637	0.96
214_Q	254_V	0.634	0.96
28_A	42_A	0.630	0.96
49_V	53_T	0.629	0.96
187_L	199_A	0.629	0.96
20_L	30_Y	0.627	0.96
196_S	245_N	0.626	0.96
111_A	115_V	0.625	0.96
21_V	25_G	0.625	0.96
87_D	92_S	0.624	0.96
36_H	40_M	0.624	0.96
114_V	163_Q	0.622	0.96
189_A	208_P	0.621	0.96
217_I	248_V	0.615	0.96
71_R	83_L	0.612	0.96
75_T	78_Y	0.612	0.96
37_R	44_G	0.611	0.95
173_V	225_Q	0.611	0.95
99_R	102_G	0.608	0.95
220_R	223_V	0.608	0.95
130_T	137_K	0.607	0.95
158_L	177_V	0.605	0.95
174_V	177_V	0.604	0.95
71_R	79_I	0.601	0.95
202_Y	206_R	0.601	0.95
198_A	250_R	0.596	0.95
217_I	251_D	0.593	0.95
101_L	112_V	0.591	0.95
32_V	49_V	0.587	0.94
205_L	226_E	0.584	0.94
135_S	139_P	0.583	0.94
25_G	28_A	0.583	0.94
155_A	158_L	0.583	0.94
17_L	35_I	0.583	0.94
194_L	199_A	0.582	0.94
203_L	208_P	0.581	0.94
223_V	235_E	0.580	0.94
110_A	113_V	0.579	0.94
138_F	141_A	0.579	0.94
196_S	233_R	0.578	0.94
181_S	190_T	0.578	0.94
47_E	51_G	0.575	0.94
208_P	253_I	0.574	0.94
111_A	120_L	0.574	0.94
190_T	193_L	0.574	0.94
168_V	206_R	0.568	0.93
230_F	245_N	0.568	0.93
64_T	67_D	0.568	0.93
217_I	243_I	0.566	0.93
17_L	21_V	0.562	0.93
17_L	36_H	0.562	0.93
199_A	246_H	0.561	0.93
146_V	226_E	0.560	0.93
21_V	24_C	0.560	0.93
18_A	89_A	0.556	0.93
17_L	25_G	0.556	0.93
157_G	160_A	0.554	0.93
24_C	27_V	0.550	0.92
35_I	44_G	0.550	0.92
53_T	62_G	0.549	0.92
22_L	47_E	0.547	0.92
30_Y	37_R	0.544	0.92
21_V	26_A	0.542	0.92
33_G	42_A	0.542	0.92
181_S	197_A	0.541	0.92
29_G	34_W	0.540	0.92
75_T	79_I	0.536	0.91
180_A	229_V	0.535	0.91
32_V	36_H	0.535	0.91
251_D	254_V	0.531	0.91
180_A	188_V	0.530	0.91
23_L	34_W	0.529	0.91
63_T	66_V	0.528	0.91
180_A	191_R	0.527	0.91
113_V	116_V	0.527	0.91
177_V	191_R	0.526	0.91
238_S	254_V	0.522	0.90
26_A	39_V	0.522	0.90
116_V	119_V	0.522	0.90
64_T	69_T	0.522	0.90
215_V	222_G	0.520	0.90
119_V	129_V	0.516	0.90
15_Y	22_L	0.514	0.89
191_R	230_F	0.513	0.89
63_T	81_A	0.510	0.89
239_R	246_H	0.510	0.89
122_G	149_R	0.510	0.89
207_Q	245_N	0.508	0.89
31_L	39_V	0.505	0.89
44_G	50_E	0.504	0.89
61_S	64_T	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4hw9A	3	0.5869	100	0.362	Contact Map
5ajiA	3	0.6178	100	0.366	Contact Map
3udcA	3	0.5946	100	0.392	Contact Map
3mlqE	1	0.1467	19.8	0.942	Contact Map
1nz9A	1	0.1815	19.4	0.942	Contact Map
4l5gA	1	0.2124	16.4	0.944	Contact Map
2lt1A	1	0.2355	16.3	0.944	Contact Map
2e6zA	1	0.1931	13.5	0.946	Contact Map
1iz6A	1	0.2278	11.9	0.947	Contact Map
2lwjA	1	0.2239	10.2	0.949	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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