GREMLIN Database
Q9HQ04 - Uncharacterized protein
UniProt: Q9HQ04 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 259 (227)
Sequences: 5008 (3941)
Seq/√Len: 261.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_G156_A7.1881.00
225_Q235_E4.6211.00
216_A221_E4.2101.00
214_Q237_D3.7071.00
206_R230_F3.4581.00
191_R195_A3.4301.00
215_V224_V3.2081.00
214_Q221_E3.1001.00
216_A254_V3.0071.00
232_T245_N2.8221.00
247_L251_D2.7331.00
236_A242_V2.6971.00
225_Q241_Y2.6001.00
216_A219_S2.4791.00
192_Q195_A2.4651.00
214_Q223_V2.4401.00
226_E233_R2.4341.00
111_A160_A2.3051.00
126_E149_R2.2211.00
26_A30_Y2.2211.00
222_G234_I2.1811.00
189_A194_L2.1561.00
216_A256_V2.1511.00
111_A164_L2.1201.00
193_L199_A2.0091.00
180_A187_L1.9301.00
218_G252_G1.8781.00
240_E254_V1.8741.00
30_Y34_W1.8431.00
170_A173_V1.6471.00
177_V181_S1.6391.00
25_G29_G1.5681.00
85_A89_A1.5541.00
35_I39_V1.5491.00
22_L25_G1.5291.00
221_E237_D1.5071.00
31_L35_I1.4971.00
236_A240_E1.4791.00
178_Y189_A1.4741.00
34_W38_R1.4351.00
177_V190_T1.4171.00
247_L252_G1.3991.00
48_I52_T1.3811.00
52_T62_G1.3471.00
190_T198_A1.3311.00
182_V194_L1.3301.00
218_G251_D1.3281.00
215_V248_V1.3151.00
18_A30_Y1.3141.00
203_L228_D1.3131.00
30_Y33_G1.3061.00
206_R231_V1.2831.00
25_G81_A1.2721.00
114_V156_A1.2711.00
38_R41_L1.2661.00
16_G20_L1.2631.00
33_G37_R1.2601.00
208_P233_R1.2571.00
48_I51_G1.2541.00
175_F178_Y1.2431.00
104_I108_V1.2251.00
208_P231_V1.2221.00
209_Y232_T1.2211.00
68_L72_F1.2141.00
237_D256_V1.2081.00
178_Y181_S1.2001.00
137_K141_A1.2001.00
71_R74_S1.1991.00
18_A22_L1.1931.00
242_V254_V1.1891.00
29_G33_G1.1781.00
200_G254_V1.1701.00
153_V157_G1.1671.00
178_Y182_V1.1601.00
66_V72_F1.1561.00
220_R242_V1.1491.00
34_W37_R1.1381.00
180_A192_Q1.1331.00
84_V87_D1.1231.00
77_V81_A1.1171.00
20_L23_L1.1171.00
215_V234_I1.1141.00
161_L166_V1.1071.00
207_Q210_G1.1061.00
202_Y230_F1.1031.00
172_L181_S1.1021.00
196_S246_H1.0991.00
15_Y19_T1.0931.00
193_L249_F1.0901.00
70_A74_S1.0691.00
195_A246_H1.0651.00
83_L87_D1.0621.00
65_T68_L1.0501.00
72_F76_V1.0481.00
23_L28_A1.0431.00
118_G152_V1.0321.00
115_V119_V1.0261.00
74_S78_Y1.0211.00
21_V38_R1.0141.00
158_L168_V1.0021.00
192_Q246_H0.9981.00
49_V54_V0.9961.00
240_E256_V0.9961.00
130_T145_A0.9961.00
247_L250_R0.9951.00
177_V180_A0.9941.00
214_Q256_V0.9931.00
174_V190_T0.9881.00
192_Q196_S0.9771.00
144_V148_A0.9751.00
238_S256_V0.9631.00
198_A249_F0.9561.00
208_P227_V0.9531.00
218_G247_L0.9481.00
154_L158_L0.9461.00
23_L27_V0.9451.00
195_A250_R0.9441.00
27_V30_Y0.9351.00
17_L20_L0.9171.00
107_S110_A0.9171.00
196_S248_V0.9161.00
20_L24_C0.9101.00
101_L106_P0.9081.00
137_K140_E0.9031.00
175_F229_V0.8981.00
37_R42_A0.8981.00
234_I239_R0.8961.00
209_Y215_V0.8921.00
52_T63_T0.8821.00
103_S106_P0.8781.00
152_V156_A0.8691.00
167_A170_A0.8681.00
189_A198_A0.8671.00
181_S187_L0.8661.00
51_G54_V0.8651.00
72_F75_T0.8631.00
180_A190_T0.8621.00
133_L136_V0.8591.00
69_T73_V0.8591.00
235_E239_R0.8591.00
202_Y249_F0.8591.00
87_D90_Q0.8581.00
134_R138_F0.8531.00
150_Y154_L0.8521.00
172_L177_V0.8521.00
62_G75_T0.8470.99
193_L239_R0.8420.99
178_Y187_L0.8400.99
203_L245_N0.8400.99
102_G106_P0.8390.99
196_S199_A0.8330.99
49_V52_T0.8300.99
39_V43_A0.8300.99
26_A29_G0.8290.99
33_G36_H0.8280.99
182_V198_A0.8270.99
146_V149_R0.8260.99
231_V240_E0.8180.99
37_R41_L0.8160.99
236_A257_H0.8150.99
22_L29_G0.8140.99
28_A43_A0.8130.99
166_V170_A0.8120.99
221_E256_V0.8070.99
17_L29_G0.8050.99
18_A26_A0.8030.99
50_E54_V0.8030.99
136_V141_A0.8020.99
212_G223_V0.7970.99
34_W39_V0.7930.99
173_V176_G0.7920.99
224_V234_I0.7880.99
142_S146_V0.7880.99
174_V179_L0.7860.99
191_R246_H0.7850.99
18_A29_G0.7850.99
50_E53_T0.7820.99
246_H250_R0.7820.99
220_R254_V0.7820.99
234_I243_I0.7800.99
223_V237_D0.7780.99
231_V257_H0.7780.99
81_A85_A0.7770.99
47_E50_E0.7760.99
122_G153_V0.7750.99
147_A151_T0.7730.99
36_H39_V0.7690.99
22_L26_A0.7670.99
220_R252_G0.7670.99
203_L248_V0.7580.99
195_A240_E0.7560.99
203_L209_Y0.7560.99
182_V187_L0.7560.99
206_R228_D0.7530.99
209_Y253_I0.7530.99
125_V152_V0.7470.99
104_I107_S0.7460.99
145_A149_R0.7450.99
106_P110_A0.7430.99
142_S226_E0.7420.99
209_Y248_V0.7410.99
182_V188_V0.7400.99
111_A118_G0.7400.99
160_A164_L0.7390.99
38_R42_A0.7380.99
234_I237_D0.7380.99
21_V37_R0.7350.99
196_S244_P0.7350.99
216_A236_A0.7330.99
192_Q250_R0.7300.98
27_V31_L0.7290.98
33_G43_A0.7250.98
144_V150_Y0.7230.98
228_D245_N0.7210.98
233_R241_Y0.7200.98
113_V117_V0.7190.98
77_V80_V0.7110.98
228_D231_V0.7080.98
236_A254_V0.7070.98
159_V162_S0.7000.98
232_T253_I0.7000.98
82_V86_L0.7000.98
119_V122_G0.6980.98
71_R75_T0.6960.98
196_S230_F0.6950.98
125_V149_R0.6940.98
203_L235_E0.6910.98
190_T229_V0.6860.98
39_V42_A0.6830.98
188_V193_L0.6820.98
143_V198_A0.6770.98
208_P245_N0.6740.97
170_A208_P0.6740.97
118_G122_G0.6720.97
174_V257_H0.6720.97
119_V153_V0.6720.97
173_V180_A0.6700.97
181_S230_F0.6670.97
80_V84_V0.6640.97
114_V159_V0.6620.97
173_V201_V0.6610.97
174_V181_S0.6600.97
116_V120_L0.6570.97
162_S167_A0.6550.97
62_G69_T0.6510.97
101_L104_I0.6500.97
217_I220_R0.6460.97
150_Y193_L0.6410.97
15_Y40_M0.6410.97
232_T256_V0.6370.96
214_Q254_V0.6340.96
28_A42_A0.6300.96
49_V53_T0.6290.96
187_L199_A0.6290.96
20_L30_Y0.6270.96
196_S245_N0.6260.96
111_A115_V0.6250.96
21_V25_G0.6250.96
87_D92_S0.6240.96
36_H40_M0.6240.96
114_V163_Q0.6220.96
189_A208_P0.6210.96
217_I248_V0.6150.96
71_R83_L0.6120.96
75_T78_Y0.6120.96
37_R44_G0.6110.95
173_V225_Q0.6110.95
99_R102_G0.6080.95
220_R223_V0.6080.95
130_T137_K0.6070.95
158_L177_V0.6050.95
174_V177_V0.6040.95
71_R79_I0.6010.95
202_Y206_R0.6010.95
198_A250_R0.5960.95
217_I251_D0.5930.95
101_L112_V0.5910.95
32_V49_V0.5870.94
205_L226_E0.5840.94
135_S139_P0.5830.94
25_G28_A0.5830.94
155_A158_L0.5830.94
17_L35_I0.5830.94
194_L199_A0.5820.94
203_L208_P0.5810.94
223_V235_E0.5800.94
110_A113_V0.5790.94
138_F141_A0.5790.94
196_S233_R0.5780.94
181_S190_T0.5780.94
47_E51_G0.5750.94
208_P253_I0.5740.94
111_A120_L0.5740.94
190_T193_L0.5740.94
168_V206_R0.5680.93
230_F245_N0.5680.93
64_T67_D0.5680.93
217_I243_I0.5660.93
17_L21_V0.5620.93
17_L36_H0.5620.93
199_A246_H0.5610.93
146_V226_E0.5600.93
21_V24_C0.5600.93
18_A89_A0.5560.93
17_L25_G0.5560.93
157_G160_A0.5540.93
24_C27_V0.5500.92
35_I44_G0.5500.92
53_T62_G0.5490.92
22_L47_E0.5470.92
30_Y37_R0.5440.92
21_V26_A0.5420.92
33_G42_A0.5420.92
181_S197_A0.5410.92
29_G34_W0.5400.92
75_T79_I0.5360.91
180_A229_V0.5350.91
32_V36_H0.5350.91
251_D254_V0.5310.91
180_A188_V0.5300.91
23_L34_W0.5290.91
63_T66_V0.5280.91
180_A191_R0.5270.91
113_V116_V0.5270.91
177_V191_R0.5260.91
238_S254_V0.5220.90
26_A39_V0.5220.90
116_V119_V0.5220.90
64_T69_T0.5220.90
215_V222_G0.5200.90
119_V129_V0.5160.90
15_Y22_L0.5140.89
191_R230_F0.5130.89
63_T81_A0.5100.89
239_R246_H0.5100.89
122_G149_R0.5100.89
207_Q245_N0.5080.89
31_L39_V0.5050.89
44_G50_E0.5040.89
61_S64_T0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hw9A 3 0.5869 100 0.362 Contact Map
5ajiA 3 0.6178 100 0.366 Contact Map
3udcA 3 0.5946 100 0.392 Contact Map
3mlqE 1 0.1467 19.8 0.942 Contact Map
1nz9A 1 0.1815 19.4 0.942 Contact Map
4l5gA 1 0.2124 16.4 0.944 Contact Map
2lt1A 1 0.2355 16.3 0.944 Contact Map
2e6zA 1 0.1931 13.5 0.946 Contact Map
1iz6A 1 0.2278 11.9 0.947 Contact Map
2lwjA 1 0.2239 10.2 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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