Q9HQ03 - HALSA - GREMLIN Contacts

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Q9HQ03 - Uncharacterized protein

UniProt:	Q9HQ03	Sequences: MTRPPDLLADVLDGIDALLVFSPSGSYYDRVDDVEGVDVVVVATENAVGAETFVELPLAFDDVREQIRFGIEGALSEGVVADGDELGCVAPFLSEEVDMVTRTRANAGTQSSVYELFASTRAEPGVIRDVFDVAIELGRKGQKGKPVGALFVVGDAGKVMTKSRPLSYNPFEKSHVHVGDPIVNVMLKEFSRLDGAFVISDSGKIVSSYRYLEPGAEGTDIPKGLGARHMAAGAITRDTNAVAIVLSESDGLVRAFRNGELVLELDPEDN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	270 (247)
Sequences:	129 (94)
Seq/√Len:	6.0

HALSA - Q9HQ03

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
159_V	239_T	4.096	0.94
43_A	244_I	3.207	0.83
190_F	193_L	3.103	0.80
163_S	210_R	3.020	0.78
147_V	152_V	2.931	0.76
137_L	191_S	2.805	0.73
221_I	260_E	2.732	0.71
160_M	191_S	2.581	0.66
40_V	242_V	2.502	0.63
147_V	225_L	2.406	0.60
242_V	258_N	2.347	0.58
70_G	214_P	2.339	0.58
66_Q	74_A	2.308	0.57
40_V	89_V	2.288	0.56
53_F	198_V	2.265	0.55
158_K	215_G	2.262	0.55
137_L	248_E	2.244	0.55
89_V	110_Q	2.219	0.54
244_I	248_E	2.215	0.54
189_E	249_S	2.197	0.53
87_G	100_V	2.165	0.52
152_V	231_A	2.074	0.49
222_P	257_R	2.010	0.46
130_V	253_V	1.992	0.46
71_I	86_L	1.927	0.43
116_L	253_V	1.918	0.43
222_P	256_F	1.915	0.43
120_T	126_V	1.905	0.43
163_S	212_L	1.900	0.42
158_K	250_D	1.892	0.42
153_V	178_V	1.834	0.40
232_A	243_A	1.832	0.40
91_P	98_D	1.822	0.40
63_V	91_P	1.794	0.39
148_G	228_R	1.693	0.36
24_S	33_D	1.692	0.35
101_T	138_G	1.676	0.35
185_V	191_S	1.658	0.34
80_V	136_E	1.653	0.34
151_F	189_E	1.631	0.34
196_A	227_A	1.616	0.33
113_V	219_T	1.602	0.33
84_D	147_V	1.590	0.32
227_A	244_I	1.564	0.31
210_R	219_T	1.560	0.31
232_A	241_A	1.547	0.31
39_V	198_V	1.533	0.30
72_E	133_V	1.531	0.30
51_E	100_V	1.522	0.30
40_V	43_A	1.519	0.30
120_T	133_V	1.484	0.29
176_V	185_V	1.471	0.29
22_S	25_G	1.453	0.28
138_G	253_V	1.448	0.28
41_V	178_V	1.445	0.28
150_L	196_A	1.398	0.27
150_L	207_S	1.393	0.26
145_K	206_V	1.392	0.26
152_V	183_V	1.383	0.26
39_V	51_E	1.379	0.26
70_G	118_A	1.370	0.26
164_R	245_V	1.334	0.25
88_C	124_P	1.329	0.25
41_V	227_A	1.327	0.25
122_A	125_G	1.321	0.25
74_A	237_R	1.318	0.24
126_V	190_F	1.309	0.24
171_F	222_P	1.304	0.24
127_I	202_S	1.288	0.24
80_V	102_R	1.282	0.23
199_I	236_T	1.281	0.23
237_R	257_R	1.280	0.23
168_Y	246_L	1.277	0.23
89_V	199_I	1.272	0.23
132_D	135_I	1.261	0.23
75_L	232_A	1.259	0.23
152_V	196_A	1.248	0.23
164_R	236_T	1.245	0.23
171_F	196_A	1.235	0.22
68_R	128_R	1.235	0.22
74_A	88_C	1.234	0.22
124_P	253_V	1.224	0.22
105_A	233_G	1.219	0.22
150_L	261_L	1.213	0.22
159_V	243_A	1.211	0.22
74_A	214_P	1.208	0.22
161_T	266_D	1.200	0.21
212_L	241_A	1.186	0.21
171_F	181_P	1.183	0.21
155_D	165_P	1.182	0.21
92_F	137_L	1.180	0.21
131_F	241_A	1.161	0.21
24_S	29_D	1.161	0.21
75_L	85_E	1.159	0.20
97_V	231_A	1.152	0.20
71_I	123_E	1.144	0.20
130_V	133_V	1.137	0.20
80_V	235_I	1.136	0.20
197_F	225_L	1.133	0.20
236_T	246_L	1.131	0.20
31_V	35_E	1.120	0.20
169_N	211_Y	1.118	0.20
221_I	261_L	1.117	0.20
221_I	262_V	1.112	0.19
55_E	190_F	1.108	0.19
189_E	203_G	1.092	0.19
165_P	209_Y	1.090	0.19
25_G	30_R	1.090	0.19
126_V	169_N	1.089	0.19
33_D	49_G	1.084	0.19
167_S	190_F	1.081	0.19
98_D	171_F	1.075	0.19
89_V	97_V	1.072	0.19
173_K	190_F	1.071	0.19
126_V	225_L	1.071	0.19
137_L	256_F	1.069	0.18
127_I	183_V	1.064	0.18
123_E	160_M	1.061	0.18
176_V	204_K	1.056	0.18
45_E	86_L	1.043	0.18
114_Y	185_V	1.032	0.18
171_F	227_A	1.021	0.17
74_A	202_S	1.017	0.17
91_P	196_A	1.012	0.17
222_P	261_L	1.011	0.17
237_R	261_L	1.009	0.17
89_V	265_L	1.002	0.17
57_P	181_P	1.001	0.17
58_L	78_G	0.996	0.17
149_A	236_T	0.992	0.17
61_D	90_A	0.986	0.17
149_A	184_N	0.982	0.17
110_Q	232_A	0.979	0.17
68_R	265_L	0.969	0.16
133_V	137_L	0.965	0.16
173_K	267_P	0.959	0.16
147_V	191_S	0.952	0.16
261_L	264_E	0.951	0.16
245_V	261_L	0.951	0.16
39_V	100_V	0.946	0.16
126_V	230_M	0.945	0.16
166_L	232_A	0.943	0.16
104_R	205_I	0.942	0.16
38_D	45_E	0.939	0.16
132_D	172_E	0.936	0.16
53_F	131_F	0.927	0.16
25_G	28_Y	0.926	0.16
40_V	102_R	0.925	0.16
98_D	196_A	0.922	0.16
140_K	149_A	0.919	0.15
143_K	209_Y	0.919	0.15
40_V	198_V	0.919	0.15
84_D	102_R	0.910	0.15
39_V	44_T	0.909	0.15
171_F	212_L	0.903	0.15
165_P	253_V	0.896	0.15
86_L	91_P	0.894	0.15
125_G	181_P	0.891	0.15
162_K	227_A	0.878	0.15
88_C	222_P	0.876	0.15
147_V	248_E	0.863	0.14
208_S	242_V	0.852	0.14
127_I	191_S	0.848	0.14
239_T	243_A	0.842	0.14
205_I	236_T	0.838	0.14
21_F	131_F	0.838	0.14
130_V	262_V	0.836	0.14
44_T	260_E	0.834	0.14
68_R	257_R	0.832	0.14
49_G	193_L	0.832	0.14
185_V	192_R	0.827	0.14
37_V	41_V	0.823	0.14
57_P	98_D	0.823	0.14
91_P	256_F	0.821	0.14
78_G	242_V	0.818	0.14
37_V	227_A	0.818	0.14
80_V	126_V	0.816	0.14
33_D	39_V	0.812	0.14
159_V	208_S	0.811	0.14
24_S	242_V	0.809	0.14
126_V	139_R	0.808	0.14
133_V	262_V	0.802	0.13
74_A	137_L	0.800	0.13
108_G	235_I	0.795	0.13
20_V	213_E	0.790	0.13
131_F	167_S	0.789	0.13
67_I	85_E	0.788	0.13
135_I	236_T	0.785	0.13
61_D	237_R	0.784	0.13
107_A	232_A	0.783	0.13
41_V	64_R	0.782	0.13
50_A	199_I	0.782	0.13
32_D	39_V	0.781	0.13
133_V	212_L	0.776	0.13
167_S	209_Y	0.775	0.13
50_A	53_F	0.774	0.13
149_A	187_L	0.773	0.13
175_H	252_L	0.772	0.13
104_R	180_D	0.769	0.13
164_R	217_E	0.768	0.13
78_G	127_I	0.767	0.13
225_L	235_I	0.765	0.13
242_V	257_R	0.762	0.13
137_L	246_L	0.760	0.13
33_D	78_G	0.758	0.13
127_I	138_G	0.757	0.13
149_A	178_V	0.752	0.13
40_V	151_F	0.752	0.13
27_Y	30_R	0.747	0.13
135_I	147_V	0.747	0.13
45_E	85_E	0.744	0.13
81_A	89_V	0.744	0.13
33_D	118_A	0.741	0.12
127_I	237_R	0.738	0.12
139_R	262_V	0.734	0.12
56_L	219_T	0.731	0.12
141_G	226_G	0.727	0.12
141_G	229_H	0.727	0.12
141_G	247_S	0.727	0.12
141_G	195_G	0.727	0.12
154_G	170_P	0.727	0.12
229_H	247_S	0.727	0.12
170_P	195_G	0.727	0.12
170_P	224_G	0.727	0.12
170_P	226_G	0.727	0.12
170_P	229_H	0.727	0.12
170_P	247_S	0.727	0.12
195_G	247_S	0.727	0.12
141_G	224_G	0.727	0.12
141_G	194_D	0.727	0.12
141_G	170_P	0.727	0.12
141_G	154_G	0.727	0.12
194_D	226_G	0.727	0.12
154_G	195_G	0.727	0.12
195_G	229_H	0.727	0.12
194_D	229_H	0.727	0.12
154_G	247_S	0.727	0.12
154_G	229_H	0.727	0.12
195_G	224_G	0.727	0.12
154_G	226_G	0.727	0.12
154_G	224_G	0.727	0.12
194_D	247_S	0.727	0.12
194_D	224_G	0.727	0.12
224_G	247_S	0.727	0.12
224_G	229_H	0.727	0.12
226_G	229_H	0.727	0.12
154_G	194_D	0.727	0.12
195_G	226_G	0.727	0.12
170_P	194_D	0.727	0.12
226_G	247_S	0.727	0.12
198_V	218_G	0.725	0.12
126_V	178_V	0.720	0.12
44_T	47_A	0.720	0.12
150_L	199_I	0.718	0.12
150_L	165_P	0.717	0.12
178_V	242_V	0.712	0.12
155_D	193_L	0.712	0.12
39_V	43_A	0.712	0.12
30_R	38_D	0.711	0.12
191_S	246_L	0.711	0.12
183_V	267_P	0.709	0.12
38_D	99_M	0.707	0.12
173_K	176_V	0.705	0.12
32_D	40_V	0.705	0.12
185_V	246_L	0.701	0.12
143_K	250_D	0.700	0.12
68_R	175_H	0.700	0.12
124_P	131_F	0.696	0.12
80_V	240_N	0.696	0.12
126_V	262_V	0.696	0.12
104_R	245_V	0.691	0.12
40_V	258_N	0.687	0.12
142_Q	185_V	0.685	0.12
176_V	246_L	0.682	0.12
168_Y	209_Y	0.679	0.12
91_P	202_S	0.669	0.11
62_D	89_V	0.666	0.11
61_D	93_L	0.666	0.11
208_S	248_E	0.664	0.11
71_I	180_D	0.659	0.11
207_S	214_P	0.658	0.11
40_V	84_D	0.657	0.11
156_A	237_R	0.652	0.11
30_R	34_V	0.651	0.11
67_I	217_E	0.651	0.11
152_V	227_A	0.650	0.11
182_I	234_A	0.650	0.11
160_M	239_T	0.649	0.11
104_R	186_M	0.648	0.11
43_A	99_M	0.643	0.11
111_S	220_D	0.639	0.11
166_L	222_P	0.638	0.11
155_D	190_F	0.636	0.11
197_F	203_G	0.636	0.11
180_D	227_A	0.635	0.11
20_V	51_E	0.634	0.11
207_S	242_V	0.633	0.11
37_V	51_E	0.629	0.11
64_R	67_I	0.626	0.11
83_G	137_L	0.625	0.11
25_G	33_D	0.621	0.11
116_L	260_E	0.619	0.11
179_G	252_L	0.618	0.11
234_A	251_G	0.618	0.11
122_A	266_D	0.615	0.11
56_L	113_V	0.614	0.11
43_A	105_A	0.614	0.11
130_V	249_S	0.611	0.11
67_I	90_A	0.611	0.11
38_D	89_V	0.610	0.11
80_V	88_C	0.608	0.11
142_Q	189_E	0.607	0.11
43_A	51_E	0.606	0.11
221_I	255_A	0.604	0.10
211_Y	214_P	0.603	0.10
88_C	256_F	0.600	0.10
107_A	130_V	0.596	0.10
75_L	217_E	0.594	0.10
73_G	265_L	0.591	0.10
84_D	261_L	0.587	0.10
236_T	242_V	0.586	0.10
51_E	111_S	0.585	0.10
136_E	147_V	0.583	0.10
163_S	207_S	0.578	0.10
169_N	230_M	0.577	0.10
133_V	187_L	0.577	0.10
71_I	199_I	0.576	0.10
205_I	260_E	0.574	0.10
20_V	41_V	0.571	0.10
153_V	264_E	0.570	0.10
126_V	157_G	0.569	0.10
148_G	235_I	0.566	0.10
228_R	235_I	0.566	0.10
31_V	202_S	0.564	0.10
122_A	176_V	0.564	0.10
112_S	207_S	0.564	0.10
53_F	174_S	0.563	0.10
102_R	255_A	0.562	0.10
38_D	100_V	0.562	0.10
150_L	227_A	0.560	0.10
121_R	237_R	0.557	0.10
58_L	267_P	0.555	0.10
200_S	216_A	0.551	0.10
102_R	115_E	0.550	0.10
201_D	217_E	0.550	0.10
157_G	173_K	0.549	0.10
136_E	256_F	0.548	0.10
149_A	172_E	0.540	0.10
143_K	176_V	0.539	0.10
79_V	255_A	0.529	0.10
29_D	77_E	0.528	0.10
67_I	158_K	0.528	0.10
97_V	253_V	0.528	0.10
64_R	110_Q	0.527	0.10
133_V	240_N	0.525	0.09
106_N	265_L	0.525	0.09
22_S	27_Y	0.522	0.09
78_G	236_T	0.515	0.09
82_D	178_V	0.513	0.09
71_I	101_T	0.513	0.09
196_A	199_I	0.512	0.09
160_M	212_L	0.512	0.09
132_D	263_L	0.510	0.09
217_E	253_V	0.510	0.09
176_V	186_M	0.508	0.09
181_P	255_A	0.505	0.09
201_D	250_D	0.503	0.09
90_A	223_K	0.502	0.09
57_P	177_H	0.502	0.09
88_C	214_P	0.500	0.09

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rv7A	1	0.5111	100	0.723	Contact Map
2fb5A	3	0.7037	100	0.728	Contact Map
3c1yA	5	0.5074	99.9	0.744	Contact Map
3khdA	3	0.3926	96	0.935	Contact Map
3gg8A	3	0.3889	95.9	0.935	Contact Map
1a3wA	3	0.3889	95.8	0.936	Contact Map
4drsA	3	0.3667	95.8	0.936	Contact Map
4kctB	3	0.3926	95.6	0.937	Contact Map
3gr4A	4	0.3926	95.6	0.937	Contact Map
1e0tA	3	0.3852	95.3	0.938	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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