GREMLIN Database
Q9HQ03 - Uncharacterized protein
UniProt: Q9HQ03 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (247)
Sequences: 129 (94)
Seq/√Len: 6.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_V239_T4.0960.94
43_A244_I3.2070.83
190_F193_L3.1030.80
163_S210_R3.0200.78
147_V152_V2.9310.76
137_L191_S2.8050.73
221_I260_E2.7320.71
160_M191_S2.5810.66
40_V242_V2.5020.63
147_V225_L2.4060.60
242_V258_N2.3470.58
70_G214_P2.3390.58
66_Q74_A2.3080.57
40_V89_V2.2880.56
53_F198_V2.2650.55
158_K215_G2.2620.55
137_L248_E2.2440.55
89_V110_Q2.2190.54
244_I248_E2.2150.54
189_E249_S2.1970.53
87_G100_V2.1650.52
152_V231_A2.0740.49
222_P257_R2.0100.46
130_V253_V1.9920.46
71_I86_L1.9270.43
116_L253_V1.9180.43
222_P256_F1.9150.43
120_T126_V1.9050.43
163_S212_L1.9000.42
158_K250_D1.8920.42
153_V178_V1.8340.40
232_A243_A1.8320.40
91_P98_D1.8220.40
63_V91_P1.7940.39
148_G228_R1.6930.36
24_S33_D1.6920.35
101_T138_G1.6760.35
185_V191_S1.6580.34
80_V136_E1.6530.34
151_F189_E1.6310.34
196_A227_A1.6160.33
113_V219_T1.6020.33
84_D147_V1.5900.32
227_A244_I1.5640.31
210_R219_T1.5600.31
232_A241_A1.5470.31
39_V198_V1.5330.30
72_E133_V1.5310.30
51_E100_V1.5220.30
40_V43_A1.5190.30
120_T133_V1.4840.29
176_V185_V1.4710.29
22_S25_G1.4530.28
138_G253_V1.4480.28
41_V178_V1.4450.28
150_L196_A1.3980.27
150_L207_S1.3930.26
145_K206_V1.3920.26
152_V183_V1.3830.26
39_V51_E1.3790.26
70_G118_A1.3700.26
164_R245_V1.3340.25
88_C124_P1.3290.25
41_V227_A1.3270.25
122_A125_G1.3210.25
74_A237_R1.3180.24
126_V190_F1.3090.24
171_F222_P1.3040.24
127_I202_S1.2880.24
80_V102_R1.2820.23
199_I236_T1.2810.23
237_R257_R1.2800.23
168_Y246_L1.2770.23
89_V199_I1.2720.23
132_D135_I1.2610.23
75_L232_A1.2590.23
152_V196_A1.2480.23
164_R236_T1.2450.23
171_F196_A1.2350.22
68_R128_R1.2350.22
74_A88_C1.2340.22
124_P253_V1.2240.22
105_A233_G1.2190.22
150_L261_L1.2130.22
159_V243_A1.2110.22
74_A214_P1.2080.22
161_T266_D1.2000.21
212_L241_A1.1860.21
171_F181_P1.1830.21
155_D165_P1.1820.21
92_F137_L1.1800.21
131_F241_A1.1610.21
24_S29_D1.1610.21
75_L85_E1.1590.20
97_V231_A1.1520.20
71_I123_E1.1440.20
130_V133_V1.1370.20
80_V235_I1.1360.20
197_F225_L1.1330.20
236_T246_L1.1310.20
31_V35_E1.1200.20
169_N211_Y1.1180.20
221_I261_L1.1170.20
221_I262_V1.1120.19
55_E190_F1.1080.19
189_E203_G1.0920.19
165_P209_Y1.0900.19
25_G30_R1.0900.19
126_V169_N1.0890.19
33_D49_G1.0840.19
167_S190_F1.0810.19
98_D171_F1.0750.19
89_V97_V1.0720.19
173_K190_F1.0710.19
126_V225_L1.0710.19
137_L256_F1.0690.18
127_I183_V1.0640.18
123_E160_M1.0610.18
176_V204_K1.0560.18
45_E86_L1.0430.18
114_Y185_V1.0320.18
171_F227_A1.0210.17
74_A202_S1.0170.17
91_P196_A1.0120.17
222_P261_L1.0110.17
237_R261_L1.0090.17
89_V265_L1.0020.17
57_P181_P1.0010.17
58_L78_G0.9960.17
149_A236_T0.9920.17
61_D90_A0.9860.17
149_A184_N0.9820.17
110_Q232_A0.9790.17
68_R265_L0.9690.16
133_V137_L0.9650.16
173_K267_P0.9590.16
147_V191_S0.9520.16
261_L264_E0.9510.16
245_V261_L0.9510.16
39_V100_V0.9460.16
126_V230_M0.9450.16
166_L232_A0.9430.16
104_R205_I0.9420.16
38_D45_E0.9390.16
132_D172_E0.9360.16
53_F131_F0.9270.16
25_G28_Y0.9260.16
40_V102_R0.9250.16
98_D196_A0.9220.16
140_K149_A0.9190.15
143_K209_Y0.9190.15
40_V198_V0.9190.15
84_D102_R0.9100.15
39_V44_T0.9090.15
171_F212_L0.9030.15
165_P253_V0.8960.15
86_L91_P0.8940.15
125_G181_P0.8910.15
162_K227_A0.8780.15
88_C222_P0.8760.15
147_V248_E0.8630.14
208_S242_V0.8520.14
127_I191_S0.8480.14
239_T243_A0.8420.14
205_I236_T0.8380.14
21_F131_F0.8380.14
130_V262_V0.8360.14
44_T260_E0.8340.14
68_R257_R0.8320.14
49_G193_L0.8320.14
185_V192_R0.8270.14
37_V41_V0.8230.14
57_P98_D0.8230.14
91_P256_F0.8210.14
78_G242_V0.8180.14
37_V227_A0.8180.14
80_V126_V0.8160.14
33_D39_V0.8120.14
159_V208_S0.8110.14
24_S242_V0.8090.14
126_V139_R0.8080.14
133_V262_V0.8020.13
74_A137_L0.8000.13
108_G235_I0.7950.13
20_V213_E0.7900.13
131_F167_S0.7890.13
67_I85_E0.7880.13
135_I236_T0.7850.13
61_D237_R0.7840.13
107_A232_A0.7830.13
41_V64_R0.7820.13
50_A199_I0.7820.13
32_D39_V0.7810.13
133_V212_L0.7760.13
167_S209_Y0.7750.13
50_A53_F0.7740.13
149_A187_L0.7730.13
175_H252_L0.7720.13
104_R180_D0.7690.13
164_R217_E0.7680.13
78_G127_I0.7670.13
225_L235_I0.7650.13
242_V257_R0.7620.13
137_L246_L0.7600.13
33_D78_G0.7580.13
127_I138_G0.7570.13
149_A178_V0.7520.13
40_V151_F0.7520.13
27_Y30_R0.7470.13
135_I147_V0.7470.13
45_E85_E0.7440.13
81_A89_V0.7440.13
33_D118_A0.7410.12
127_I237_R0.7380.12
139_R262_V0.7340.12
56_L219_T0.7310.12
141_G226_G0.7270.12
141_G229_H0.7270.12
141_G247_S0.7270.12
141_G195_G0.7270.12
154_G170_P0.7270.12
229_H247_S0.7270.12
170_P195_G0.7270.12
170_P224_G0.7270.12
170_P226_G0.7270.12
170_P229_H0.7270.12
170_P247_S0.7270.12
195_G247_S0.7270.12
141_G224_G0.7270.12
141_G194_D0.7270.12
141_G170_P0.7270.12
141_G154_G0.7270.12
194_D226_G0.7270.12
154_G195_G0.7270.12
195_G229_H0.7270.12
194_D229_H0.7270.12
154_G247_S0.7270.12
154_G229_H0.7270.12
195_G224_G0.7270.12
154_G226_G0.7270.12
154_G224_G0.7270.12
194_D247_S0.7270.12
194_D224_G0.7270.12
224_G247_S0.7270.12
224_G229_H0.7270.12
226_G229_H0.7270.12
154_G194_D0.7270.12
195_G226_G0.7270.12
170_P194_D0.7270.12
226_G247_S0.7270.12
198_V218_G0.7250.12
126_V178_V0.7200.12
44_T47_A0.7200.12
150_L199_I0.7180.12
150_L165_P0.7170.12
178_V242_V0.7120.12
155_D193_L0.7120.12
39_V43_A0.7120.12
30_R38_D0.7110.12
191_S246_L0.7110.12
183_V267_P0.7090.12
38_D99_M0.7070.12
173_K176_V0.7050.12
32_D40_V0.7050.12
185_V246_L0.7010.12
143_K250_D0.7000.12
68_R175_H0.7000.12
124_P131_F0.6960.12
80_V240_N0.6960.12
126_V262_V0.6960.12
104_R245_V0.6910.12
40_V258_N0.6870.12
142_Q185_V0.6850.12
176_V246_L0.6820.12
168_Y209_Y0.6790.12
91_P202_S0.6690.11
62_D89_V0.6660.11
61_D93_L0.6660.11
208_S248_E0.6640.11
71_I180_D0.6590.11
207_S214_P0.6580.11
40_V84_D0.6570.11
156_A237_R0.6520.11
30_R34_V0.6510.11
67_I217_E0.6510.11
152_V227_A0.6500.11
182_I234_A0.6500.11
160_M239_T0.6490.11
104_R186_M0.6480.11
43_A99_M0.6430.11
111_S220_D0.6390.11
166_L222_P0.6380.11
155_D190_F0.6360.11
197_F203_G0.6360.11
180_D227_A0.6350.11
20_V51_E0.6340.11
207_S242_V0.6330.11
37_V51_E0.6290.11
64_R67_I0.6260.11
83_G137_L0.6250.11
25_G33_D0.6210.11
116_L260_E0.6190.11
179_G252_L0.6180.11
234_A251_G0.6180.11
122_A266_D0.6150.11
56_L113_V0.6140.11
43_A105_A0.6140.11
130_V249_S0.6110.11
67_I90_A0.6110.11
38_D89_V0.6100.11
80_V88_C0.6080.11
142_Q189_E0.6070.11
43_A51_E0.6060.11
221_I255_A0.6040.10
211_Y214_P0.6030.10
88_C256_F0.6000.10
107_A130_V0.5960.10
75_L217_E0.5940.10
73_G265_L0.5910.10
84_D261_L0.5870.10
236_T242_V0.5860.10
51_E111_S0.5850.10
136_E147_V0.5830.10
163_S207_S0.5780.10
169_N230_M0.5770.10
133_V187_L0.5770.10
71_I199_I0.5760.10
205_I260_E0.5740.10
20_V41_V0.5710.10
153_V264_E0.5700.10
126_V157_G0.5690.10
148_G235_I0.5660.10
228_R235_I0.5660.10
31_V202_S0.5640.10
122_A176_V0.5640.10
112_S207_S0.5640.10
53_F174_S0.5630.10
102_R255_A0.5620.10
38_D100_V0.5620.10
150_L227_A0.5600.10
121_R237_R0.5570.10
58_L267_P0.5550.10
200_S216_A0.5510.10
102_R115_E0.5500.10
201_D217_E0.5500.10
157_G173_K0.5490.10
136_E256_F0.5480.10
149_A172_E0.5400.10
143_K176_V0.5390.10
79_V255_A0.5290.10
29_D77_E0.5280.10
67_I158_K0.5280.10
97_V253_V0.5280.10
64_R110_Q0.5270.10
133_V240_N0.5250.09
106_N265_L0.5250.09
22_S27_Y0.5220.09
78_G236_T0.5150.09
82_D178_V0.5130.09
71_I101_T0.5130.09
196_A199_I0.5120.09
160_M212_L0.5120.09
132_D263_L0.5100.09
217_E253_V0.5100.09
176_V186_M0.5080.09
181_P255_A0.5050.09
201_D250_D0.5030.09
90_A223_K0.5020.09
57_P177_H0.5020.09
88_C214_P0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rv7A 1 0.5111 100 0.723 Contact Map
2fb5A 3 0.7037 100 0.728 Contact Map
3c1yA 5 0.5074 99.9 0.744 Contact Map
3khdA 3 0.3926 96 0.935 Contact Map
3gg8A 3 0.3889 95.9 0.935 Contact Map
1a3wA 3 0.3889 95.8 0.936 Contact Map
4drsA 3 0.3667 95.8 0.936 Contact Map
4kctB 3 0.3926 95.6 0.937 Contact Map
3gr4A 4 0.3926 95.6 0.937 Contact Map
1e0tA 3 0.3852 95.3 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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