GREMLIN Database
HTR9 - Halobacterial transducer protein 9
UniProt: Q9HQ00 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 481 (413)
Sequences: 19669 (15626)
Seq/√Len: 768.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_A166_R3.0011.00
175_A185_I2.8231.00
161_A169_A2.5451.00
170_T199_A2.4511.00
78_P81_A2.3901.00
192_T195_G2.3701.00
306_R372_E2.1641.00
145_Q149_Q2.1501.00
271_L407_E2.1471.00
156_V186_Q2.1451.00
160_D186_Q2.1381.00
124_H128_F2.1051.00
146_S150_A2.0781.00
155_L188_G2.0661.00
306_R376_D2.0571.00
288_D390_R2.0561.00
156_V190_N2.0501.00
182_D185_I2.0501.00
305_N308_E2.0261.00
302_A376_D2.0121.00
277_A281_D1.9631.00
160_D164_A1.9311.00
160_D193_E1.9301.00
315_D319_G1.9261.00
396_A400_D1.8791.00
309_D312_E1.8721.00
121_P125_T1.8641.00
170_T196_D1.8561.00
392_E396_A1.8121.00
192_T196_D1.7951.00
399_E403_A1.7931.00
162_Y195_G1.7901.00
292_A386_T1.7841.00
253_E256_S1.7771.00
289_V394_A1.7751.00
283_A402_M1.7751.00
162_Y194_F1.7621.00
159_L194_F1.7421.00
304_Q381_V1.7401.00
284_D288_D1.7261.00
170_T192_T1.7251.00
274_D277_A1.7101.00
435_E438_A1.6891.00
159_L191_L1.6861.00
72_N76_D1.6841.00
281_D397_Q1.6761.00
312_E315_D1.6691.00
270_R274_D1.6631.00
393_D396_A1.6461.00
229_L446_L1.6431.00
199_A203_T1.6401.00
120_T124_H1.6261.00
367_E371_S1.6071.00
200_A204_E1.5971.00
160_D190_N1.5811.00
389_D393_D1.5781.00
470_D473_E1.5761.00
69_A72_N1.5751.00
414_A417_E1.5711.00
299_D379_D1.5661.00
300_V380_T1.5501.00
127_E131_V1.5361.00
442_E445_D1.5291.00
267_T270_R1.5281.00
462_E466_A1.5281.00
403_A407_E1.5201.00
311_D374_Q1.5141.00
186_Q189_R1.5111.00
159_L190_N1.5001.00
128_F132_I1.4981.00
123_Y127_E1.4971.00
359_A363_A1.4951.00
463_A466_A1.4901.00
236_N442_E1.4861.00
281_D284_D1.4751.00
413_E417_E1.4751.00
299_D380_T1.4751.00
170_T195_G1.4741.00
119_A123_Y1.4651.00
280_S284_D1.4641.00
318_T367_E1.4621.00
112_N116_W1.4531.00
263_D266_A1.4511.00
266_A270_R1.4481.00
153_G156_V1.4441.00
260_E263_D1.4401.00
354_A357_E1.4311.00
284_D287_A1.4301.00
141_S145_Q1.4231.00
305_N309_D1.4191.00
400_D403_A1.4151.00
301_E305_N1.4141.00
287_A399_E1.4111.00
68_R72_N1.4091.00
306_R309_D1.4091.00
206_H210_E1.4071.00
466_A470_D1.4051.00
221_E225_E1.3991.00
263_D267_T1.3981.00
155_L187_I1.3981.00
309_D365_H1.3961.00
427_N431_A1.3951.00
292_A390_R1.3881.00
357_E361_S1.3871.00
350_E353_K1.3811.00
219_V223_S1.3771.00
278_A400_D1.3641.00
378_A382_T1.3641.00
113_T117_F1.3611.00
166_R169_A1.3591.00
361_S365_H1.3591.00
261_V419_I1.3581.00
469_H473_E1.3561.00
281_D400_D1.3551.00
120_T123_Y1.3511.00
403_A406_E1.3511.00
273_D277_A1.3461.00
272_A409_V1.3451.00
385_V389_D1.3401.00
273_D413_E1.3371.00
235_T238_S1.3331.00
277_A280_S1.3321.00
407_E410_T1.3301.00
364_G368_S1.3281.00
224_A228_E1.3271.00
389_D392_E1.3211.00
196_D200_A1.3201.00
204_E470_D1.3181.00
102_Y106_D1.3151.00
97_L101_D1.3151.00
88_V92_D1.3151.00
452_T455_A1.3141.00
295_S298_S1.3061.00
449_D452_T1.3021.00
156_V160_D1.2991.00
195_G199_A1.2981.00
72_N75_A1.2931.00
434_E438_A1.2911.00
104_Y108_T1.2871.00
294_D298_S1.2871.00
245_E249_A1.2841.00
98_L101_D1.2801.00
256_S260_E1.2751.00
252_Q256_S1.2741.00
302_A305_N1.2671.00
173_I192_T1.2661.00
285_M393_D1.2631.00
103_V106_D1.2631.00
445_D449_D1.2591.00
102_Y109_V1.2581.00
382_T385_V1.2581.00
282_A401_A1.2491.00
159_L187_I1.2481.00
276_S406_E1.2461.00
406_E410_T1.2461.00
92_D96_A1.2451.00
66_G69_A1.2411.00
111_G114_D1.2371.00
154_E172_D1.2361.00
259_D263_D1.2341.00
124_H127_E1.2241.00
239_T242_T1.2211.00
218_A221_E1.2201.00
332_S350_E1.2171.00
293_A391_I1.2001.00
361_S364_G1.2001.00
456_D459_S1.1921.00
78_P82_H1.1881.00
271_L274_D1.1881.00
155_L191_L1.1851.00
105_E109_V1.1821.00
291_T295_S1.1821.00
232_A235_T1.1791.00
298_S302_A1.1781.00
307_I377_T1.1761.00
459_S463_A1.1751.00
103_V107_T1.1711.00
290_A395_V1.1611.00
104_Y107_T1.1561.00
441_D445_D1.1561.00
287_A291_T1.1551.00
203_T207_N1.1501.00
175_A182_D1.1481.00
214_A218_A1.1481.00
231_T235_T1.1481.00
125_T128_F1.1401.00
197_T200_A1.1391.00
259_D427_N1.1381.00
204_E207_N1.1371.00
65_D69_A1.1251.00
298_S301_E1.1251.00
309_D372_E1.1201.00
225_E228_E1.1181.00
164_A193_E1.1141.00
300_V384_L1.1071.00
173_I188_G1.1071.00
452_T456_D1.1061.00
294_D392_E1.1041.00
301_E385_V1.1041.00
371_S375_R1.1041.00
171_V192_T1.1041.00
291_T294_D1.1021.00
318_T363_A1.1001.00
299_D383_D1.0971.00
235_T239_T1.0931.00
270_R273_D1.0921.00
410_T414_A1.0911.00
274_D400_D1.0871.00
71_A75_A1.0851.00
110_A114_D1.0841.00
316_V362_N1.0821.00
286_M394_A1.0791.00
212_L216_S1.0731.00
173_I189_R1.0721.00
73_K78_P1.0721.00
294_D388_T1.0701.00
155_L159_L1.0691.00
254_I426_T1.0691.00
269_E273_D1.0691.00
445_D448_D1.0651.00
256_S259_D1.0651.00
276_S409_V1.0641.00
424_D428_E1.0641.00
91_A94_S1.0631.00
455_A459_S1.0631.00
207_N210_E1.0631.00
157_D160_D1.0581.00
421_Q424_D1.0561.00
158_T171_V1.0561.00
207_N211_R1.0551.00
161_A164_A1.0531.00
82_H86_D1.0531.00
246_T249_A1.0511.00
276_S280_S1.0481.00
304_Q308_E1.0471.00
475_V478_L1.0451.00
93_E97_L1.0431.00
424_D427_N1.0351.00
365_H368_S1.0301.00
154_E157_D1.0231.00
153_G157_D1.0221.00
386_T389_D1.0211.00
142_A146_S1.0171.00
203_T206_H1.0161.00
167_F198_L1.0141.00
396_A399_E1.0141.00
214_A217_Q1.0131.00
368_S372_E1.0121.00
63_N67_S1.0091.00
438_A442_E1.0071.00
390_R393_D1.0021.00
274_D407_E1.0011.00
264_T414_A1.0011.00
210_E214_A0.9991.00
229_L233_Q0.9991.00
228_E231_T0.9991.00
117_F121_P0.9951.00
138_R142_A0.9941.00
205_V208_D0.9931.00
102_Y105_E0.9931.00
364_G367_E0.9921.00
252_Q434_E0.9911.00
80_D83_H0.9871.00
228_E232_A0.9861.00
87_G90_L0.9841.00
133_E137_D0.9821.00
184_Y188_G0.9821.00
382_T386_T0.9811.00
397_Q400_D0.9801.00
448_D452_T0.9801.00
275_G408_I0.9791.00
156_V187_I0.9751.00
69_A73_K0.9701.00
204_E208_D0.9701.00
188_G192_T0.9701.00
360_Q364_G0.9681.00
358_D361_S0.9681.00
139_S143_R0.9681.00
238_S242_T0.9651.00
171_V188_G0.9651.00
115_L119_A0.9621.00
304_Q378_A0.9621.00
464_Q478_L0.9611.00
92_D95_Y0.9521.00
92_D99_T0.9511.00
210_E472_D0.9491.00
158_T161_A0.9481.00
104_Y109_V0.9421.00
152_F184_Y0.9421.00
282_A398_V0.9391.00
107_T110_A0.9341.00
67_S71_A0.9321.00
193_E196_D0.9311.00
428_E431_A0.9261.00
102_Y108_T0.9261.00
169_A195_G0.9251.00
268_A412_V0.9251.00
269_E416_A0.9251.00
97_L100_G0.9231.00
89_G93_E0.9201.00
474_S477_E0.9201.00
438_A441_D0.9181.00
275_G405_F0.9161.00
466_A469_H0.9141.00
297_T388_T0.9101.00
94_S97_L0.9091.00
154_E158_T0.9091.00
368_S371_S0.9071.00
147_E151_L0.9061.00
172_D192_T0.9051.00
279_A401_A0.9031.00
158_T169_A0.9021.00
162_Y191_L0.9021.00
297_T385_V0.9001.00
375_R379_D0.8991.00
152_F187_I0.8981.00
64_D68_R0.8981.00
242_T246_T0.8971.00
417_E421_Q0.8961.00
271_L411_A0.8941.00
89_G92_D0.8941.00
121_P124_H0.8941.00
332_S353_K0.8931.00
221_E224_A0.8921.00
116_W120_T0.8831.00
232_A236_N0.8831.00
217_Q221_E0.8821.00
151_L184_Y0.8811.00
247_L433_A0.8781.00
288_D291_T0.8781.00
71_A74_V0.8771.00
300_V381_V0.8771.00
96_A100_G0.8741.00
309_D369_L0.8691.00
260_E418_G0.8671.00
313_V369_L0.8671.00
292_A295_S0.8671.00
145_Q148_L0.8631.00
302_A306_R0.8631.00
116_W119_A0.8581.00
249_A253_E0.8571.00
73_K81_A0.8561.00
405_F408_I0.8531.00
64_D67_S0.8481.00
181_D185_I0.8471.00
193_E197_T0.8461.00
226_I229_L0.8421.00
212_L215_A0.8411.00
191_L194_F0.8381.00
267_T411_A0.8341.00
157_D161_A0.8331.00
114_D118_I0.8321.00
289_V391_I0.8311.00
269_E413_E0.8311.00
281_D393_D0.8291.00
217_Q465_S0.8291.00
233_Q247_L0.8261.00
189_R192_T0.8261.00
213_E217_Q0.8251.00
459_S462_E0.8191.00
169_A173_I0.8181.00
402_M406_E0.8181.00
131_V135_V0.8171.00
137_D141_S0.8151.00
290_A392_E0.8141.00
296_V383_D0.8131.00
233_Q243_E0.8111.00
80_D84_E0.8111.00
462_E465_S0.8111.00
143_R146_S0.8101.00
70_L74_V0.8091.00
161_A194_F0.8091.00
266_A420_E0.8051.00
409_V413_E0.8001.00
96_A99_T0.8001.00
308_E378_A0.8001.00
245_E437_A0.7971.00
74_V77_T0.7951.00
296_V387_T0.7951.00
79_I83_H0.7951.00
88_V91_A0.7931.00
472_D476_S0.7921.00
465_S469_H0.7901.00
108_T111_G0.7891.00
233_Q240_V0.7881.00
285_M390_R0.7841.00
267_T271_L0.7821.00
105_E108_T0.7821.00
473_E476_S0.7801.00
159_L162_Y0.7791.00
158_T191_L0.7781.00
150_A154_E0.7781.00
358_D365_H0.7771.00
287_A395_V0.7731.00
295_S383_D0.7721.00
285_M397_Q0.7691.00
211_R214_A0.7691.00
431_A435_E0.7681.00
205_V209_V0.7671.00
379_D382_T0.7641.00
227_D231_T0.7621.00
65_D68_R0.7601.00
296_V384_L0.7581.00
319_G358_D0.7561.00
318_T322_E0.7551.00
420_E424_D0.7541.00
77_T82_H0.7461.00
149_Q153_G0.7451.00
153_G186_Q0.7421.00
111_G115_L0.7391.00
302_A379_D0.7381.00
202_I205_V0.7381.00
288_D292_A0.7371.00
236_N439_M0.7361.00
262_V266_A0.7351.00
417_E420_E0.7351.00
125_T129_R0.7301.00
106_D111_G0.7281.00
297_T301_E0.7261.00
257_T421_Q0.7251.00
106_D109_V0.7251.00
388_T392_E0.7241.00
148_L151_L0.7211.00
280_S402_M0.7201.00
244_V440_V0.7191.00
197_T477_E0.7191.00
62_L65_D0.7181.00
286_M289_V0.7141.00
253_E421_Q0.7121.00
329_L337_R0.7121.00
399_E402_M0.7111.00
247_L429_Q0.7111.00
223_S454_V0.7111.00
74_V78_P0.7101.00
322_E360_Q0.7091.00
312_E316_V0.7071.00
288_D393_D0.7021.00
307_I373_I0.7021.00
319_G322_E0.7021.00
273_D276_S0.7011.00
149_Q184_Y0.7011.00
173_I185_I0.7011.00
112_N115_L0.6981.00
242_T245_E0.6961.00
375_R378_A0.6951.00
287_A290_A0.6951.00
92_D98_L0.6941.00
249_A252_Q0.6941.00
279_A398_V0.6941.00
200_A203_T0.6931.00
163_D193_E0.6921.00
350_E354_A0.6921.00
67_S70_L0.6921.00
261_V418_G0.6911.00
151_L183_E0.6901.00
467_M470_D0.6891.00
273_D409_V0.6861.00
410_T413_E0.6861.00
201_H205_V0.6861.00
226_I233_Q0.6861.00
67_S74_V0.6821.00
446_L450_I0.6801.00
293_A387_T0.6781.00
303_L373_I0.6781.00
278_A404_S0.6781.00
167_F202_I0.6771.00
204_E474_S0.6771.00
81_A85_Y0.6771.00
281_D285_M0.6761.00
308_E312_E0.6741.00
194_F198_L0.6731.00
92_D97_L0.6731.00
89_G96_A0.6691.00
89_G94_S0.6641.00
94_S101_D0.6631.00
314_V367_E0.6621.00
434_E437_A0.6611.00
232_A442_E0.6611.00
95_Y99_T0.6591.00
278_A281_D0.6581.00
452_T459_S0.6551.00
435_E439_M0.6541.00
163_D190_N0.6541.00
251_V426_T0.6521.00
158_T162_Y0.6521.00
280_S406_E0.6491.00
295_S299_D0.6491.00
248_S433_A0.6491.00
312_E365_H0.6471.00
314_V318_T0.6461.00
135_V139_S0.6451.00
318_T364_G0.6451.00
471_L478_L0.6421.00
444_A448_D0.6421.00
233_Q236_N0.6361.00
225_E449_D0.6361.00
81_A84_E0.6361.00
191_L195_G0.6341.00
310_I370_V0.6331.00
243_E246_T0.6331.00
414_A418_G0.6321.00
93_E96_A0.6301.00
453_A456_D0.6291.00
182_D188_G0.6291.00
374_Q378_A0.6291.00
301_E304_Q0.6291.00
457_I460_Q0.6291.00
150_A153_G0.6281.00
87_G91_A0.6261.00
218_A460_Q0.6261.00
156_V184_Y0.6241.00
372_E376_D0.6241.00
118_I122_V0.6211.00
262_V420_E0.6181.00
201_H204_E0.6171.00
293_A296_V0.6141.00
211_R463_A0.6101.00
431_A434_E0.6101.00
94_S99_T0.6101.00
240_V439_M0.6091.00
464_Q468_L0.6091.00
88_V94_S0.6071.00
299_D376_D0.6071.00
90_L93_E0.6061.00
236_N239_T0.6061.00
313_V362_N0.6051.00
428_E432_S0.6031.00
113_T116_W0.6031.00
118_I121_P0.6021.00
155_L158_T0.6021.00
91_A97_L0.5991.00
248_S251_V0.5951.00
226_I454_V0.5951.00
227_D455_A0.5921.00
77_T80_D0.5921.00
73_K77_T0.5911.00
353_K357_E0.5901.00
87_G92_D0.5901.00
377_T380_T0.5891.00
460_Q463_A0.5891.00
272_A276_S0.5871.00
391_I394_A0.5861.00
307_I313_V0.5861.00
209_V213_E0.5861.00
226_I230_S0.5841.00
290_A294_D0.5831.00
111_G116_W0.5821.00
325_N353_K0.5811.00
98_L105_E0.5811.00
83_H86_D0.5801.00
315_D318_T0.5801.00
240_V436_I0.5781.00
323_Q351_E0.5761.00
313_V370_V0.5761.00
114_D117_F0.5751.00
104_Y111_G0.5741.00
90_L94_S0.5731.00
283_A287_A0.5731.00
303_L380_T0.5731.00
88_V95_Y0.5721.00
238_S444_A0.5701.00
240_V440_V0.5651.00
272_A275_G0.5641.00
91_A96_A0.5631.00
437_A441_D0.5631.00
268_A411_A0.5631.00
147_E150_A0.5601.00
356_A359_A0.5601.00
240_V244_V0.5581.00
164_A197_T0.5581.00
237_V443_T0.5581.00
165_G194_F0.5571.00
216_S461_T0.5561.00
205_V475_V0.5561.00
423_S426_T0.5551.00
158_T195_G0.5541.00
407_E411_A0.5531.00
75_A79_I0.5521.00
213_E216_S0.5521.00
278_A397_Q0.5491.00
165_G201_H0.5481.00
265_S412_V0.5481.00
422_V425_A0.5451.00
244_V247_L0.5431.00
248_S437_A0.5421.00
132_I139_S0.5411.00
463_A467_M0.5411.00
73_K76_D0.5401.00
377_T381_V0.5381.00
154_E173_I0.5381.00
380_T384_L0.5371.00
279_A282_A0.5341.00
185_I189_R0.5321.00
313_V316_V0.5321.00
468_L478_L0.5301.00
295_S386_T0.5281.00
297_T384_L0.5261.00
293_A384_L0.5251.00
128_F131_V0.5241.00
279_A405_F0.5241.00
155_L184_Y0.5231.00
126_G130_G0.5231.00
274_D404_S0.5221.00
285_M288_D0.5211.00
69_A87_G0.5181.00
264_T267_T0.5181.00
286_M398_V0.5161.00
288_D386_T0.5131.00
134_I137_D0.5121.00
371_S374_Q0.5101.00
398_V402_M0.5081.00
123_Y126_G0.5081.00
218_A456_D0.5061.00
81_A86_D0.5051.00
234_S448_D0.5051.00
241_A244_V0.5041.00
70_L85_Y0.5031.00
68_R71_A0.5011.00
222_S453_A0.5011.00
132_I136_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.632 100 0.332 Contact Map
2ch7A 2 0.6133 100 0.473 Contact Map
1qu7A 2 0.4678 100 0.477 Contact Map
3g67A 2 0.4345 100 0.555 Contact Map
4i3mA 2 0.3056 99.9 0.724 Contact Map
4cq4A 4 0.1788 99.4 0.832 Contact Map
2f95B 2 0.1019 99.3 0.84 Contact Map
4gycB 2 0.1247 99.1 0.851 Contact Map
3zccA 2 0.2204 98.8 0.868 Contact Map
4i5sA 2 0.5904 98.3 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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