Q9HPZ8 - HALSA - GREMLIN Contacts

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Q9HPZ8 - Uncharacterized protein

UniProt:	Q9HPZ8	Sequences: MRVIRATTTEEYEDALRVRFAVFVDEQGVPADMEVDDHDDTATHFVAYDTMTGSQDATRAVAAARLRAYEGSVGKVERVAVRASRRGNGVGATVMDAVEDAARERFAELYLHAQSRVAEFYATRGYHREGEPFMEAGIEHVAMRKRL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	147 (129)
Sequences:	3271 (2491)
Seq/√Len:	219.3

ECOLI - ELAA YIID
BACSU - YJCF YYBD YYAT YITI
HALSA - Q9HPZ8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
64_A	98_V	2.910	1.00
99_E	126_Y	2.896	1.00
118_A	128_R	2.599	1.00
112_H	133_F	2.457	1.00
20_F	34_E	2.202	1.00
115_S	132_P	2.082	1.00
97_A	100_D	2.074	1.00
132_P	139_E	2.018	1.00
18_V	80_A	1.978	1.00
92_A	124_R	1.954	1.00
14_D	48_Y	1.808	1.00
18_V	82_R	1.800	1.00
67_R	77_E	1.784	1.00
61_V	85_R	1.760	1.00
99_E	145_K	1.732	1.00
118_A	141_V	1.721	1.00
95_M	124_R	1.693	1.00
47_A	90_V	1.676	1.00
129_E	142_A	1.653	1.00
12_Y	16_L	1.642	1.00
76_V	95_M	1.639	1.00
108_E	144_R	1.634	1.00
46_V	60_A	1.623	1.00
21_A	82_R	1.587	1.00
47_A	62_A	1.565	1.00
63_A	80_A	1.560	1.00
62_A	81_V	1.542	1.00
21_A	25_D	1.519	1.00
122_A	128_R	1.510	1.00
101_A	105_R	1.501	1.00
48_Y	60_A	1.491	1.00
118_A	122_A	1.468	1.00
129_E	144_R	1.467	1.00
133_F	142_A	1.465	1.00
99_E	109_L	1.464	1.00
92_A	123_T	1.459	1.00
134_M	137_G	1.421	1.00
119_E	122_A	1.340	1.00
134_M	139_E	1.337	1.00
17_R	21_A	1.331	1.00
92_A	96_D	1.320	1.00
29_V	138_I	1.318	1.00
130_G	142_A	1.306	1.00
29_V	136_A	1.303	1.00
33_M	136_A	1.299	1.00
112_H	142_A	1.293	1.00
64_A	79_V	1.275	1.00
59_R	84_S	1.274	1.00
69_Y	75_K	1.268	1.00
45_F	98_V	1.262	1.00
20_F	31_A	1.258	1.00
110_Y	142_A	1.234	1.00
73_V	110_Y	1.229	1.00
79_V	95_M	1.211	1.00
45_F	101_A	1.210	1.00
128_R	141_V	1.209	1.00
16_L	35_V	1.206	1.00
112_H	135_E	1.198	1.00
15_A	46_V	1.197	1.00
101_A	104_E	1.193	1.00
43_T	101_A	1.174	1.00
50_T	58_T	1.168	1.00
49_D	85_R	1.154	1.00
27_Q	114_Q	1.150	1.00
93_T	97_A	1.130	1.00
20_F	24_V	1.130	1.00
49_D	61_V	1.088	1.00
43_T	105_R	1.087	1.00
21_A	33_M	1.077	1.00
15_A	63_A	1.043	1.00
103_R	145_K	1.010	1.00
110_Y	144_R	1.010	1.00
66_L	102_A	1.007	1.00
85_R	88_N	0.990	1.00
75_K	110_Y	0.981	1.00
114_Q	140_H	0.977	1.00
20_F	35_V	0.974	1.00
20_F	25_D	0.962	1.00
76_V	79_V	0.954	1.00
24_V	31_A	0.945	1.00
115_S	118_A	0.936	1.00
13_E	16_L	0.933	1.00
96_D	100_D	0.932	1.00
37_D	40_D	0.929	0.99
14_D	17_R	0.928	0.99
26_E	86_R	0.916	0.99
38_H	67_R	0.906	0.99
10_E	14_D	0.895	0.99
102_A	109_L	0.889	0.99
74_G	106_F	0.887	0.99
73_V	108_E	0.876	0.99
62_A	94_V	0.866	0.99
113_A	143_M	0.856	0.99
67_R	75_K	0.855	0.99
100_D	104_E	0.847	0.99
76_V	98_V	0.836	0.99
68_A	106_F	0.836	0.99
30_P	33_M	0.835	0.99
97_A	101_A	0.832	0.99
64_A	94_V	0.823	0.99
9_T	13_E	0.820	0.99
25_D	30_P	0.818	0.99
45_F	64_A	0.817	0.99
117_V	120_F	0.816	0.99
75_K	111_L	0.815	0.99
91_G	120_F	0.810	0.99
49_D	59_R	0.797	0.98
61_V	90_V	0.781	0.98
66_L	101_A	0.775	0.98
93_T	96_D	0.774	0.98
49_D	88_N	0.774	0.98
10_E	40_D	0.758	0.98
16_L	20_F	0.752	0.98
42_A	67_R	0.752	0.98
18_V	60_A	0.751	0.98
21_A	84_S	0.751	0.98
115_S	139_E	0.744	0.98
109_L	126_Y	0.744	0.98
96_D	124_R	0.742	0.98
82_R	85_R	0.742	0.98
75_K	112_H	0.735	0.97
62_A	90_V	0.729	0.97
17_R	37_D	0.721	0.97
59_R	82_R	0.714	0.97
48_Y	58_T	0.712	0.97
89_G	92_A	0.684	0.96
47_A	93_T	0.676	0.96
50_T	59_R	0.675	0.96
126_Y	145_K	0.673	0.96
76_V	126_Y	0.672	0.96
118_A	132_P	0.671	0.96
24_V	34_E	0.670	0.96
90_V	93_T	0.668	0.95
76_V	109_L	0.667	0.95
11_E	15_A	0.659	0.95
39_D	77_E	0.653	0.95
47_A	61_V	0.652	0.95
29_V	135_E	0.652	0.95
20_F	30_P	0.651	0.95
45_F	66_L	0.651	0.95
45_F	97_A	0.650	0.95
115_S	141_V	0.649	0.95
74_G	102_A	0.647	0.95
11_E	46_V	0.645	0.95
99_E	124_R	0.643	0.94
26_E	83_A	0.642	0.94
18_V	63_A	0.633	0.94
128_R	132_P	0.627	0.94
12_Y	39_D	0.621	0.93
30_P	34_E	0.619	0.93
102_A	106_F	0.611	0.93
111_L	121_Y	0.607	0.93
36_D	65_R	0.602	0.92
88_N	91_G	0.601	0.92
81_V	90_V	0.599	0.92
13_E	35_V	0.595	0.92
38_H	41_T	0.594	0.92
33_M	135_E	0.592	0.92
76_V	111_L	0.583	0.91
122_A	127_H	0.582	0.91
111_L	143_M	0.581	0.91
13_E	37_D	0.581	0.91
100_D	103_R	0.578	0.91
23_F	114_Q	0.577	0.91
44_H	63_A	0.574	0.90
132_P	141_V	0.574	0.90
23_F	26_E	0.574	0.90
135_E	138_I	0.573	0.90
94_V	97_A	0.572	0.90
62_A	91_G	0.570	0.90
77_E	114_Q	0.563	0.89
111_L	117_V	0.554	0.89
27_Q	140_H	0.553	0.89
70_E	73_V	0.548	0.88
72_S	107_A	0.548	0.88
42_A	68_A	0.547	0.88
24_V	30_P	0.546	0.88
22_V	86_R	0.546	0.88
23_F	27_Q	0.542	0.88
40_D	43_T	0.540	0.87
85_R	90_V	0.537	0.87
131_E	141_V	0.534	0.87
66_L	74_G	0.531	0.87
67_R	74_G	0.525	0.86
26_E	78_R	0.525	0.86
87_G	92_A	0.522	0.86
27_Q	78_R	0.520	0.85
78_R	114_Q	0.515	0.85
23_F	78_R	0.510	0.84
13_E	17_R	0.509	0.84
77_E	140_H	0.508	0.84
20_F	33_M	0.507	0.84
26_E	114_Q	0.505	0.84
13_E	40_D	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2g0bA	4	0.9456	99.9	0.45	Contact Map
1q2yA	1	0.9388	99.9	0.466	Contact Map
1xebA	2	0.9388	99.9	0.469	Contact Map
1kzfA	1	0.8707	99.9	0.473	Contact Map
3p2hA	1	0.9116	99.9	0.475	Contact Map
3efaA	2	0.9524	99.9	0.483	Contact Map
2jdcA	1	0.9252	99.9	0.484	Contact Map
1ro5A	5	0.9524	99.9	0.497	Contact Map
1yvkA	3	0.898	99.7	0.615	Contact Map
3gy9A	3	0.9116	99.7	0.615	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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