GREMLIN Database
Q9HPZ8 - Uncharacterized protein
UniProt: Q9HPZ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 147 (129)
Sequences: 3271 (2491)
Seq/√Len: 219.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_A98_V2.9101.00
99_E126_Y2.8961.00
118_A128_R2.5991.00
112_H133_F2.4571.00
20_F34_E2.2021.00
115_S132_P2.0821.00
97_A100_D2.0741.00
132_P139_E2.0181.00
18_V80_A1.9781.00
92_A124_R1.9541.00
14_D48_Y1.8081.00
18_V82_R1.8001.00
67_R77_E1.7841.00
61_V85_R1.7601.00
99_E145_K1.7321.00
118_A141_V1.7211.00
95_M124_R1.6931.00
47_A90_V1.6761.00
129_E142_A1.6531.00
12_Y16_L1.6421.00
76_V95_M1.6391.00
108_E144_R1.6341.00
46_V60_A1.6231.00
21_A82_R1.5871.00
47_A62_A1.5651.00
63_A80_A1.5601.00
62_A81_V1.5421.00
21_A25_D1.5191.00
122_A128_R1.5101.00
101_A105_R1.5011.00
48_Y60_A1.4911.00
118_A122_A1.4681.00
129_E144_R1.4671.00
133_F142_A1.4651.00
99_E109_L1.4641.00
92_A123_T1.4591.00
134_M137_G1.4211.00
119_E122_A1.3401.00
134_M139_E1.3371.00
17_R21_A1.3311.00
92_A96_D1.3201.00
29_V138_I1.3181.00
130_G142_A1.3061.00
29_V136_A1.3031.00
33_M136_A1.2991.00
112_H142_A1.2931.00
64_A79_V1.2751.00
59_R84_S1.2741.00
69_Y75_K1.2681.00
45_F98_V1.2621.00
20_F31_A1.2581.00
110_Y142_A1.2341.00
73_V110_Y1.2291.00
79_V95_M1.2111.00
45_F101_A1.2101.00
128_R141_V1.2091.00
16_L35_V1.2061.00
112_H135_E1.1981.00
15_A46_V1.1971.00
101_A104_E1.1931.00
43_T101_A1.1741.00
50_T58_T1.1681.00
49_D85_R1.1541.00
27_Q114_Q1.1501.00
93_T97_A1.1301.00
20_F24_V1.1301.00
49_D61_V1.0881.00
43_T105_R1.0871.00
21_A33_M1.0771.00
15_A63_A1.0431.00
103_R145_K1.0101.00
110_Y144_R1.0101.00
66_L102_A1.0071.00
85_R88_N0.9901.00
75_K110_Y0.9811.00
114_Q140_H0.9771.00
20_F35_V0.9741.00
20_F25_D0.9621.00
76_V79_V0.9541.00
24_V31_A0.9451.00
115_S118_A0.9361.00
13_E16_L0.9331.00
96_D100_D0.9321.00
37_D40_D0.9290.99
14_D17_R0.9280.99
26_E86_R0.9160.99
38_H67_R0.9060.99
10_E14_D0.8950.99
102_A109_L0.8890.99
74_G106_F0.8870.99
73_V108_E0.8760.99
62_A94_V0.8660.99
113_A143_M0.8560.99
67_R75_K0.8550.99
100_D104_E0.8470.99
76_V98_V0.8360.99
68_A106_F0.8360.99
30_P33_M0.8350.99
97_A101_A0.8320.99
64_A94_V0.8230.99
9_T13_E0.8200.99
25_D30_P0.8180.99
45_F64_A0.8170.99
117_V120_F0.8160.99
75_K111_L0.8150.99
91_G120_F0.8100.99
49_D59_R0.7970.98
61_V90_V0.7810.98
66_L101_A0.7750.98
93_T96_D0.7740.98
49_D88_N0.7740.98
10_E40_D0.7580.98
16_L20_F0.7520.98
42_A67_R0.7520.98
18_V60_A0.7510.98
21_A84_S0.7510.98
115_S139_E0.7440.98
109_L126_Y0.7440.98
96_D124_R0.7420.98
82_R85_R0.7420.98
75_K112_H0.7350.97
62_A90_V0.7290.97
17_R37_D0.7210.97
59_R82_R0.7140.97
48_Y58_T0.7120.97
89_G92_A0.6840.96
47_A93_T0.6760.96
50_T59_R0.6750.96
126_Y145_K0.6730.96
76_V126_Y0.6720.96
118_A132_P0.6710.96
24_V34_E0.6700.96
90_V93_T0.6680.95
76_V109_L0.6670.95
11_E15_A0.6590.95
39_D77_E0.6530.95
47_A61_V0.6520.95
29_V135_E0.6520.95
20_F30_P0.6510.95
45_F66_L0.6510.95
45_F97_A0.6500.95
115_S141_V0.6490.95
74_G102_A0.6470.95
11_E46_V0.6450.95
99_E124_R0.6430.94
26_E83_A0.6420.94
18_V63_A0.6330.94
128_R132_P0.6270.94
12_Y39_D0.6210.93
30_P34_E0.6190.93
102_A106_F0.6110.93
111_L121_Y0.6070.93
36_D65_R0.6020.92
88_N91_G0.6010.92
81_V90_V0.5990.92
13_E35_V0.5950.92
38_H41_T0.5940.92
33_M135_E0.5920.92
76_V111_L0.5830.91
122_A127_H0.5820.91
111_L143_M0.5810.91
13_E37_D0.5810.91
100_D103_R0.5780.91
23_F114_Q0.5770.91
44_H63_A0.5740.90
132_P141_V0.5740.90
23_F26_E0.5740.90
135_E138_I0.5730.90
94_V97_A0.5720.90
62_A91_G0.5700.90
77_E114_Q0.5630.89
111_L117_V0.5540.89
27_Q140_H0.5530.89
70_E73_V0.5480.88
72_S107_A0.5480.88
42_A68_A0.5470.88
24_V30_P0.5460.88
22_V86_R0.5460.88
23_F27_Q0.5420.88
40_D43_T0.5400.87
85_R90_V0.5370.87
131_E141_V0.5340.87
66_L74_G0.5310.87
67_R74_G0.5250.86
26_E78_R0.5250.86
87_G92_A0.5220.86
27_Q78_R0.5200.85
78_R114_Q0.5150.85
23_F78_R0.5100.84
13_E17_R0.5090.84
77_E140_H0.5080.84
20_F33_M0.5070.84
26_E114_Q0.5050.84
13_E40_D0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2g0bA 4 0.9456 99.9 0.45 Contact Map
1q2yA 1 0.9388 99.9 0.466 Contact Map
1xebA 2 0.9388 99.9 0.469 Contact Map
1kzfA 1 0.8707 99.9 0.473 Contact Map
3p2hA 1 0.9116 99.9 0.475 Contact Map
3efaA 2 0.9524 99.9 0.483 Contact Map
2jdcA 1 0.9252 99.9 0.484 Contact Map
1ro5A 5 0.9524 99.9 0.497 Contact Map
1yvkA 3 0.898 99.7 0.615 Contact Map
3gy9A 3 0.9116 99.7 0.615 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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