GREMLIN Database
Y1401 - UPF0179 protein VNG_1401C
UniProt: Q9HPZ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (138)
Sequences: 137 (101)
Seq/√Len: 8.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_C107_C3.8990.98
101_C132_C2.8820.87
80_P93_A2.7420.85
56_L78_T2.6740.83
13_P48_D2.4800.78
81_S140_L2.3930.75
27_E63_E2.1820.68
61_H109_P2.1410.66
60_V112_A2.0650.63
61_H68_V1.9520.59
22_P64_G1.8960.56
42_V120_I1.8330.54
23_A69_D1.8310.54
30_P78_T1.7600.51
39_T42_V1.7570.51
93_A143_F1.7260.49
25_D46_V1.6720.47
12_D115_D1.6320.45
79_V84_A1.6300.45
24_D46_V1.6110.44
62_D67_A1.5700.43
77_A143_F1.5680.43
4_T61_H1.5500.42
37_N100_E1.5340.41
12_D140_L1.5160.40
19_Y118_Y1.5150.40
10_L73_T1.5040.40
10_L88_S1.4940.40
32_R86_A1.4910.39
9_R22_P1.4500.38
32_R125_G1.4330.37
95_P120_I1.3980.36
107_C132_C1.3870.35
8_P66_V1.3680.35
83_G117_E1.3590.34
4_T11_A1.3460.34
64_G104_H1.3290.33
73_T124_D1.3030.32
46_V69_D1.2990.32
33_Q110_A1.2950.32
86_A122_E1.2940.32
20_H110_A1.2750.31
34_Q77_A1.2680.31
106_F140_L1.2630.31
125_G128_P1.2610.31
118_Y138_L1.2580.30
20_H30_P1.2580.30
115_D123_I1.2520.30
82_K115_D1.2500.30
23_A89_K1.2490.30
46_V49_V1.2320.29
25_D92_L1.2180.29
16_E50_R1.2120.29
12_D143_F1.1990.28
22_P37_N1.1840.28
6_L13_P1.1750.28
39_T116_T1.1580.27
82_K86_A1.1540.27
45_E71_E1.1500.27
98_H105_E1.1430.26
52_G62_D1.1230.26
12_D48_D1.1170.26
55_V64_G1.1150.26
3_I106_F1.1100.25
10_L111_G1.1050.25
41_G79_V1.1000.25
16_E96_C1.0810.24
42_V116_T1.0770.24
63_E123_I1.0750.24
16_E64_G1.0710.24
43_R59_A1.0560.24
32_R81_S1.0490.23
33_Q52_G1.0370.23
20_H82_K1.0330.23
91_K112_A1.0270.23
48_D69_D1.0210.23
47_T71_E1.0190.23
8_P55_V1.0000.22
14_G116_T0.9980.22
12_D18_V0.9970.22
106_F117_E0.9970.22
19_Y136_R0.9770.21
18_V102_P0.9690.21
16_E47_T0.9660.21
19_Y91_K0.9620.21
6_L108_E0.9590.21
16_E43_R0.9500.21
122_E144_A0.9390.20
19_Y57_D0.9380.20
38_L70_V0.9370.20
46_V51_E0.9350.20
61_H138_L0.9320.20
49_V137_D0.9230.20
9_R62_D0.9100.19
9_R120_I0.8990.19
74_T142_E0.8900.19
15_T89_K0.8830.19
96_C99_T0.8810.19
14_G111_G0.8790.19
22_P36_L0.8720.18
30_P110_A0.8470.18
33_Q113_S0.8460.18
86_A133_A0.8440.18
19_Y59_A0.8430.18
49_V74_T0.8430.18
13_P88_S0.8420.18
60_V98_H0.8360.18
48_D144_A0.8350.18
61_H75_I0.8340.18
3_I39_T0.8330.17
74_T93_A0.8330.17
45_E119_Q0.8280.17
43_R57_D0.8210.17
104_H108_E0.8210.17
51_E55_V0.8190.17
88_S125_G0.8160.17
65_A71_E0.8150.17
61_H111_G0.8100.17
66_V88_S0.7980.17
6_L15_T0.7930.17
79_V139_T0.7920.17
120_I142_E0.7920.17
122_E126_E0.7920.17
34_Q72_P0.7850.16
24_D110_A0.7770.16
69_D73_T0.7720.16
109_P141_V0.7680.16
10_L22_P0.7680.16
24_D114_F0.7640.16
91_K122_E0.7630.16
3_I87_G0.7620.16
19_Y50_R0.7590.16
107_C138_L0.7450.15
39_T118_Y0.7420.15
7_G61_H0.7410.15
13_P76_P0.7300.15
19_Y121_A0.7230.15
42_V105_E0.7210.15
3_I6_L0.7190.15
8_P91_K0.7190.15
63_E121_A0.7160.15
41_G96_C0.7150.15
28_G59_A0.7140.15
84_A141_V0.7050.15
16_E21_G0.7030.15
91_K118_Y0.6890.14
66_V126_E0.6770.14
68_V139_T0.6720.14
3_I57_D0.6710.14
25_D104_H0.6700.14
75_I111_G0.6690.14
117_E126_E0.6620.14
56_L84_A0.6570.14
20_H39_T0.6560.14
34_Q100_E0.6560.14
49_V143_F0.6530.14
8_P88_S0.6490.13
7_G75_I0.6410.13
101_C138_L0.6410.13
135_D139_T0.6350.13
8_P73_T0.6320.13
38_L50_R0.6260.13
36_L78_T0.6250.13
8_P33_Q0.6170.13
85_Y88_S0.6130.13
10_L37_N0.6120.13
128_P142_E0.6100.13
8_P22_P0.6070.13
99_T144_A0.6030.13
72_P118_Y0.6010.13
40_E90_G0.6010.13
82_K92_L0.5930.12
105_E124_D0.5930.12
30_P104_H0.5820.12
64_G142_E0.5790.12
6_L23_A0.5760.12
19_Y33_Q0.5690.12
43_R92_L0.5660.12
36_L62_D0.5610.12
63_E120_I0.5600.12
97_P100_E0.5580.12
12_D32_R0.5570.12
31_Y139_T0.5510.12
60_V121_A0.5490.12
19_Y140_L0.5470.12
103_S128_P0.5440.11
48_D74_T0.5430.11
6_L83_G0.5410.11
41_G125_G0.5390.11
51_E73_T0.5350.11
6_L60_V0.5340.11
25_D32_R0.5330.11
64_G67_A0.5310.11
46_V143_F0.5270.11
13_P50_R0.5260.11
71_E91_K0.5230.11
25_D83_G0.5200.11
80_P83_G0.5110.11
4_T109_P0.5090.11
27_E107_C0.5080.11
48_D67_A0.5040.11
99_T110_A0.5030.11
41_G73_T0.5020.11
42_V118_Y0.5020.11
117_E140_L0.5010.11
97_P102_P0.5000.11
67_A80_P0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hikA 1 0.4324 26.3 0.948 Contact Map
1d2vC 2 0.3108 10.2 0.957 Contact Map
1c3gA 2 0.5203 8 0.959 Contact Map
2k5iA 1 0.6959 6.5 0.961 Contact Map
1giyD 1 0.5676 4.2 0.964 Contact Map
1kg2A 1 0.3311 3.9 0.965 Contact Map
2p26A 1 0.8108 3.7 0.965 Contact Map
2p28B 1 0.4662 3.5 0.966 Contact Map
2napA 1 0.3716 3.2 0.966 Contact Map
1rl2A 1 0.5811 3 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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