GREMLIN Database
Q9HPZ4 - Uncharacterized protein
UniProt: Q9HPZ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 124 (100)
Sequences: 10044 (6187)
Seq/√Len: 618.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_S104_E2.8041.00
45_K52_S2.7691.00
53_R57_R2.7081.00
69_N83_S2.7031.00
71_R83_S2.4741.00
75_A79_A2.4321.00
34_L68_V2.3591.00
69_N85_T2.2721.00
33_D47_S2.1161.00
34_L44_L1.9231.00
73_E81_Y1.9181.00
87_K105_W1.8141.00
73_E79_A1.7231.00
94_V97_A1.7141.00
97_A100_C1.6961.00
84_L88_G1.6701.00
35_Q92_F1.6511.00
60_D63_Q1.6291.00
93_P97_A1.6011.00
30_V58_V1.5691.00
39_K47_S1.5531.00
54_T57_R1.4921.00
38_E83_S1.4691.00
27_R61_D1.4481.00
89_E92_F1.4301.00
27_R58_V1.3811.00
67_F88_G1.3781.00
70_R80_T1.3661.00
38_E81_Y1.3601.00
18_S98_I1.3041.00
86_A89_E1.3011.00
21_Q65_L1.2961.00
90_S101_W1.2621.00
24_S61_D1.2421.00
87_K90_S1.2081.00
52_S56_S1.2051.00
18_S102_A1.1701.00
99_E103_E1.1531.00
72_L77_P1.1531.00
17_D106_L1.1441.00
34_L39_K1.1221.00
73_E77_P1.1221.00
63_Q68_V1.1181.00
24_S58_V1.1161.00
27_R62_L1.1091.00
42_N46_R1.1001.00
67_F91_L1.0841.00
39_K43_E1.0791.00
31_L84_L1.0731.00
87_K108_V1.0641.00
71_R81_Y1.0551.00
41_F56_S1.0511.00
74_E77_P1.0281.00
56_S60_D1.0271.00
40_R81_Y1.0041.00
54_T58_V0.9901.00
73_E78_V0.9881.00
72_L80_T0.9811.00
90_S105_W0.9781.00
50_A55_L0.9631.00
92_F96_D0.9521.00
83_S89_E0.9521.00
21_Q67_F0.9491.00
28_L95_F0.9461.00
24_S27_R0.9361.00
73_E76_S0.9141.00
72_L78_V0.9061.00
30_V48_T0.9041.00
91_L101_W0.9011.00
51_S54_T0.8951.00
41_F52_S0.8731.00
43_E46_R0.8711.00
66_G87_K0.8691.00
36_D39_K0.8571.00
27_R65_L0.8561.00
33_D44_L0.8431.00
96_D100_C0.8371.00
100_C104_E0.8231.00
16_I20_E0.8061.00
94_V98_I0.8041.00
93_P100_C0.8021.00
61_D65_L0.7991.00
42_N45_K0.7821.00
32_H35_Q0.7731.00
32_H99_E0.7651.00
11_A16_I0.7391.00
30_V50_A0.7341.00
72_L76_S0.7271.00
14_H103_E0.7231.00
76_S80_T0.7221.00
39_K44_L0.7101.00
11_A20_E0.7041.00
33_D36_D0.7001.00
26_W50_A0.6931.00
45_K55_L0.6891.00
26_W55_L0.6851.00
57_R61_D0.6831.00
17_D105_W0.6741.00
40_R73_E0.6661.00
96_D99_E0.6631.00
19_L91_L0.6631.00
35_Q96_D0.6621.00
34_L38_E0.6561.00
35_Q84_L0.6541.00
34_L63_Q0.6541.00
72_L75_A0.6541.00
50_A80_T0.6481.00
91_L94_V0.6361.00
105_W108_V0.6351.00
102_A106_L0.6351.00
63_Q72_L0.6331.00
15_V106_L0.6291.00
19_L98_I0.6291.00
36_D47_S0.6251.00
101_W105_W0.6151.00
31_L91_L0.6151.00
19_L28_L0.6131.00
37_G89_E0.6121.00
38_E44_L0.6001.00
17_D109_D0.6001.00
86_A90_S0.5981.00
87_K109_D0.5851.00
75_A78_V0.5821.00
77_P80_T0.5821.00
26_W54_T0.5801.00
62_L67_F0.5751.00
100_C103_E0.5691.00
11_A17_D0.5671.00
35_Q39_K0.5671.00
103_E106_L0.5651.00
29_I48_T0.5651.00
29_I33_D0.5511.00
33_D39_K0.5470.99
63_Q70_R0.5430.99
75_A81_Y0.5420.99
52_S58_V0.5350.99
40_R43_E0.5320.99
94_V102_A0.5310.99
15_V32_H0.5280.99
38_E43_E0.5270.99
43_E47_S0.5260.99
71_R74_E0.5240.99
87_K106_L0.5150.99
76_S79_A0.5150.99
16_I28_L0.5140.99
41_F45_K0.5120.99
42_N52_S0.5060.99
90_S93_P0.5050.99
104_E107_A0.5030.99
32_H41_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gcvA 3 0.879 99.9 0.4 Contact Map
4a5nA 2 0.8387 99.8 0.482 Contact Map
1yyvA 2 0.871 99.7 0.492 Contact Map
1z7uA 2 0.8871 99.7 0.508 Contact Map
2f2eA 4 0.9516 99.7 0.508 Contact Map
2hztA 2 0.7581 99.7 0.512 Contact Map
2fswA 2 0.8226 99.7 0.519 Contact Map
4hw0A 2 0.7903 99.6 0.544 Contact Map
3df8A 2 0.8145 99.5 0.572 Contact Map
4hqeA 2 0.8468 99.4 0.6 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.006 seconds.