GREMLIN Database
Q9HPZ3 - Transcription regulator
UniProt: Q9HPZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 133 (124)
Sequences: 4686 (2609)
Seq/√Len: 234.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_T21_Q3.0571.00
8_A16_T2.9441.00
23_R27_E2.9221.00
36_G124_S2.7521.00
84_R97_V2.6811.00
23_R29_G2.4581.00
87_H92_E2.4111.00
51_G103_G2.2371.00
85_E92_E2.2221.00
25_L103_G2.2171.00
28_Q97_V2.2081.00
21_Q50_V2.1111.00
54_T100_E2.0501.00
96_V122_I2.0241.00
9_D12_D2.0171.00
48_S130_E1.8871.00
61_T73_W1.8671.00
41_R129_F1.8071.00
52_C101_C1.7251.00
73_W115_P1.6911.00
54_T99_A1.6671.00
61_T74_D1.6591.00
25_L51_G1.6301.00
57_F120_Y1.6211.00
42_D65_A1.6181.00
55_T76_A1.5641.00
110_Q118_E1.5451.00
25_L50_V1.5201.00
32_R35_S1.5131.00
24_V125_V1.5021.00
28_Q84_R1.5011.00
82_E97_V1.4621.00
54_T80_A1.4601.00
83_R118_E1.4371.00
73_W116_T1.4341.00
39_V42_D1.3771.00
38_H41_R1.3741.00
48_S53_D1.3581.00
88_S91_M1.3571.00
53_D128_D1.3461.00
98_C101_C1.3261.00
20_D23_R1.3071.00
26_R51_G1.2941.00
82_E102_G1.2921.00
89_N92_E1.2751.00
59_G62_K1.2621.00
43_E131_P1.2531.00
82_E99_A1.2381.00
42_D64_D1.2191.00
10_D27_E1.2121.00
97_V102_G1.1921.00
111_D117_G1.1891.00
37_D124_S1.1551.00
20_D125_V1.1511.00
46_T76_A1.1381.00
37_D128_D1.1151.00
12_D15_A1.0681.00
10_D26_R1.0631.00
12_D16_T1.0621.00
86_D93_R1.0611.00
46_T55_T1.0411.00
41_R47_Y1.0221.00
49_C98_C1.0081.00
44_D60_E0.9941.00
77_D80_A0.9621.00
22_Y26_R0.9561.00
13_W16_T0.9531.00
43_E129_F0.9471.00
11_T15_A0.9331.00
83_R94_T0.9321.00
48_S128_D0.9231.00
13_W26_R0.9211.00
49_C101_C0.9141.00
19_D23_R0.9081.00
34_F40_D0.9051.00
34_F39_V0.9001.00
10_D14_A0.8890.99
25_L126_A0.8770.99
80_A100_E0.8760.99
14_A22_Y0.8610.99
38_H129_F0.8540.99
73_W114_D0.8530.99
49_C52_C0.8490.99
22_Y27_E0.8450.99
87_H90_G0.8390.99
42_D67_C0.8340.99
80_A99_A0.8320.99
52_C98_C0.8290.99
31_E125_V0.8230.99
20_D24_V0.8170.99
13_W51_G0.8110.99
48_S55_T0.8100.99
51_G101_C0.8060.99
63_F67_C0.8050.99
8_A12_D0.7850.99
38_H124_S0.7730.98
105_L122_I0.7620.98
39_V64_D0.7610.98
96_V105_L0.7580.98
8_A13_W0.7560.98
62_K65_A0.7530.98
63_F73_W0.7510.98
20_D32_R0.7450.98
47_Y59_G0.7370.98
10_D22_Y0.7220.98
81_I105_L0.7210.98
110_Q117_G0.7190.98
9_D13_W0.7110.97
28_Q102_G0.7100.97
40_D64_D0.7090.97
122_I127_L0.7080.97
28_Q88_S0.7060.97
36_G39_V0.7030.97
58_D76_A0.6980.97
50_V103_G0.6830.97
111_D114_D0.6780.97
41_R62_K0.6770.97
50_V126_A0.6770.97
79_D99_A0.6750.96
39_V71_S0.6730.96
86_D107_H0.6670.96
75_A83_R0.6670.96
63_F116_T0.6580.96
108_V118_E0.6530.96
44_D59_G0.6520.96
26_R103_G0.6500.96
20_D29_G0.6490.96
50_V128_D0.6420.95
75_A79_D0.6350.95
57_F108_V0.6250.95
30_T104_H0.6250.95
58_D61_T0.6240.95
67_C71_S0.6230.94
75_A120_Y0.6180.94
13_W22_Y0.6110.94
33_P89_N0.6100.94
96_V120_Y0.6090.94
53_D130_E0.6080.94
49_C103_G0.6080.94
46_T58_D0.6020.93
95_E121_C0.6020.93
113_P117_G0.6010.93
41_R124_S0.6000.93
74_D83_R0.5980.93
28_Q89_N0.5960.93
104_H107_H0.5920.93
93_R107_H0.5900.93
86_D91_M0.5870.93
83_R110_Q0.5820.92
21_Q125_V0.5810.92
41_R59_G0.5780.92
74_D77_D0.5730.92
57_F83_R0.5730.92
11_T14_A0.5710.92
10_D13_W0.5670.91
22_Y51_G0.5650.91
67_C90_G0.5590.91
87_H91_M0.5580.91
95_E104_H0.5580.91
58_D74_D0.5550.90
41_R72_F0.5490.90
122_I126_A0.5480.90
109_F119_R0.5450.90
59_G129_F0.5400.89
35_S39_V0.5380.89
14_A18_T0.5340.89
75_A81_I0.5340.89
88_S93_R0.5310.88
7_D10_D0.5310.88
39_V47_Y0.5290.88
83_R96_V0.5290.88
44_D131_P0.5260.88
30_T95_E0.5250.88
16_T22_Y0.5180.87
33_P36_G0.5180.87
80_A101_C0.5170.87
96_V108_V0.5170.87
57_F96_V0.5130.87
109_F121_C0.5120.86
112_G118_E0.5110.86
83_R120_Y0.5110.86
75_A96_V0.5060.86
86_D94_T0.5050.86
113_P118_E0.5020.85
110_Q113_P0.5010.85
74_D115_P0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cxkA 2 0.9774 100 0.02 Contact Map
2k8dA 1 0.9925 100 0.024 Contact Map
3hcgA 3 0.9699 100 0.037 Contact Map
3e0oA 3 0.9624 100 0.037 Contact Map
3e0mA 4 1 100 0.038 Contact Map
3hcjA 1 1 100 0.046 Contact Map
2l1uA 1 0.9323 100 0.05 Contact Map
3maoA 1 0.7444 100 0.271 Contact Map
2kv1A 1 0.7895 100 0.276 Contact Map
5amhA 1 0.6692 66.7 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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