GREMLIN Database
Q9HPZ1 - Uncharacterized protein
UniProt: Q9HPZ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 132 (123)
Sequences: 5631 (4131)
Seq/√Len: 372.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_N61_D3.2841.00
79_T89_A2.5201.00
32_M102_G2.3491.00
66_V99_V2.2851.00
63_N101_T2.2481.00
110_D113_T2.2121.00
59_S103_E2.1411.00
66_V72_V2.0231.00
7_T73_T2.0221.00
7_T75_G1.9861.00
27_V30_T1.9501.00
75_G91_E1.9421.00
32_M100_A1.9151.00
9_T71_T1.8871.00
94_D97_G1.8761.00
80_H87_T1.8351.00
29_V60_V1.8101.00
29_V58_L1.7961.00
77_S89_A1.7811.00
75_G93_R1.7371.00
23_V31_Y1.7091.00
93_R98_V1.6901.00
121_D125_R1.6761.00
9_T73_T1.6401.00
91_E98_V1.6261.00
61_D101_T1.6071.00
60_V100_A1.5671.00
52_D111_P1.5541.00
70_D94_D1.5421.00
87_T103_E1.5151.00
74_V92_V1.5101.00
90_Y104_T1.5091.00
84_T116_P1.4731.00
32_M92_V1.4591.00
11_D71_T1.4311.00
82_G85_S1.4271.00
79_T103_E1.4191.00
65_P114_G1.3941.00
91_E101_T1.3931.00
11_D41_T1.3751.00
120_P123_W1.3721.00
85_S105_V1.3451.00
38_A42_D1.3431.00
89_A103_E1.2921.00
124_R128_D1.2881.00
94_D99_V1.2841.00
35_A76_A1.2791.00
26_A30_T1.2711.00
15_Q30_T1.2621.00
33_E36_R1.2571.00
56_V61_D1.2201.00
41_T69_A1.1951.00
109_L114_G1.1841.00
84_T107_V1.1771.00
11_D38_A1.1701.00
12_V23_V1.1511.00
83_D118_S1.1431.00
13_R16_D1.1341.00
35_A74_V1.1271.00
58_L104_T1.1151.00
6_F76_A1.1131.00
64_R97_G1.0921.00
57_N105_V1.0801.00
71_T95_D1.0761.00
45_G48_P1.0671.00
45_G49_T1.0521.00
110_D117_R1.0481.00
9_T95_D1.0271.00
25_N58_L1.0231.00
87_T105_V1.0071.00
63_N98_V1.0061.00
16_D30_T0.9991.00
77_S91_E0.9931.00
54_V109_L0.9861.00
56_V105_V0.9601.00
79_T87_T0.9581.00
98_V101_T0.9461.00
25_N62_F0.9371.00
76_A90_Y0.9161.00
31_Y72_V0.9091.00
73_T95_D0.9001.00
10_V74_V0.8901.00
57_N103_E0.8861.00
122_D125_R0.8761.00
125_R128_D0.8691.00
72_V99_V0.8671.00
51_L108_A0.8551.00
6_F42_D0.8531.00
89_A101_T0.8451.00
78_I88_M0.8351.00
8_E38_A0.8351.00
121_D124_R0.8331.00
50_D112_D0.8281.00
84_T118_S0.8271.00
12_V31_Y0.8211.00
56_V63_N0.8201.00
36_R55_V0.8191.00
20_M54_V0.8091.00
32_M60_V0.8031.00
13_R34_Q0.7881.00
13_R30_T0.7811.00
36_R90_Y0.7721.00
10_V31_Y0.7721.00
121_D128_D0.7691.00
25_N29_V0.7531.00
8_E35_A0.7511.00
30_T33_E0.7501.00
58_L102_G0.7421.00
14_Y17_H0.7321.00
20_M24_N0.7201.00
14_Y19_T0.7121.00
11_D69_A0.7050.99
81_V124_R0.7040.99
24_N33_E0.7020.99
74_V90_Y0.6970.99
76_A88_M0.6950.99
73_T96_D0.6900.99
39_Y78_I0.6640.99
38_A41_T0.6630.99
16_D31_Y0.6470.99
10_V34_Q0.6420.99
56_V107_V0.6420.99
24_N27_V0.6270.99
8_E34_Q0.6250.99
117_R123_W0.6220.99
27_V31_Y0.6190.99
81_V127_I0.6160.99
73_T93_R0.6140.99
36_R106_Q0.6090.98
58_L62_F0.6080.98
86_F119_V0.6050.98
122_D126_A0.6010.98
49_T122_D0.5950.98
22_H65_P0.5930.98
88_M106_Q0.5920.98
15_Q26_A0.5860.98
70_D95_D0.5850.98
55_V106_Q0.5810.98
56_V85_S0.5800.98
111_P114_G0.5750.98
16_D27_V0.5750.98
14_Y20_M0.5750.98
53_M108_A0.5710.98
20_M25_N0.5680.98
90_Y106_Q0.5670.98
14_Y68_F0.5660.98
34_Q38_A0.5650.98
92_V100_A0.5640.97
54_V111_P0.5640.97
25_N36_R0.5610.97
10_V13_R0.5600.97
22_H114_G0.5590.97
15_Q24_N0.5590.97
66_V100_A0.5590.97
108_A120_P0.5580.97
46_R49_T0.5540.97
85_S124_R0.5510.97
119_V124_R0.5450.97
28_Y100_A0.5440.97
55_V104_T0.5440.97
56_V84_T0.5420.97
17_H21_G0.5410.97
85_S107_V0.5390.97
23_V66_V0.5390.97
39_Y76_A0.5350.97
15_Q34_Q0.5340.97
83_D124_R0.5310.96
8_E13_R0.5290.96
22_H54_V0.5260.96
61_D103_E0.5250.96
29_V62_F0.5240.96
20_M52_D0.5190.96
17_H68_F0.5160.96
35_A90_Y0.5150.96
28_Y66_V0.5140.96
124_R127_I0.5130.96
36_R104_T0.5130.96
70_D99_V0.5080.95
81_V86_F0.5040.95
60_V102_G0.5030.95
82_G124_R0.5030.95
80_H105_V0.5020.95
118_S121_D0.5000.95
36_R88_M0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2essA 2 0.9697 100 0.287 Contact Map
2nujA 3 1 100 0.289 Contact Map
2o5uA 4 1 100 0.293 Contact Map
2ownA 3 1 100 0.294 Contact Map
2hx5A 4 0.9924 100 0.303 Contact Map
2oafA 4 1 100 0.305 Contact Map
1njkA 4 0.9697 100 0.305 Contact Map
3ck1A 4 0.9924 100 0.306 Contact Map
2w3xA 4 1 100 0.308 Contact Map
3hm0A 4 0.9015 100 0.308 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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