Q9HPY8 - HALSA - GREMLIN Contacts

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Q9HPY8 - Uncharacterized protein

UniProt:	Q9HPY8	Sequences: MRAVGEALERYSAGVYRTREFETHTPDHDAAVPPSAFVRPASGAAGDTTQWVRGEHLQTGTDALLPAPRVVFPPPNPDSGHPITTGLGLGTAGADALLSGLYEVIERDATMLAWYSTFEPLALAVPLPSDTADDDTPADAFAALARRARAESLSVTPLLCTQDVDVPVVAVAVHREAWPQFAVGSAADLNAEAAAADALAEALQNWMELRALGPEPASQESGAIGAYADRPPAAEAFIDADTTVPVDTVGPADPPTDPASELTAVLDAVADAGLDAYGARLTPRDIDAAGFEAVRVLVPAAQPLFVSEPRFGERARTVPSTLGFEPRLDRRFHPFP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	336 (302)
Sequences:	1605 (1184)
Seq/√Len:	68.1

ECOLI - YCAO
HALSA - Q9HPY8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
101_L	298_V	6.239	1.00
54_G	277_Y	4.939	1.00
168_V	187_A	4.867	1.00
157_P	195_A	4.448	1.00
91_T	95_D	4.089	1.00
154_S	176_E	3.393	1.00
123_L	169_V	3.336	1.00
266_L	276_A	3.175	1.00
157_P	171_V	3.117	1.00
56_H	59_T	3.001	1.00
97_L	278_G	2.975	1.00
104_V	301_A	2.848	1.00
173_V	202_A	2.776	1.00
157_P	169_V	2.753	1.00
53_R	62_D	2.732	1.00
155_V	199_L	2.689	1.00
125_V	157_P	2.639	1.00
278_G	296_V	2.624	1.00
188_D	193_A	2.619	1.00
54_G	279_A	2.618	1.00
105_I	166_V	2.598	1.00
58_Q	275_D	2.494	1.00
56_H	275_D	2.439	1.00
30_A	61_T	2.413	1.00
186_A	197_D	2.294	1.00
37_F	69_R	2.249	1.00
160_C	168_V	2.225	1.00
197_D	200_A	2.176	1.00
65_L	279_A	2.172	1.00
27_D	31_A	2.134	1.00
53_R	64_L	2.120	1.00
274_L	298_V	2.083	1.00
55_E	60_G	2.082	1.00
40_P	44_A	1.988	1.00
259_A	263_T	1.947	1.00
98_L	265_V	1.856	1.00
89_L	293_A	1.852	1.00
245_P	248_T	1.829	1.00
255_P	261_E	1.768	1.00
171_V	198_A	1.729	1.00
88_G	100_G	1.719	1.00
65_L	297_L	1.708	1.00
122_A	156_T	1.696	1.00
13_A	87_L	1.684	0.99
153_L	173_V	1.675	0.99
65_L	277_Y	1.635	0.99
266_L	270_A	1.630	0.99
160_C	170_A	1.600	0.99
110_T	185_S	1.593	0.99
104_V	298_V	1.579	0.99
108_D	314_R	1.578	0.99
124_A	131_T	1.568	0.99
54_G	297_L	1.541	0.99
120_P	160_C	1.524	0.99
193_A	197_D	1.508	0.99
97_L	296_V	1.486	0.99
58_Q	266_L	1.482	0.99
58_Q	270_A	1.473	0.99
12_S	286_I	1.470	0.99
274_L	300_A	1.469	0.99
122_A	158_L	1.460	0.99
112_L	161_T	1.458	0.99
102_Y	187_A	1.457	0.99
100_G	296_V	1.443	0.98
6_E	9_E	1.437	0.98
85_T	104_V	1.430	0.98
90_G	95_D	1.414	0.98
101_L	276_A	1.408	0.98
102_Y	189_L	1.404	0.98
141_F	195_A	1.403	0.98
269_V	276_A	1.386	0.98
96_A	294_V	1.378	0.98
87_L	295_R	1.377	0.98
161_T	167_P	1.373	0.98
141_F	199_L	1.372	0.98
264_A	268_A	1.364	0.98
133_D	192_E	1.364	0.98
282_T	290_G	1.364	0.98
70_V	281_L	1.356	0.98
98_L	262_L	1.351	0.98
28_H	31_A	1.339	0.97
98_L	102_Y	1.339	0.97
94_A	259_A	1.335	0.97
268_A	271_D	1.332	0.97
213_G	216_P	1.319	0.97
153_L	206_W	1.312	0.97
186_A	200_A	1.307	0.97
91_T	186_A	1.300	0.97
13_A	281_L	1.297	0.97
123_L	157_P	1.277	0.97
95_D	186_A	1.265	0.96
63_A	277_Y	1.258	0.96
93_G	294_V	1.249	0.96
267_D	270_A	1.247	0.96
247_D	251_P	1.246	0.96
99_S	197_D	1.246	0.96
52_V	67_A	1.246	0.96
169_V	195_A	1.245	0.96
227_Y	230_R	1.235	0.96
12_S	283_P	1.223	0.96
263_T	267_D	1.223	0.96
223_A	226_A	1.216	0.95
210_R	216_P	1.214	0.95
255_P	260_S	1.209	0.95
37_F	297_L	1.205	0.95
140_A	196_A	1.181	0.95
146_R	150_A	1.179	0.95
148_A	203_L	1.173	0.94
70_V	279_A	1.171	0.94
170_A	185_S	1.170	0.94
188_D	197_D	1.165	0.94
302_Q	312_G	1.164	0.94
186_A	204_Q	1.159	0.94
103_E	201_E	1.145	0.94
210_R	213_G	1.145	0.94
91_T	188_D	1.142	0.94
2_R	204_Q	1.134	0.93
235_E	239_D	1.129	0.93
97_L	262_L	1.128	0.93
6_E	201_E	1.116	0.93
105_I	164_V	1.110	0.93
169_V	191_A	1.106	0.92
104_V	296_V	1.092	0.92
91_T	200_A	1.091	0.92
98_L	258_P	1.088	0.92
121_L	159_L	1.085	0.92
26_P	48_T	1.084	0.92
142_A	146_R	1.082	0.92
6_E	103_E	1.073	0.91
257_D	260_S	1.061	0.91
41_A	44_A	1.061	0.91
95_D	188_D	1.059	0.91
23_T	50_Q	1.052	0.90
90_G	188_D	1.046	0.90
55_E	59_T	1.040	0.90
154_S	174_H	1.038	0.90
244_V	248_T	1.038	0.90
6_E	10_R	1.035	0.90
101_L	265_V	1.032	0.90
5_G	291_F	1.031	0.90
112_L	116_S	1.020	0.89
54_G	70_V	1.019	0.89
245_P	249_V	1.014	0.89
98_L	189_L	1.012	0.89
269_V	274_L	1.011	0.89
255_P	264_A	1.010	0.89
106_E	204_Q	1.005	0.88
139_D	143_A	1.003	0.88
126_P	145_A	0.999	0.88
298_V	301_A	0.994	0.88
237_F	240_A	0.985	0.87
5_G	91_T	0.980	0.87
188_D	194_A	0.978	0.87
166_V	265_V	0.971	0.87
93_G	97_L	0.962	0.86
159_L	167_P	0.959	0.86
109_A	162_Q	0.954	0.86
54_G	65_L	0.952	0.85
60_G	270_A	0.947	0.85
85_T	188_D	0.945	0.85
97_L	294_V	0.936	0.84
161_T	164_V	0.931	0.84
95_D	197_D	0.926	0.84
72_F	75_P	0.924	0.84
65_L	70_V	0.924	0.84
148_A	202_A	0.918	0.83
111_M	302_Q	0.918	0.83
5_G	80_G	0.918	0.83
269_V	301_A	0.906	0.82
260_S	263_T	0.901	0.82
278_G	294_V	0.892	0.81
226_A	230_R	0.883	0.81
100_G	132_A	0.882	0.81
36_A	275_D	0.880	0.81
186_A	193_A	0.879	0.81
57_L	278_G	0.878	0.80
133_D	142_A	0.876	0.80
90_G	99_S	0.875	0.80
26_P	29_D	0.874	0.80
208_E	213_G	0.872	0.80
155_V	202_A	0.868	0.80
282_T	286_I	0.866	0.80
90_G	186_A	0.866	0.80
40_P	45_A	0.862	0.79
111_M	304_L	0.857	0.79
32_V	297_L	0.856	0.79
101_L	269_V	0.852	0.78
200_A	204_Q	0.852	0.78
211_A	216_P	0.852	0.78
31_A	64_L	0.852	0.78
85_T	90_G	0.850	0.78
59_T	275_D	0.850	0.78
267_D	271_D	0.848	0.78
91_T	197_D	0.843	0.78
89_L	99_S	0.839	0.77
248_T	253_D	0.836	0.77
149_R	154_S	0.828	0.76
23_T	259_A	0.826	0.76
232_P	237_F	0.825	0.76
9_E	201_E	0.825	0.76
11_Y	285_D	0.823	0.76
107_R	201_E	0.823	0.76
143_A	147_R	0.823	0.76
124_A	243_T	0.822	0.76
234_A	238_I	0.818	0.76
6_E	106_E	0.817	0.75
283_P	292_E	0.816	0.75
189_L	261_E	0.815	0.75
112_L	314_R	0.814	0.75
33_P	36_A	0.812	0.75
163_D	314_R	0.805	0.74
141_F	196_A	0.804	0.74
85_T	304_L	0.797	0.74
163_D	272_A	0.797	0.74
210_R	215_E	0.795	0.73
67_A	71_V	0.795	0.73
51_W	54_G	0.788	0.73
93_G	280_R	0.782	0.72
223_A	242_T	0.779	0.72
56_H	276_A	0.771	0.71
5_G	212_L	0.770	0.71
232_P	236_A	0.765	0.71
182_A	209_L	0.761	0.70
2_R	90_G	0.760	0.70
75_P	316_R	0.758	0.70
184_G	198_A	0.756	0.70
2_R	193_A	0.754	0.69
258_P	261_E	0.753	0.69
173_V	206_W	0.746	0.69
112_L	163_D	0.745	0.68
111_M	307_S	0.745	0.68
101_L	297_L	0.740	0.68
86_G	103_E	0.739	0.68
109_A	161_T	0.737	0.68
171_V	195_A	0.737	0.68
276_A	298_V	0.729	0.67
57_L	97_L	0.727	0.67
84_T	304_L	0.725	0.66
167_P	268_A	0.725	0.66
301_A	314_R	0.725	0.66
161_T	166_V	0.725	0.66
92_A	95_D	0.724	0.66
234_A	237_F	0.724	0.66
214_P	217_A	0.719	0.66
90_G	204_Q	0.717	0.66
100_G	305_F	0.715	0.65
95_D	299_P	0.714	0.65
202_A	206_W	0.714	0.65
186_A	189_L	0.714	0.65
68_P	71_V	0.714	0.65
149_R	176_E	0.712	0.65
282_T	302_Q	0.711	0.65
103_E	107_R	0.710	0.65
110_T	113_A	0.705	0.64
145_A	155_V	0.705	0.64
84_T	174_H	0.704	0.64
9_E	106_E	0.703	0.64
184_G	202_A	0.701	0.64
103_E	106_E	0.700	0.64
84_T	220_E	0.699	0.64
85_T	95_D	0.698	0.63
84_T	108_D	0.698	0.63
6_E	107_R	0.697	0.63
41_A	316_R	0.696	0.63
313_E	316_R	0.693	0.63
20_E	23_T	0.692	0.63
236_A	239_D	0.692	0.63
152_S	176_E	0.692	0.63
33_P	37_F	0.691	0.63
148_A	151_E	0.686	0.62
70_V	87_L	0.685	0.62
89_L	197_D	0.684	0.62
5_G	87_L	0.683	0.62
161_T	165_D	0.682	0.62
211_A	215_E	0.677	0.61
156_T	174_H	0.677	0.61
101_L	266_L	0.673	0.61
21_F	64_L	0.673	0.61
70_V	297_L	0.673	0.61
212_L	216_P	0.672	0.61
112_L	302_Q	0.671	0.60
84_T	87_L	0.670	0.60
24_H	27_D	0.669	0.60
12_S	50_Q	0.668	0.60
27_D	36_A	0.666	0.60
95_D	200_A	0.665	0.60
5_G	111_M	0.661	0.59
87_L	281_L	0.660	0.59
108_D	114_W	0.659	0.59
169_V	172_A	0.658	0.59
28_H	32_V	0.654	0.58
108_D	163_D	0.654	0.58
163_D	298_V	0.650	0.58
49_T	79_S	0.650	0.58
71_V	295_R	0.648	0.58
54_G	63_A	0.647	0.58
86_G	201_E	0.646	0.58
102_Y	265_V	0.645	0.57
106_E	201_E	0.641	0.57
146_R	149_R	0.641	0.57
88_G	294_V	0.641	0.57
37_F	51_W	0.641	0.57
60_G	151_E	0.640	0.57
31_A	34_P	0.639	0.57
192_E	244_V	0.638	0.57
259_A	266_L	0.635	0.56
10_R	14_G	0.635	0.56
183_V	205_N	0.635	0.56
34_P	280_R	0.635	0.56
118_F	121_L	0.633	0.56
88_G	280_R	0.632	0.56
60_G	240_A	0.632	0.56
91_T	204_Q	0.632	0.56
99_S	186_A	0.631	0.56
108_D	198_A	0.631	0.56
78_D	81_H	0.626	0.55
256_T	267_D	0.626	0.55
124_A	133_D	0.624	0.55
84_T	188_D	0.623	0.55
228_A	231_P	0.621	0.55
123_L	185_S	0.618	0.54
251_P	271_D	0.617	0.54
2_R	197_D	0.614	0.54
253_D	256_T	0.614	0.54
100_G	266_L	0.613	0.54
210_R	214_P	0.613	0.54
270_A	275_D	0.612	0.53
87_L	202_A	0.612	0.53
18_T	21_F	0.609	0.53
85_T	107_R	0.608	0.53
149_R	245_P	0.606	0.53
85_T	186_A	0.604	0.53
172_A	183_V	0.603	0.52
109_A	168_V	0.601	0.52
95_D	99_S	0.601	0.52
62_D	277_Y	0.600	0.52
88_G	106_E	0.600	0.52
99_S	205_N	0.600	0.52
208_E	211_A	0.599	0.52
221_S	230_R	0.598	0.52
21_F	24_H	0.596	0.52
5_G	89_L	0.595	0.51
171_V	175_R	0.595	0.51
110_T	230_R	0.594	0.51
263_T	271_D	0.593	0.51
61_T	260_S	0.593	0.51
76_N	246_V	0.591	0.51
112_L	162_Q	0.590	0.51
51_W	279_A	0.588	0.51
59_T	92_A	0.585	0.50
211_A	214_P	0.585	0.50
184_G	201_E	0.584	0.50
115_Y	302_Q	0.582	0.50
54_G	62_D	0.582	0.50
8_L	172_A	0.580	0.50
97_L	100_G	0.578	0.49
98_L	101_L	0.577	0.49
244_V	249_V	0.575	0.49
3_A	106_E	0.575	0.49
113_A	120_P	0.572	0.49
14_G	208_E	0.571	0.49
29_D	271_D	0.570	0.48
145_A	199_L	0.569	0.48
204_Q	305_F	0.567	0.48
283_P	291_F	0.567	0.48
34_P	45_A	0.564	0.48
18_T	57_L	0.563	0.48
277_Y	300_A	0.563	0.48
12_S	282_T	0.561	0.47
87_L	312_G	0.560	0.47
57_L	262_L	0.560	0.47
14_G	205_N	0.560	0.47
215_E	218_S	0.560	0.47
20_E	24_H	0.560	0.47
161_T	180_Q	0.558	0.47
232_P	235_E	0.557	0.47
51_W	282_T	0.556	0.47
194_A	297_L	0.554	0.47
133_D	235_E	0.553	0.46
286_I	290_G	0.553	0.46
164_V	168_V	0.552	0.46
142_A	145_A	0.551	0.46
279_A	297_L	0.551	0.46
106_E	167_P	0.551	0.46
219_Q	223_A	0.548	0.46
2_R	200_A	0.547	0.46
147_R	155_V	0.545	0.45
89_L	291_F	0.545	0.45
158_L	306_V	0.544	0.45
304_L	308_E	0.544	0.45
188_D	200_A	0.543	0.45
170_A	175_R	0.542	0.45
226_A	231_P	0.542	0.45
206_W	210_R	0.541	0.45
143_A	146_R	0.540	0.45
90_G	106_E	0.539	0.45
23_T	271_D	0.538	0.45
81_H	295_R	0.538	0.45
133_D	271_D	0.538	0.45
171_V	199_L	0.536	0.44
121_L	316_R	0.536	0.44
10_R	114_W	0.535	0.44
99_S	200_A	0.535	0.44
167_P	291_F	0.534	0.44
56_H	277_Y	0.533	0.44
91_T	193_A	0.532	0.44
141_F	192_E	0.532	0.44
171_V	211_A	0.531	0.44
280_R	292_E	0.531	0.44
160_C	172_A	0.531	0.44
302_Q	313_E	0.531	0.44
220_E	226_A	0.530	0.44
99_S	302_Q	0.529	0.44
87_L	206_W	0.529	0.44
211_A	217_A	0.527	0.43
197_D	204_Q	0.527	0.43
189_L	265_V	0.527	0.43
235_E	243_T	0.526	0.43
269_V	272_A	0.526	0.43
303_P	307_S	0.526	0.43
146_R	177_A	0.522	0.43
83_I	185_S	0.521	0.43
14_G	212_L	0.521	0.43
131_T	246_V	0.520	0.43
243_T	247_D	0.519	0.42
171_V	202_A	0.516	0.42
57_L	266_L	0.516	0.42
21_F	225_G	0.516	0.42
191_A	249_V	0.515	0.42
34_P	40_P	0.514	0.42
182_A	205_N	0.514	0.42
82_P	85_T	0.513	0.42
84_T	230_R	0.513	0.42
65_L	261_E	0.513	0.42
186_A	194_A	0.511	0.41
5_G	114_W	0.510	0.41
14_G	210_R	0.510	0.41
118_F	160_C	0.510	0.41
197_D	302_Q	0.509	0.41
312_G	315_A	0.509	0.41
108_D	184_G	0.508	0.41
109_A	112_L	0.507	0.41
99_S	148_A	0.506	0.41
248_T	251_P	0.505	0.41
47_D	77_P	0.505	0.41
247_D	252_A	0.504	0.41
84_T	114_W	0.504	0.41
175_R	234_A	0.503	0.41
89_L	205_N	0.503	0.41
189_L	227_Y	0.503	0.41
175_R	276_A	0.501	0.40
153_L	202_A	0.501	0.40
26_P	30_A	0.500	0.40

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4v1tA	2	0.9464	100	0.213	Contact Map
4q86A	3	0.9137	100	0.338	Contact Map
1tafA	2	0.1339	13.2	0.965	Contact Map
4wyqB	1	0.2232	10.2	0.966	Contact Map
4j56E	1	0.2798	9.4	0.967	Contact Map
2e5kA	1	0.2351	9	0.967	Contact Map
3s81A	2	0.4345	6.1	0.97	Contact Map
4dkkA	2	0.2946	6	0.97	Contact Map
3uoeA	2	0.2857	6	0.97	Contact Map
2iw1A	1	0.2738	5.7	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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