GREMLIN Database
Q9HPY8 - Uncharacterized protein
UniProt: Q9HPY8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 336 (302)
Sequences: 1605 (1184)
Seq/√Len: 68.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_L298_V6.2391.00
54_G277_Y4.9391.00
168_V187_A4.8671.00
157_P195_A4.4481.00
91_T95_D4.0891.00
154_S176_E3.3931.00
123_L169_V3.3361.00
266_L276_A3.1751.00
157_P171_V3.1171.00
56_H59_T3.0011.00
97_L278_G2.9751.00
104_V301_A2.8481.00
173_V202_A2.7761.00
157_P169_V2.7531.00
53_R62_D2.7321.00
155_V199_L2.6891.00
125_V157_P2.6391.00
278_G296_V2.6241.00
188_D193_A2.6191.00
54_G279_A2.6181.00
105_I166_V2.5981.00
58_Q275_D2.4941.00
56_H275_D2.4391.00
30_A61_T2.4131.00
186_A197_D2.2941.00
37_F69_R2.2491.00
160_C168_V2.2251.00
197_D200_A2.1761.00
65_L279_A2.1721.00
27_D31_A2.1341.00
53_R64_L2.1201.00
274_L298_V2.0831.00
55_E60_G2.0821.00
40_P44_A1.9881.00
259_A263_T1.9471.00
98_L265_V1.8561.00
89_L293_A1.8521.00
245_P248_T1.8291.00
255_P261_E1.7681.00
171_V198_A1.7291.00
88_G100_G1.7191.00
65_L297_L1.7081.00
122_A156_T1.6961.00
13_A87_L1.6840.99
153_L173_V1.6750.99
65_L277_Y1.6350.99
266_L270_A1.6300.99
160_C170_A1.6000.99
110_T185_S1.5930.99
104_V298_V1.5790.99
108_D314_R1.5780.99
124_A131_T1.5680.99
54_G297_L1.5410.99
120_P160_C1.5240.99
193_A197_D1.5080.99
97_L296_V1.4860.99
58_Q266_L1.4820.99
58_Q270_A1.4730.99
12_S286_I1.4700.99
274_L300_A1.4690.99
122_A158_L1.4600.99
112_L161_T1.4580.99
102_Y187_A1.4570.99
100_G296_V1.4430.98
6_E9_E1.4370.98
85_T104_V1.4300.98
90_G95_D1.4140.98
101_L276_A1.4080.98
102_Y189_L1.4040.98
141_F195_A1.4030.98
269_V276_A1.3860.98
96_A294_V1.3780.98
87_L295_R1.3770.98
161_T167_P1.3730.98
141_F199_L1.3720.98
264_A268_A1.3640.98
133_D192_E1.3640.98
282_T290_G1.3640.98
70_V281_L1.3560.98
98_L262_L1.3510.98
28_H31_A1.3390.97
98_L102_Y1.3390.97
94_A259_A1.3350.97
268_A271_D1.3320.97
213_G216_P1.3190.97
153_L206_W1.3120.97
186_A200_A1.3070.97
91_T186_A1.3000.97
13_A281_L1.2970.97
123_L157_P1.2770.97
95_D186_A1.2650.96
63_A277_Y1.2580.96
93_G294_V1.2490.96
267_D270_A1.2470.96
247_D251_P1.2460.96
99_S197_D1.2460.96
52_V67_A1.2460.96
169_V195_A1.2450.96
227_Y230_R1.2350.96
12_S283_P1.2230.96
263_T267_D1.2230.96
223_A226_A1.2160.95
210_R216_P1.2140.95
255_P260_S1.2090.95
37_F297_L1.2050.95
140_A196_A1.1810.95
146_R150_A1.1790.95
148_A203_L1.1730.94
70_V279_A1.1710.94
170_A185_S1.1700.94
188_D197_D1.1650.94
302_Q312_G1.1640.94
186_A204_Q1.1590.94
103_E201_E1.1450.94
210_R213_G1.1450.94
91_T188_D1.1420.94
2_R204_Q1.1340.93
235_E239_D1.1290.93
97_L262_L1.1280.93
6_E201_E1.1160.93
105_I164_V1.1100.93
169_V191_A1.1060.92
104_V296_V1.0920.92
91_T200_A1.0910.92
98_L258_P1.0880.92
121_L159_L1.0850.92
26_P48_T1.0840.92
142_A146_R1.0820.92
6_E103_E1.0730.91
257_D260_S1.0610.91
41_A44_A1.0610.91
95_D188_D1.0590.91
23_T50_Q1.0520.90
90_G188_D1.0460.90
55_E59_T1.0400.90
154_S174_H1.0380.90
244_V248_T1.0380.90
6_E10_R1.0350.90
101_L265_V1.0320.90
5_G291_F1.0310.90
112_L116_S1.0200.89
54_G70_V1.0190.89
245_P249_V1.0140.89
98_L189_L1.0120.89
269_V274_L1.0110.89
255_P264_A1.0100.89
106_E204_Q1.0050.88
139_D143_A1.0030.88
126_P145_A0.9990.88
298_V301_A0.9940.88
237_F240_A0.9850.87
5_G91_T0.9800.87
188_D194_A0.9780.87
166_V265_V0.9710.87
93_G97_L0.9620.86
159_L167_P0.9590.86
109_A162_Q0.9540.86
54_G65_L0.9520.85
60_G270_A0.9470.85
85_T188_D0.9450.85
97_L294_V0.9360.84
161_T164_V0.9310.84
95_D197_D0.9260.84
72_F75_P0.9240.84
65_L70_V0.9240.84
148_A202_A0.9180.83
111_M302_Q0.9180.83
5_G80_G0.9180.83
269_V301_A0.9060.82
260_S263_T0.9010.82
278_G294_V0.8920.81
226_A230_R0.8830.81
100_G132_A0.8820.81
36_A275_D0.8800.81
186_A193_A0.8790.81
57_L278_G0.8780.80
133_D142_A0.8760.80
90_G99_S0.8750.80
26_P29_D0.8740.80
208_E213_G0.8720.80
155_V202_A0.8680.80
282_T286_I0.8660.80
90_G186_A0.8660.80
40_P45_A0.8620.79
111_M304_L0.8570.79
32_V297_L0.8560.79
101_L269_V0.8520.78
200_A204_Q0.8520.78
211_A216_P0.8520.78
31_A64_L0.8520.78
85_T90_G0.8500.78
59_T275_D0.8500.78
267_D271_D0.8480.78
91_T197_D0.8430.78
89_L99_S0.8390.77
248_T253_D0.8360.77
149_R154_S0.8280.76
23_T259_A0.8260.76
232_P237_F0.8250.76
9_E201_E0.8250.76
11_Y285_D0.8230.76
107_R201_E0.8230.76
143_A147_R0.8230.76
124_A243_T0.8220.76
234_A238_I0.8180.76
6_E106_E0.8170.75
283_P292_E0.8160.75
189_L261_E0.8150.75
112_L314_R0.8140.75
33_P36_A0.8120.75
163_D314_R0.8050.74
141_F196_A0.8040.74
85_T304_L0.7970.74
163_D272_A0.7970.74
210_R215_E0.7950.73
67_A71_V0.7950.73
51_W54_G0.7880.73
93_G280_R0.7820.72
223_A242_T0.7790.72
56_H276_A0.7710.71
5_G212_L0.7700.71
232_P236_A0.7650.71
182_A209_L0.7610.70
2_R90_G0.7600.70
75_P316_R0.7580.70
184_G198_A0.7560.70
2_R193_A0.7540.69
258_P261_E0.7530.69
173_V206_W0.7460.69
112_L163_D0.7450.68
111_M307_S0.7450.68
101_L297_L0.7400.68
86_G103_E0.7390.68
109_A161_T0.7370.68
171_V195_A0.7370.68
276_A298_V0.7290.67
57_L97_L0.7270.67
84_T304_L0.7250.66
167_P268_A0.7250.66
301_A314_R0.7250.66
161_T166_V0.7250.66
92_A95_D0.7240.66
234_A237_F0.7240.66
214_P217_A0.7190.66
90_G204_Q0.7170.66
100_G305_F0.7150.65
95_D299_P0.7140.65
202_A206_W0.7140.65
186_A189_L0.7140.65
68_P71_V0.7140.65
149_R176_E0.7120.65
282_T302_Q0.7110.65
103_E107_R0.7100.65
110_T113_A0.7050.64
145_A155_V0.7050.64
84_T174_H0.7040.64
9_E106_E0.7030.64
184_G202_A0.7010.64
103_E106_E0.7000.64
84_T220_E0.6990.64
85_T95_D0.6980.63
84_T108_D0.6980.63
6_E107_R0.6970.63
41_A316_R0.6960.63
313_E316_R0.6930.63
20_E23_T0.6920.63
236_A239_D0.6920.63
152_S176_E0.6920.63
33_P37_F0.6910.63
148_A151_E0.6860.62
70_V87_L0.6850.62
89_L197_D0.6840.62
5_G87_L0.6830.62
161_T165_D0.6820.62
211_A215_E0.6770.61
156_T174_H0.6770.61
101_L266_L0.6730.61
21_F64_L0.6730.61
70_V297_L0.6730.61
212_L216_P0.6720.61
112_L302_Q0.6710.60
84_T87_L0.6700.60
24_H27_D0.6690.60
12_S50_Q0.6680.60
27_D36_A0.6660.60
95_D200_A0.6650.60
5_G111_M0.6610.59
87_L281_L0.6600.59
108_D114_W0.6590.59
169_V172_A0.6580.59
28_H32_V0.6540.58
108_D163_D0.6540.58
163_D298_V0.6500.58
49_T79_S0.6500.58
71_V295_R0.6480.58
54_G63_A0.6470.58
86_G201_E0.6460.58
102_Y265_V0.6450.57
106_E201_E0.6410.57
146_R149_R0.6410.57
88_G294_V0.6410.57
37_F51_W0.6410.57
60_G151_E0.6400.57
31_A34_P0.6390.57
192_E244_V0.6380.57
259_A266_L0.6350.56
10_R14_G0.6350.56
183_V205_N0.6350.56
34_P280_R0.6350.56
118_F121_L0.6330.56
88_G280_R0.6320.56
60_G240_A0.6320.56
91_T204_Q0.6320.56
99_S186_A0.6310.56
108_D198_A0.6310.56
78_D81_H0.6260.55
256_T267_D0.6260.55
124_A133_D0.6240.55
84_T188_D0.6230.55
228_A231_P0.6210.55
123_L185_S0.6180.54
251_P271_D0.6170.54
2_R197_D0.6140.54
253_D256_T0.6140.54
100_G266_L0.6130.54
210_R214_P0.6130.54
270_A275_D0.6120.53
87_L202_A0.6120.53
18_T21_F0.6090.53
85_T107_R0.6080.53
149_R245_P0.6060.53
85_T186_A0.6040.53
172_A183_V0.6030.52
109_A168_V0.6010.52
95_D99_S0.6010.52
62_D277_Y0.6000.52
88_G106_E0.6000.52
99_S205_N0.6000.52
208_E211_A0.5990.52
221_S230_R0.5980.52
21_F24_H0.5960.52
5_G89_L0.5950.51
171_V175_R0.5950.51
110_T230_R0.5940.51
263_T271_D0.5930.51
61_T260_S0.5930.51
76_N246_V0.5910.51
112_L162_Q0.5900.51
51_W279_A0.5880.51
59_T92_A0.5850.50
211_A214_P0.5850.50
184_G201_E0.5840.50
115_Y302_Q0.5820.50
54_G62_D0.5820.50
8_L172_A0.5800.50
97_L100_G0.5780.49
98_L101_L0.5770.49
244_V249_V0.5750.49
3_A106_E0.5750.49
113_A120_P0.5720.49
14_G208_E0.5710.49
29_D271_D0.5700.48
145_A199_L0.5690.48
204_Q305_F0.5670.48
283_P291_F0.5670.48
34_P45_A0.5640.48
18_T57_L0.5630.48
277_Y300_A0.5630.48
12_S282_T0.5610.47
87_L312_G0.5600.47
57_L262_L0.5600.47
14_G205_N0.5600.47
215_E218_S0.5600.47
20_E24_H0.5600.47
161_T180_Q0.5580.47
232_P235_E0.5570.47
51_W282_T0.5560.47
194_A297_L0.5540.47
133_D235_E0.5530.46
286_I290_G0.5530.46
164_V168_V0.5520.46
142_A145_A0.5510.46
279_A297_L0.5510.46
106_E167_P0.5510.46
219_Q223_A0.5480.46
2_R200_A0.5470.46
147_R155_V0.5450.45
89_L291_F0.5450.45
158_L306_V0.5440.45
304_L308_E0.5440.45
188_D200_A0.5430.45
170_A175_R0.5420.45
226_A231_P0.5420.45
206_W210_R0.5410.45
143_A146_R0.5400.45
90_G106_E0.5390.45
23_T271_D0.5380.45
81_H295_R0.5380.45
133_D271_D0.5380.45
171_V199_L0.5360.44
121_L316_R0.5360.44
10_R114_W0.5350.44
99_S200_A0.5350.44
167_P291_F0.5340.44
56_H277_Y0.5330.44
91_T193_A0.5320.44
141_F192_E0.5320.44
171_V211_A0.5310.44
280_R292_E0.5310.44
160_C172_A0.5310.44
302_Q313_E0.5310.44
220_E226_A0.5300.44
99_S302_Q0.5290.44
87_L206_W0.5290.44
211_A217_A0.5270.43
197_D204_Q0.5270.43
189_L265_V0.5270.43
235_E243_T0.5260.43
269_V272_A0.5260.43
303_P307_S0.5260.43
146_R177_A0.5220.43
83_I185_S0.5210.43
14_G212_L0.5210.43
131_T246_V0.5200.43
243_T247_D0.5190.42
171_V202_A0.5160.42
57_L266_L0.5160.42
21_F225_G0.5160.42
191_A249_V0.5150.42
34_P40_P0.5140.42
182_A205_N0.5140.42
82_P85_T0.5130.42
84_T230_R0.5130.42
65_L261_E0.5130.42
186_A194_A0.5110.41
5_G114_W0.5100.41
14_G210_R0.5100.41
118_F160_C0.5100.41
197_D302_Q0.5090.41
312_G315_A0.5090.41
108_D184_G0.5080.41
109_A112_L0.5070.41
99_S148_A0.5060.41
248_T251_P0.5050.41
47_D77_P0.5050.41
247_D252_A0.5040.41
84_T114_W0.5040.41
175_R234_A0.5030.41
89_L205_N0.5030.41
189_L227_Y0.5030.41
175_R276_A0.5010.40
153_L202_A0.5010.40
26_P30_A0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4v1tA 2 0.9464 100 0.213 Contact Map
4q86A 3 0.9137 100 0.338 Contact Map
1tafA 2 0.1339 13.2 0.965 Contact Map
4wyqB 1 0.2232 10.2 0.966 Contact Map
4j56E 1 0.2798 9.4 0.967 Contact Map
2e5kA 1 0.2351 9 0.967 Contact Map
3s81A 2 0.4345 6.1 0.97 Contact Map
4dkkA 2 0.2946 6 0.97 Contact Map
3uoeA 2 0.2857 6 0.97 Contact Map
2iw1A 1 0.2738 5.7 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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