GREMLIN Database
Q9HPY7 - Uncharacterized protein
UniProt: Q9HPY7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (264)
Sequences: 107 (85)
Seq/√Len: 5.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_V70_V3.4910.83
58_A68_L2.9060.70
216_L219_D2.7030.64
34_F97_G2.5810.60
130_G267_A2.3940.54
221_S236_S2.3850.54
141_E172_G2.3040.51
29_T103_T2.2440.49
190_L205_I2.2060.48
227_V269_D2.1940.47
143_A190_L2.1880.47
92_N163_A2.1870.47
123_L140_A2.1740.47
22_L265_K2.1580.46
92_N165_D2.1140.45
129_V141_E2.0680.43
41_L163_A2.0400.42
34_F115_T2.0280.42
220_I262_L2.0140.41
210_A262_L1.9770.40
168_R184_D1.9450.39
218_Y236_S1.9210.39
127_R155_D1.8930.38
23_G29_T1.8840.37
220_I229_I1.8780.37
48_R79_D1.8290.36
51_V154_A1.7980.35
58_A70_V1.7820.34
31_E37_D1.7640.34
166_R187_L1.7590.34
82_D95_E1.7540.33
35_G155_D1.7440.33
56_E244_D1.7420.33
278_E282_V1.7240.33
203_V236_S1.7230.33
113_L144_Y1.7190.32
33_V41_L1.7160.32
76_T96_D1.7000.32
45_D68_L1.6970.32
123_L127_R1.6680.31
67_T179_V1.6660.31
60_D113_L1.6660.31
103_T125_T1.6650.31
239_K261_R1.6520.30
180_G212_K1.6460.30
176_N179_V1.6450.30
223_W230_A1.6330.30
78_K217_L1.6300.30
106_V135_D1.6280.30
45_D131_G1.6190.30
250_T261_R1.5660.28
233_A236_S1.5350.27
157_F172_G1.5320.27
126_G181_D1.4910.26
121_A229_I1.4910.26
200_L222_K1.4870.26
109_R131_G1.4860.26
186_V209_V1.4780.26
54_L246_G1.4570.25
126_G148_N1.4560.25
112_M130_G1.4410.25
230_A252_K1.4190.24
203_V221_S1.4170.24
89_T121_A1.4140.24
243_E252_K1.4080.24
190_L199_G1.4050.24
164_I168_R1.3720.23
20_N222_K1.3660.23
217_L220_I1.3660.23
92_N123_L1.3600.23
73_D227_V1.3570.23
164_I205_I1.3530.23
236_S243_E1.3460.23
75_R104_V1.3410.22
183_F210_A1.3400.22
260_P264_L1.3340.22
86_V180_G1.3320.22
177_A181_D1.3310.22
217_L257_V1.3280.22
157_F171_L1.3240.22
122_L176_N1.3150.22
207_L230_A1.3050.22
218_Y221_S1.3010.22
42_Y76_T1.2910.21
81_M164_I1.2860.21
257_V271_L1.2770.21
138_D152_A1.2660.21
81_M111_P1.2630.21
130_G139_L1.2470.20
30_L76_T1.2430.20
147_A247_L1.2380.20
33_V51_V1.2370.20
218_Y243_E1.2360.20
195_G242_L1.2250.20
180_G184_D1.2190.20
113_L150_D1.2190.20
31_E103_T1.2160.20
181_D283_A1.2050.20
28_D150_D1.1920.19
117_E244_D1.1900.19
80_V193_A1.1850.19
22_L79_D1.1790.19
80_V209_V1.1760.19
58_A64_P1.1730.19
66_P161_T1.1710.19
24_T155_D1.1540.18
35_G113_L1.1500.18
56_E117_E1.1500.18
103_T195_G1.1430.18
72_A200_L1.1420.18
156_E278_E1.1420.18
21_L28_D1.1380.18
169_E282_V1.1350.18
28_D214_R1.1330.18
83_D202_E1.1310.18
175_I222_K1.1250.18
200_L217_L1.1250.18
250_T260_P1.1200.18
160_R235_F1.1130.18
81_M249_D1.1120.18
64_P89_T1.1070.18
66_P234_T1.1040.17
51_V73_D1.0980.17
231_S234_T1.0920.17
126_G129_V1.0770.17
134_T202_E1.0720.17
31_E36_D1.0680.17
243_E256_D1.0680.17
128_F144_Y1.0600.17
149_T195_G1.0560.17
209_V232_K1.0550.17
23_G241_K1.0540.17
26_V29_T1.0470.16
144_Y148_N1.0460.16
46_P51_V1.0410.16
99_L171_L1.0360.16
40_E245_L1.0280.16
116_E177_A1.0240.16
123_L128_F1.0230.16
154_A249_D1.0220.16
60_D122_L1.0180.16
95_E137_D1.0170.16
22_L27_A1.0110.16
78_K240_T1.0110.16
161_T167_V1.0100.16
49_H103_T1.0100.16
112_M139_L1.0090.16
159_L167_V1.0030.16
207_L221_S1.0020.16
207_L236_S0.9970.16
121_A197_G0.9940.15
230_A236_S0.9880.15
94_V248_V0.9870.15
210_A220_I0.9860.15
130_G181_D0.9850.15
26_V122_L0.9830.15
243_E250_T0.9810.15
208_L236_S0.9810.15
221_S233_A0.9780.15
31_E113_L0.9750.15
226_D238_T0.9750.15
78_K221_S0.9720.15
31_E49_H0.9580.15
231_S237_R0.9570.15
114_V191_E0.9530.15
28_D31_E0.9490.15
163_A275_P0.9460.15
184_D213_N0.9460.15
67_T122_L0.9450.15
222_K232_K0.9450.15
199_G280_A0.9420.15
119_A228_G0.9410.15
25_T113_L0.9410.15
231_S250_T0.9400.15
34_F94_V0.9390.15
203_V243_E0.9380.15
239_K251_E0.9360.15
94_V163_A0.9350.14
206_S280_A0.9190.14
75_R79_D0.9160.14
176_N251_E0.9150.14
156_E198_E0.9090.14
172_G187_L0.9050.14
78_K203_V0.9000.14
217_L262_L0.8990.14
218_Y233_A0.8980.14
132_L283_A0.8970.14
25_T158_A0.8950.14
150_D153_A0.8930.14
257_V261_R0.8890.14
87_A99_L0.8880.14
52_E80_V0.8860.14
168_R216_L0.8850.14
80_V154_A0.8850.14
80_V122_L0.8720.13
170_T232_K0.8720.13
24_T49_H0.8680.13
102_R211_A0.8680.13
23_G95_E0.8660.13
203_V218_Y0.8630.13
28_D143_A0.8630.13
60_D188_A0.8600.13
207_L223_W0.8600.13
30_L42_Y0.8590.13
45_D108_N0.8580.13
110_S238_T0.8550.13
223_W252_K0.8540.13
201_D206_S0.8490.13
184_D222_K0.8460.13
27_A58_A0.8430.13
203_V233_A0.8420.13
161_T235_F0.8390.13
229_I248_V0.8390.13
164_I212_K0.8390.13
149_T196_D0.8380.13
56_E185_D0.8380.13
90_A192_T0.8360.13
47_S59_N0.8350.13
108_N113_L0.8260.13
63_T212_K0.8200.13
49_H284_E0.8190.13
78_K255_I0.8190.13
107_E115_T0.8130.13
34_F116_E0.8100.13
218_Y232_K0.8090.13
260_P263_R0.8080.13
66_P134_T0.8070.13
90_A194_R0.8060.13
208_L221_S0.8030.12
213_N256_D0.8000.12
27_A64_P0.7920.12
182_D202_E0.7890.12
88_S161_T0.7800.12
191_E272_E0.7780.12
55_V86_V0.7780.12
27_A138_D0.7780.12
131_G178_D0.7770.12
151_W177_A0.7770.12
252_K256_D0.7740.12
40_E149_T0.7730.12
53_A137_D0.7720.12
243_E251_E0.7700.12
150_D247_L0.7670.12
23_G191_E0.7650.12
54_L87_A0.7570.12
127_R145_D0.7550.12
249_D271_L0.7540.12
217_L230_A0.7530.12
205_I269_D0.7510.12
207_L220_I0.7490.12
80_V274_A0.7480.12
117_E121_A0.7470.12
259_R263_R0.7450.12
114_V266_L0.7420.12
239_K250_T0.7360.12
45_D284_E0.7360.12
161_T237_R0.7350.12
25_T28_D0.7340.11
201_D208_L0.7300.11
246_G264_L0.7300.11
174_D189_S0.7260.11
229_I265_K0.7230.11
30_L179_V0.7190.11
69_R277_P0.7170.11
233_A250_T0.7140.11
204_T238_T0.7070.11
43_V266_L0.7070.11
233_A251_E0.7050.11
25_T150_D0.7040.11
106_V178_D0.7030.11
201_D270_R0.7010.11
187_L196_D0.6980.11
106_V131_G0.6960.11
144_Y272_E0.6910.11
20_N129_V0.6880.11
104_V144_Y0.6880.11
231_S239_K0.6870.11
64_P97_G0.6850.11
28_D76_T0.6840.11
83_D208_L0.6830.11
197_G240_T0.6810.11
153_A198_E0.6800.11
61_Y98_S0.6760.11
45_D164_I0.6750.11
42_Y48_R0.6730.11
71_L155_D0.6720.11
39_D58_A0.6680.11
132_L183_F0.6680.11
185_D189_S0.6660.11
78_K236_S0.6650.11
113_L247_L0.6590.11
27_A276_A0.6590.11
48_R52_E0.6570.10
26_V43_V0.6530.10
255_I262_L0.6520.10
39_D97_G0.6500.10
224_G230_A0.6490.10
221_S243_E0.6490.10
112_M165_D0.6450.10
132_L262_L0.6440.10
249_D267_A0.6430.10
78_K218_Y0.6420.10
157_F180_G0.6380.10
48_R51_V0.6360.10
278_E283_A0.6330.10
258_G264_L0.6330.10
34_F117_E0.6330.10
81_M147_A0.6310.10
166_R271_L0.6270.10
92_N119_A0.6200.10
77_L206_S0.6190.10
26_V106_V0.6160.10
77_L183_F0.6150.10
197_G226_D0.6150.10
78_K220_I0.6140.10
150_D169_E0.6120.10
80_V86_V0.6110.10
133_A273_D0.6080.10
253_V264_L0.6050.10
28_D138_D0.6050.10
55_V182_D0.6040.10
114_V147_A0.6040.10
78_K224_G0.6040.10
253_V258_G0.6010.10
80_V125_T0.6000.10
254_P264_L0.5980.10
176_N248_V0.5980.10
198_E201_D0.5980.10
233_A243_E0.5980.10
93_L242_L0.5950.10
98_S276_A0.5930.10
42_Y248_V0.5930.10
130_G166_R0.5930.10
193_A206_S0.5890.10
77_L157_F0.5870.10
68_L174_D0.5860.10
160_R237_R0.5850.10
79_D108_N0.5830.10
225_E234_T0.5830.10
54_L90_A0.5810.10
97_G163_A0.5770.10
193_A199_G0.5760.10
80_V145_D0.5750.10
20_N195_G0.5740.10
76_T181_D0.5740.10
106_V137_D0.5720.09
160_R225_E0.5700.09
105_D227_V0.5700.09
85_I173_D0.5700.09
77_L132_L0.5660.09
95_E116_E0.5650.09
126_G189_S0.5610.09
94_V245_L0.5600.09
204_T280_A0.5590.09
131_G284_E0.5580.09
20_N25_T0.5570.09
24_T113_L0.5550.09
176_N241_K0.5520.09
68_L146_A0.5510.09
56_E267_A0.5510.09
35_G143_A0.5500.09
217_L236_S0.5490.09
151_W157_F0.5480.09
39_D142_T0.5470.09
60_D96_D0.5440.09
88_S220_I0.5410.09
31_E144_Y0.5410.09
70_V113_L0.5410.09
78_K207_L0.5400.09
52_E194_R0.5390.09
58_A146_A0.5390.09
161_T224_G0.5380.09
31_E227_V0.5350.09
34_F173_D0.5350.09
73_D248_V0.5330.09
97_G130_G0.5330.09
214_R275_P0.5320.09
261_R264_L0.5270.09
99_L219_D0.5250.09
148_N166_R0.5230.09
115_T140_A0.5220.09
70_V163_A0.5210.09
83_D161_T0.5190.09
42_Y181_D0.5180.09
87_A239_K0.5180.09
116_E178_D0.5170.09
168_R213_N0.5150.09
115_T156_E0.5150.09
62_D90_A0.5120.09
27_A71_L0.5120.09
22_L222_K0.5090.09
26_V32_G0.5070.09
20_N79_D0.5060.09
124_E188_A0.5030.09
142_T176_N0.5020.09
38_P213_N0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p4wA 2 0.3403 92.9 0.947 Contact Map
4g6qA 4 0.3542 88.8 0.952 Contact Map
2dqlA 2 0.3715 78 0.958 Contact Map
2eshA 2 0.3333 77.7 0.958 Contact Map
1yg2A 2 0.2743 74.5 0.959 Contact Map
3hhhA 2 0.3264 71.7 0.96 Contact Map
2zfwA 2 0.3576 70.4 0.961 Contact Map
3l09A 4 0.3403 68.4 0.961 Contact Map
2e1nA 2 0.3576 67.5 0.961 Contact Map
3r0aA 2 0.3819 66.6 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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