GREMLIN Database
GLYA - Serine hydroxymethyltransferase
UniProt: Q9HPY5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 415 (406)
Sequences: 4079 (1813)
Seq/√Len: 90.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_Q190_D4.3451.00
158_R191_A4.3071.00
74_E78_A3.3291.00
162_D191_A3.2871.00
107_T221_F3.0781.00
179_E213_A2.9791.00
289_E374_A2.9231.00
156_A159_E2.8621.00
150_G304_S2.8571.00
113_K139_E2.8411.00
80_A237_I2.8081.00
152_L157_L2.7711.00
224_G237_I2.7601.00
19_G71_D2.6861.00
146_D149_T2.6701.00
158_R162_D2.6421.00
158_R184_R2.5901.00
379_T403_T2.5851.00
331_V388_I2.5531.00
373_D376_A2.5401.00
386_R403_T2.5371.00
273_N277_D2.5181.00
28_L367_L2.4581.00
183_E187_A2.4041.00
159_E163_A2.3811.00
285_A289_E2.3431.00
286_Q373_D2.3171.00
160_H164_F2.3121.00
209_A284_A2.3091.00
113_K164_F2.2691.00
296_E300_E2.2351.00
16_A71_D2.2271.00
211_E288_V2.1631.00
89_V239_M2.1341.00
286_Q374_A2.1131.00
301_H382_D2.0581.00
178_R311_D2.0501.00
297_R381_A2.0491.00
372_F380_V2.0181.00
301_H385_A2.0151.00
198_A219_A2.0121.00
74_E77_V2.0051.00
157_L185_I1.9901.00
141_E164_F1.9871.00
303_F385_A1.9831.00
80_A224_G1.9801.00
297_R300_E1.9631.00
387_V400_V1.9611.00
383_C400_V1.9591.00
342_L362_I1.9421.00
367_L377_M1.9381.00
114_I140_V1.9081.00
177_P305_L1.8791.00
297_R378_E1.8771.00
45_Q264_N1.8771.00
16_A72_V1.8751.00
297_R382_D1.8731.00
108_L168_M1.7951.00
88_H240_C1.7721.00
78_A82_E1.7651.00
325_D352_R1.7531.00
240_C245_A1.7431.00
203_I212_H1.7391.00
390_N393_D1.6981.00
156_A160_H1.6701.00
113_K141_E1.6671.00
19_G68_Y1.6481.00
36_H413_Q1.6171.00
68_Y71_D1.6011.00
286_Q289_E1.5941.00
88_H249_D1.5911.00
376_A411_Y1.5791.00
293_V297_R1.5771.00
38_S274_E1.5741.00
97_S126_S1.5691.00
45_Q267_G1.5651.00
13_V72_V1.5621.00
171_S185_I1.5591.00
82_E276_L1.5581.00
320_R352_R1.5581.00
30_M367_L1.5551.00
185_I196_H1.5531.00
290_N368_T1.5501.00
294_L377_M1.5491.00
399_D403_T1.5251.00
291_A310_T1.5201.00
154_Y184_R1.5131.00
211_E284_A1.5131.00
379_T383_C1.5111.00
21_R25_N1.4981.00
294_L381_A1.4971.00
281_E285_A1.4841.00
220_D241_D1.4731.00
88_H245_A1.4610.99
104_Y170_V1.4590.99
245_A249_D1.4540.99
385_A389_D1.4520.99
211_E285_A1.4420.99
375_D378_E1.4320.99
337_D397_Y1.4320.99
120_T346_T1.4180.99
101_M133_F1.4080.99
83_L275_A1.4080.99
13_V270_V1.4010.99
22_H26_D1.4000.99
295_G315_V1.3920.99
334_E391_L1.3730.99
49_L72_V1.3640.99
86_A216_V1.3490.99
87_D241_D1.3330.99
168_M197_M1.3320.99
297_R301_H1.3320.99
304_S318_D1.3130.99
16_A68_Y1.3110.99
27_T336_E1.3110.99
338_V387_V1.3070.99
304_S321_E1.3020.99
282_E285_A1.2990.99
214_S217_G1.2930.99
107_T244_F1.2910.99
203_I312_T1.2890.99
15_D19_G1.2880.99
80_A272_F1.2740.99
212_H312_T1.2710.99
146_D153_D1.2700.99
89_V237_I1.2560.98
383_C403_T1.2560.98
339_G405_A1.2530.98
294_L298_L1.2500.98
140_V170_V1.2500.98
396_V400_V1.2490.98
372_F377_M1.2450.98
224_G272_F1.2450.98
200_I239_M1.2440.98
303_F322_S1.2440.98
108_L112_D1.2390.98
54_A262_M1.2300.98
244_F247_D1.2200.98
322_S389_D1.2200.98
59_G74_E1.2080.98
103_V221_F1.2070.98
147_A349_D1.2030.98
296_E378_E1.1940.98
210_G281_E1.1930.98
141_E160_H1.1920.98
338_V400_V1.1900.98
320_R351_T1.1850.98
102_G252_V1.1840.98
109_A112_D1.1840.98
49_L69_A1.1800.98
387_V397_Y1.1800.98
295_G305_L1.1760.98
27_T339_G1.1690.98
367_L380_V1.1550.97
197_M223_T1.1550.97
301_H386_R1.1530.97
346_T350_E1.1510.97
26_D405_A1.1510.97
112_D167_D1.1460.97
182_W212_H1.1380.97
145_V349_D1.1370.97
9_V273_N1.1360.97
14_A18_T1.1360.97
171_S198_A1.1230.97
29_A341_V1.1200.97
76_A269_A1.1150.97
293_V378_E1.1140.97
155_E184_R1.1130.97
146_D156_A1.1110.97
379_T410_Q1.1070.97
184_R187_A1.1060.97
158_R187_A1.1010.96
37_V42_M1.1000.96
64_G332_E1.0930.96
326_I388_I1.0890.96
299_Q308_G1.0860.96
301_H378_E1.0850.96
195_L244_F1.0820.96
220_D244_F1.0810.96
382_D386_R1.0780.96
109_A167_D1.0780.96
107_T195_L1.0770.96
342_L360_I1.0750.96
7_R14_A1.0740.96
292_A296_E1.0640.96
220_D242_E1.0590.96
21_R48_E1.0540.95
190_D220_D1.0500.95
379_T382_D1.0460.95
298_L385_A1.0410.95
337_D394_E1.0400.95
386_R399_D1.0400.95
117_L144_E1.0400.95
69_A262_M1.0390.95
173_F180_V1.0370.95
339_G401_A1.0290.95
13_V16_A1.0280.95
171_S196_H1.0270.95
86_A239_M1.0250.95
200_I207_V1.0230.95
87_D242_E1.0190.94
28_L372_F1.0110.94
154_Y157_L1.0080.94
383_C407_L1.0080.94
116_S126_S1.0070.94
179_E212_H1.0060.94
376_A407_L0.9980.94
54_A66_C0.9970.94
334_E387_V0.9960.94
118_D142_Q0.9950.94
304_S308_G0.9900.94
186_Q220_D0.9880.94
352_R356_D0.9880.94
88_H248_I0.9840.93
289_E373_D0.9840.93
301_H389_D0.9790.93
101_M256_A0.9740.93
183_E218_V0.9690.93
402_D406_D0.9690.93
88_H241_D0.9670.93
108_L114_I0.9670.93
116_S142_Q0.9630.93
175_A316_L0.9620.93
109_A136_Q0.9590.92
154_Y185_I0.9580.92
106_A251_A0.9570.92
338_V397_Y0.9560.92
405_A409_E0.9550.92
335_L342_L0.9530.92
398_A402_D0.9530.92
118_D121_H0.9500.92
139_E164_F0.9490.92
327_S352_R0.9470.92
115_L141_E0.9460.92
241_D244_F0.9450.92
233_G267_G0.9450.92
10_D79_R0.9420.92
386_R396_V0.9350.92
252_V256_A0.9340.91
296_E299_Q0.9340.91
315_V362_I0.9300.91
173_F203_I0.9290.91
291_A365_P0.9290.91
87_D240_C0.9260.91
173_F312_T0.9260.91
396_V399_D0.9190.91
85_G210_G0.9180.91
13_V49_L0.9120.90
231_R369_T0.9110.90
305_L315_V0.9080.90
333_G337_D0.9030.90
18_T21_R0.9010.90
12_E273_N0.8990.90
195_L221_F0.8990.90
373_D411_Y0.8980.90
304_S347_V0.8960.90
146_D349_D0.8960.90
104_Y114_I0.8910.89
338_V383_C0.8900.89
11_P14_A0.8900.89
105_F138_Y0.8900.89
376_A410_Q0.8890.89
44_A270_V0.8880.89
223_T238_V0.8870.89
76_A91_V0.8850.89
161_A169_I0.8840.89
322_S385_A0.8830.89
162_D192_V0.8820.89
284_A287_V0.8810.89
12_E15_D0.8800.89
237_I272_F0.8790.89
273_N276_L0.8770.89
98_S101_M0.8760.89
11_P15_D0.8740.89
162_D165_E0.8730.88
303_F317_V0.8720.88
178_R309_G0.8710.88
41_V271_G0.8710.88
386_R400_V0.8700.88
221_F244_F0.8700.88
379_T406_D0.8660.88
17_L44_A0.8610.88
330_D392_G0.8570.88
291_A315_V0.8560.87
316_L345_N0.8550.87
180_V185_I0.8530.87
372_F407_L0.8520.87
391_L397_Y0.8510.87
16_A19_G0.8460.87
53_Y227_H0.8460.87
401_A405_A0.8440.87
402_D405_A0.8420.87
133_F137_L0.8420.87
39_E43_E0.8390.86
327_S330_D0.8360.86
183_E186_Q0.8340.86
160_H163_A0.8330.86
26_D409_E0.8310.86
299_Q305_L0.8290.86
300_E378_E0.8280.86
293_V374_A0.8250.85
330_D334_E0.8230.85
390_N397_Y0.8200.85
104_Y140_V0.8190.85
13_V75_L0.8170.85
152_L180_V0.8160.85
118_D144_E0.8140.85
169_I185_I0.8070.84
13_V273_N0.8060.84
80_A239_M0.8060.84
94_H98_S0.8030.84
171_S200_I0.8000.84
121_H147_A0.8000.84
159_E162_D0.7980.84
147_A150_G0.7960.83
78_A81_K0.7950.83
177_P315_V0.7920.83
372_F411_Y0.7890.83
17_L49_L0.7850.83
400_V403_T0.7830.82
71_D74_E0.7790.82
282_E286_Q0.7760.82
171_S219_A0.7740.82
103_V197_M0.7700.81
9_V40_A0.7690.81
240_C248_I0.7670.81
157_L188_A0.7660.81
120_T350_E0.7660.81
63_Y227_H0.7650.81
231_R283_Y0.7650.81
284_A365_P0.7600.80
130_P140_V0.7600.80
372_F376_A0.7600.80
103_V108_L0.7580.80
240_C249_D0.7580.80
275_A280_F0.7570.80
390_N396_V0.7430.79
381_A385_A0.7420.79
6_V17_L0.7410.79
350_E353_S0.7390.79
203_I207_V0.7380.78
53_Y63_Y0.7350.78
97_S252_V0.7330.78
387_V396_V0.7320.78
26_D339_G0.7310.78
80_A89_V0.7300.78
6_V43_E0.7300.78
86_A222_V0.7300.78
319_L322_S0.7300.78
217_G222_V0.7300.78
186_Q196_H0.7290.78
77_V81_K0.7260.77
103_V223_T0.7260.77
81_K89_V0.7250.77
108_L197_M0.7240.77
216_V222_V0.7240.77
243_A247_D0.7190.77
394_E398_A0.7180.77
298_L381_A0.7180.77
403_T406_D0.7180.77
406_D410_Q0.7180.77
117_L180_V0.7150.76
334_E397_Y0.7150.76
332_E336_E0.7140.76
280_F287_V0.7070.75
11_P40_A0.7030.75
233_G271_G0.7020.75
183_E217_G0.7020.75
196_H219_A0.7010.75
387_V391_L0.7010.75
301_H381_A0.7000.75
94_H261_L0.7000.75
209_A285_A0.6970.74
288_V292_A0.6960.74
110_P137_L0.6960.74
297_R385_A0.6930.74
9_V277_D0.6910.74
105_F251_A0.6910.74
294_L362_I0.6900.74
397_Y401_A0.6900.74
397_Y400_V0.6890.74
115_L161_A0.6880.73
329_G355_F0.6880.73
115_L164_F0.6870.73
72_V262_M0.6850.73
378_E382_D0.6840.73
280_F284_A0.6830.73
87_D244_F0.6820.73
364_T377_M0.6820.73
115_L142_Q0.6800.73
105_F256_A0.6790.72
80_A84_F0.6780.72
170_V197_M0.6770.72
182_W203_I0.6770.72
204_T229_T0.6740.72
115_L140_V0.6740.72
288_V364_T0.6730.72
334_E390_N0.6710.72
157_L160_H0.6710.72
179_E214_S0.6700.71
247_D250_S0.6690.71
86_A214_S0.6690.71
200_I208_A0.6670.71
375_D411_Y0.6670.71
330_D352_R0.6660.71
189_A196_H0.6660.71
153_D156_A0.6630.71
240_C244_F0.6620.71
334_E337_D0.6610.70
157_L171_S0.6580.70
42_M51_N0.6570.70
114_I168_M0.6570.70
130_P355_F0.6550.70
306_V319_L0.6530.70
207_V212_H0.6530.70
133_F138_Y0.6520.69
315_V364_T0.6520.69
399_D406_D0.6510.69
330_D391_L0.6510.69
406_D409_E0.6500.69
206_L288_V0.6470.69
293_V296_E0.6460.69
399_D402_D0.6460.69
36_H366_A0.6440.68
155_E159_E0.6440.68
336_E339_G0.6430.68
104_Y168_M0.6420.68
81_K86_A0.6420.68
22_H25_N0.6420.68
25_N413_Q0.6410.68
327_S356_D0.6400.68
77_V249_D0.6370.68
241_D245_A0.6370.68
27_T408_C0.6360.68
319_L325_D0.6360.68
131_A250_S0.6360.68
61_R70_D0.6340.67
334_E338_V0.6310.67
305_L317_V0.6280.67
53_Y259_G0.6280.67
394_E397_Y0.6260.66
116_S140_V0.6250.66
326_I330_D0.6250.66
107_T168_M0.6250.66
117_L154_Y0.6230.66
189_A194_A0.6230.66
177_P314_L0.6210.66
156_A164_F0.6200.66
14_A43_E0.6190.65
284_A288_V0.6190.65
242_E246_D0.6190.65
232_A271_G0.6180.65
19_G22_H0.6170.65
244_F248_I0.6160.65
217_G241_D0.6160.65
34_E53_Y0.6140.65
362_I384_I0.6130.65
382_D403_T0.6090.64
67_E336_E0.6090.64
86_A241_D0.6090.64
182_W207_V0.6090.64
317_V342_L0.6090.64
82_E85_G0.6070.64
333_G336_E0.6070.64
231_R274_E0.6050.64
383_C386_R0.6050.64
346_T353_S0.6040.64
113_K160_H0.6040.64
93_P252_V0.6030.63
286_Q368_T0.6020.63
6_V40_A0.5990.63
383_C387_V0.5980.63
274_E283_Y0.5980.63
279_A282_E0.5980.63
171_S180_V0.5980.63
37_V41_V0.5980.63
137_L251_A0.5970.63
187_A191_A0.5960.63
298_L305_L0.5950.62
155_E191_A0.5920.62
88_H242_E0.5910.62
158_R188_A0.5910.62
209_A281_E0.5900.62
390_N394_E0.5890.62
12_E82_E0.5890.62
97_S132_N0.5890.62
336_E341_V0.5890.62
177_P307_S0.5890.62
251_A256_A0.5880.61
75_L273_N0.5870.61
353_S356_D0.5870.61
155_E158_R0.5860.61
303_F389_D0.5860.61
293_V377_M0.5850.61
216_V239_M0.5850.61
121_H144_E0.5840.61
319_L347_V0.5840.61
289_E292_A0.5830.61
101_M132_N0.5820.61
105_F133_F0.5810.61
271_G275_A0.5810.61
109_A139_E0.5800.60
299_Q304_S0.5790.60
367_L372_F0.5790.60
398_A401_A0.5790.60
97_S104_Y0.5760.60
87_D245_A0.5760.60
268_K272_F0.5760.60
297_R377_M0.5760.60
100_N223_T0.5760.60
246_D250_S0.5750.60
207_V312_T0.5740.60
233_G264_N0.5730.60
76_A272_F0.5720.59
74_E262_M0.5720.59
154_Y180_V0.5690.59
303_F384_I0.5670.59
183_E190_D0.5650.58
103_V168_M0.5640.58
370_R412_P0.5640.58
326_I331_V0.5630.58
335_L360_I0.5620.58
16_A49_L0.5610.58
375_D382_D0.5600.58
288_V291_A0.5600.58
45_Q263_H0.5600.58
94_H97_S0.5590.58
335_L384_I0.5580.58
37_V50_T0.5560.57
220_D245_A0.5550.57
277_D282_E0.5550.57
97_S101_M0.5540.57
101_M105_F0.5530.57
62_Y131_A0.5510.57
17_L48_E0.5510.57
55_E61_R0.5490.56
198_A203_I0.5490.56
37_V267_G0.5490.56
83_L272_F0.5490.56
242_E245_A0.5480.56
68_Y72_V0.5480.56
287_V364_T0.5470.56
292_A311_D0.5460.56
101_M137_L0.5450.56
42_M48_E0.5450.56
181_E184_R0.5440.56
142_Q160_H0.5440.56
13_V68_Y0.5420.55
377_M380_V0.5400.55
327_S357_P0.5400.55
75_L79_R0.5380.55
346_T355_F0.5370.55
318_D321_E0.5360.55
105_F137_L0.5340.54
150_G347_V0.5340.54
105_F136_Q0.5330.54
261_L264_N0.5330.54
146_D151_R0.5330.54
322_S325_D0.5330.54
27_T67_E0.5330.54
395_S398_A0.5320.54
174_S201_A0.5290.54
272_F276_L0.5280.53
64_G341_V0.5280.53
376_A379_T0.5280.53
262_M265_I0.5250.53
376_A380_V0.5240.53
226_T237_I0.5230.53
108_L167_D0.5220.53
60_S355_F0.5220.53
94_H268_K0.5210.52
29_A366_A0.5210.52
79_R270_V0.5200.52
121_H349_D0.5200.52
275_A284_A0.5190.52
83_L276_L0.5190.52
209_A214_S0.5180.52
150_G303_F0.5180.52
179_E288_V0.5170.52
66_C268_K0.5150.52
17_L47_S0.5150.52
169_I188_A0.5130.51
151_R178_R0.5130.51
101_M138_Y0.5120.51
66_C261_L0.5120.51
12_E71_D0.5110.51
278_P282_E0.5110.51
372_F408_C0.5110.51
46_S50_T0.5090.51
211_E281_E0.5090.51
34_E227_H0.5080.51
45_Q48_E0.5080.51
332_E342_L0.5070.51
350_E355_F0.5070.51
226_T235_G0.5060.50
84_F204_T0.5060.50
204_T224_G0.5050.50
114_I167_D0.5040.50
402_D409_E0.5040.50
161_A188_A0.5040.50
298_L362_I0.5030.50
240_C247_D0.5030.50
64_G336_E0.5030.50
126_S140_V0.5020.50
98_S261_L0.5020.50
289_E293_V0.5020.50
201_A223_T0.5010.50
287_V291_A0.5010.50
35_N283_Y0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rv3A 3 0.9928 100 0.45 Contact Map
3ou5A 2 0.9108 100 0.482 Contact Map
3h7fA 2 0.9928 100 0.573 Contact Map
4wxgA 2 0.9831 100 0.588 Contact Map
3n0lA 2 0.9542 100 0.618 Contact Map
3ecdA 2 0.9157 100 0.621 Contact Map
3gbxA 2 0.9229 100 0.626 Contact Map
2dkjA 2 0.9663 100 0.634 Contact Map
4msoA 2 0.9301 100 0.645 Contact Map
2vi8A 2 0.9759 100 0.645 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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