GREMLIN Database
FOLD - Bifunctional protein FolD
UniProt: Q9HPY4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (278)
Sequences: 4766 (2939)
Seq/√Len: 176.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_A287_S4.0611.00
149_A180_K3.4931.00
82_A111_A3.1931.00
91_H289_Q3.1411.00
159_E204_R3.1281.00
252_D255_S3.0611.00
74_A107_R2.9921.00
197_D200_A2.8841.00
80_T83_E2.6571.00
13_Q150_H2.6501.00
159_E201_H2.6181.00
163_V218_I2.5301.00
6_D9_A2.5271.00
33_R64_E2.4011.00
78_F111_A2.3361.00
156_D185_N2.2301.00
30_V91_H2.2171.00
212_C217_L2.2091.00
225_G259_A2.1451.00
216_E252_D2.1071.00
55_D275_R2.1051.00
66_V80_T2.0991.00
208_V223_L2.0951.00
72_A77_L2.0651.00
82_A86_A2.0541.00
15_R58_E2.0511.00
237_V245_Y2.0221.00
220_G255_S2.0121.00
121_F168_I1.9631.00
174_A190_I1.9251.00
219_D222_M1.8911.00
26_E31_T1.8711.00
228_V261_S1.8651.00
146_K149_A1.8601.00
160_V177_L1.8551.00
136_F285_A1.8521.00
223_L256_A1.8381.00
95_V108_V1.8261.00
4_I253_Y1.8231.00
155_P207_V1.8001.00
145_Q180_K1.7861.00
253_Y263_I1.7781.00
33_R62_A1.7711.00
202_T208_V1.7271.00
41_D46_E1.7241.00
47_T247_L1.7171.00
237_V246_E1.6831.00
156_D194_H1.6691.00
19_T23_E1.6631.00
199_A203_R1.6411.00
146_K280_Y1.6331.00
18_L283_L1.6241.00
201_H204_R1.5821.00
59_V279_L1.5801.00
206_D224_S1.5521.00
10_V151_Q1.5471.00
130_V175_N1.5111.00
137_K176_L1.4951.00
219_D252_D1.4861.00
158_A196_D1.4821.00
251_V256_A1.4711.00
178_A190_I1.4681.00
239_A246_E1.4611.00
38_L46_E1.4421.00
229_V251_V1.4401.00
208_V218_I1.4341.00
146_K277_M1.4161.00
146_K150_H1.4061.00
162_V173_L1.4021.00
68_I72_A1.3961.00
202_T222_M1.3941.00
15_R55_D1.3911.00
284_A288_E1.3751.00
154_D158_A1.3541.00
161_V191_C1.3411.00
74_A78_F1.3401.00
74_A104_P1.3401.00
18_L59_V1.3341.00
64_E90_V1.3231.00
17_D150_H1.3211.00
200_A204_R1.3131.00
47_T51_M1.3101.00
3_E262_A1.2951.00
142_H280_Y1.2951.00
219_D255_S1.2911.00
68_I80_T1.2841.00
220_G259_A1.2811.00
254_D257_E1.2781.00
165_R185_N1.2751.00
220_G256_A1.2741.00
142_H284_A1.2741.00
62_A90_V1.2651.00
41_D70_P1.2611.00
191_C201_H1.2511.00
20_G23_E1.2491.00
10_V150_H1.2471.00
73_S76_T1.2291.00
24_T28_A1.2271.00
153_V262_A1.2241.00
165_R193_S1.2241.00
224_S227_P1.2141.00
5_I151_Q1.2111.00
14_L18_L1.2091.00
216_E248_V1.2061.00
161_V205_A1.1991.00
22_V61_I1.1961.00
53_Q57_E1.1921.00
191_C195_T1.1911.00
191_C198_L1.1861.00
239_A245_Y1.1791.00
35_A66_V1.1681.00
97_D109_L1.1671.00
53_Q65_D1.1551.00
8_D12_A1.1521.00
71_E76_T1.1451.00
223_L227_P1.1421.00
104_P107_R1.1381.00
50_S54_Q1.1251.00
203_R259_A1.1171.00
126_V130_V1.1071.00
161_V201_H1.1071.00
64_E87_R1.1061.00
35_A90_V1.1041.00
38_L67_R1.1001.00
185_N194_H1.1001.00
216_E254_D1.0991.00
61_I283_L1.0981.00
62_A89_D1.0951.00
12_A16_A1.0871.00
24_T27_T1.0791.00
74_A103_V1.0771.00
16_A19_T1.0731.00
199_A222_M1.0671.00
16_A20_G1.0531.00
212_C235_N1.0521.00
35_A84_L1.0501.00
23_E27_T1.0501.00
214_V217_L1.0380.99
237_V248_V1.0150.99
5_I10_V1.0100.99
46_E67_R1.0100.99
143_G273_M1.0090.99
158_A207_V1.0080.99
9_A13_Q1.0070.99
256_A263_I1.0050.99
199_A221_D1.0050.99
41_D67_R0.9980.99
30_V286_A0.9820.99
128_K133_T0.9800.99
75_D79_D0.9790.99
5_I262_A0.9750.99
37_V84_L0.9700.99
160_V186_A0.9650.99
31_T62_A0.9630.99
20_G24_T0.9570.99
238_D245_Y0.9560.99
187_T195_T0.9540.99
215_P237_V0.9450.99
56_C279_L0.9430.99
110_S123_P0.9390.99
56_C61_I0.9370.99
78_F107_R0.9350.99
55_D59_V0.9330.99
142_H146_K0.9320.99
49_V96_Q0.9280.99
85_N113_D0.9230.99
14_L276_A0.9210.99
79_D83_E0.9200.99
46_E50_S0.9190.99
55_D279_L0.9130.99
193_S212_C0.9130.99
57_E62_A0.9120.99
148_L151_Q0.9110.99
144_V232_V0.9050.99
163_V212_C0.9020.99
255_S258_A0.9010.99
151_Q262_A0.8990.99
171_K178_A0.8970.99
78_F82_A0.8940.98
66_V83_E0.8840.98
15_R276_A0.8790.98
189_T201_H0.8760.98
76_T79_D0.8750.98
103_V108_V0.8720.98
18_L276_A0.8700.98
272_P275_R0.8700.98
83_E87_R0.8690.98
155_P186_A0.8680.98
134_P284_A0.8660.98
163_V208_V0.8640.98
91_H286_A0.8610.98
33_R90_V0.8600.98
34_L118_V0.8570.98
137_K142_H0.8560.98
10_V13_Q0.8520.98
21_A283_L0.8520.98
10_V147_L0.8500.98
147_L273_M0.8480.98
17_D280_Y0.8460.98
132_G171_K0.8430.98
8_D268_G0.8420.98
36_T63_A0.8350.98
84_L93_I0.8340.98
25_L29_G0.8330.98
218_I222_M0.8300.98
185_N192_H0.8290.98
14_L277_M0.8250.97
185_N193_S0.8240.97
167_N171_K0.8240.97
145_Q155_P0.8240.97
147_L264_T0.8230.97
253_Y257_E0.8210.97
139_C277_M0.8200.97
78_F108_V0.8180.97
54_Q58_E0.8180.97
228_V262_A0.8180.97
53_Q67_R0.8130.97
210_A235_N0.8040.97
145_Q149_A0.8020.97
72_A80_T0.8010.97
51_M54_Q0.8010.97
95_V112_V0.7980.97
124_E128_K0.7910.97
129_L137_K0.7840.97
199_A202_T0.7820.96
66_V84_L0.7820.96
35_A64_E0.7800.96
159_E196_D0.7800.96
215_P234_I0.7720.96
285_A289_Q0.7710.96
13_Q17_D0.7650.96
256_A259_A0.7640.96
5_I230_I0.7610.96
200_A203_R0.7600.96
163_V210_A0.7540.96
210_A251_V0.7520.96
122_H125_N0.7500.96
216_E237_V0.7490.96
209_V232_V0.7470.95
159_E189_T0.7440.95
106_E133_T0.7430.95
142_H277_M0.7400.95
17_D20_G0.7380.95
18_L22_V0.7370.95
145_Q160_V0.7340.95
226_D260_A0.7290.95
12_A58_E0.7180.94
235_N248_V0.7140.94
215_P248_V0.7120.94
144_V230_I0.7070.94
77_L108_V0.7060.94
22_V25_L0.7060.94
61_I279_L0.7060.94
78_F103_V0.7040.94
47_T234_I0.7020.94
236_R247_L0.7010.94
25_L30_V0.6960.93
81_V108_V0.6940.93
17_D146_K0.6940.93
162_V188_V0.6930.93
77_L103_V0.6910.93
51_M275_R0.6860.93
124_E135_R0.6850.93
69_D72_A0.6850.93
36_T53_Q0.6830.93
11_A15_R0.6770.92
23_E26_E0.6730.92
39_M77_L0.6730.92
165_R192_H0.6710.92
21_A280_Y0.6710.92
84_L90_V0.6700.92
227_P261_S0.6690.92
110_S128_K0.6630.92
52_K96_Q0.6620.92
156_D196_D0.6620.92
88_E289_Q0.6600.91
13_Q16_A0.6590.91
106_E110_S0.6580.91
93_I112_V0.6560.91
277_M280_Y0.6470.91
26_E30_V0.6460.91
17_D21_A0.6460.91
47_T50_S0.6450.91
280_Y284_A0.6450.91
214_V219_D0.6450.91
160_V173_L0.6430.90
18_L21_A0.6430.90
114_P122_H0.6410.90
51_M234_I0.6410.90
218_I223_L0.6400.90
162_V177_L0.6380.90
210_A218_I0.6350.90
148_L153_V0.6330.90
25_L286_A0.6330.90
56_C63_A0.6320.90
229_V256_A0.6310.90
173_L209_V0.6300.89
37_V80_T0.6290.89
25_L283_L0.6270.89
97_D121_F0.6250.89
254_D258_A0.6240.89
97_D105_D0.6240.89
47_T236_R0.6230.89
141_P173_L0.6230.89
10_V146_K0.6230.89
76_T80_T0.6210.89
44_A236_R0.6200.89
231_D249_G0.6190.89
175_N178_A0.6180.89
226_D261_S0.6170.88
147_L272_P0.6150.88
153_V228_V0.6130.88
81_V85_N0.6130.88
161_V202_T0.6110.88
227_P260_A0.6100.88
153_V207_V0.6060.88
22_V29_G0.6020.87
7_G11_A0.6010.87
72_A103_V0.6010.87
49_V52_K0.6000.87
107_R111_A0.6000.87
177_L209_V0.5990.87
53_Q63_A0.5980.87
77_L99_T0.5960.87
123_P126_V0.5950.87
110_S133_T0.5930.86
54_Q57_E0.5930.86
187_T191_C0.5930.86
123_P131_G0.5910.86
6_D268_G0.5900.86
22_V26_E0.5890.86
25_L31_T0.5890.86
199_A219_D0.5890.86
165_R194_H0.5860.86
118_V285_A0.5860.86
166_S266_V0.5860.86
22_V59_V0.5850.86
193_S214_V0.5840.86
156_D193_S0.5830.86
64_E89_D0.5830.86
9_A12_A0.5790.85
208_V229_V0.5780.85
52_K272_P0.5780.85
3_E151_Q0.5770.85
223_L260_A0.5760.85
155_P180_K0.5760.85
115_A289_Q0.5740.85
230_I270_V0.5740.85
12_A15_R0.5740.85
19_T58_E0.5730.85
36_T65_D0.5730.85
14_L280_Y0.5720.84
79_D82_A0.5720.84
163_V202_T0.5700.84
279_L282_T0.5690.84
161_V208_V0.5660.84
148_L155_P0.5660.84
164_G233_G0.5650.84
43_Q47_T0.5650.84
15_R59_V0.5620.83
38_L49_V0.5620.83
21_A24_T0.5610.83
178_A192_H0.5580.83
57_E61_I0.5570.83
169_V173_L0.5560.83
257_E263_I0.5550.83
5_I150_H0.5550.83
132_G179_Q0.5520.82
39_M99_T0.5500.82
96_Q275_R0.5470.82
158_A228_V0.5450.82
215_P235_N0.5430.81
251_V263_I0.5430.81
45_S96_Q0.5420.81
203_R221_D0.5420.81
193_S217_L0.5400.81
126_V131_G0.5400.81
125_N135_R0.5400.81
118_V282_T0.5390.81
22_V283_L0.5390.81
16_A58_E0.5370.81
14_L146_K0.5360.80
171_K179_Q0.5350.80
115_A288_E0.5310.80
121_F126_V0.5280.79
147_L270_V0.5270.79
37_V81_V0.5260.79
86_A113_D0.5250.79
234_I266_V0.5250.79
131_G167_N0.5210.79
28_A86_A0.5200.78
33_R89_D0.5190.78
114_P124_E0.5180.78
66_V72_A0.5170.78
220_G258_A0.5170.78
234_I247_L0.5160.78
78_F85_N0.5140.78
7_G272_P0.5120.77
43_Q236_R0.5110.77
36_T52_K0.5110.77
35_A65_D0.5110.77
26_E29_G0.5110.77
202_T218_I0.5100.77
129_L134_P0.5090.77
115_A128_K0.5080.77
202_T223_L0.5080.77
151_Q228_V0.5070.77
37_V66_V0.5050.76
225_G261_S0.5050.76
153_V158_A0.5040.76
231_D267_P0.5040.76
128_K131_G0.5030.76
55_D58_E0.5030.76
129_L135_R0.5020.76
234_I237_V0.5020.76
52_K275_R0.5000.76
99_T103_V0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cjxA 2 0.9697 100 0.299 Contact Map
3l07A 2 0.9461 100 0.307 Contact Map
4a5oA 2 0.9495 100 0.314 Contact Map
2c2xA 2 0.9428 100 0.314 Contact Map
4a26A 2 0.9731 100 0.318 Contact Map
1b0aA 2 0.963 100 0.321 Contact Map
3p2oA 2 0.9428 100 0.331 Contact Map
4b4uA 2 0.9461 100 0.337 Contact Map
1a4iA 2 0.9663 100 0.351 Contact Map
1edzA 2 0.9057 100 0.431 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0098 seconds.